Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics

Project Information

SALAMANDRA

Grant agreement ID: 951477

DOI

10.3030/951477

EC signature date 19 February 2021

Start date 1 September 2021

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 9 559 650,00

EU contribution

€ 9 559 650,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (3)

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Author(s): Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Published in: Issue 1, 2023
Publisher: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92331

Coupling spiking neural networks and mechanical simulations to investigate walking and swimming in salamanders

Author(s): Pazzaglia, Alessandro; Bicanski, Andrej; Arreguit, Jonathan; Ferrario, Andrea; Ryczko, Dimitri; Ijspeert, Auke
Published in: Issue 2, 2023
Publisher: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92332

An integrated neuromechanical model of the mouse to study neural control of locomotion

Author(s): Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Published in: Issue 3, 2023
Publisher: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92326

Peer reviewed articles (16)

Macrophages modulate fibrosis during newt lens regeneration

Author(s): Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun, Katia Del Rio-Tsonis
Published in: Stem Cell Research & Therapy, Issue 15, 2024, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-024-03740-1

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

Author(s): Andrea Juárez Tello, Cornelis Immanuel van der Zouwen, Léonie Dejas, Juan Duque-Yate, Joël Boutin, Katherine Medina-Ortiz, Jacinthlyn Sylvia Suresh, Jordan Swiegers, Philippe Sarret, Dimitri Ryczko
Published in: Cell Reports, Issue 43, 2024, Page(s) 114187, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.114187

Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey

Author(s): Oliver Hausdörfer, Astha Gupta, Auke J Ijspeert, Daniel Renjewski
Published in: Bioinspiration & Biomimetics, Issue 20, 2025, Page(s) 026024, ISSN 1748-3182
Publisher: Institute of Physics Publishing
DOI: 10.1088/1748-3190/adb8b1

Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish

Author(s): Kotaro Yasui, Astha Gupta, Qiyuan Fu, Shura Suzuki, Jeffrey Hainer, Laura Paez, Keegan Lutek, Jonathan Arreguit, Takeshi Kano, Emily M. Standen, Auke J. Ijspeert, Akio Ishiguro
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, Page(s) 1-12, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2422248122

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Author(s): Dimitri Ryczko
Published in: The Neuroscientist, Issue epub ahead of print, 2022, Page(s) epub ahead of print, ISSN 1073-8584
Publisher: Sage Science Press
DOI: 10.1177/10738584221139136

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord

Author(s): Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
Published in: PLOS Computational Biology, Issue 21, 2025, Page(s) e1012101, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012101

FARMS: Framework for Animal and Robot Modeling and Simulation

Author(s): Arreguit, Jonathan; Ramalingasetty, Shravan; Ijspeert, Auke
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: BioRxiv
DOI: 10.1101/2023.09.25.559130

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Author(s): Thomas Brown, Ketan Mishra, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Bastian Fromm, Marc R. Friedländer, Lennart Rikk, Miyuki Suzuki, Ken-ichi T. Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina R. Oliveira, Ekaterina Osipova, Nicholas D. Leigh, Maximina H. Yun, András Simon
Published in: Cell Genomics, Issue 5, 2025, Page(s) 100761, ISSN 2666-979X
Publisher: Elsevier BV
DOI: 10.1016/j.xgen.2025.100761

Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice

Author(s): Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F. Roitman, Dimitri Ryczko
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-05572-2

Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors

Author(s): Xiangxiao Liu, Matthew D. Loring, Luca Zunino, Kaitlyn E. Fouke, François A. Longchamp, Alexandre Bernardino, Auke J. Ijspeert, Eva A. Naumann
Published in: Science Robotics, Issue 10, 2025, ISSN 2470-9476
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adv4408

From retina to motoneurons: A substrate for visuomotor transformation in salamanders

Author(s): Aurélie Flaive, Dimitri Ryczko
Published in: Journal of Comparative Neurology, Issue 530(14), 2022, Page(s) 2518-2536, ISSN 0021-9967
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/cne.25348

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Author(s): Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere , Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Published in: Science, 2022, ISSN 1095-9203
Publisher: AAAS
DOI: 10.1126/science.abp9186

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Author(s): Ijspeert, Auke; Daley, Monica
Published in: Journal of Experimental Biology, 2023, ISSN 0022-0949
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jeb.245784

Locomotor pattern generation and descending control: a historical perspective

Author(s): Réjean Dubuc; Jean-Marie Cabelguen; Dimitri Ryczko
Published in: Journal of Neurophysiology, Issue 1, 2023, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00204.2023

Understanding the microenvironment and how this controls cell fate

Author(s): Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
Published in: Developmental Cell, Issue 58, 2023, Page(s) 2819-2821, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2023.11.025

Investigating the effect of morphology on the terrestrial gaits of amphibious fish using a reconfigurable robot

Author(s): Louis Gevers, Astha Gupta, Laura Paez, Qiyuan Fu, Emily Standen, Auke Ijspeert
Published in: Bioinspiration & Biomimetics, Issue 20, 2025, Page(s) 046002, ISSN 1748-3182
Publisher: Institute of Physics Publishing
DOI: 10.1088/1748-3190/addc27

Non-peer reviewed articles (1)

Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome

Author(s): Thomas Brown, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Miyuki Suzuki, Ken-ichi Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina Oliveira, Ekaterina Osipova, Nicholas Leigh, Andras Simon, Maximina Yun
Published in: bioRxiv, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.19.512763