Straightening training, research and innovation capacities in the valorization of bio-renewable resource

Informazioni relative al progetto

Biomass4Synthons

ID dell’accordo di sovvenzione: 951996

DOI

10.3030/951996

Progetto chiuso

Data della firma CE 30 Giugno 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2024

Finanziato da

• Twinning of research institutions

Costo totale

€ 900 000,00

Contributo UE

€ 900 000,00

Coordinato da

Faculdade de Farmácia da Universidade de Lisboa
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (10)

Biomass4Synthons Summer Schools

FFUL and IOCCP-BAS will prepare the summer schools.

For all KPIs - Impact assessment in the 3-year period before Biomass4Synthons

The impact assessment will be done at the outset of the project

Report of the industry meeting

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Biomass4Synthons Thematic Workshop

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 2.2

Public awareness movement

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Resume of the Project publications

Communication will be done through the project website, promotional brochure and flyer, press releases or newsletters, presented in Section 2.2.

Impact evaluation by the project terminus and estimate the next 3-year period

The impact assessment will be done at the terminus.

"Event ""Knowledge Transfer Zone"" through meetings between enterprises and research institutions"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

"Event ""The industrial day"" related to flow chemistry applications"

Biomass4Synthons planned a challenge competition point toward rising entrepreneurial skills over a hands-on and motivating approach. These initiative will embrace students and the research community that together will envision how to take innovation to the market. Experts from the partnering institutions will be invited to provide inspiring lectures and to stimulate brainstorming.

KPIs discrimination for Biomass4Synthons

The KPIs will be carefully examinated with the Consortium members and an ultimate list of these KPIs will be assembled at M2

Websites, patent fillings, videos etc. (3)

Creation of the project brand and logo

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Brochure and flyer development

Communication will be done through the project website promotional brochure and flyer press releases or newsletters presented in Section 22

Website launch

We envision that the dissemination and exploitation results will be achieved through the engagement activities presented in Section 22

Pubblicazioni

Peer reviewed articles (31)

Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol

Autori: Cláudia Bento, Marianna Katz, Maria M. M. Santos, Carlos A. M. Afonso
Pubblicato in: Organic Process Research & Development, Numero 28, 2024, Pagina/e 860-890, ISSN 1083-6160
Editore: American Chemical Society
DOI: 10.1021/acs.oprd.3c00428

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

Autori: Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
Pubblicato in: Angewandte Chemie International Edition, Numero 62, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304449

A direct Diels–Alder reaction of chitin derived 3-acetamido-5-acetylfuran

Autori: Juliana G. Pereira, João M. J. M. Ravasco, João R. Vale, Fausto Queda, Rafael F. A. Gomes
Pubblicato in: Green Chemistry, Numero 24, 2024, Pagina/e 7131-7136, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/d2gc00253a

Preparation of Aminals under Continuous Flow Conditions

Autori: Rafael F. A. Gomes, Carlos A. M. Afonso
Pubblicato in: Journal of Chemical Education, Numero 100, 2023, Pagina/e 4728-4733, ISSN 0021-9584
Editore: American Chemical Society
DOI: 10.1021/acs.jchemed.3c00306

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of bio-based cyclopentenones

Autori: Lídia A. S. Cavaca, Jaime A. S. Coelho, Susana D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Pubblicato in: Reaction Chemistry & Engineering, Numero 8, 2024, Pagina/e 482-489, ISSN 2058-9883
Editore: Royal Society of Chemistry
DOI: 10.1039/d2re00292b

One-Pot Transformation of Salicylaldehydes to Spiroepoxydienones via the Adler–Becker Reaction in a Continuous Flow

Autori: Andreia A. Rosatella* and Carlos A. M. Afonso*
Pubblicato in: ACS Omega, 2022, Pagina/e 11570–11577, ISSN 2470-1343
Editore: ACS Publications
DOI: 10.1021/acsomega.1c05559

(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Autori: Milene Fortunato, Filipa Siopa, Carlos Afonso
Pubblicato in: Molbank, Numero 2021/2, 2021, Pagina/e M1199, ISSN 1422-8599
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/m1199

Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A

Autori: Rafael F. A. Gomes, João R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Pubblicato in: Organic Letters, Numero 25, 2023, Pagina/e 4188-4192, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.3c01513

Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Autori: Rafael F. A. Gomes; Vera M. S. Isca; Vera M. S. Isca; Késsia Andrade; Patrícia Rijo; Patrícia Rijo; Carlos A. M. Afonso
Pubblicato in: Chemmedchem, Numero 2, 2021, Pagina/e 2781– 2785, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100369

CO2 Adsorption on Modified Mesoporous Silicas: The Role of the Adsorption Sites.

Autori: Martin Ravutsov; Yavor Mitrev; Pavletta Shestakova; Hristina Lazarova; Svilen P. Simeonov; Margarita Popova
Pubblicato in: Volume 11, Numero 1, 2021, Pagina/e 2831, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano11112831

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Autori: Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble
Pubblicato in: Beilstein Journal of Organic Chemistry, Numero 19, 2023, Pagina/e 582-592, ISSN 1860-5397
Editore: Beilstein-Institut
DOI: 10.3762/bjoc.19.43

High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to <i>trans</i>-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines

Autori: Lídia A. S. Cavaca, Tiago M. P. Santos, Joao M. J. M. Ravasco, Rafael F. A. Gomes, Carlos A. M. Afonso
Pubblicato in: The Journal of Organic Chemistry, Numero 89, 2024, Pagina/e 6677-6683, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.3c01040

Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones

Autori: Miroslav Dangalov, Adolfo Fernández-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Pubblicato in: ACS Catalysis, Numero 13, 2023, Pagina/e 1916-1925, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.2c04867

From Pyridine to (−)‐Agelastatin A

Autori: João R. Vale, Milene A. G. Fortunato, Késsia H. S. Andrade, Ângelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Pubblicato in: Advanced Synthesis &amp; Catalysis, Numero 365, 2023, Pagina/e 2240-2247, ISSN 1615-4150
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202300560

Preparation of Thioaminals in Water

Autori: Lídia A. S. Cavaca; Rafael F. A. Gomes; Carlos A. M. Afonso
Pubblicato in: Molecules; Volume 27; Numero 5; Pages: 1673, Numero 4, 2022, Pagina/e 1673, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051673

Site-Selective C–H Functionalization of Arenes Enabled by Noncovalent Interactions

Autori: Adolfo Fernández-Figueiras, Martin A. Ravutsov, and Svilen P. Simeonov*
Pubblicato in: ACS Omega, 2022, Pagina/e 6439–6448, ISSN 2470-1343
Editore: ACS Publications
DOI: 10.1021/acsomega.1c05830

Recent Advances on Diels-Alder-Driven Preparation of Bio-Based Aromatics.

Autori: João M. J. M. Ravasco; Rafael F. A. Gomes
Pubblicato in: Chemsuschem, Numero 2, 2021, Pagina/e 3047–305, ISSN 1864-5631
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100813

Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid

Autori: Martin A. Ravutsov, Maya M. Marinova, Atanas Kurutos, Svilen P. Simeonov
Pubblicato in: Sustainable Chemistry and Pharmacy, Numero 38, 2024, Pagina/e 101491, ISSN 2352-5541
Editore: MDPI
DOI: 10.1016/j.scp.2024.101491

4-Ketovalero lactone (KVL): A gateway molecule for diversification of the furanic platform

Autori: Raquel M. Durão, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Pubblicato in: Sustainable Chemistry and Pharmacy, Numero 39, 2024, Pagina/e 101553, ISSN 2352-5541
Editore: Elsevier
DOI: 10.1016/j.scp.2024.101553

Cu‐Catalyzed Tandem Oxidation‐Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Autori: Hristo Petkov, Martin A. Ravutsov, Manuel J. Verganista, Yavor N. Mitrev, Nuno R. Candeias, Svilen P. Simeonov
Pubblicato in: ChemSusChem, Numero 17, 2024, ISSN 1864-5631
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202400013

Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

Autori: Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
Pubblicato in: ChemMedChem, Numero 18, 2023, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202300104

2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Autori: Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
Pubblicato in: Organic &amp; Biomolecular Chemistry, Numero 22, 2024, Pagina/e 2902-2915, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d4ob00199k

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Autori: Hristo Petkov, Svilen P. Simeonov
Pubblicato in: Applied Sciences, Numero 13, 2023, Pagina/e 6616, ISSN 2076-3417
Editore: MDPI
DOI: 10.3390/app13116616

Semi-continuous and continuous processes for enantiomeric separation

Autori: Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Pubblicato in: Green Chemistry, Numero 24, 2024, Pagina/e 4328-4362, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/d1gc03668h

Base-promoted direct amidation of esters: beyond the current scope and practical applications

Autori: Ivaylo Slavchev, Jas. S. Ward, Kari Rissanen, Georgi M. Dobrikov, Svilen Simeonov
Pubblicato in: RSC Advances, Numero 12, 2024, Pagina/e 20555-20562, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/d2ra03524c

Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams

Autori: Georgy Grancharov, Mariya-Desislava Atanasova, Radostina Kalinova, Pencho Tuleshkov, Petar D. Petrov, Maya K. Marinova, Martin A. Ravutsov, Svilen P. Simeonov
Pubblicato in: Polymers, Numero 15, 2023, Pagina/e 4148, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym15204148

Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived δ-Lactone-Fused Cyclopentenones

Autori: Dr. Rafael F. A. Gomes, Joao M. J. M. Ravasco, Késsia H. S. Andrade, Dr. Jaime A. S. Coelho, Prof. Rui Moreira, Rafael Oliveira, Prof. Fátima Nogueira, Prof. Carlos A. M. Afonso
Pubblicato in: ChemSusChem, 2022, ISSN 1864-5631
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202102204

Modular synthesis of 2-furyl carbinols from 3-benzyldimethylsilylfurfural platforms relying on oxygen-assisted C–Si bond functionalization

Autori: Sebastien Curpanen, Per Reichert, Gabriele Lupidi, Giovanni Poli, Julie Oble, Alejandro Perez-Luna
Pubblicato in: Beilstein Journal of Organic Chemistry, Numero 18, 2022, Pagina/e 1256-1263, ISSN 1860-5397
Editore: Beilstein-Institut
DOI: 10.3762/bjoc.18.131

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

Autori: Katya Kamenova, Lyubomira Radeva, Krassimira Yoncheva, Filip Ublekov, Martin A. Ravutsov, Maya K. Marinova, Svilen P. Simeonov, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov
Pubblicato in: Polymers, Numero 14, 2024, Pagina/e 3694, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym14173694

Sustainable synthesis of nitrogen-rich aromatics from chitin: Opportunities and challenges

Autori: Nicholas Bossons, Rafael F.A. Gomes
Pubblicato in: Current Opinion in Green and Sustainable Chemistry, Numero 49, 2024, Pagina/e 100961, ISSN 2452-2236
Editore: Elsevier
DOI: 10.1016/j.cogsc.2024.100961

Silica-Supported Copper for the Preparation of trans-4,5-Diamino-Cyclopent-2-Enones under Continuous Flow Conditions

Autori: Rafael F. A. Gomes; Lídia A. S. Cavaca; João Gonçalves; Ruben Ramos; Andreia F. Peixoto; Blanca I. Arias-Serrano; Blanca I. Arias-Serrano; Carlos A. M. Afonso
Pubblicato in: ACS Sustainable Chem. Eng., Numero 2, 2021, Pagina/e 16038–16043, ISSN 2168-0485
Editore: American Chemical Society
DOI: 10.1021/acssuschemeng.1c00884

Thesis and dissertations (3)

Photochemical Reactions of Acylsilanes Towards the Construction of Carbon-Carbon Bonds

Autori: João R. Vale
Pubblicato in: 2023, ISBN 978-952-03-2773-6
Editore: Tampere University

Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer

Autori: Jesus, Rita Rodrigues Fernandes de
Pubblicato in: Numero 1, 2021
Editore: Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Electrochemical oxidation of abietanes

Autori: Martins, Inês Alexandra de Sá
Pubblicato in: Numero 2021/09, 2021
Editore: University of Lisnon