Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics

Informazioni relative al progetto

SALAMANDRA

ID dell’accordo di sovvenzione: 951477

DOI

10.3030/951477

Data della firma CE 19 Febbraio 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 9 559 650,00

Contributo UE

€ 9 559 650,00

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Conference proceedings (5)

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autori: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Pubblicato in: Proceedings of the 11th International Symposium on Adaptive Motion of Animals and Machines, Numero 5, 2023
Editore: University of Osaka Institutional Knowledge Archive

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autori: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Pubblicato in: Numero 1, 2023
Editore: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92331

Coupling spiking neural networks and mechanical simulations to investigate walking and swimming in salamanders

Autori: Pazzaglia, Alessandro; Bicanski, Andrej; Arreguit, Jonathan; Ferrario, Andrea; Ryczko, Dimitri; Ijspeert, Auke
Pubblicato in: Proceedings of the 11th International Symposium on Adaptive Motion of Animals and Machines, Numero 2, 2023
Editore: University of Osaka Institutional Knowledge Archive
DOI: 10.18910/92332

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autori: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Pubblicato in: Proceedings of 11th International Symposium on Adaptive Motion in Animals and Machines Symposium, Numero 5, 2023
Editore: University of Osaka Institutional Knowledge Archive

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autori: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Pubblicato in: Numero 3, 2023
Editore: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92326

Peer reviewed articles (17)

Energy efficiency and neural control of continuous versus intermittent swimming in a fishlike robot

Autori: Xiangxiao Liu, François A. Longchamp, Luca Zunino, Louis Gevers, Lisa R. Schneider, Selina I. Bothner, André Guignard, Alessandro Crespi, Guillaume Bellegarda, Alexandre Bernardino, Eva A. Naumann, Auke J. Ijspeert
Pubblicato in: Science Robotics, Numero 11, 2026, ISSN 2470-9476
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adw7868

Macrophages modulate fibrosis during newt lens regeneration

Autori: Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun, Katia Del Rio-Tsonis
Pubblicato in: Stem Cell Research & Therapy, Numero 15, 2024, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-024-03740-1

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

Autori: Andrea Juárez Tello, Cornelis Immanuel van der Zouwen, Léonie Dejas, Juan Duque-Yate, Joël Boutin, Katherine Medina-Ortiz, Jacinthlyn Sylvia Suresh, Jordan Swiegers, Philippe Sarret, Dimitri Ryczko
Pubblicato in: Cell Reports, Numero 43, 2024, Pagina/e 114187, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.114187

Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey

Autori: Oliver Hausdörfer, Astha Gupta, Auke J Ijspeert, Daniel Renjewski
Pubblicato in: Bioinspiration & Biomimetics, Numero 20, 2025, Pagina/e 026024, ISSN 1748-3182
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-3190/adb8b1

Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish

Autori: Kotaro Yasui, Astha Gupta, Qiyuan Fu, Shura Suzuki, Jeffrey Hainer, Laura Paez, Keegan Lutek, Jonathan Arreguit, Takeshi Kano, Emily M. Standen, Auke J. Ijspeert, Akio Ishiguro
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, Pagina/e 1-12, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2422248122

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Autori: Dimitri Ryczko
Pubblicato in: The Neuroscientist, Numero epub ahead of print, 2022, Pagina/e epub ahead of print, ISSN 1073-8584
Editore: Sage Science Press
DOI: 10.1177/10738584221139136

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord

Autori: Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
Pubblicato in: PLOS Computational Biology, Numero 21, 2025, Pagina/e e1012101, ISSN 1553-7358
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012101

FARMS: Framework for Animal and Robot Modeling and Simulation

Autori: Arreguit, Jonathan; Ramalingasetty, Shravan; Ijspeert, Auke
Pubblicato in: BioRxiv, 2023, ISSN 2692-8205
Editore: BioRxiv
DOI: 10.1101/2023.09.25.559130

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Autori: Thomas Brown, Ketan Mishra, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Bastian Fromm, Marc R. Friedländer, Lennart Rikk, Miyuki Suzuki, Ken-ichi T. Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina R. Oliveira, Ekaterina Osipova, Nicholas D. Leigh, Maximina H. Yun, András Simon
Pubblicato in: Cell Genomics, Numero 5, 2025, Pagina/e 100761, ISSN 2666-979X
Editore: Elsevier BV
DOI: 10.1016/j.xgen.2025.100761

Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice

Autori: Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F. Roitman, Dimitri Ryczko
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-05572-2

Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors

Autori: Xiangxiao Liu, Matthew D. Loring, Luca Zunino, Kaitlyn E. Fouke, François A. Longchamp, Alexandre Bernardino, Auke J. Ijspeert, Eva A. Naumann
Pubblicato in: Science Robotics, Numero 10, 2025, ISSN 2470-9476
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adv4408

From retina to motoneurons: A substrate for visuomotor transformation in salamanders

Autori: Aurélie Flaive, Dimitri Ryczko
Pubblicato in: Journal of Comparative Neurology, Numero 530(14), 2022, Pagina/e 2518-2536, ISSN 0021-9967
Editore: John Wiley & Sons Inc.
DOI: 10.1002/cne.25348

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Autori: Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere , Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Pubblicato in: Science, 2022, ISSN 1095-9203
Editore: AAAS
DOI: 10.1126/science.abp9186

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Autori: Ijspeert, Auke; Daley, Monica
Pubblicato in: Journal of Experimental Biology, 2023, ISSN 0022-0949
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jeb.245784

Locomotor pattern generation and descending control: a historical perspective

Autori: Réjean Dubuc; Jean-Marie Cabelguen; Dimitri Ryczko
Pubblicato in: Journal of Neurophysiology, Numero 1, 2023, ISSN 0022-3077
Editore: American Physiological Society
DOI: 10.1152/jn.00204.2023

Understanding the microenvironment and how this controls cell fate

Autori: Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
Pubblicato in: Developmental Cell, Numero 58, 2023, Pagina/e 2819-2821, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2023.11.025

Investigating the effect of morphology on the terrestrial gaits of amphibious fish using a reconfigurable robot

Autori: Louis Gevers, Astha Gupta, Laura Paez, Qiyuan Fu, Emily Standen, Auke Ijspeert
Pubblicato in: Bioinspiration & Biomimetics, Numero 20, 2025, Pagina/e 046002, ISSN 1748-3182
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-3190/addc27

Non-peer reviewed articles (1)

Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome

Autori: Thomas Brown, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Miyuki Suzuki, Ken-ichi Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina Oliveira, Ekaterina Osipova, Nicholas Leigh, Andras Simon, Maximina Yun
Pubblicato in: bioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.19.512763