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Evolution of neuronal cell types, development and circuitry in the insect visual system: breaking down behavioural evolution into its constituent elements

Descrizione del progetto

Approfondimenti sull’evoluzione dei comportamenti

In che modo evolvono i meccanismi responsabili dello sviluppo neuronale, e quali effetti hanno sulla varietà dei neuroni? Questa è una delle domande fondamentali a cui il progetto BehaEvoDevo, finanziato dall’UE, cercherà di rispondere. Il progetto indagherà l’evoluzione e lo sviluppo del comportamento utilizzando come modello il sistema visivo degli insetti, in particolare quello della Drosophila. Il lavoro svolto nell’ambito di BehaEvoDevo offrirà la prima valutazione completa dei meccanismi che guidano l’evoluzione di nuovi comportamenti degli insetti. Inoltre, fornirà un modello che la comunità potrà utilizzare per confrontare i propri dati in diversi cladi dell’albero filogenetico e compararli a varie modalità sensoriali.

Obiettivo

One of the holy grails of neuroscience is to understand how complex behaviours arise. However, surprisingly little is known about how behaviours evolve. My proposal will delve into Behavioural Evolution and Development (BehaEvoDevo) in an unbiased and comprehensive way using the insect visual system as a model. The visual system of Drosophila has been described extensively in terms of cell type composition, development, circuitry, and behaviour. My expertise in this system will be the springboard to address four fundamental questions: 1) How different is the cell type composition in the brains of different animals? 2) How do the mechanisms that are responsible for neuronal development evolve and how do they affect neuronal diversity? 3) What are the differences in the circuitry that underlies specific behaviours in different animals? 4) How do differences in neuronal composition, neuronal features, or circuitry drive different behaviours? I will combine cutting edge techniques, such as single-cell sequencing, with advanced genetic tools in Drosophila, and adapt innovative tools for genetic manipulation and circuit function in different non-model insects. I will compare how cell type composition, neuronal specification and differentiation, as well as circuitry, affect specific behaviours. I will examine phylogenetically diverse insects to generate a deep understanding of the mechanisms that are most important for the evolution of different behaviours. Moreover, I will identify fundamental principles about how developmental processes, such as neuronal specification and differentiation, evolve to control different behaviours. The cumulative results of this proposal will offer the first comprehensive assessment of the mechanisms that drive evolution of new behaviours across insects; it will also generate a blueprint for the community to compare their data in different clades of the phylogenetic tree as well as to different sensory modalities.

Meccanismo di finanziamento

ERC-STG - Starting Grant

Istituzione ospitante

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Contribution nette de l'UE
€ 1 632 647,00
Indirizzo
RUE MICHEL ANGE 3
75794 Paris
Francia

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Regione
Ile-de-France Ile-de-France Paris
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 1 632 647,00

Beneficiari (1)