MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body

Información del proyecto

ANGIE

Identificador del acuerdo de subvención: 952152

DOI

10.3030/952152

Proyecto cerrado

Fecha de la firma de la CE 29 Mayo 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 4 000 000,00

Aportación de la UE

€ 4 000 000,00

Coordinado por

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (10)

Report on the interface between electromagnetic and angiography systems

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Report 1 on actions to create interdisciplin. community around targeted drug delivery

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Report 3 on measures to create innovation eco-system around ANGIE technology

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Dissemination and Communication Plan

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Dissemination and Communication Plan update 1

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Report 3 on actions to create interdisciplinary community around targeted drug delivery

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Report 1 on measures to create innovation eco-system around ANGIE technology

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Dissemination and Communication Plan update 2

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Report 2 on actions to create interdisciplinary community around targeted drug delivery

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Report 2 on measures to create innovation eco-system around ANGIE technology

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Demonstrators, pilots, prototypes (2)

Prototype of electromagnetic system for navigation and actuation

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Perfused 3D models of the vascular network with different tortuosity and clot sites

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Publicaciones

Peer reviewed articles (19)

3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

Autores: Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmartí-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pané
Publicado en: Advanced functional materials, 2023, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202212952

A Human‐Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices

Autores: Simone Gervasoni, Norman Pedrini, Tarik Rifai, Cedric Fischer, Fabian C. Landers, Michael Mattmann, Roland Dreyfus, Silvia Viviani, Andrea Veciana, Enea Masina, Buse Aktas, Josep Puigmartí‐Luis, Christophe Chautems, Salvador Pané, Quentin Boehler, Philipp Gruber, Bradley J. Nelson
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310701

Patient-specific placental vessel segmentation with limited data

Autores: Gary Sarwin, Jonas Lussi, Simone Gervasoni, Ueli Moehrlen, Nicole Ochsenbein, Bradley J. Nelson
Publicado en: Journal of Robotic Surgery, Edición 18, 2024, ISSN 1863-2483
Editor: Springer Verlag
DOI: 10.1007/s11701-024-01981-z

A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats

Autores: Aristidis Tsatsakis Elisavet Renieri Dimitris Tsoukalas Ana Maria Buga Evangelia Sarandi Elena Vakonaki Persefoni Fragkiadaki Athanasios Alegakis Dragana Nikitovic Daniela Calina Demetrios A. Spandidos Anca Oana Docea
Publicado en: Molecular Medicine Reports, Edición Volume 28, Edición 6, 2023, ISSN 1791-2997
Editor: Spandidos Publications
DOI: 10.3892/mmr.2023.13119

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Autores: Spanakis Marios, Fragkiadaki Persefoni, Renieri Elisavet, Vakonaki Elena, Fragkiadoulaki Irene, Alegakis Athanasios, Kiriakakis Mixalis, Panagiotou Nikolaos, Ntoumou Eleni, Gratsias Ioannis, Zoubaneas Evangelos, Morozova Galina Dmitrievna, Ovchinnikova Marina Alekseevna, Tsitsimpikou Christina, Tsarouhas Konstantinos, Drakoulis Nikolaos, Skalny Anatoly Viktorovich, Tsatsakis Aristides
Publicado en: Frontiers in Sports and Active Living, 2024, ISSN 2624-9367
Editor: Frontiers
DOI: 10.3389/fspor.2023.1327792

Toward More Inclusive Networks and Initiatives in Innovation Ecosystems: Protocol for a Systematic Review

Autores: Georgia Ntina; Eirini Mavromanolaki; Andreas D Flouris
Publicado en: JMIR Research Protocol, 2022, Página(s) e34071, ISSN 1929-0748
Editor: JMIR Publications Inc.
DOI: 10.2196/34071

Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms

Autores: Harun Torlakcik, Semih Sevim, Pedro Alves, Michael Mattmann, Joaquim Llacer‐Wintle, Maria Pinto, Rosa Moreira, Andreas D. Flouris, Fabian C. Landers, Xiang‐Zhong Chen, Josep Puigmartí‐Luis, Quentin Boehler, Tiago Sotto Mayor, Minsoo Kim, Bradley J. Nelson, Salvador Pané
Publicado en: Advanced Science, Edición 11, 2024, ISSN 2198-3844
Editor: Weinheim: Wiley-VCH
DOI: 10.1002/advs.202404061

Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability

Autores: Vitaly Pustovalov, Fabian C. Landers, Lukas Hertle, Hyeon Ko, Joaquin Llacer‐Wintle, Hao Ye, Andrea Veciana, Carlos Franco, Roger Sanchis‐Gual, Xiang‐Zhong Chen, Eva Pellicer, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Publicado en: Advanced Engineering Materials, Edición 26, 2024, ISSN 1438-1656
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adem.202400307

A Naturally Inspired Extrusion‐Based Microfluidic Approach for Manufacturing Tailorable Magnetic Soft Continuum Microrobotic Devices

Autores: Lukas Hertle, Semih Sevim, Jiawei Zhu, Vitaly Pustovalov, Andrea Veciana, Joaquin Llacer‐Wintle, Fabian C. Landers, Hao Ye, Xiang‐Zhong Chen, Hannes Vogler, Ueli Grossniklaus, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402309

Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes

Autores: Minsoo Kim, Donghoon Kim, Mathieu Mirjolet, Nick A. Shepelin, Thomas Lippert, Hongsoo Choi, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202404825

Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems

Autores: Von Arx Denis; Fischer Cedric; Torlakcik Harun; Pané Salvador; Nelson Bradley; J.Boehler Quentin
Publicado en: Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems, 2023, ISSN 1552-3098
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TRO.2023.3340324

On-Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines

Autores: F. C. Landers, V. Gantenbein, L. Hertle, A. Veciana, J. Llacer-Wintle, X.-Z. Chen, H. Ye, C. Franco, J. Puigmartí-Luis, M. Kim, B. J. Nelson, S. Pané
Publicado en: Advanced Materials, 2023, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310084

3D Motion Manipulation for Micro- and Nanomachines: Progress and Future Directions

Autores: Hai Huang, Shihao Yang, Yulong Ying, Xiangzhong Chen, Josep Puigmartí-Luis, Li Zhang, Salvador Pané
Publicado en: Advanced Materials, 2023, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202305925

Autonomous 3D positional control of a magnetic microrobot using reinforcement learning

Autores: Sarmad Ahmad Abbasi, Awais Ahmed, Seungmin Noh, Nader Latifi Gharamaleki, Seonhyoung Kim, A. M. Masum Bulbul Chowdhury, Jin-young Kim, Salvador Pané, Bradley J. Nelson, Hongsoo Choi
Publicado en: Nature Machine Intelligence, Edición 6, 2024, Página(s) 92-105, ISSN 2522-5839
Editor: NPG
DOI: 10.1038/s42256-023-00779-2

Magnetically Assisted Robotic Fetal Surgery for the Treatment of Spina Bifida

Autores: Gervasoni, Simone; Lussi, Jonas; Viviani, Silvia; Boehler, Quentin; Ochsenbein, Nicole; Moehrlen, Ueli; Nelson, Bradley J.; Gervasoni, Simone
Publicado en: IEEE Transactions on Medical Robotics and Bionics, 2022, Página(s) 85-93, ISSN 2576-3202
Editor: IEEE
DOI: 10.3929/ethz-b-000531109

Magnetically Guided Laser Surgery for the Treatment of Twin-to-Twin Transfusion Syndrome

Autores: Lussi, J., Gervasoni, S., Mattille, M., Dreyfus, R., Boehler, Q., Reinehr, M., Ochsenbein, N., Nelson, B.J. and Moehrlen, U.
Publicado en: Advanced Intelligent Systems, Edición Volume 4, Edición 11, 2022, ISSN 2640-4567
Editor: Wiley-VCH GmbH
DOI: 10.1002/aisy.202200182

Site-specific PEGylation of recombinant tissue-type plasminogen activator

Autores: Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Król, Salvador Pané, Tessa Lühmann
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición Volume 192, 2023, Página(s) 79-87, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2023.09.017

Powering and Fabrication of Small-Scale Robotics Systems

Autores: Salvador Pané; Pedro D. Wendel-García; Yonca Belce; Xiang-Zhong Chen; Josep Puigmartí-Luis
Publicado en: Current Robotics Reports, Edición 2, 2021, Página(s) 1 - 14, ISSN 2662-4087
Editor: Springer
DOI: 10.1007/s43154-021-00066-1

Dexterous helical magnetic robot for improved endovascular access

Autores: Dreyfus R, Boehler Q, Lyttle S, Gruber P, Lussi J, Chautems C, Gervasoni S, Berberat J, Seibold D, Ochsenbein-Kölble N, Reinehr M, Weisskopf M, Remonda L, Nelson BJ. Dexterous helical magnetic robot for improved endovascular access.
Publicado en: Science Robotics, Edición Vol 9, Edición 87, 2024, ISSN 2470-9476
Editor: American Association for the Advancement of Science
DOI: 10.3929/ethz-b-000659728

Conference proceedings (8)

In Vitro Navigation of a Magnetic Sphere using a Model Predictive Controller for Neurovascular Targeted Drug Delivery Applications

Autores: null null, D Sivakumaran, F. C Landers, Q Boehler, C Chautems, S Pané, B. J Nelson, null null
Publicado en: Proceedings of The 14th Hamlyn Symposium on Medical Robotics 2022, 2022, Página(s) 109-110
Editor: The Hamlyn Centre, Imperial College London London, UK
DOI: 10.31256/hsmr2022.54

Soft-hard magnetically driven microrobotic devices

Autores: F C Landers; C. J. Alcantara; Josep Puigmartí-Luis; Bradley J. Nelson; Salvador Pané
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.18332/pht/142296

Microfluidic technologies for chemistry, materials science and biotechnology

Autores: Josep Puigmartí-Luis
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.18332/pht/142301

Magnetic small-scale robots: Principles, applications and challenges

Autores: Salvador Pané; J. Puigmartí; M. Pinto; E. Mavromanolaki; A. Flouris; T. S. Mayor; Tessa Lühmann; D. Sargent; Bradley J. Nelson
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.3929/ethz-b-000526973

Evolution, gaps, and trends in the origins of innovation ecosystems

Autores: E. Mavromanolaki; G. Ntina; S. Karatsali; P. Smarianaki; M. Pinto; R. Moreira; S. Pané; T. S. Mayor, J; Puigmartí; A. D. Flouris
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.18332/pht/142303

In flow controlled synthesis of blood clots

Autores: R. S. Herrera-Restrepo; P. Martinez-Bulit; A. D. Flouris; M. Pinto; R. Moreira; E. Mavromanolaki; T. S. Mayor; S. Pané; J. Ignés; and J. Puigmartí-Luis
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.18332/pht/142302

3D interlocked metal-organic magnetic microrobots

Autores: F. Landers; S. Pané
Publicado en: International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2022
Editor: MARSS

Marrying inorganics and biologics: Opportunities and challenges

Autores: K. Meiners; M. Richter; F. Landers; S. Pané; T. Lühmann
Publicado en: Public Health and Toxicology, 2021
Editor: EU European Publishing
DOI: 10.18332/pht/142300

Monographic books (1)

Emerging Issues on Targeted Drug Delivery

Autores: Vliora Maria, Tsatsakis Aristidis, Kallinteri Paraskevi, Kallkach Aparicio Mariel
Publicado en: 2024, Página(s) Scientific Research Publishing, ISBN 979-8-89507-901-0
Editor: Scientific Research Publishing
DOI: 10.5281/zenodo.14621049

Non-peer reviewed articles (1)

Clinically Ready Magnetic Microrobots for Targeted Therapies

Autores: Fabian C. Landers, Lukas Hertle, Vitaly Pustovalov, Derick Sivakumaran, Oliver Brinkmann, Kirstin Meiners, Pascal Theiler, Valentin Gantenbein, Andrea Veciana, Michael Mattmann, Silas Riss, Simone Gervasoni, Christophe Chautems, Hao Ye, Semih Sevim, Andreas D. Flouris, Josep Puigmartí-Luis, Tiago Sotto Mayor, Pedro Alves, Tessa Lühmann, Xiangzhong Chen, Nicole Ochsenbein, Ueli Moehrlen, Philipp
Publicado en: arXiv, 2025, ISSN 2331-8422
Editor: Cornell University
DOI: 10.48550/arxiv.2501.11553