Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3S

Informacje na temat projektu

NCBio

Identyfikator umowy o grant: 951923

DOI

10.3030/951923

Data podpisania przez KE 10 Czerwca 2020

Data rozpoczęcia 1 Stycznia 2021

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• Establishing ‚ERA Chairs’

Koszt całkowity

€ 2 479 972,50

Wkład UE

€ 2 479 972,50

Koordynowany przez

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (7)

Neural Cell Biology Doctoral Training Plan
Neural Cell Biology Group´s annual activity reports 3

Neural Cell Biology Groups annual activity reports 3

Neural Cell Biology Group´s annual activity reports 2

Neural Cell Biology Groups annual activity reports 2

Report on the research career support in Neural Cell Biology 1
Bi-annual capacity building and knowledge transfer plans 2
Neural Cell Biology Group´s annual activity reports 1

Neural Cell Biology Groups annual activity reports 1

Bi-annual capacity building and knowledge transfer plans 1

Open Research Data Pilot (2)

NCbio promotional toolkit 1
Launch of NCbio webpage

Websites, patent fillings, videos etc. (1)

Data Management Plan

Publikacje

Peer reviewed articles (18)

Localized astrogenesis regulates gyrification of the cerebral cortex

Autorzy: Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori, Takayuki Kannon, Kazuyoshi Hosomichi, Michal Slezak, Matthew G. Holt, Atsushi Tajima, Osamu Hori, Hiroshi Kawasaki
Opublikowane w: Science Advances, Numer 8, 2024, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi5209

Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

Autorzy: Maria João Pereira, Rajagopal Ayana, Matthew G. Holt, Lutgarde Arckens
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 11, 2023, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2023.1193130

Association of Serum Biomarkers With Neurocognitive Decline After PCI in Small Cell Lung Cancer: An Exploratory Study of the Phase III NCT01780675 Trial

Autorzy: Haiyan Zeng, Lizza E.L. Hendriks, José Belderbos, Lloyd Brandts, Inge Compter, Ludwig Dubois, Matthew G. Holt, Ruud Houben, Sanne Schagen, Xin Zhang, Teresa Prezzemolo, Dirk De Ruysscher
Opublikowane w: Clinical Lung Cancer, Numer 25, 2024, Strona(/y) 653-659.e1, ISSN 1525-7304
Wydawca: Cancer Information Group
DOI: 10.1016/j.cllc.2024.08.008

Astrocyte heterogeneity and interactions with local neural circuits

Autorzy: Matthew G. Holt
Opublikowane w: Essays in Biochemistry, Numer 67, 2023, Strona(/y) 93-106, ISSN 0071-1365
Wydawca: Portland Press, Ltd.
DOI: 10.1042/ebc20220136

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Autorzy: Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston
Opublikowane w: EMBO Molecular Medicine, Numer 15, 2023, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216805

Corrigendum to “A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions” [Neuroscience 508 (2023) 40–51]

Autorzy: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Opublikowane w: Neuroscience, Numer 528, 2023, Strona(/y) 140-141, ISSN 0306-4522
Wydawca: Elsevier BV
DOI: 10.1016/j.neuroscience.2023.06.003

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Autorzy: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Opublikowane w: Molecular Neurodegeneration, Numer 19, 2024, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-023-00699-0

Regulatory T cells as a possible new target in epilepsy?

Autorzy: Evelien Hendrix, Maxime Vande Vyver, Matthew Holt, Ilse Smolders
Opublikowane w: Epilepsia, Numer 65, 2024, Strona(/y) 2227-2237, ISSN 0013-9580
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/epi.18038

Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report

Autorzy: Ahmed Abdelfattah, Srinivasa Rao Allu, Robert E. Campbell, Xiaojun Cheng, Tomáš Cižmár, Irene Costantini, Valentina Emiliani, Natalie Fomin-Thunemann, Ariel Gilad, Tomás Fernández Alfonso, Christopher G. L. Ferri, Andrew Harris, Elizabeth M. C. Hillman, Matthew G. Holt, Kivilcim Kiliç, Evan W. Miller, Rickson C. Mesquita, K.M. Naga Srinivas Nadella, U. Valentin Nägerl, Citlali Perez Campos
Opublikowane w: Neurophotonics, Numer 9, 2024, ISSN 2329-423X
Wydawca: Society of Photo-Optical Instrumentation Engineers
DOI: 10.1117/1.nph.9.s1.013001

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

Autorzy: P. Bielefeld, A. Martirosyan, S. Martín-Suárez, A. Apresyan, G. F. Meerhoff, F. Pestana, S. Poovathingal, N. Reijner, W. Koning, R. A. Clement, I. Van der Veen, E. M. Toledo, O. Polzer, I. Durá, S. Hovhannisyan, B. S. Nilges, A. Bogdoll, N. D. Kashikar, P. J. Lucassen, T. G. Belgard, J. M. Encinas, M. G. Holt, C. P. Fitzsimons
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-49299-6

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Autorzy: Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaitre, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar Tareen, Carlos P. Roca, Kailash Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, Teresa Prezzemol
Opublikowane w: Nature Immunology, 2022, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1101/2022.02.28.482297

Astrocyte structural heterogeneity in the mouse hippocampus

Autorzy: João Filipe Viana, João Luís Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sónia Guerra‐Gomes, Cátia Domingos, Alberto Pauletti, Jérôme Wahis, Chen Liu, Corrado Calì, Christian Henneberger, Matthew G. Holt, João Filipe Oliveira
Opublikowane w: Glia, Numer 71, 2023, Strona(/y) 1667-1682, ISSN 0894-1491
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/glia.24362

A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions

Autorzy: Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Opublikowane w: Neuroscience, Numer 508, 2023, Strona(/y) 40-51, ISSN 0306-4522
Wydawca: Elsevier BV
DOI: 10.1016/j.neuroscience.2022.11.029

A conformational switch controlling the toxicity of the prion protein

Autorzy: Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R. Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G. Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Opublikowane w: Nature Structural & Molecular Biology, Numer 29, 2022, Strona(/y) 831-840, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/s41594-022-00814-7

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Autorzy: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark Fiers, Matthew Holt, Dietmar Rudolf Thal, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Rik Vandenberghe, Uwe Himmelreich, Vincent Bonin, Bart De Strooper
Opublikowane w: Cell Reports, Numer 40, 2024, Strona(/y) 111280, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111280

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Autorzy: Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Opublikowane w: EMBO Molecular Medicine, Numer 14, 2023, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809824

The astrocyte <scp>α1A</scp>‐adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

Autorzy: Jérôme Wahis, Cansu Akkaya, Andre M. Kirunda, Aline Mak, Karen Zeise, Jens Verhaert, Hayk Gasparyan, Sargis Hovhannisyan, Matthew G. Holt
Opublikowane w: Glia, Numer 72, 2024, Strona(/y) 1955-1973, ISSN 0894-1491
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/glia.24591

AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System

Autorzy: Marika Marino, Matthew G. Holt
Opublikowane w: Frontiers in Neurology, Numer 13, 2022, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.870799

Book chapters (1)

Studying the Role of Astrocytes at Synapses Using Single-Cell Transcriptomics

Autorzy: Francisco Pestana, T. Grant Belgard, Thierry Voet, Matthew G. Holt
Opublikowane w: Neuromethods, New Technologies for Glutamate Interaction, 2024, Strona(/y) 173-206
Wydawca: Springer US
DOI: 10.1007/978-1-0716-3742-5_9