Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3S

Información del proyecto

NCBio

Identificador del acuerdo de subvención: 951923

DOI

10.3030/951923

Fecha de la firma de la CE 10 Junio 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Establishing ‚ERA Chairs’

Coste total

€ 2 479 972,50

Aportación de la UE

€ 2 479 972,50

Coordinado por

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (7)

Neural Cell Biology Doctoral Training Plan
Neural Cell Biology Group´s annual activity reports 3

Neural Cell Biology Groups annual activity reports 3

Neural Cell Biology Group´s annual activity reports 2

Neural Cell Biology Groups annual activity reports 2

Report on the research career support in Neural Cell Biology 1
Bi-annual capacity building and knowledge transfer plans 2
Neural Cell Biology Group´s annual activity reports 1

Neural Cell Biology Groups annual activity reports 1

Bi-annual capacity building and knowledge transfer plans 1

Open Research Data Pilot (2)

NCbio promotional toolkit 1
Launch of NCbio webpage

Websites, patent fillings, videos etc. (1)

Data Management Plan

Publicaciones

Peer reviewed articles (18)

Localized astrogenesis regulates gyrification of the cerebral cortex

Autores: Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori, Takayuki Kannon, Kazuyoshi Hosomichi, Michal Slezak, Matthew G. Holt, Atsushi Tajima, Osamu Hori, Hiroshi Kawasaki
Publicado en: Science Advances, Edición 8, 2024, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi5209

Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

Autores: Maria João Pereira, Rajagopal Ayana, Matthew G. Holt, Lutgarde Arckens
Publicado en: Frontiers in Cell and Developmental Biology, Edición 11, 2023, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2023.1193130

Association of Serum Biomarkers With Neurocognitive Decline After PCI in Small Cell Lung Cancer: An Exploratory Study of the Phase III NCT01780675 Trial

Autores: Haiyan Zeng, Lizza E.L. Hendriks, José Belderbos, Lloyd Brandts, Inge Compter, Ludwig Dubois, Matthew G. Holt, Ruud Houben, Sanne Schagen, Xin Zhang, Teresa Prezzemolo, Dirk De Ruysscher
Publicado en: Clinical Lung Cancer, Edición 25, 2024, Página(s) 653-659.e1, ISSN 1525-7304
Editor: Cancer Information Group
DOI: 10.1016/j.cllc.2024.08.008

Astrocyte heterogeneity and interactions with local neural circuits

Autores: Matthew G. Holt
Publicado en: Essays in Biochemistry, Edición 67, 2023, Página(s) 93-106, ISSN 0071-1365
Editor: Portland Press, Ltd.
DOI: 10.1042/ebc20220136

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Autores: Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston
Publicado en: EMBO Molecular Medicine, Edición 15, 2023, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216805

Corrigendum to “A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions” [Neuroscience 508 (2023) 40–51]

Autores: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Publicado en: Neuroscience, Edición 528, 2023, Página(s) 140-141, ISSN 0306-4522
Editor: Elsevier BV
DOI: 10.1016/j.neuroscience.2023.06.003

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Autores: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publicado en: Molecular Neurodegeneration, Edición 19, 2024, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-023-00699-0

Regulatory T cells as a possible new target in epilepsy?

Autores: Evelien Hendrix, Maxime Vande Vyver, Matthew Holt, Ilse Smolders
Publicado en: Epilepsia, Edición 65, 2024, Página(s) 2227-2237, ISSN 0013-9580
Editor: Blackwell Publishing Inc.
DOI: 10.1111/epi.18038

Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report

Autores: Ahmed Abdelfattah, Srinivasa Rao Allu, Robert E. Campbell, Xiaojun Cheng, Tomáš Cižmár, Irene Costantini, Valentina Emiliani, Natalie Fomin-Thunemann, Ariel Gilad, Tomás Fernández Alfonso, Christopher G. L. Ferri, Andrew Harris, Elizabeth M. C. Hillman, Matthew G. Holt, Kivilcim Kiliç, Evan W. Miller, Rickson C. Mesquita, K.M. Naga Srinivas Nadella, U. Valentin Nägerl, Citlali Perez Campos
Publicado en: Neurophotonics, Edición 9, 2024, ISSN 2329-423X
Editor: Society of Photo-Optical Instrumentation Engineers
DOI: 10.1117/1.nph.9.s1.013001

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

Autores: P. Bielefeld, A. Martirosyan, S. Martín-Suárez, A. Apresyan, G. F. Meerhoff, F. Pestana, S. Poovathingal, N. Reijner, W. Koning, R. A. Clement, I. Van der Veen, E. M. Toledo, O. Polzer, I. Durá, S. Hovhannisyan, B. S. Nilges, A. Bogdoll, N. D. Kashikar, P. J. Lucassen, T. G. Belgard, J. M. Encinas, M. G. Holt, C. P. Fitzsimons
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-49299-6

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Autores: Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaitre, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar Tareen, Carlos P. Roca, Kailash Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, Teresa Prezzemol
Publicado en: Nature Immunology, 2022, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1101/2022.02.28.482297

Astrocyte structural heterogeneity in the mouse hippocampus

Autores: João Filipe Viana, João Luís Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sónia Guerra‐Gomes, Cátia Domingos, Alberto Pauletti, Jérôme Wahis, Chen Liu, Corrado Calì, Christian Henneberger, Matthew G. Holt, João Filipe Oliveira
Publicado en: Glia, Edición 71, 2023, Página(s) 1667-1682, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24362

A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions

Autores: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Publicado en: Neuroscience, Edición 508, 2023, Página(s) 40-51, ISSN 0306-4522
Editor: Elsevier BV
DOI: 10.1016/j.neuroscience.2022.11.029

A conformational switch controlling the toxicity of the prion protein

Autores: Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R. Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G. Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Publicado en: Nature Structural & Molecular Biology, Edición 29, 2022, Página(s) 831-840, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-022-00814-7

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Autores: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark Fiers, Matthew Holt, Dietmar Rudolf Thal, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Rik Vandenberghe, Uwe Himmelreich, Vincent Bonin, Bart De Strooper
Publicado en: Cell Reports, Edición 40, 2024, Página(s) 111280, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111280

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Autores: Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Publicado en: EMBO Molecular Medicine, Edición 14, 2023, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809824

The astrocyte <scp>α1A</scp>‐adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

Autores: Jérôme Wahis, Cansu Akkaya, Andre M. Kirunda, Aline Mak, Karen Zeise, Jens Verhaert, Hayk Gasparyan, Sargis Hovhannisyan, Matthew G. Holt
Publicado en: Glia, Edición 72, 2024, Página(s) 1955-1973, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24591

AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System

Autores: Marika Marino, Matthew G. Holt
Publicado en: Frontiers in Neurology, Edición 13, 2022, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.870799

Book chapters (1)

Studying the Role of Astrocytes at Synapses Using Single-Cell Transcriptomics

Autores: Francisco Pestana, T. Grant Belgard, Thierry Voet, Matthew G. Holt
Publicado en: Neuromethods, New Technologies for Glutamate Interaction, 2024, Página(s) 173-206
Editor: Springer US
DOI: 10.1007/978-1-0716-3742-5_9