Straightening training, research and innovation capacities in the valorization of bio-renewable resource

Información del proyecto

Biomass4Synthons

Identificador del acuerdo de subvención: 951996

DOI

10.3030/951996

Proyecto cerrado

Fecha de la firma de la CE 30 Junio 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• Twinning of research institutions

Coste total

€ 900 000,00

Aportación de la UE

€ 900 000,00

Coordinado por

Faculdade de Farmácia da Universidade de Lisboa
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (10)

Biomass4Synthons Summer Schools

FFUL and IOCCP-BAS will prepare the summer schools.

For all KPIs - Impact assessment in the 3-year period before Biomass4Synthons

The impact assessment will be done at the outset of the project

Report of the industry meeting

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Biomass4Synthons Thematic Workshop

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 2.2

Public awareness movement

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Resume of the Project publications

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Impact evaluation by the project terminus and estimate the next 3-year period

The impact assessment will be done at the terminus.

"Event ""Knowledge Transfer Zone"" through meetings between enterprises and research institutions"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

"Event ""The industrial day"" related to flow chemistry applications"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

KPIs discrimination for Biomass4Synthons

The KPIs will be carefully examinated with the Consortium members and an ultimate list of these KPIs will be assembled at M2

Websites, patent fillings, videos etc. (3)

Creation of the project brand and logo

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Brochure and flyer development

Communication will be done through the project website promotional brochure and flyer press releases or newsletters presented in Section 22

Website launch

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Publicaciones

Peer reviewed articles (31)

Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol

Autores: Cláudia Bento, Marianna Katz, Maria M. M. Santos, Carlos A. M. Afonso
Publicado en: Organic Process Research & Development, Edición 28, 2024, Página(s) 860-890, ISSN 1083-6160
Editor: American Chemical Society
DOI: 10.1021/acs.oprd.3c00428

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

Autores: Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
Publicado en: Angewandte Chemie International Edition, Edición 62, 2023, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304449

A direct Diels–Alder reaction of chitin derived 3-acetamido-5-acetylfuran

Autores: Juliana G. Pereira, João M. J. M. Ravasco, João R. Vale, Fausto Queda, Rafael F. A. Gomes
Publicado en: Green Chemistry, Edición 24, 2024, Página(s) 7131-7136, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/d2gc00253a

Preparation of Aminals under Continuous Flow Conditions

Autores: Rafael F. A. Gomes, Carlos A. M. Afonso
Publicado en: Journal of Chemical Education, Edición 100, 2023, Página(s) 4728-4733, ISSN 0021-9584
Editor: American Chemical Society
DOI: 10.1021/acs.jchemed.3c00306

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Autores: Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Publicado en: Reaction Chemistry & Engineering, Edición 8, 2024, Página(s) 482-489, ISSN 2058-9883
Editor: Royal Society of Chemistry
DOI: 10.1039/d2re00292b

One-Pot Transformation of Salicylaldehydes to Spiroepoxydienones via the Adler–Becker Reaction in a Continuous Flow

Autores: Andreia A. Rosatella* and Carlos A. M. Afonso*
Publicado en: ACS Omega, 2022, Página(s) 11570–11577, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.1c05559

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Autores: Milene Fortunato, Filipa Siopa, Carlos Afonso
Publicado en: Molbank, Edición 2021/2, 2021, Página(s) M1199, ISSN 1422-8599
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/m1199

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A

Autores: Rafael F. A. Gomes, João R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Publicado en: Organic Letters, Edición 25, 2023, Página(s) 4188-4192, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.3c01513

Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Autores: Rafael F. A. Gomes; Vera M. S. Isca; Vera M. S. Isca; Késsia Andrade; Patrícia Rijo; Patrícia Rijo; Carlos A. M. Afonso
Publicado en: Chemmedchem, Edición 2, 2021, Página(s) 2781– 2785, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100369

CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites.

Autores: Martin Ravutsov; Yavor Mitrev; Pavletta Shestakova; Hristina Lazarova; Svilen P. Simeonov; Margarita Popova
Publicado en: Volume 11, Edición 1, 2021, Página(s) 2831, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano11112831

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Autores: Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble
Publicado en: Beilstein Journal of Organic Chemistry, Edición 19, 2023, Página(s) 582-592, ISSN 1860-5397
Editor: Beilstein-Institut
DOI: 10.3762/bjoc.19.43

High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to <i>trans</i>-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines

Autores: Lídia A. S. Cavaca, Tiago M. P. Santos, Joao M. J. M. Ravasco, Rafael F. A. Gomes, Carlos A. M. Afonso
Publicado en: The Journal of Organic Chemistry, Edición 89, 2024, Página(s) 6677-6683, ISSN 0022-3263
Editor: American Chemical Society
DOI: 10.1021/acs.joc.3c01040

Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones

Autores: Miroslav Dangalov, Adolfo Fernández-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Publicado en: ACS Catalysis, Edición 13, 2023, Página(s) 1916-1925, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.2c04867

From Pyridine to (−)‐Agelastatin A

Autores: João R. Vale, Milene A. G. Fortunato, Késsia H. S. Andrade, Ângelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Publicado en: Advanced Synthesis &amp; Catalysis, Edición 365, 2023, Página(s) 2240-2247, ISSN 1615-4150
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202300560

Preparation of Thioaminals in Water

Autores: Lídia A. S. Cavaca; Rafael F. A. Gomes; Carlos A. M. Afonso
Publicado en: Molecules; Volume 27; Edición 5; Pages: 1673, Edición 4, 2022, Página(s) 1673, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051673

Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions

Autores: Adolfo Fernández-Figueiras, Martin A. Ravutsov, and Svilen P. Simeonov*
Publicado en: ACS Omega, 2022, Página(s) 6439–6448, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.1c05830

Recent Advances on Diels-Alder-Driven Preparation of Bio-Based Aromatics.

Autores: João M. J. M. Ravasco; Rafael F. A. Gomes
Publicado en: Chemsuschem, Edición 2, 2021, Página(s) 3047–305, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100813

Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid

Autores: Martin A. Ravutsov, Maya M. Marinova, Atanas Kurutos, Svilen P. Simeonov
Publicado en: Sustainable Chemistry and Pharmacy, Edición 38, 2024, Página(s) 101491, ISSN 2352-5541
Editor: MDPI
DOI: 10.1016/j.scp.2024.101491

4-Ketovalero lactone (KVL): A gateway molecule for diversification of the furanic platform

Autores: Raquel M. Durão, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Publicado en: Sustainable Chemistry and Pharmacy, Edición 39, 2024, Página(s) 101553, ISSN 2352-5541
Editor: Elsevier
DOI: 10.1016/j.scp.2024.101553

Cu‐Catalyzed Tandem Oxidation‐Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Autores: Hristo Petkov, Martin A. Ravutsov, Manuel J. Verganista, Yavor N. Mitrev, Nuno R. Candeias, Svilen P. Simeonov
Publicado en: ChemSusChem, Edición 17, 2024, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202400013

Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

Autores: Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Publicado en: ChemMedChem, Edición 18, 2023, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202300104

2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Autores: Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
Publicado en: Organic &amp; Biomolecular Chemistry, Edición 22, 2024, Página(s) 2902-2915, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/d4ob00199k

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Autores: Hristo Petkov, Svilen P. Simeonov
Publicado en: Applied Sciences, Edición 13, 2023, Página(s) 6616, ISSN 2076-3417
Editor: MDPI
DOI: 10.3390/app13116616

Semi-continuous and continuous processes for enantiomeric separation

Autores: Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Publicado en: Green Chemistry, Edición 24, 2024, Página(s) 4328-4362, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/d1gc03668h

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Autores: Ivaylo Slavchev, Jas. S. Ward, Kari Rissanen, Georgi M. Dobrikov, Svilen Simeonov
Publicado en: RSC Advances, Edición 12, 2024, Página(s) 20555-20562, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/d2ra03524c

Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams

Autores: Georgy Grancharov, Mariya-Desislava Atanasova, Radostina Kalinova, Pencho Tuleshkov, Petar D. Petrov, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Publicado en: Polymers, Edición 15, 2023, Página(s) 4148, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym15204148

Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones

Autores: Dr. Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Dr. Jaime A. S. Coelho, Prof. Rui Moreira, Rafael Oliveira, Prof. Fátima Nogueira, Prof. Carlos A. M. Afonso
Publicado en: ChemSusChem, 2022, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202102204

Modular synthesis of 2-furyl carbinols from 3-benzyldimethylsilylfurfural platforms relying on oxygen-assisted C–Si bond functionalization

Autores: Sebastien Curpanen, Per Reichert, Gabriele Lupidi, Giovanni Poli, Julie Oble, Alejandro Perez-Luna
Publicado en: Beilstein Journal of Organic Chemistry, Edición 18, 2022, Página(s) 1256-1263, ISSN 1860-5397
Editor: Beilstein-Institut
DOI: 10.3762/bjoc.18.131

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

Autores: Katya Kamenova, Lyubomira Radeva, Krassimira Yoncheva, Filip Ublekov, Martin A. Ravutsov, Maya K. Marinova, Svilen P. Simeonov, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov
Publicado en: Polymers, Edición 14, 2024, Página(s) 3694, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym14173694

Sustainable synthesis of nitrogen-rich aromatics from chitin: Opportunities and challenges

Autores: Nicholas Bossons, Rafael F.A. Gomes
Publicado en: Current Opinion in Green and Sustainable Chemistry, Edición 49, 2024, Página(s) 100961, ISSN 2452-2236
Editor: Elsevier
DOI: 10.1016/j.cogsc.2024.100961

Silica-Supported Copper for the Preparation of trans-4,5-Diamino-Cyclopent-2-Enones under Continuous Flow Conditions

Autores: Rafael F. A. Gomes; Lídia A. S. Cavaca; João Gonçalves; Ruben Ramos; Andreia F. Peixoto; Blanca I. Arias-Serrano; Blanca I. Arias-Serrano; Carlos A. M. Afonso
Publicado en: ACS Sustainable Chem. Eng., Edición 2, 2021, Página(s) 16038–16043, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/acssuschemeng.1c00884

Thesis and dissertations (3)

Photochemical Reactions of Acylsilanes Towards the Construction of Carbon-Carbon Bonds

Autores: João R. Vale
Publicado en: 2023, ISBN 978-952-03-2773-6
Editor: Tampere University

Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer

Autores: Jesus, Rita Rodrigues Fernandes de
Publicado en: Edición 1, 2021
Editor: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Electrochemical oxidation of abietanes

Autores: Martins, Inês Alexandra de Sá
Publicado en: Edición 2021/09, 2021
Editor: University of Lisnon