Straightening training, research and innovation capacities in the valorization of bio-renewable resource

Deliverables

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Brochure and flyer development

Communication will be done through the project website promotional brochure and flyer press releases or newsletters presented in Section 22

Website launch

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

For all KPIs - Impact assessment in the 3-year period before Biomass4Synthons

The impact assessment will be done at the outset of the project

KPIs discrimination for Biomass4Synthons

The KPIs will be carefully examinated with the Consortium members and an ultimate list of these KPIs will be assembled at M2

Publications

Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane‐1,2,5‐triol from Furfuryl Alcohol

Author(s): Svilen P. Simeonov, Martin A. Ravutsov, Marko D. Mihovilovic
Published in: ChemSusChem, Issue 12/12, 2019, Page(s) 2748-2754, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.201900601

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

Author(s): Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
Published in: Angewandte Chemie International Edition, Issue 62, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304449

A direct Diels–Alder reaction of chitin derived 3-acetamido-5-acetylfuran

Author(s): Juliana G. Pereira, João M. J. M. Ravasco, João R. Vale, Fausto Queda, Rafael F. A. Gomes
Published in: Green Chemistry, Issue 24, 2024, Page(s) 7131-7136, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc00253a

Preparation of Aminals under Continuous Flow Conditions

Author(s): Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: Journal of Chemical Education, Issue 100, 2023, Page(s) 4728-4733, ISSN 0021-9584
Publisher: American Chemical Society
DOI: 10.1021/acs.jchemed.3c00306

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Author(s): Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: Reaction Chemistry & Engineering, Issue 8, 2024, Page(s) 482-489, ISSN 2058-9883
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2re00292b

One-Pot Transformation of Salicylaldehydes to Spiroepoxydienones via the Adler–Becker Reaction in a Continuous Flow

Author(s): Andreia A. Rosatella* and Carlos A. M. Afonso*
Published in: ACS Omega, 2022, Page(s) 11570–11577, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.1c05559

Aqueous-Phase Hydrogenation of Levulinic Acid Using Formic Acid as a Sustainable Reducing Agent Over Pt Catalysts Supported on Mesoporous Zirconia

Author(s): M. Al-Naji, M. Popova, Z. Chen, N. Wilde, R. Gläser
Published in: ACS Sustainable Chemistry & Engineering, Issue 8/1, 2019, Page(s) 393-402, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.9b05546

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Author(s): Milene Fortunato, Filipa Siopa, Carlos Afonso
Published in: Molbank, Issue 2021/2, 2021, Page(s) M1199, ISSN 1422-8599
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/m1199

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A

Author(s): Rafael F. A. Gomes, João R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Published in: Organic Letters, Issue 25, 2023, Page(s) 4188-4192, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.3c01513

Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Author(s): Rafael F. A. Gomes; Vera M. S. Isca; Vera M. S. Isca; Késsia Andrade; Patrícia Rijo; Patrícia Rijo; Carlos A. M. Afonso
Published in: Chemmedchem, Issue 2, 2021, Page(s) 2781– 2785, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100369

CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites.

Author(s): Martin Ravutsov; Yavor Mitrev; Pavletta Shestakova; Hristina Lazarova; Svilen P. Simeonov; Margarita Popova
Published in: Volume 11, Issue 1, 2021, Page(s) 2831, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11112831

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Author(s): Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble
Published in: Beilstein Journal of Organic Chemistry, Issue 19, 2023, Page(s) 582-592, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.19.43

High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to <i>trans</i>-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines

Author(s): Lídia A. S. Cavaca, Tiago M. P. Santos, Joao M. J. M. Ravasco, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: The Journal of Organic Chemistry, Issue 89, 2024, Page(s) 6677-6683, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c01040

Achmatowicz rearrangement enables hydrogenolysis-free gas-phase synthesis of pentane-1,2,5-triol from furfuryl alcohol

Author(s): Svilen P. Simeonov, Hristina I. Lazarova, Maya K. Marinova, Margarita D. Popova
Published in: Green Chemistry, Issue 21/20, 2019, Page(s) 5657-5664, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9gc02888a

Chitin-glucan complex – Based biopolymeric structures using biocompatible ionic liquids

Author(s): Inês C. Ferreira, Diana Araújo, Pierre Voisin, Vítor D. Alves, Andreia A. Rosatella, Carlos A.M. Afonso, Filomena Freitas, Luísa A. Neves
Published in: Carbohydrate Polymers, Issue 247, 2020, Page(s) 116679, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2020.116679

Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones

Author(s): Miroslav Dangalov, Adolfo Fernández-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Published in: ACS Catalysis, Issue 13, 2023, Page(s) 1916-1925, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c04867

From Pyridine to (−)‐Agelastatin A

Author(s): João R. Vale, Milene A. G. Fortunato, Késsia H. S. Andrade, Ângelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Published in: Advanced Synthesis & Catalysis, Issue 365, 2023, Page(s) 2240-2247, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202300560

Preparation of Thioaminals in Water

Author(s): Lídia A. S. Cavaca; Rafael F. A. Gomes; Carlos A. M. Afonso
Published in: Molecules; Volume 27; Issue 5; Pages: 1673, Issue 4, 2022, Page(s) 1673, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051673

Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions

Author(s): Adolfo Fernández-Figueiras, Martin A. Ravutsov, and Svilen P. Simeonov*
Published in: ACS Omega, 2022, Page(s) 6439–6448, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.1c05830

Recent Advances on Diels-Alder-Driven Preparation of Bio-Based Aromatics.

Author(s): João M. J. M. Ravasco; Rafael F. A. Gomes
Published in: Chemsuschem, Issue 2, 2021, Page(s) 3047–305, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100813

Direct Conversion of Activated 5-Hydroxymethylfurfural into δ-Lactone-Fused Cyclopentenones

Author(s): Rafael F. A. Gomes, Jaime A. S. Coelho, Carlos A. M. Afonso
Published in: ChemSusChem, Issue 12/2, 2019, Page(s) 420-425, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.201802537

Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid

Author(s): Martin A. Ravutsov, Maya M. Marinova, Atanas Kurutos, Svilen P. Simeonov
Published in: Sustainable Chemistry and Pharmacy, Issue 38, 2024, Page(s) 101491, ISSN 2352-5541
Publisher: MDPI
DOI: 10.1016/j.scp.2024.101491

Reactive Dimerization of an N-Heterocyclic Plumbylene: C−H Activation with Pb II

Author(s): Robin Guthardt, Jan Oetzel, Julia I. Schweizer, Clemens Bruhn, Robert Langer, Martin Maurer, Jan Vícha, Pavletta Shestakova, Max C. Holthausen, Ulrich Siemeling
Published in: Angewandte Chemie International Edition, Issue 58/5, 2019, Page(s) 1387-1391, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811559

4-Ketovalero lactone (KVL): A gateway molecule for diversification of the furanic platform

Author(s): Raquel M. Durão, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Published in: Sustainable Chemistry and Pharmacy, Issue 39, 2024, Page(s) 101553, ISSN 2352-5541
Publisher: Elsevier
DOI: 10.1016/j.scp.2024.101553

Cu‐Catalyzed Tandem Oxidation‐Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Author(s): Hristo Petkov, Martin A. Ravutsov, Manuel J. Verganista, Yavor N. Mitrev, Nuno R. Candeias, Svilen P. Simeonov
Published in: ChemSusChem, Issue 17, 2024, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202400013

Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

Author(s): Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: ChemMedChem, Issue 18, 2023, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202300104

Valorization of Oleuropein via Tunable Acid-Promoted Methanolysis

Author(s): Lídia A. S. Cavaca, Catarina A. B. Rodrigues, Svilen P. Simeonov, Rafael F. A. Gomes, Jaime A. S. Coelho, Gustavo P. Romanelli, Angel G. Sathicq, José J. Martínez, Carlos A. M. Afonso
Published in: ChemSusChem, Issue 11/14, 2018, Page(s) 2300-2305, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.201800980

Going Beyond the Limits of the Biorenewable Platform: Sodium Dithionite-Promoted Stabilization of 5-Hydroxymethylfurfural

Author(s): Rafael F. A. Gomes, Yavor N. Mitrev, Svilen P. Simeonov, Carlos A. M. Afonso
Published in: ChemSusChem, Issue 11/10, 2018, Page(s) 1612-1616, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.201800297

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Author(s): Hristo Petkov, Svilen P. Simeonov
Published in: Applied Sciences, Issue 13, 2023, Page(s) 6616, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app13116616

Semi-continuous and continuous processes for enantiomeric separation

Author(s): Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Published in: Green Chemistry, Issue 24, 2024, Page(s) 4328-4362, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1gc03668h

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Author(s): Ivaylo Slavchev, Jas. S. Ward, Kari Rissanen, Georgi M. Dobrikov, Svilen Simeonov
Published in: RSC Advances, Issue 12, 2024, Page(s) 20555-20562, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra03524c

Creating Diversity from Biomass: A Tandem Bio/Metal‐Catalysis towards Chemoselective Synthesis of Densely Substituted Furans

Author(s): João M. J. M. Ravasco, Carlos M. Monteiro, Filipa Siopa, Alexandre F. Trindade, Julie Oble, Giovanni Poli, Svilen P. Simeonov, Carlos A. M. Afonso
Published in: ChemSusChem, Issue 12/20, 2019, Page(s) 4629-4635, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.201902051

Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams

Author(s): Georgy Grancharov, Mariya-Desislava Atanasova, Radostina Kalinova, Pencho Tuleshkov, Petar D. Petrov, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Published in: Polymers, Issue 15, 2023, Page(s) 4148, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym15204148

Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones

Author(s): Dr. Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Dr. Jaime A. S. Coelho, Prof. Rui Moreira, Rafael Oliveira, Prof. Fátima Nogueira, Prof. Carlos A. M. Afonso
Published in: ChemSusChem, 2022, ISSN 1864-5631
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202102204

Modular synthesis of 2-furyl carbinols from 3-benzyldimethylsilylfurfural platforms relying on oxygen-assisted C–Si bond functionalization

Author(s): Sebastien Curpanen, Per Reichert, Gabriele Lupidi, Giovanni Poli, Julie Oble, Alejandro Perez-Luna
Published in: Beilstein Journal of Organic Chemistry, Issue 18, 2022, Page(s) 1256-1263, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.18.131

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

Author(s): Katya Kamenova, Lyubomira Radeva, Krassimira Yoncheva, Filip Ublekov, Martin A. Ravutsov, Maya K. Marinova, Svilen P. Simeonov, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov
Published in: Polymers, Issue 14, 2024, Page(s) 3694, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14173694

Sustainable synthesis of nitrogen-rich aromatics from chitin: Opportunities and challenges

Author(s): Nicholas Bossons, Rafael F.A. Gomes
Published in: Current Opinion in Green and Sustainable Chemistry, Issue 49, 2024, Page(s) 100961, ISSN 2452-2236
Publisher: Elsevier
DOI: 10.1016/j.cogsc.2024.100961

Rediscovering aminal chemistry: copper( ii ) catalysed formation under mild conditions

Author(s): Juliana G. Pereira, João P. M. António, Ricardo Mendonça, Rafael F. A. Gomes, Carlos A. M. Afonso
Published in: Green Chemistry, Issue 22/21, 2020, Page(s) 7484-7490, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0gc01977a

Silica-Supported Copper for the Preparation of trans-4,5-Diamino-Cyclopent-2-Enones under Continuous Flow Conditions

Author(s): Rafael F. A. Gomes; Lídia A. S. Cavaca; João Gonçalves; Ruben Ramos; Andreia F. Peixoto; Blanca I. Arias-Serrano; Blanca I. Arias-Serrano; Carlos A. M. Afonso
Published in: ACS Sustainable Chem. Eng., Issue 2, 2021, Page(s) 16038–16043, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.1c00884

Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors

Author(s): Nikolay T. Tzvetkov, Hans-Georg Stammler, Maya G. Georgieva, Daniela Russo, Immacolata Faraone, Aneliya A. Balacheva, Silvia Hristova, Atanas G. Atanasov, Luigi Milella, Liudmil Antonov, Marcus Gastreich
Published in: European Journal of Medicinal Chemistry, Issue 179, 2019, Page(s) 404-422, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2019.06.041

Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer

Author(s): Jesus, Rita Rodrigues Fernandes de
Published in: Issue 1, 2021
Publisher: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Searching for OpenAIRE data...

Deliverables

Publications

Share this page

Download