Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics

Información del proyecto

SALAMANDRA

Identificador del acuerdo de subvención: 951477

DOI

10.3030/951477

Fecha de la firma de la CE 19 Febrero 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 9 559 650,00

Aportación de la UE

€ 9 559 650,00

Coordinado por

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Conference proceedings (3)

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autores: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Publicado en: Edición 1, 2023
Editor: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92331

Coupling spiking neural networks and mechanical simulations to investigate walking and swimming in salamanders

Autores: Pazzaglia, Alessandro; Bicanski, Andrej; Arreguit, Jonathan; Ferrario, Andrea; Ryczko, Dimitri; Ijspeert, Auke
Publicado en: Edición 2, 2023
Editor: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92332

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autores: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Publicado en: Edición 3, 2023
Editor: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92326

Peer reviewed articles (16)

Macrophages modulate fibrosis during newt lens regeneration

Autores: Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun, Katia Del Rio-Tsonis
Publicado en: Stem Cell Research & Therapy, Edición 15, 2024, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-024-03740-1

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

Autores: Andrea Juárez Tello, Cornelis Immanuel van der Zouwen, Léonie Dejas, Juan Duque-Yate, Joël Boutin, Katherine Medina-Ortiz, Jacinthlyn Sylvia Suresh, Jordan Swiegers, Philippe Sarret, Dimitri Ryczko
Publicado en: Cell Reports, Edición 43, 2024, Página(s) 114187, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.114187

Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey

Autores: Oliver Hausdörfer, Astha Gupta, Auke J Ijspeert, Daniel Renjewski
Publicado en: Bioinspiration & Biomimetics, Edición 20, 2025, Página(s) 026024, ISSN 1748-3182
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-3190/adb8b1

Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish

Autores: Kotaro Yasui, Astha Gupta, Qiyuan Fu, Shura Suzuki, Jeffrey Hainer, Laura Paez, Keegan Lutek, Jonathan Arreguit, Takeshi Kano, Emily M. Standen, Auke J. Ijspeert, Akio Ishiguro
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, Página(s) 1-12, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2422248122

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Autores: Dimitri Ryczko
Publicado en: The Neuroscientist, Edición epub ahead of print, 2022, Página(s) epub ahead of print, ISSN 1073-8584
Editor: Sage Science Press
DOI: 10.1177/10738584221139136

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord

Autores: Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
Publicado en: PLOS Computational Biology, Edición 21, 2025, Página(s) e1012101, ISSN 1553-7358
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012101

FARMS: Framework for Animal and Robot Modeling and Simulation

Autores: Arreguit, Jonathan; Ramalingasetty, Shravan; Ijspeert, Auke
Publicado en: BioRxiv, 2023, ISSN 2692-8205
Editor: BioRxiv
DOI: 10.1101/2023.09.25.559130

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Autores: Thomas Brown, Ketan Mishra, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Bastian Fromm, Marc R. Friedländer, Lennart Rikk, Miyuki Suzuki, Ken-ichi T. Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina R. Oliveira, Ekaterina Osipova, Nicholas D. Leigh, Maximina H. Yun, András Simon
Publicado en: Cell Genomics, Edición 5, 2025, Página(s) 100761, ISSN 2666-979X
Editor: Elsevier BV
DOI: 10.1016/j.xgen.2025.100761

Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice

Autores: Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F. Roitman, Dimitri Ryczko
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-05572-2

Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors

Autores: Xiangxiao Liu, Matthew D. Loring, Luca Zunino, Kaitlyn E. Fouke, François A. Longchamp, Alexandre Bernardino, Auke J. Ijspeert, Eva A. Naumann
Publicado en: Science Robotics, Edición 10, 2025, ISSN 2470-9476
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adv4408

From retina to motoneurons: A substrate for visuomotor transformation in salamanders

Autores: Aurélie Flaive, Dimitri Ryczko
Publicado en: Journal of Comparative Neurology, Edición 530(14), 2022, Página(s) 2518-2536, ISSN 0021-9967
Editor: John Wiley & Sons Inc.
DOI: 10.1002/cne.25348

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Autores: Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere , Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Publicado en: Science, 2022, ISSN 1095-9203
Editor: AAAS
DOI: 10.1126/science.abp9186

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Autores: Ijspeert, Auke; Daley, Monica
Publicado en: Journal of Experimental Biology, 2023, ISSN 0022-0949
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jeb.245784

Locomotor pattern generation and descending control: a historical perspective

Autores: Réjean Dubuc; Jean-Marie Cabelguen; Dimitri Ryczko
Publicado en: Journal of Neurophysiology, Edición 1, 2023, ISSN 0022-3077
Editor: American Physiological Society
DOI: 10.1152/jn.00204.2023

Understanding the microenvironment and how this controls cell fate

Autores: Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
Publicado en: Developmental Cell, Edición 58, 2023, Página(s) 2819-2821, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2023.11.025

Investigating the effect of morphology on the terrestrial gaits of amphibious fish using a reconfigurable robot

Autores: Louis Gevers, Astha Gupta, Laura Paez, Qiyuan Fu, Emily Standen, Auke Ijspeert
Publicado en: Bioinspiration & Biomimetics, Edición 20, 2025, Página(s) 046002, ISSN 1748-3182
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-3190/addc27

Non-peer reviewed articles (1)

Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome

Autores: Thomas Brown, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Miyuki Suzuki, Ken-ichi Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina Oliveira, Ekaterina Osipova, Nicholas Leigh, Andras Simon, Maximina Yun
Publicado en: bioRxiv, 2022, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.19.512763