Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics

Informazioni relative al progetto

SALAMANDRA

ID dell’accordo di sovvenzione: 951477

DOI

10.3030/951477

Data della firma CE 19 Febbraio 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 9 559 650,00

Contributo UE

€ 9 559 650,00

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Conference proceedings (3)

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autori: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Pubblicato in: Numero 1, 2023
Editore: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92331

Coupling spiking neural networks and mechanical simulations to investigate walking and swimming in salamanders

Autori: Pazzaglia, Alessandro; Bicanski, Andrej; Arreguit, Jonathan; Ferrario, Andrea; Ryczko, Dimitri; Ijspeert, Auke
Pubblicato in: Numero 2, 2023
Editore: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92332

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autori: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Pubblicato in: Numero 3, 2023
Editore: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92326

Peer reviewed articles (16)

Macrophages modulate fibrosis during newt lens regeneration

Autori: Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun, Katia Del Rio-Tsonis
Pubblicato in: Stem Cell Research & Therapy, Numero 15, 2024, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-024-03740-1

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

Autori: Andrea Juárez Tello, Cornelis Immanuel van der Zouwen, Léonie Dejas, Juan Duque-Yate, Joël Boutin, Katherine Medina-Ortiz, Jacinthlyn Sylvia Suresh, Jordan Swiegers, Philippe Sarret, Dimitri Ryczko
Pubblicato in: Cell Reports, Numero 43, 2024, Pagina/e 114187, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.114187

Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey

Autori: Oliver Hausdörfer, Astha Gupta, Auke J Ijspeert, Daniel Renjewski
Pubblicato in: Bioinspiration & Biomimetics, Numero 20, 2025, Pagina/e 026024, ISSN 1748-3182
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-3190/adb8b1

Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish

Autori: Kotaro Yasui, Astha Gupta, Qiyuan Fu, Shura Suzuki, Jeffrey Hainer, Laura Paez, Keegan Lutek, Jonathan Arreguit, Takeshi Kano, Emily M. Standen, Auke J. Ijspeert, Akio Ishiguro
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, Pagina/e 1-12, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2422248122

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Autori: Dimitri Ryczko
Pubblicato in: The Neuroscientist, Numero epub ahead of print, 2022, Pagina/e epub ahead of print, ISSN 1073-8584
Editore: Sage Science Press
DOI: 10.1177/10738584221139136

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord

Autori: Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
Pubblicato in: PLOS Computational Biology, Numero 21, 2025, Pagina/e e1012101, ISSN 1553-7358
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012101

FARMS: Framework for Animal and Robot Modeling and Simulation

Autori: Arreguit, Jonathan; Ramalingasetty, Shravan; Ijspeert, Auke
Pubblicato in: BioRxiv, 2023, ISSN 2692-8205
Editore: BioRxiv
DOI: 10.1101/2023.09.25.559130

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Autori: Thomas Brown, Ketan Mishra, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Bastian Fromm, Marc R. Friedländer, Lennart Rikk, Miyuki Suzuki, Ken-ichi T. Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina R. Oliveira, Ekaterina Osipova, Nicholas D. Leigh, Maximina H. Yun, András Simon
Pubblicato in: Cell Genomics, Numero 5, 2025, Pagina/e 100761, ISSN 2666-979X
Editore: Elsevier BV
DOI: 10.1016/j.xgen.2025.100761

Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice

Autori: Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F. Roitman, Dimitri Ryczko
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-05572-2

Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors

Autori: Xiangxiao Liu, Matthew D. Loring, Luca Zunino, Kaitlyn E. Fouke, François A. Longchamp, Alexandre Bernardino, Auke J. Ijspeert, Eva A. Naumann
Pubblicato in: Science Robotics, Numero 10, 2025, ISSN 2470-9476
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adv4408

From retina to motoneurons: A substrate for visuomotor transformation in salamanders

Autori: Aurélie Flaive, Dimitri Ryczko
Pubblicato in: Journal of Comparative Neurology, Numero 530(14), 2022, Pagina/e 2518-2536, ISSN 0021-9967
Editore: John Wiley & Sons Inc.
DOI: 10.1002/cne.25348

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Autori: Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere , Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Pubblicato in: Science, 2022, ISSN 1095-9203
Editore: AAAS
DOI: 10.1126/science.abp9186

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Autori: Ijspeert, Auke; Daley, Monica
Pubblicato in: Journal of Experimental Biology, 2023, ISSN 0022-0949
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jeb.245784

Locomotor pattern generation and descending control: a historical perspective

Autori: Réjean Dubuc; Jean-Marie Cabelguen; Dimitri Ryczko
Pubblicato in: Journal of Neurophysiology, Numero 1, 2023, ISSN 0022-3077
Editore: American Physiological Society
DOI: 10.1152/jn.00204.2023

Understanding the microenvironment and how this controls cell fate

Autori: Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
Pubblicato in: Developmental Cell, Numero 58, 2023, Pagina/e 2819-2821, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2023.11.025

Investigating the effect of morphology on the terrestrial gaits of amphibious fish using a reconfigurable robot

Autori: Louis Gevers, Astha Gupta, Laura Paez, Qiyuan Fu, Emily Standen, Auke Ijspeert
Pubblicato in: Bioinspiration & Biomimetics, Numero 20, 2025, Pagina/e 046002, ISSN 1748-3182
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-3190/addc27

Non-peer reviewed articles (1)

Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome

Autori: Thomas Brown, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Miyuki Suzuki, Ken-ichi Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina Oliveira, Ekaterina Osipova, Nicholas Leigh, Andras Simon, Maximina Yun
Pubblicato in: bioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.19.512763