MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body

Project Information

ANGIE

Grant agreement ID: 952152

DOI

10.3030/952152

Project closed

EC signature date 29 May 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 4 000 000,00

EU contribution

€ 4 000 000,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

Report on the interface between electromagnetic and angiography systems

s.a.

Report 1 on actions to create interdisciplin. community around targeted drug delivery

sa

Report 3 on measures to create innovation eco-system around ANGIE technology

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Dissemination and Communication Plan

sa

Dissemination and Communication Plan update 1

s.a.

Report 3 on actions to create interdisciplinary community around targeted drug delivery

s.a.

Report 1 on measures to create innovation eco-system around ANGIE technology

sa

Dissemination and Communication Plan update 2

s.a.

Report 2 on actions to create interdisciplinary community around targeted drug delivery

s.a.

Report 2 on measures to create innovation eco-system around ANGIE technology

s.a.

Demonstrators, pilots, prototypes (2)

Prototype of electromagnetic system for navigation and actuation

s.a.

Perfused 3D models of the vascular network with different tortuosity and clot sites

s.a.

Publications

Peer reviewed articles (19)

3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

Author(s): Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmartí-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pané
Published in: Advanced functional materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202212952

A Human‐Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices

Author(s): Simone Gervasoni, Norman Pedrini, Tarik Rifai, Cedric Fischer, Fabian C. Landers, Michael Mattmann, Roland Dreyfus, Silvia Viviani, Andrea Veciana, Enea Masina, Buse Aktas, Josep Puigmartí‐Luis, Christophe Chautems, Salvador Pané, Quentin Boehler, Philipp Gruber, Bradley J. Nelson
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310701

Patient-specific placental vessel segmentation with limited data

Author(s): Gary Sarwin, Jonas Lussi, Simone Gervasoni, Ueli Moehrlen, Nicole Ochsenbein, Bradley J. Nelson
Published in: Journal of Robotic Surgery, Issue 18, 2024, ISSN 1863-2483
Publisher: Springer Verlag
DOI: 10.1007/s11701-024-01981-z

A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats

Author(s): Aristidis Tsatsakis Elisavet Renieri Dimitris Tsoukalas Ana Maria Buga Evangelia Sarandi Elena Vakonaki Persefoni Fragkiadaki Athanasios Alegakis Dragana Nikitovic Daniela Calina Demetrios A. Spandidos Anca Oana Docea
Published in: Molecular Medicine Reports, Issue Volume 28, Issue 6, 2023, ISSN 1791-2997
Publisher: Spandidos Publications
DOI: 10.3892/mmr.2023.13119

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Author(s): Spanakis Marios, Fragkiadaki Persefoni, Renieri Elisavet, Vakonaki Elena, Fragkiadoulaki Irene, Alegakis Athanasios, Kiriakakis Mixalis, Panagiotou Nikolaos, Ntoumou Eleni, Gratsias Ioannis, Zoubaneas Evangelos, Morozova Galina Dmitrievna, Ovchinnikova Marina Alekseevna, Tsitsimpikou Christina, Tsarouhas Konstantinos, Drakoulis Nikolaos, Skalny Anatoly Viktorovich, Tsatsakis Aristides
Published in: Frontiers in Sports and Active Living, 2024, ISSN 2624-9367
Publisher: Frontiers
DOI: 10.3389/fspor.2023.1327792

Toward More Inclusive Networks and Initiatives in Innovation Ecosystems: Protocol for a Systematic Review

Author(s): Georgia Ntina; Eirini Mavromanolaki; Andreas D Flouris
Published in: JMIR Research Protocol, 2022, Page(s) e34071, ISSN 1929-0748
Publisher: JMIR Publications Inc.
DOI: 10.2196/34071

Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms

Author(s): Harun Torlakcik, Semih Sevim, Pedro Alves, Michael Mattmann, Joaquim Llacer‐Wintle, Maria Pinto, Rosa Moreira, Andreas D. Flouris, Fabian C. Landers, Xiang‐Zhong Chen, Josep Puigmartí‐Luis, Quentin Boehler, Tiago Sotto Mayor, Minsoo Kim, Bradley J. Nelson, Salvador Pané
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Weinheim: Wiley-VCH
DOI: 10.1002/advs.202404061

Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability

Author(s): Vitaly Pustovalov, Fabian C. Landers, Lukas Hertle, Hyeon Ko, Joaquin Llacer‐Wintle, Hao Ye, Andrea Veciana, Carlos Franco, Roger Sanchis‐Gual, Xiang‐Zhong Chen, Eva Pellicer, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Published in: Advanced Engineering Materials, Issue 26, 2024, ISSN 1438-1656
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adem.202400307

A Naturally Inspired Extrusion‐Based Microfluidic Approach for Manufacturing Tailorable Magnetic Soft Continuum Microrobotic Devices

Author(s): Lukas Hertle, Semih Sevim, Jiawei Zhu, Vitaly Pustovalov, Andrea Veciana, Joaquin Llacer‐Wintle, Fabian C. Landers, Hao Ye, Xiang‐Zhong Chen, Hannes Vogler, Ueli Grossniklaus, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402309

Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes

Author(s): Minsoo Kim, Donghoon Kim, Mathieu Mirjolet, Nick A. Shepelin, Thomas Lippert, Hongsoo Choi, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202404825

Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems

Author(s): Von Arx Denis; Fischer Cedric; Torlakcik Harun; Pané Salvador; Nelson Bradley; J.Boehler Quentin
Published in: Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems, 2023, ISSN 1552-3098
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TRO.2023.3340324

On-Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines

Author(s): F. C. Landers, V. Gantenbein, L. Hertle, A. Veciana, J. Llacer-Wintle, X.-Z. Chen, H. Ye, C. Franco, J. Puigmartí-Luis, M. Kim, B. J. Nelson, S. Pané
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310084

3D Motion Manipulation for Micro- and Nanomachines: Progress and Future Directions

Author(s): Hai Huang, Shihao Yang, Yulong Ying, Xiangzhong Chen, Josep Puigmartí-Luis, Li Zhang, Salvador Pané
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202305925

Autonomous 3D positional control of a magnetic microrobot using reinforcement learning

Author(s): Sarmad Ahmad Abbasi, Awais Ahmed, Seungmin Noh, Nader Latifi Gharamaleki, Seonhyoung Kim, A. M. Masum Bulbul Chowdhury, Jin-young Kim, Salvador Pané, Bradley J. Nelson, Hongsoo Choi
Published in: Nature Machine Intelligence, Issue 6, 2024, Page(s) 92-105, ISSN 2522-5839
Publisher: NPG
DOI: 10.1038/s42256-023-00779-2

Magnetically Assisted Robotic Fetal Surgery for the Treatment of Spina Bifida

Author(s): Gervasoni, Simone; Lussi, Jonas; Viviani, Silvia; Boehler, Quentin; Ochsenbein, Nicole; Moehrlen, Ueli; Nelson, Bradley J.; Gervasoni, Simone
Published in: IEEE Transactions on Medical Robotics and Bionics, 2022, Page(s) 85-93, ISSN 2576-3202
Publisher: IEEE
DOI: 10.3929/ethz-b-000531109

Magnetically Guided Laser Surgery for the Treatment of Twin-to-Twin Transfusion Syndrome

Author(s): Lussi, J., Gervasoni, S., Mattille, M., Dreyfus, R., Boehler, Q., Reinehr, M., Ochsenbein, N., Nelson, B.J. and Moehrlen, U.
Published in: Advanced Intelligent Systems, Issue Volume 4, Issue 11, 2022, ISSN 2640-4567
Publisher: Wiley-VCH GmbH
DOI: 10.1002/aisy.202200182

Site-specific PEGylation of recombinant tissue-type plasminogen activator

Author(s): Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Król, Salvador Pané, Tessa Lühmann
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue Volume 192, 2023, Page(s) 79-87, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2023.09.017

Powering and Fabrication of Small-Scale Robotics Systems

Author(s): Salvador Pané; Pedro D. Wendel-García; Yonca Belce; Xiang-Zhong Chen; Josep Puigmartí-Luis
Published in: Current Robotics Reports, Issue 2, 2021, Page(s) 1 - 14, ISSN 2662-4087
Publisher: Springer
DOI: 10.1007/s43154-021-00066-1

Dexterous helical magnetic robot for improved endovascular access

Author(s): Dreyfus R, Boehler Q, Lyttle S, Gruber P, Lussi J, Chautems C, Gervasoni S, Berberat J, Seibold D, Ochsenbein-Kölble N, Reinehr M, Weisskopf M, Remonda L, Nelson BJ. Dexterous helical magnetic robot for improved endovascular access.
Published in: Science Robotics, Issue Vol 9, Issue 87, 2024, ISSN 2470-9476
Publisher: American Association for the Advancement of Science
DOI: 10.3929/ethz-b-000659728

Conference proceedings (8)

In Vitro Navigation of a Magnetic Sphere using a Model Predictive Controller for Neurovascular Targeted Drug Delivery Applications

Author(s): null null, D Sivakumaran, F. C Landers, Q Boehler, C Chautems, S Pané, B. J Nelson, null null
Published in: Proceedings of The 14th Hamlyn Symposium on Medical Robotics 2022, 2022, Page(s) 109-110
Publisher: The Hamlyn Centre, Imperial College London London, UK
DOI: 10.31256/hsmr2022.54

Soft-hard magnetically driven microrobotic devices

Author(s): F C Landers; C. J. Alcantara; Josep Puigmartí-Luis; Bradley J. Nelson; Salvador Pané
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142296

Microfluidic technologies for chemistry, materials science and biotechnology

Author(s): Josep Puigmartí-Luis
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142301

Magnetic small-scale robots: Principles, applications and challenges

Author(s): Salvador Pané; J. Puigmartí; M. Pinto; E. Mavromanolaki; A. Flouris; T. S. Mayor; Tessa Lühmann; D. Sargent; Bradley J. Nelson
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.3929/ethz-b-000526973

Evolution, gaps, and trends in the origins of innovation ecosystems

Author(s): E. Mavromanolaki; G. Ntina; S. Karatsali; P. Smarianaki; M. Pinto; R. Moreira; S. Pané; T. S. Mayor, J; Puigmartí; A. D. Flouris
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142303

In flow controlled synthesis of blood clots

Author(s): R. S. Herrera-Restrepo; P. Martinez-Bulit; A. D. Flouris; M. Pinto; R. Moreira; E. Mavromanolaki; T. S. Mayor; S. Pané; J. Ignés; and J. Puigmartí-Luis
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142302

3D interlocked metal-organic magnetic microrobots

Author(s): F. Landers; S. Pané
Published in: International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2022
Publisher: MARSS

Marrying inorganics and biologics: Opportunities and challenges

Author(s): K. Meiners; M. Richter; F. Landers; S. Pané; T. Lühmann
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142300

Monographic books (1)

Emerging Issues on Targeted Drug Delivery

Author(s): Vliora Maria, Tsatsakis Aristidis, Kallinteri Paraskevi, Kallkach Aparicio Mariel
Published in: 2024, Page(s) Scientific Research Publishing, ISBN 979-8-89507-901-0
Publisher: Scientific Research Publishing
DOI: 10.5281/zenodo.14621049

Non-peer reviewed articles (1)

Clinically Ready Magnetic Microrobots for Targeted Therapies

Author(s): Fabian C. Landers, Lukas Hertle, Vitaly Pustovalov, Derick Sivakumaran, Oliver Brinkmann, Kirstin Meiners, Pascal Theiler, Valentin Gantenbein, Andrea Veciana, Michael Mattmann, Silas Riss, Simone Gervasoni, Christophe Chautems, Hao Ye, Semih Sevim, Andreas D. Flouris, Josep Puigmartí-Luis, Tiago Sotto Mayor, Pedro Alves, Tessa Lühmann, Xiangzhong Chen, Nicole Ochsenbein, Ueli Moehrlen, Philipp
Published in: arXiv, 2025, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/arxiv.2501.11553