Straightening training, research and innovation capacities in the valorization of bio-renewable resource

Informations projet

Biomass4Synthons

N° de convention de subvention: 951996

DOI

10.3030/951996

Projet clôturé

Date de signature de la CE 30 Juin 2020

Date de début 1 Janvier 2021

Date de fin 30 Juin 2024

Financé au titre de

• Twinning of research institutions

Coût total

€ 900 000,00

Contribution de l’UE

€ 900 000,00

Coordonné par

Faculdade de Farmácia da Universidade de Lisboa
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Biomass4Synthons Summer Schools

FFUL and IOCCP-BAS will prepare the summer schools.

For all KPIs - Impact assessment in the 3-year period before Biomass4Synthons

The impact assessment will be done at the outset of the project

Report of the industry meeting

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Biomass4Synthons Thematic Workshop

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 2.2

Public awareness movement

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Resume of the Project publications

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Impact evaluation by the project terminus and estimate the next 3-year period

The impact assessment will be done at the terminus.

"Event ""Knowledge Transfer Zone"" through meetings between enterprises and research institutions"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

"Event ""The industrial day"" related to flow chemistry applications"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

KPIs discrimination for Biomass4Synthons

The KPIs will be carefully examinated with the Consortium members and an ultimate list of these KPIs will be assembled at M2

Websites, patent fillings, videos etc. (3)

Creation of the project brand and logo

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Brochure and flyer development

Communication will be done through the project website promotional brochure and flyer press releases or newsletters presented in Section 22

Website launch

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Publications

Peer reviewed articles (31)

Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol

Auteurs: Cláudia Bento, Marianna Katz, Maria M. M. Santos, Carlos A. M. Afonso
Publié dans: Organic Process Research & Development, Numéro 28, 2024, Page(s) 860-890, ISSN 1083-6160
Éditeur: American Chemical Society
DOI: 10.1021/acs.oprd.3c00428

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

Auteurs: Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
Publié dans: Angewandte Chemie International Edition, Numéro 62, 2023, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304449

A direct Diels–Alder reaction of chitin derived 3-acetamido-5-acetylfuran

Auteurs: Juliana G. Pereira, João M. J. M. Ravasco, João R. Vale, Fausto Queda, Rafael F. A. Gomes
Publié dans: Green Chemistry, Numéro 24, 2024, Page(s) 7131-7136, ISSN 1463-9262
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2gc00253a

Preparation of Aminals under Continuous Flow Conditions

Auteurs: Rafael F. A. Gomes, Carlos A. M. Afonso
Publié dans: Journal of Chemical Education, Numéro 100, 2023, Page(s) 4728-4733, ISSN 0021-9584
Éditeur: American Chemical Society
DOI: 10.1021/acs.jchemed.3c00306

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Auteurs: Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Publié dans: Reaction Chemistry & Engineering, Numéro 8, 2024, Page(s) 482-489, ISSN 2058-9883
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2re00292b

One-Pot Transformation of Salicylaldehydes to Spiroepoxydienones via the Adler–Becker Reaction in a Continuous Flow

Auteurs: Andreia A. Rosatella* and Carlos A. M. Afonso*
Publié dans: ACS Omega, 2022, Page(s) 11570–11577, ISSN 2470-1343
Éditeur: ACS Publications
DOI: 10.1021/acsomega.1c05559

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Auteurs: Milene Fortunato, Filipa Siopa, Carlos Afonso
Publié dans: Molbank, Numéro 2021/2, 2021, Page(s) M1199, ISSN 1422-8599
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/m1199

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A

Auteurs: Rafael F. A. Gomes, João R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Publié dans: Organic Letters, Numéro 25, 2023, Page(s) 4188-4192, ISSN 1523-7060
Éditeur: American Chemical Society
DOI: 10.1021/acs.orglett.3c01513

Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Auteurs: Rafael F. A. Gomes; Vera M. S. Isca; Vera M. S. Isca; Késsia Andrade; Patrícia Rijo; Patrícia Rijo; Carlos A. M. Afonso
Publié dans: Chemmedchem, Numéro 2, 2021, Page(s) 2781– 2785, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100369

CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites.

Auteurs: Martin Ravutsov; Yavor Mitrev; Pavletta Shestakova; Hristina Lazarova; Svilen P. Simeonov; Margarita Popova
Publié dans: Volume 11, Numéro 1, 2021, Page(s) 2831, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano11112831

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Auteurs: Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble
Publié dans: Beilstein Journal of Organic Chemistry, Numéro 19, 2023, Page(s) 582-592, ISSN 1860-5397
Éditeur: Beilstein-Institut
DOI: 10.3762/bjoc.19.43

High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to <i>trans</i>-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines

Auteurs: Lídia A. S. Cavaca, Tiago M. P. Santos, Joao M. J. M. Ravasco, Rafael F. A. Gomes, Carlos A. M. Afonso
Publié dans: The Journal of Organic Chemistry, Numéro 89, 2024, Page(s) 6677-6683, ISSN 0022-3263
Éditeur: American Chemical Society
DOI: 10.1021/acs.joc.3c01040

Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones

Auteurs: Miroslav Dangalov, Adolfo Fernández-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Publié dans: ACS Catalysis, Numéro 13, 2023, Page(s) 1916-1925, ISSN 2155-5435
Éditeur: American Chemical Society
DOI: 10.1021/acscatal.2c04867

From Pyridine to (−)‐Agelastatin A

Auteurs: João R. Vale, Milene A. G. Fortunato, Késsia H. S. Andrade, Ângelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Publié dans: Advanced Synthesis &amp; Catalysis, Numéro 365, 2023, Page(s) 2240-2247, ISSN 1615-4150
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202300560

Preparation of Thioaminals in Water

Auteurs: Lídia A. S. Cavaca; Rafael F. A. Gomes; Carlos A. M. Afonso
Publié dans: Molecules; Volume 27; Numéro 5; Pages: 1673, Numéro 4, 2022, Page(s) 1673, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051673

Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions

Auteurs: Adolfo Fernández-Figueiras, Martin A. Ravutsov, and Svilen P. Simeonov*
Publié dans: ACS Omega, 2022, Page(s) 6439–6448, ISSN 2470-1343
Éditeur: ACS Publications
DOI: 10.1021/acsomega.1c05830

Recent Advances on Diels-Alder-Driven Preparation of Bio-Based Aromatics.

Auteurs: João M. J. M. Ravasco; Rafael F. A. Gomes
Publié dans: Chemsuschem, Numéro 2, 2021, Page(s) 3047–305, ISSN 1864-5631
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100813

Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid

Auteurs: Martin A. Ravutsov, Maya M. Marinova, Atanas Kurutos, Svilen P. Simeonov
Publié dans: Sustainable Chemistry and Pharmacy, Numéro 38, 2024, Page(s) 101491, ISSN 2352-5541
Éditeur: MDPI
DOI: 10.1016/j.scp.2024.101491

4-Ketovalero lactone (KVL): A gateway molecule for diversification of the furanic platform

Auteurs: Raquel M. Durão, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Publié dans: Sustainable Chemistry and Pharmacy, Numéro 39, 2024, Page(s) 101553, ISSN 2352-5541
Éditeur: Elsevier
DOI: 10.1016/j.scp.2024.101553

Cu‐Catalyzed Tandem Oxidation‐Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Auteurs: Hristo Petkov, Martin A. Ravutsov, Manuel J. Verganista, Yavor N. Mitrev, Nuno R. Candeias, Svilen P. Simeonov
Publié dans: ChemSusChem, Numéro 17, 2024, ISSN 1864-5631
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202400013

Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

Auteurs: Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Publié dans: ChemMedChem, Numéro 18, 2023, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202300104

2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Auteurs: Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
Publié dans: Organic &amp; Biomolecular Chemistry, Numéro 22, 2024, Page(s) 2902-2915, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4ob00199k

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Auteurs: Hristo Petkov, Svilen P. Simeonov
Publié dans: Applied Sciences, Numéro 13, 2023, Page(s) 6616, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app13116616

Semi-continuous and continuous processes for enantiomeric separation

Auteurs: Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Publié dans: Green Chemistry, Numéro 24, 2024, Page(s) 4328-4362, ISSN 1463-9262
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1gc03668h

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Auteurs: Ivaylo Slavchev, Jas. S. Ward, Kari Rissanen, Georgi M. Dobrikov, Svilen Simeonov
Publié dans: RSC Advances, Numéro 12, 2024, Page(s) 20555-20562, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2ra03524c

Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams

Auteurs: Georgy Grancharov, Mariya-Desislava Atanasova, Radostina Kalinova, Pencho Tuleshkov, Petar D. Petrov, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Publié dans: Polymers, Numéro 15, 2023, Page(s) 4148, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym15204148

Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones

Auteurs: Dr. Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Dr. Jaime A. S. Coelho, Prof. Rui Moreira, Rafael Oliveira, Prof. Fátima Nogueira, Prof. Carlos A. M. Afonso
Publié dans: ChemSusChem, 2022, ISSN 1864-5631
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202102204

Modular synthesis of 2-furyl carbinols from 3-benzyldimethylsilylfurfural platforms relying on oxygen-assisted C–Si bond functionalization

Auteurs: Sebastien Curpanen, Per Reichert, Gabriele Lupidi, Giovanni Poli, Julie Oble, Alejandro Perez-Luna
Publié dans: Beilstein Journal of Organic Chemistry, Numéro 18, 2022, Page(s) 1256-1263, ISSN 1860-5397
Éditeur: Beilstein-Institut
DOI: 10.3762/bjoc.18.131

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

Auteurs: Katya Kamenova, Lyubomira Radeva, Krassimira Yoncheva, Filip Ublekov, Martin A. Ravutsov, Maya K. Marinova, Svilen P. Simeonov, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov
Publié dans: Polymers, Numéro 14, 2024, Page(s) 3694, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym14173694

Sustainable synthesis of nitrogen-rich aromatics from chitin: Opportunities and challenges

Auteurs: Nicholas Bossons, Rafael F.A. Gomes
Publié dans: Current Opinion in Green and Sustainable Chemistry, Numéro 49, 2024, Page(s) 100961, ISSN 2452-2236
Éditeur: Elsevier
DOI: 10.1016/j.cogsc.2024.100961

Silica-Supported Copper for the Preparation of trans-4,5-Diamino-Cyclopent-2-Enones under Continuous Flow Conditions

Auteurs: Rafael F. A. Gomes; Lídia A. S. Cavaca; João Gonçalves; Ruben Ramos; Andreia F. Peixoto; Blanca I. Arias-Serrano; Blanca I. Arias-Serrano; Carlos A. M. Afonso
Publié dans: ACS Sustainable Chem. Eng., Numéro 2, 2021, Page(s) 16038–16043, ISSN 2168-0485
Éditeur: American Chemical Society
DOI: 10.1021/acssuschemeng.1c00884

Thesis and dissertations (3)

Photochemical Reactions of Acylsilanes Towards the Construction of Carbon-Carbon Bonds

Auteurs: João R. Vale
Publié dans: 2023, ISBN 978-952-03-2773-6
Éditeur: Tampere University

Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer

Auteurs: Jesus, Rita Rodrigues Fernandes de
Publié dans: Numéro 1, 2021
Éditeur: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Electrochemical oxidation of abietanes

Auteurs: Martins, Inês Alexandra de Sá
Publié dans: Numéro 2021/09, 2021
Éditeur: University of Lisnon