Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics

Información del proyecto

SALAMANDRA

Identificador del acuerdo de subvención: 951477

DOI

10.3030/951477

Fecha de la firma de la CE 19 Febrero 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 9 559 650,00

Aportación de la UE

€ 9 559 650,00

Coordinado por

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Conference proceedings (5)

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autores: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Publicado en: Proceedings of the 11th International Symposium on Adaptive Motion of Animals and Machines, Edición 5, 2023
Editor: University of Osaka Institutional Knowledge Archive

Bio-inspired Controllers Facilitate Sim-to-Real Transfer

Autores: Gupta, Astha; Melo, Kamilo; Arreguit, Jonathan; Paez, Laura; Estrada, Matthew; Ijspeert, Auke
Publicado en: Edición 1, 2023
Editor: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92331

Coupling spiking neural networks and mechanical simulations to investigate walking and swimming in salamanders

Autores: Pazzaglia, Alessandro; Bicanski, Andrej; Arreguit, Jonathan; Ferrario, Andrea; Ryczko, Dimitri; Ijspeert, Auke
Publicado en: Proceedings of the 11th International Symposium on Adaptive Motion of Animals and Machines, Edición 2, 2023
Editor: University of Osaka Institutional Knowledge Archive
DOI: 10.18910/92332

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autores: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Publicado en: Proceedings of 11th International Symposium on Adaptive Motion in Animals and Machines Symposium, Edición 5, 2023
Editor: University of Osaka Institutional Knowledge Archive

An integrated neuromechanical model of the mouse to study neural control of locomotion

Autores: Ramalingasetty, Shravan Tata; Markin, Sergey N.; Lockhart, Andrew B.; Arreguit, Jonathan; Shevtsova, Natalia A.; Ijspeert, Auke J.; Rybak, Ilya A.; Danner, Simon M.
Publicado en: Edición 3, 2023
Editor: Adaptive Motion of Animals and Machines Organizing Committee
DOI: 10.18910/92326

Peer reviewed articles (17)

Energy efficiency and neural control of continuous versus intermittent swimming in a fishlike robot

Autores: Xiangxiao Liu, François A. Longchamp, Luca Zunino, Louis Gevers, Lisa R. Schneider, Selina I. Bothner, André Guignard, Alessandro Crespi, Guillaume Bellegarda, Alexandre Bernardino, Eva A. Naumann, Auke J. Ijspeert
Publicado en: Science Robotics, Edición 11, 2026, ISSN 2470-9476
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adw7868

Macrophages modulate fibrosis during newt lens regeneration

Autores: Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun, Katia Del Rio-Tsonis
Publicado en: Stem Cell Research & Therapy, Edición 15, 2024, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-024-03740-1

Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns

Autores: Andrea Juárez Tello, Cornelis Immanuel van der Zouwen, Léonie Dejas, Juan Duque-Yate, Joël Boutin, Katherine Medina-Ortiz, Jacinthlyn Sylvia Suresh, Jordan Swiegers, Philippe Sarret, Dimitri Ryczko
Publicado en: Cell Reports, Edición 43, 2024, Página(s) 114187, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.114187

Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey

Autores: Oliver Hausdörfer, Astha Gupta, Auke J Ijspeert, Daniel Renjewski
Publicado en: Bioinspiration & Biomimetics, Edición 20, 2025, Página(s) 026024, ISSN 1748-3182
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-3190/adb8b1

Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish

Autores: Kotaro Yasui, Astha Gupta, Qiyuan Fu, Shura Suzuki, Jeffrey Hainer, Laura Paez, Keegan Lutek, Jonathan Arreguit, Takeshi Kano, Emily M. Standen, Auke J. Ijspeert, Akio Ishiguro
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, Página(s) 1-12, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2422248122

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Autores: Dimitri Ryczko
Publicado en: The Neuroscientist, Edición epub ahead of print, 2022, Página(s) epub ahead of print, ISSN 1073-8584
Editor: Sage Science Press
DOI: 10.1177/10738584221139136

Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord

Autores: Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
Publicado en: PLOS Computational Biology, Edición 21, 2025, Página(s) e1012101, ISSN 1553-7358
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1012101

FARMS: Framework for Animal and Robot Modeling and Simulation

Autores: Arreguit, Jonathan; Ramalingasetty, Shravan; Ijspeert, Auke
Publicado en: BioRxiv, 2023, ISSN 2692-8205
Editor: BioRxiv
DOI: 10.1101/2023.09.25.559130

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Autores: Thomas Brown, Ketan Mishra, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Bastian Fromm, Marc R. Friedländer, Lennart Rikk, Miyuki Suzuki, Ken-ichi T. Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina R. Oliveira, Ekaterina Osipova, Nicholas D. Leigh, Maximina H. Yun, András Simon
Publicado en: Cell Genomics, Edición 5, 2025, Página(s) 100761, ISSN 2666-979X
Editor: Elsevier BV
DOI: 10.1016/j.xgen.2025.100761

Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice

Autores: Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F. Roitman, Dimitri Ryczko
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-05572-2

Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors

Autores: Xiangxiao Liu, Matthew D. Loring, Luca Zunino, Kaitlyn E. Fouke, François A. Longchamp, Alexandre Bernardino, Auke J. Ijspeert, Eva A. Naumann
Publicado en: Science Robotics, Edición 10, 2025, ISSN 2470-9476
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scirobotics.adv4408

From retina to motoneurons: A substrate for visuomotor transformation in salamanders

Autores: Aurélie Flaive, Dimitri Ryczko
Publicado en: Journal of Comparative Neurology, Edición 530(14), 2022, Página(s) 2518-2536, ISSN 0021-9967
Editor: John Wiley & Sons Inc.
DOI: 10.1002/cne.25348

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Autores: Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere , Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Publicado en: Science, 2022, ISSN 1095-9203
Editor: AAAS
DOI: 10.1126/science.abp9186

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Autores: Ijspeert, Auke; Daley, Monica
Publicado en: Journal of Experimental Biology, 2023, ISSN 0022-0949
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jeb.245784

Locomotor pattern generation and descending control: a historical perspective

Autores: Réjean Dubuc; Jean-Marie Cabelguen; Dimitri Ryczko
Publicado en: Journal of Neurophysiology, Edición 1, 2023, ISSN 0022-3077
Editor: American Physiological Society
DOI: 10.1152/jn.00204.2023

Understanding the microenvironment and how this controls cell fate

Autores: Elaine Fuchs, Erik Sahai, Ashani T. Weeraratna, Benjamin Deneen, Carmen Chak-Lui Wong, András Simon
Publicado en: Developmental Cell, Edición 58, 2023, Página(s) 2819-2821, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2023.11.025

Investigating the effect of morphology on the terrestrial gaits of amphibious fish using a reconfigurable robot

Autores: Louis Gevers, Astha Gupta, Laura Paez, Qiyuan Fu, Emily Standen, Auke Ijspeert
Publicado en: Bioinspiration & Biomimetics, Edición 20, 2025, Página(s) 046002, ISSN 1748-3182
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-3190/addc27

Non-peer reviewed articles (1)

Sequencing and chromosome-scale assembly of the giant Pleurodeles waltl genome

Autores: Thomas Brown, Ahmed Elewa, Svetlana Iarovenko, Elaiyaraja Subramanian, Alberto Joven Araus, Andreas Petzold, Miyuki Suzuki, Ken-ichi Suzuki, Toshinori Hayashi, Atsushi Toyoda, Catarina Oliveira, Ekaterina Osipova, Nicholas Leigh, Andras Simon, Maximina Yun
Publicado en: bioRxiv, 2022, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.10.19.512763