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Evolution of neuronal cell types, development and circuitry in the insect visual system: breaking down behavioural evolution into its constituent elements

Projektbeschreibung

Wie sich das Verhalten entwickelt

Wie entstehen die Mechanismen, die für die neuronale Entwicklung verantwortlich sind, und wie wirken sie sich auf die neuronale Diversität aus? Das sind zwei der fundamentalen Fragen, denen das EU-finanzierte Projekt BehaEvoDevo nachgehen wird. Es wird die Verhaltensevolution und -entwicklung am Beispiel des visuellen Systems von Insekten untersuchen – dem visuellen System der Drosophila. Die Arbeit von BehaEvoDevo wird zur ersten vollständigen Bewertung der Mechanismen führen, welche für die Entwicklung neuer Verhaltensweisen bei Insekten verantwortlich sind. Außerdem wird das Projekt einen Bauplan erstellen, anhand dessen die Wissenschaftsgemeinde ihre Daten an verschiedenen Stämmen des phylogenetischen Baumes und mit unterschiedlichen sensorischen Modalitäten vergleichen kann.

Ziel

One of the holy grails of neuroscience is to understand how complex behaviours arise. However, surprisingly little is known about how behaviours evolve. My proposal will delve into Behavioural Evolution and Development (BehaEvoDevo) in an unbiased and comprehensive way using the insect visual system as a model. The visual system of Drosophila has been described extensively in terms of cell type composition, development, circuitry, and behaviour. My expertise in this system will be the springboard to address four fundamental questions: 1) How different is the cell type composition in the brains of different animals? 2) How do the mechanisms that are responsible for neuronal development evolve and how do they affect neuronal diversity? 3) What are the differences in the circuitry that underlies specific behaviours in different animals? 4) How do differences in neuronal composition, neuronal features, or circuitry drive different behaviours? I will combine cutting edge techniques, such as single-cell sequencing, with advanced genetic tools in Drosophila, and adapt innovative tools for genetic manipulation and circuit function in different non-model insects. I will compare how cell type composition, neuronal specification and differentiation, as well as circuitry, affect specific behaviours. I will examine phylogenetically diverse insects to generate a deep understanding of the mechanisms that are most important for the evolution of different behaviours. Moreover, I will identify fundamental principles about how developmental processes, such as neuronal specification and differentiation, evolve to control different behaviours. The cumulative results of this proposal will offer the first comprehensive assessment of the mechanisms that drive evolution of new behaviours across insects; it will also generate a blueprint for the community to compare their data in different clades of the phylogenetic tree as well as to different sensory modalities.

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Netto-EU-Beitrag
€ 1 632 647,00
Adresse
RUE MICHEL ANGE 3
75794 Paris
Frankreich

Auf der Karte ansehen

Region
Ile-de-France Ile-de-France Paris
Aktivitätstyp
Research Organisations
Links
Gesamtkosten
€ 1 632 647,00

Begünstigte (1)