MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body

Project Information

ANGIE

Grant agreement ID: 952152

DOI 10.3030/952152

EC signature date 29 May 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 4 000 000,00

EU contribution € 4 000 000,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

Deliverables

Documents, reports (7)

Report on the interface between electromagnetic and angiography systems

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Report 1 on actions to create interdisciplin. community around targeted drug delivery

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Dissemination and Communication Plan

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Dissemination and Communication Plan update 1

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Report 1 on measures to create innovation eco-system around ANGIE technology

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Report 2 on actions to create interdisciplinary community around targeted drug delivery

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Report 2 on measures to create innovation eco-system around ANGIE technology

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Demonstrators, pilots, prototypes (1)

Prototype of electromagnetic system for navigation and actuation

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Publications

Peer reviewed articles (10)

3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

Author(s): Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmartí-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pané
Published in: Advanced functional materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202212952

A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats

Author(s): Aristidis Tsatsakis Elisavet Renieri Dimitris Tsoukalas Ana Maria Buga Evangelia Sarandi Elena Vakonaki Persefoni Fragkiadaki Athanasios Alegakis Dragana Nikitovic Daniela Calina Demetrios A. Spandidos Anca Oana Docea
Published in: Molecular Medicine Reports, Issue Volume 28, Issue 6, 2023, ISSN 1791-2997
Publisher: Spandidos Publications
DOI: 10.3892/mmr.2023.13119

Toward More Inclusive Networks and Initiatives in Innovation Ecosystems: Protocol for a Systematic Review

Author(s): Georgia Ntina; Eirini Mavromanolaki; Andreas D Flouris
Published in: JMIR Research Protocol, 2022, Page(s) e34071, ISSN 1929-0748
Publisher: JMIR Publications Inc.
DOI: 10.2196/34071

On-Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines

Author(s): F. C. Landers, V. Gantenbein, L. Hertle, A. Veciana, J. Llacer-Wintle, X.-Z. Chen, H. Ye, C. Franco, J. Puigmartí-Luis, M. Kim, B. J. Nelson, S. Pané
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310084

3D Motion Manipulation for Micro- and Nanomachines: Progress and Future Directions

Author(s): Hai Huang, Shihao Yang, Yulong Ying, Xiangzhong Chen, Josep Puigmartí-Luis, Li Zhang, Salvador Pané
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202305925

Magnetically Assisted Robotic Fetal Surgery for the Treatment of Spina Bifida

Author(s): Gervasoni, Simone; Lussi, Jonas; Viviani, Silvia; Boehler, Quentin; Ochsenbein, Nicole; Moehrlen, Ueli; Nelson, Bradley J.; Gervasoni, Simone
Published in: IEEE Transactions on Medical Robotics and Bionics, 2022, Page(s) 85-93, ISSN 2576-3202
Publisher: IEEE
DOI: 10.3929/ethz-b-000531109

Magnetically Guided Laser Surgery for the Treatment of Twin-to-Twin Transfusion Syndrome

Author(s): Lussi, J., Gervasoni, S., Mattille, M., Dreyfus, R., Boehler, Q., Reinehr, M., Ochsenbein, N., Nelson, B.J. and Moehrlen, U.
Published in: Advanced Intelligent Systems, Issue Volume 4, Issue 11, 2022, ISSN 2640-4567
Publisher: Wiley-VCH GmbH
DOI: 10.1002/aisy.202200182

Site-specific PEGylation of recombinant tissue-type plasminogen activator

Author(s): Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Król, Salvador Pané, Tessa Lühmann
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue Volume 192, 2023, Page(s) 79-87, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2023.09.017

Powering and Fabrication of Small-Scale Robotics Systems

Author(s): Salvador Pané; Pedro D. Wendel-García; Yonca Belce; Xiang-Zhong Chen; Josep Puigmartí-Luis
Published in: Current Robotics Reports, Issue 2, 2021, Page(s) 1 - 14, ISSN 2662-4087
Publisher: Springer
DOI: 10.1007/s43154-021-00066-1

Dexterous helical magnetic robot for improved endovascular access

Author(s): Dreyfus R, Boehler Q, Lyttle S, Gruber P, Lussi J, Chautems C, Gervasoni S, Berberat J, Seibold D, Ochsenbein-Kölble N, Reinehr M, Weisskopf M, Remonda L, Nelson BJ. Dexterous helical magnetic robot for improved endovascular access.
Published in: Science Robotics, Issue Vol 9, Issue 87, 2024, ISSN 2470-9476
Publisher: American Association for the Advancement of Science
DOI: 10.3929/ethz-b-000659728

Conference proceedings (8)

In Vitro Navigation of a Magnetic Sphere Using a Model Predictive Controller for Neurovascular Targeted Drug Delivery Applications

Author(s): Derick Sivakumaran; Fabian Christopher Landers; Quentin Boehler; Christophe Chautems; Salvador Pané and Bradley J. Nelson
Published in: Hamlyn Symposium on Medical Robotics 2022, 2022
Publisher: EasyChair

Soft-hard magnetically driven microrobotic devices

Author(s): F C Landers; C. J. Alcantara; Josep Puigmartí-Luis; Bradley J. Nelson; Salvador Pané
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142296

Microfluidic technologies for chemistry, materials science and biotechnology

Author(s): Josep Puigmartí-Luis
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142301

Magnetic small-scale robots: Principles, applications and challenges

Author(s): Salvador Pané; J. Puigmartí; M. Pinto; E. Mavromanolaki; A. Flouris; T. S. Mayor; Tessa Lühmann; D. Sargent; Bradley J. Nelson
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.3929/ethz-b-000526973

Evolution, gaps, and trends in the origins of innovation ecosystems

Author(s): E. Mavromanolaki; G. Ntina; S. Karatsali; P. Smarianaki; M. Pinto; R. Moreira; S. Pané; T. S. Mayor, J; Puigmartí; A. D. Flouris
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142303

In flow controlled synthesis of blood clots

Author(s): R. S. Herrera-Restrepo; P. Martinez-Bulit; A. D. Flouris; M. Pinto; R. Moreira; E. Mavromanolaki; T. S. Mayor; S. Pané; J. Ignés; and J. Puigmartí-Luis
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142302

3D interlocked metal-organic magnetic microrobots

Author(s): F. Landers; S. Pané
Published in: International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2022
Publisher: MARSS

Marrying inorganics and biologics: Opportunities and challenges

Author(s): K. Meiners; M. Richter; F. Landers; S. Pané; T. Lühmann
Published in: Public Health and Toxicology, 2021
Publisher: EU European Publishing
DOI: 10.18332/pht/142300