Straightening training, research and innovation capacities in the valorization of bio-renewable resource

Project Information

Biomass4Synthons

Grant agreement ID: 951996

DOI

10.3030/951996

Project closed

EC signature date 30 June 2020

Start date 1 January 2021

End date 30 June 2024

Funded under

Twinning of research institutions

Total cost

€ 900 000,00

EU contribution

€ 900 000,00

900 000,00

Coordinated by

Faculdade de Farmácia da Universidade de Lisboa
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Biomass4Synthons Summer Schools

FFUL and IOCCP-BAS will prepare the summer schools.

For all KPIs - Impact assessment in the 3-year period before Biomass4Synthons

The impact assessment will be done at the outset of the project

Report of the industry meeting

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Biomass4Synthons Thematic Workshop

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 2.2

Public awareness movement

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Resume of the Project publications

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Impact evaluation by the project terminus and estimate the next 3-year period

The impact assessment will be done at the terminus.

"Event ""Knowledge Transfer Zone"" through meetings between enterprises and research institutions"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

"Event ""The industrial day"" related to flow chemistry applications"

KPIs discrimination for Biomass4Synthons

The KPIs will be carefully examinated with the Consortium members and an ultimate list of these KPIs will be assembled at M2

Creation of the project brand and logo

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Brochure and flyer development

Communication will be done through the project website promotional brochure and flyer press releases or newsletters presented in Section 22

Website launch

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Publications

Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol

Author(s): Cláudia Bento, Marianna Katz, Maria M. M. Santos, Carlos A. M. Afonso
Published in: Organic Process Research & Development, Issue 28, 2024, Page(s) 860-890, ISSN 1083-6160
Publisher: American Chemical Society
DOI: 10.1021/acs.oprd.3c00428

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

Author(s): Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
Published in: Angewandte Chemie International Edition, Issue 62, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304449

A direct Diels–Alder reaction of chitin derived 3-acetamido-5-acetylfuran

Author(s): Juliana G. Pereira, João M. J. M. Ravasco, João R. Vale, Fausto Queda, Rafael F. A. Gomes
Published in: Green Chemistry, Issue 24, 2024, Page(s) 7131-7136, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc00253a

Preparation of Aminals under Continuous Flow Conditions

Author(s): Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: Journal of Chemical Education, Issue 100, 2023, Page(s) 4728-4733, ISSN 0021-9584
Publisher: American Chemical Society
DOI: 10.1021/acs.jchemed.3c00306

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Author(s): Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: Reaction Chemistry & Engineering, Issue 8, 2024, Page(s) 482-489, ISSN 2058-9883
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2re00292b

One-Pot Transformation of Salicylaldehydes to Spiroepoxydienones via the Adler–Becker Reaction in a Continuous Flow

Author(s): Andreia A. Rosatella* and Carlos A. M. Afonso*
Published in: ACS Omega, 2022, Page(s) 11570–11577, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.1c05559

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Author(s): Milene Fortunato, Filipa Siopa, Carlos Afonso
Published in: Molbank, Issue 2021/2, 2021, Page(s) M1199, ISSN 1422-8599
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/m1199

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A

Author(s): Rafael F. A. Gomes, João R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Published in: Organic Letters, Issue 25, 2023, Page(s) 4188-4192, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.3c01513

Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Author(s): Rafael F. A. Gomes; Vera M. S. Isca; Vera M. S. Isca; Késsia Andrade; Patrícia Rijo; Patrícia Rijo; Carlos A. M. Afonso
Published in: Chemmedchem, Issue 2, 2021, Page(s) 2781– 2785, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100369

CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites.

Author(s): Martin Ravutsov; Yavor Mitrev; Pavletta Shestakova; Hristina Lazarova; Svilen P. Simeonov; Margarita Popova
Published in: Volume 11, Issue 1, 2021, Page(s) 2831, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11112831

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Author(s): Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble
Published in: Beilstein Journal of Organic Chemistry, Issue 19, 2023, Page(s) 582-592, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.19.43

High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to <i>trans</i>-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines

Author(s): Lídia A. S. Cavaca, Tiago M. P. Santos, Joao M. J. M. Ravasco, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: The Journal of Organic Chemistry, Issue 89, 2024, Page(s) 6677-6683, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c01040

Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones

Author(s): Miroslav Dangalov, Adolfo Fernández-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Published in: ACS Catalysis, Issue 13, 2023, Page(s) 1916-1925, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c04867

From Pyridine to (−)‐Agelastatin A

Author(s): João R. Vale, Milene A. G. Fortunato, Késsia H. S. Andrade, Ângelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Published in: Advanced Synthesis & Catalysis, Issue 365, 2023, Page(s) 2240-2247, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202300560

Preparation of Thioaminals in Water

Author(s): Lídia A. S. Cavaca; Rafael F. A. Gomes; Carlos A. M. Afonso
Published in: Molecules; Volume 27; Issue 5; Pages: 1673, Issue 4, 2022, Page(s) 1673, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051673

Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions

Author(s): Adolfo Fernández-Figueiras, Martin A. Ravutsov, and Svilen P. Simeonov*
Published in: ACS Omega, 2022, Page(s) 6439–6448, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.1c05830

Recent Advances on Diels-Alder-Driven Preparation of Bio-Based Aromatics.

Author(s): João M. J. M. Ravasco; Rafael F. A. Gomes
Published in: Chemsuschem, Issue 2, 2021, Page(s) 3047–305, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100813

Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid

Author(s): Martin A. Ravutsov, Maya M. Marinova, Atanas Kurutos, Svilen P. Simeonov
Published in: Sustainable Chemistry and Pharmacy, Issue 38, 2024, Page(s) 101491, ISSN 2352-5541
Publisher: MDPI
DOI: 10.1016/j.scp.2024.101491

4-Ketovalero lactone (KVL): A gateway molecule for diversification of the furanic platform

Author(s): Raquel M. Durão, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Published in: Sustainable Chemistry and Pharmacy, Issue 39, 2024, Page(s) 101553, ISSN 2352-5541
Publisher: Elsevier
DOI: 10.1016/j.scp.2024.101553

Cu‐Catalyzed Tandem Oxidation‐Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Author(s): Hristo Petkov, Martin A. Ravutsov, Manuel J. Verganista, Yavor N. Mitrev, Nuno R. Candeias, Svilen P. Simeonov
Published in: ChemSusChem, Issue 17, 2024, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202400013

Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

Author(s): Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: ChemMedChem, Issue 18, 2023, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202300104

2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Author(s): Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
Published in: Organic & Biomolecular Chemistry, Issue 22, 2024, Page(s) 2902-2915, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4ob00199k

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Author(s): Hristo Petkov, Svilen P. Simeonov
Published in: Applied Sciences, Issue 13, 2023, Page(s) 6616, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app13116616

Semi-continuous and continuous processes for enantiomeric separation

Author(s): Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Published in: Green Chemistry, Issue 24, 2024, Page(s) 4328-4362, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1gc03668h

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Author(s): Ivaylo Slavchev, Jas. S. Ward, Kari Rissanen, Georgi M. Dobrikov, Svilen Simeonov
Published in: RSC Advances, Issue 12, 2024, Page(s) 20555-20562, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra03524c

Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams

Author(s): Georgy Grancharov, Mariya-Desislava Atanasova, Radostina Kalinova, Pencho Tuleshkov, Petar D. Petrov, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Published in: Polymers, Issue 15, 2023, Page(s) 4148, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym15204148

Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones

Author(s): Dr. Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Dr. Jaime A. S. Coelho, Prof. Rui Moreira, Rafael Oliveira, Prof. Fátima Nogueira, Prof. Carlos A. M. Afonso
Published in: ChemSusChem, 2022, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202102204

Modular synthesis of 2-furyl carbinols from 3-benzyldimethylsilylfurfural platforms relying on oxygen-assisted C–Si bond functionalization

Author(s): Sebastien Curpanen, Per Reichert, Gabriele Lupidi, Giovanni Poli, Julie Oble, Alejandro Perez-Luna
Published in: Beilstein Journal of Organic Chemistry, Issue 18, 2022, Page(s) 1256-1263, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.18.131

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

Author(s): Katya Kamenova, Lyubomira Radeva, Krassimira Yoncheva, Filip Ublekov, Martin A. Ravutsov, Maya K. Marinova, Svilen P. Simeonov, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov
Published in: Polymers, Issue 14, 2024, Page(s) 3694, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14173694

Sustainable synthesis of nitrogen-rich aromatics from chitin: Opportunities and challenges

Author(s): Nicholas Bossons, Rafael F.A. Gomes
Published in: Current Opinion in Green and Sustainable Chemistry, Issue 49, 2024, Page(s) 100961, ISSN 2452-2236
Publisher: Elsevier
DOI: 10.1016/j.cogsc.2024.100961

Silica-Supported Copper for the Preparation of trans-4,5-Diamino-Cyclopent-2-Enones under Continuous Flow Conditions

Author(s): Rafael F. A. Gomes; Lídia A. S. Cavaca; João Gonçalves; Ruben Ramos; Andreia F. Peixoto; Blanca I. Arias-Serrano; Blanca I. Arias-Serrano; Carlos A. M. Afonso
Published in: ACS Sustainable Chem. Eng., Issue 2, 2021, Page(s) 16038–16043, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.1c00884

Photochemical Reactions of Acylsilanes Towards the Construction of Carbon-Carbon Bonds

Author(s): João R. Vale
Published in: 2023, ISBN 978-952-03-2773-6
Publisher: Tampere University

Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer

Author(s): Jesus, Rita Rodrigues Fernandes de
Published in: Issue 1, 2021
Publisher: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Electrochemical oxidation of abietanes

Author(s): Martins, Inês Alexandra de Sá
Published in: Issue 2021/09, 2021
Publisher: University of Lisnon

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Deliverables

Publications

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