Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3S

Informations projet

NCBio

N° de convention de subvention: 951923

DOI

10.3030/951923

Date de signature de la CE 10 Juin 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2026

Financé au titre de

• Establishing ‚ERA Chairs’

Coût total

€ 2 479 972,50

Contribution de l’UE

€ 2 479 972,50

Coordonné par

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Neural Cell Biology Doctoral Training Plan
Neural Cell Biology Group´s annual activity reports 3

Neural Cell Biology Groups annual activity reports 3

Neural Cell Biology Group´s annual activity reports 2

Neural Cell Biology Groups annual activity reports 2

Report on the research career support in Neural Cell Biology 1
Bi-annual capacity building and knowledge transfer plans 2
Neural Cell Biology Group´s annual activity reports 1

Neural Cell Biology Groups annual activity reports 1

Bi-annual capacity building and knowledge transfer plans 1

Open Research Data Pilot (2)

NCbio promotional toolkit 1
Launch of NCbio webpage

Websites, patent fillings, videos etc. (1)

Data Management Plan

Publications

Peer reviewed articles (18)

Localized astrogenesis regulates gyrification of the cerebral cortex

Auteurs: Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori, Takayuki Kannon, Kazuyoshi Hosomichi, Michal Slezak, Matthew G. Holt, Atsushi Tajima, Osamu Hori, Hiroshi Kawasaki
Publié dans: Science Advances, Numéro 8, 2024, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi5209

Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

Auteurs: Maria João Pereira, Rajagopal Ayana, Matthew G. Holt, Lutgarde Arckens
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 11, 2023, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2023.1193130

Association of Serum Biomarkers With Neurocognitive Decline After PCI in Small Cell Lung Cancer: An Exploratory Study of the Phase III NCT01780675 Trial

Auteurs: Haiyan Zeng, Lizza E.L. Hendriks, José Belderbos, Lloyd Brandts, Inge Compter, Ludwig Dubois, Matthew G. Holt, Ruud Houben, Sanne Schagen, Xin Zhang, Teresa Prezzemolo, Dirk De Ruysscher
Publié dans: Clinical Lung Cancer, Numéro 25, 2024, Page(s) 653-659.e1, ISSN 1525-7304
Éditeur: Cancer Information Group
DOI: 10.1016/j.cllc.2024.08.008

Astrocyte heterogeneity and interactions with local neural circuits

Auteurs: Matthew G. Holt
Publié dans: Essays in Biochemistry, Numéro 67, 2023, Page(s) 93-106, ISSN 0071-1365
Éditeur: Portland Press, Ltd.
DOI: 10.1042/ebc20220136

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Auteurs: Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston
Publié dans: EMBO Molecular Medicine, Numéro 15, 2023, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216805

Corrigendum to “A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions” [Neuroscience 508 (2023) 40–51]

Auteurs: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Publié dans: Neuroscience, Numéro 528, 2023, Page(s) 140-141, ISSN 0306-4522
Éditeur: Elsevier BV
DOI: 10.1016/j.neuroscience.2023.06.003

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Auteurs: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publié dans: Molecular Neurodegeneration, Numéro 19, 2024, ISSN 1750-1326
Éditeur: BioMed Central
DOI: 10.1186/s13024-023-00699-0

Regulatory T cells as a possible new target in epilepsy?

Auteurs: Evelien Hendrix, Maxime Vande Vyver, Matthew Holt, Ilse Smolders
Publié dans: Epilepsia, Numéro 65, 2024, Page(s) 2227-2237, ISSN 0013-9580
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/epi.18038

Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report

Auteurs: Ahmed Abdelfattah, Srinivasa Rao Allu, Robert E. Campbell, Xiaojun Cheng, Tomáš Cižmár, Irene Costantini, Valentina Emiliani, Natalie Fomin-Thunemann, Ariel Gilad, Tomás Fernández Alfonso, Christopher G. L. Ferri, Andrew Harris, Elizabeth M. C. Hillman, Matthew G. Holt, Kivilcim Kiliç, Evan W. Miller, Rickson C. Mesquita, K.M. Naga Srinivas Nadella, U. Valentin Nägerl, Citlali Perez Campos
Publié dans: Neurophotonics, Numéro 9, 2024, ISSN 2329-423X
Éditeur: Society of Photo-Optical Instrumentation Engineers
DOI: 10.1117/1.nph.9.s1.013001

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

Auteurs: P. Bielefeld, A. Martirosyan, S. Martín-Suárez, A. Apresyan, G. F. Meerhoff, F. Pestana, S. Poovathingal, N. Reijner, W. Koning, R. A. Clement, I. Van der Veen, E. M. Toledo, O. Polzer, I. Durá, S. Hovhannisyan, B. S. Nilges, A. Bogdoll, N. D. Kashikar, P. J. Lucassen, T. G. Belgard, J. M. Encinas, M. G. Holt, C. P. Fitzsimons
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-49299-6

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Auteurs: Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaitre, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar Tareen, Carlos P. Roca, Kailash Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, Teresa Prezzemol
Publié dans: Nature Immunology, 2022, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1101/2022.02.28.482297

Astrocyte structural heterogeneity in the mouse hippocampus

Auteurs: João Filipe Viana, João Luís Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sónia Guerra‐Gomes, Cátia Domingos, Alberto Pauletti, Jérôme Wahis, Chen Liu, Corrado Calì, Christian Henneberger, Matthew G. Holt, João Filipe Oliveira
Publié dans: Glia, Numéro 71, 2023, Page(s) 1667-1682, ISSN 0894-1491
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/glia.24362

A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions

Auteurs: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Publié dans: Neuroscience, Numéro 508, 2023, Page(s) 40-51, ISSN 0306-4522
Éditeur: Elsevier BV
DOI: 10.1016/j.neuroscience.2022.11.029

A conformational switch controlling the toxicity of the prion protein

Auteurs: Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R. Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G. Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Publié dans: Nature Structural & Molecular Biology, Numéro 29, 2022, Page(s) 831-840, ISSN 1545-9993
Éditeur: Nature Publishing Group
DOI: 10.1038/s41594-022-00814-7

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Auteurs: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark Fiers, Matthew Holt, Dietmar Rudolf Thal, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Rik Vandenberghe, Uwe Himmelreich, Vincent Bonin, Bart De Strooper
Publié dans: Cell Reports, Numéro 40, 2024, Page(s) 111280, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111280

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Auteurs: Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Publié dans: EMBO Molecular Medicine, Numéro 14, 2023, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809824

The astrocyte <scp>α1A</scp>‐adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

Auteurs: Jérôme Wahis, Cansu Akkaya, Andre M. Kirunda, Aline Mak, Karen Zeise, Jens Verhaert, Hayk Gasparyan, Sargis Hovhannisyan, Matthew G. Holt
Publié dans: Glia, Numéro 72, 2024, Page(s) 1955-1973, ISSN 0894-1491
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/glia.24591

AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System

Auteurs: Marika Marino, Matthew G. Holt
Publié dans: Frontiers in Neurology, Numéro 13, 2022, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.870799

Book chapters (1)

Studying the Role of Astrocytes at Synapses Using Single-Cell Transcriptomics

Auteurs: Francisco Pestana, T. Grant Belgard, Thierry Voet, Matthew G. Holt
Publié dans: Neuromethods, New Technologies for Glutamate Interaction, 2024, Page(s) 173-206
Éditeur: Springer US
DOI: 10.1007/978-1-0716-3742-5_9