Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3S

Project Information

NCBio

Grant agreement ID: 951923

DOI

10.3030/951923

EC signature date 10 June 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• Establishing ‚ERA Chairs’

Total cost

€ 2 479 972,50

EU contribution

€ 2 479 972,50

Coordinated by

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (7)

Neural Cell Biology Doctoral Training Plan
Neural Cell Biology Group´s annual activity reports 3

Neural Cell Biology Groups annual activity reports 3

Neural Cell Biology Group´s annual activity reports 2

Neural Cell Biology Groups annual activity reports 2

Report on the research career support in Neural Cell Biology 1
Bi-annual capacity building and knowledge transfer plans 2
Neural Cell Biology Group´s annual activity reports 1

Neural Cell Biology Groups annual activity reports 1

Bi-annual capacity building and knowledge transfer plans 1

Open Research Data Pilot (2)

NCbio promotional toolkit 1
Launch of NCbio webpage

Websites, patent fillings, videos etc. (1)

Data Management Plan

Publications

Peer reviewed articles (18)

Localized astrogenesis regulates gyrification of the cerebral cortex

Author(s): Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori, Takayuki Kannon, Kazuyoshi Hosomichi, Michal Slezak, Matthew G. Holt, Atsushi Tajima, Osamu Hori, Hiroshi Kawasaki
Published in: Science Advances, Issue 8, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi5209

Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

Author(s): Maria João Pereira, Rajagopal Ayana, Matthew G. Holt, Lutgarde Arckens
Published in: Frontiers in Cell and Developmental Biology, Issue 11, 2023, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2023.1193130

Association of Serum Biomarkers With Neurocognitive Decline After PCI in Small Cell Lung Cancer: An Exploratory Study of the Phase III NCT01780675 Trial

Author(s): Haiyan Zeng, Lizza E.L. Hendriks, José Belderbos, Lloyd Brandts, Inge Compter, Ludwig Dubois, Matthew G. Holt, Ruud Houben, Sanne Schagen, Xin Zhang, Teresa Prezzemolo, Dirk De Ruysscher
Published in: Clinical Lung Cancer, Issue 25, 2024, Page(s) 653-659.e1, ISSN 1525-7304
Publisher: Cancer Information Group
DOI: 10.1016/j.cllc.2024.08.008

Astrocyte heterogeneity and interactions with local neural circuits

Author(s): Matthew G. Holt
Published in: Essays in Biochemistry, Issue 67, 2023, Page(s) 93-106, ISSN 0071-1365
Publisher: Portland Press, Ltd.
DOI: 10.1042/ebc20220136

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Author(s): Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston
Published in: EMBO Molecular Medicine, Issue 15, 2023, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216805

Corrigendum to “A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions” [Neuroscience 508 (2023) 40–51]

Author(s): Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Published in: Neuroscience, Issue 528, 2023, Page(s) 140-141, ISSN 0306-4522
Publisher: Elsevier BV
DOI: 10.1016/j.neuroscience.2023.06.003

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Author(s): Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Published in: Molecular Neurodegeneration, Issue 19, 2024, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-023-00699-0

Regulatory T cells as a possible new target in epilepsy?

Author(s): Evelien Hendrix, Maxime Vande Vyver, Matthew Holt, Ilse Smolders
Published in: Epilepsia, Issue 65, 2024, Page(s) 2227-2237, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.18038

Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report

Author(s): Ahmed Abdelfattah, Srinivasa Rao Allu, Robert E. Campbell, Xiaojun Cheng, Tomáš Cižmár, Irene Costantini, Valentina Emiliani, Natalie Fomin-Thunemann, Ariel Gilad, Tomás Fernández Alfonso, Christopher G. L. Ferri, Andrew Harris, Elizabeth M. C. Hillman, Matthew G. Holt, Kivilcim Kiliç, Evan W. Miller, Rickson C. Mesquita, K.M. Naga Srinivas Nadella, U. Valentin Nägerl, Citlali Perez Campos
Published in: Neurophotonics, Issue 9, 2024, ISSN 2329-423X
Publisher: Society of Photo-Optical Instrumentation Engineers
DOI: 10.1117/1.nph.9.s1.013001

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

Author(s): P. Bielefeld, A. Martirosyan, S. Martín-Suárez, A. Apresyan, G. F. Meerhoff, F. Pestana, S. Poovathingal, N. Reijner, W. Koning, R. A. Clement, I. Van der Veen, E. M. Toledo, O. Polzer, I. Durá, S. Hovhannisyan, B. S. Nilges, A. Bogdoll, N. D. Kashikar, P. J. Lucassen, T. G. Belgard, J. M. Encinas, M. G. Holt, C. P. Fitzsimons
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49299-6

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Author(s): Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaitre, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar Tareen, Carlos P. Roca, Kailash Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, Teresa Prezzemol
Published in: Nature Immunology, 2022, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1101/2022.02.28.482297

Astrocyte structural heterogeneity in the mouse hippocampus

Author(s): João Filipe Viana, João Luís Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sónia Guerra‐Gomes, Cátia Domingos, Alberto Pauletti, Jérôme Wahis, Chen Liu, Corrado Calì, Christian Henneberger, Matthew G. Holt, João Filipe Oliveira
Published in: Glia, Issue 71, 2023, Page(s) 1667-1682, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24362

A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions

Author(s): Gabriela Edwards-Faret, Filip de Vin, Michal Slezak, Lennart Gollenbeck, Ruçhan Karaman, Yohei Shinmyo, Mykhailo Y. Batiuk, Carmen Menacho Pando, Johann Urschitz, Melvin Y. Rincon, Stefan Moisyadi, Frank Schnütgen, Hiroshi Kawasaki, Dietmar Schmucker, Matthew G. Holt
Published in: Neuroscience, Issue 508, 2023, Page(s) 40-51, ISSN 0306-4522
Publisher: Elsevier BV
DOI: 10.1016/j.neuroscience.2022.11.029

A conformational switch controlling the toxicity of the prion protein

Author(s): Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R. Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G. Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Published in: Nature Structural & Molecular Biology, Issue 29, 2022, Page(s) 831-840, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00814-7

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Author(s): Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark Fiers, Matthew Holt, Dietmar Rudolf Thal, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Rik Vandenberghe, Uwe Himmelreich, Vincent Bonin, Bart De Strooper
Published in: Cell Reports, Issue 40, 2024, Page(s) 111280, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111280

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Author(s): Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Published in: EMBO Molecular Medicine, Issue 14, 2023, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809824

The astrocyte <scp>α1A</scp>‐adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

Author(s): Jérôme Wahis, Cansu Akkaya, Andre M. Kirunda, Aline Mak, Karen Zeise, Jens Verhaert, Hayk Gasparyan, Sargis Hovhannisyan, Matthew G. Holt
Published in: Glia, Issue 72, 2024, Page(s) 1955-1973, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24591

AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System

Author(s): Marika Marino, Matthew G. Holt
Published in: Frontiers in Neurology, Issue 13, 2022, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.870799

Book chapters (1)

Studying the Role of Astrocytes at Synapses Using Single-Cell Transcriptomics

Author(s): Francisco Pestana, T. Grant Belgard, Thierry Voet, Matthew G. Holt
Published in: Neuromethods, New Technologies for Glutamate Interaction, 2024, Page(s) 173-206
Publisher: Springer US
DOI: 10.1007/978-1-0716-3742-5_9