MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body

Informazioni relative al progetto

ANGIE

ID dell’accordo di sovvenzione: 952152

DOI

10.3030/952152

Progetto chiuso

Data della firma CE 29 Maggio 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 4 000 000,00

Contributo UE

€ 4 000 000,00

Coordinato da

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (10)

Report on the interface between electromagnetic and angiography systems

s.a.

Report 1 on actions to create interdisciplin. community around targeted drug delivery

sa

Report 3 on measures to create innovation eco-system around ANGIE technology

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Dissemination and Communication Plan

sa

Dissemination and Communication Plan update 1

s.a.

Report 3 on actions to create interdisciplinary community around targeted drug delivery

s.a.

Report 1 on measures to create innovation eco-system around ANGIE technology

sa

Dissemination and Communication Plan update 2

s.a.

Report 2 on actions to create interdisciplinary community around targeted drug delivery

s.a.

Report 2 on measures to create innovation eco-system around ANGIE technology

s.a.

Demonstrators, pilots, prototypes (2)

Prototype of electromagnetic system for navigation and actuation

s.a.

Perfused 3D models of the vascular network with different tortuosity and clot sites

s.a.

Pubblicazioni

Peer reviewed articles (19)

3D Printed Template-Assisted Casting of Biocompatible Polyvinyl Alcohol-Based Soft Microswimmers with Tunable Stability

Autori: Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmartí-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pané
Pubblicato in: Advanced functional materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202212952

A Human‐Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices

Autori: Simone Gervasoni, Norman Pedrini, Tarik Rifai, Cedric Fischer, Fabian C. Landers, Michael Mattmann, Roland Dreyfus, Silvia Viviani, Andrea Veciana, Enea Masina, Buse Aktas, Josep Puigmartí‐Luis, Christophe Chautems, Salvador Pané, Quentin Boehler, Philipp Gruber, Bradley J. Nelson
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310701

Patient-specific placental vessel segmentation with limited data

Autori: Gary Sarwin, Jonas Lussi, Simone Gervasoni, Ueli Moehrlen, Nicole Ochsenbein, Bradley J. Nelson
Pubblicato in: Journal of Robotic Surgery, Numero 18, 2024, ISSN 1863-2483
Editore: Springer Verlag
DOI: 10.1007/s11701-024-01981-z

A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats

Autori: Aristidis Tsatsakis Elisavet Renieri Dimitris Tsoukalas Ana Maria Buga Evangelia Sarandi Elena Vakonaki Persefoni Fragkiadaki Athanasios Alegakis Dragana Nikitovic Daniela Calina Demetrios A. Spandidos Anca Oana Docea
Pubblicato in: Molecular Medicine Reports, Numero Volume 28, Numero 6, 2023, ISSN 1791-2997
Editore: Spandidos Publications
DOI: 10.3892/mmr.2023.13119

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Autori: Spanakis Marios, Fragkiadaki Persefoni, Renieri Elisavet, Vakonaki Elena, Fragkiadoulaki Irene, Alegakis Athanasios, Kiriakakis Mixalis, Panagiotou Nikolaos, Ntoumou Eleni, Gratsias Ioannis, Zoubaneas Evangelos, Morozova Galina Dmitrievna, Ovchinnikova Marina Alekseevna, Tsitsimpikou Christina, Tsarouhas Konstantinos, Drakoulis Nikolaos, Skalny Anatoly Viktorovich, Tsatsakis Aristides
Pubblicato in: Frontiers in Sports and Active Living, 2024, ISSN 2624-9367
Editore: Frontiers
DOI: 10.3389/fspor.2023.1327792

Toward More Inclusive Networks and Initiatives in Innovation Ecosystems: Protocol for a Systematic Review

Autori: Georgia Ntina; Eirini Mavromanolaki; Andreas D Flouris
Pubblicato in: JMIR Research Protocol, 2022, Pagina/e e34071, ISSN 1929-0748
Editore: JMIR Publications Inc.
DOI: 10.2196/34071

Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms

Autori: Harun Torlakcik, Semih Sevim, Pedro Alves, Michael Mattmann, Joaquim Llacer‐Wintle, Maria Pinto, Rosa Moreira, Andreas D. Flouris, Fabian C. Landers, Xiang‐Zhong Chen, Josep Puigmartí‐Luis, Quentin Boehler, Tiago Sotto Mayor, Minsoo Kim, Bradley J. Nelson, Salvador Pané
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Weinheim: Wiley-VCH
DOI: 10.1002/advs.202404061

Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability

Autori: Vitaly Pustovalov, Fabian C. Landers, Lukas Hertle, Hyeon Ko, Joaquin Llacer‐Wintle, Hao Ye, Andrea Veciana, Carlos Franco, Roger Sanchis‐Gual, Xiang‐Zhong Chen, Eva Pellicer, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Pubblicato in: Advanced Engineering Materials, Numero 26, 2024, ISSN 1438-1656
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adem.202400307

A Naturally Inspired Extrusion‐Based Microfluidic Approach for Manufacturing Tailorable Magnetic Soft Continuum Microrobotic Devices

Autori: Lukas Hertle, Semih Sevim, Jiawei Zhu, Vitaly Pustovalov, Andrea Veciana, Joaquin Llacer‐Wintle, Fabian C. Landers, Hao Ye, Xiang‐Zhong Chen, Hannes Vogler, Ueli Grossniklaus, Josep Puigmartí‐Luis, Bradley J. Nelson, Salvador Pané
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202402309

Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes

Autori: Minsoo Kim, Donghoon Kim, Mathieu Mirjolet, Nick A. Shepelin, Thomas Lippert, Hongsoo Choi, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202404825

Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems

Autori: Von Arx Denis; Fischer Cedric; Torlakcik Harun; Pané Salvador; Nelson Bradley; J.Boehler Quentin
Pubblicato in: Simultaneous Localization and Actuation Using Electromagnetic Navigation Systems, 2023, ISSN 1552-3098
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TRO.2023.3340324

On-Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines

Autori: F. C. Landers, V. Gantenbein, L. Hertle, A. Veciana, J. Llacer-Wintle, X.-Z. Chen, H. Ye, C. Franco, J. Puigmartí-Luis, M. Kim, B. J. Nelson, S. Pané
Pubblicato in: Advanced Materials, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202310084

3D Motion Manipulation for Micro- and Nanomachines: Progress and Future Directions

Autori: Hai Huang, Shihao Yang, Yulong Ying, Xiangzhong Chen, Josep Puigmartí-Luis, Li Zhang, Salvador Pané
Pubblicato in: Advanced Materials, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202305925

Autonomous 3D positional control of a magnetic microrobot using reinforcement learning

Autori: Sarmad Ahmad Abbasi, Awais Ahmed, Seungmin Noh, Nader Latifi Gharamaleki, Seonhyoung Kim, A. M. Masum Bulbul Chowdhury, Jin-young Kim, Salvador Pané, Bradley J. Nelson, Hongsoo Choi
Pubblicato in: Nature Machine Intelligence, Numero 6, 2024, Pagina/e 92-105, ISSN 2522-5839
Editore: NPG
DOI: 10.1038/s42256-023-00779-2

Magnetically Assisted Robotic Fetal Surgery for the Treatment of Spina Bifida

Autori: Gervasoni, Simone; Lussi, Jonas; Viviani, Silvia; Boehler, Quentin; Ochsenbein, Nicole; Moehrlen, Ueli; Nelson, Bradley J.; Gervasoni, Simone
Pubblicato in: IEEE Transactions on Medical Robotics and Bionics, 2022, Pagina/e 85-93, ISSN 2576-3202
Editore: IEEE
DOI: 10.3929/ethz-b-000531109

Magnetically Guided Laser Surgery for the Treatment of Twin-to-Twin Transfusion Syndrome

Autori: Lussi, J., Gervasoni, S., Mattille, M., Dreyfus, R., Boehler, Q., Reinehr, M., Ochsenbein, N., Nelson, B.J. and Moehrlen, U.
Pubblicato in: Advanced Intelligent Systems, Numero Volume 4, Numero 11, 2022, ISSN 2640-4567
Editore: Wiley-VCH GmbH
DOI: 10.1002/aisy.202200182

Site-specific PEGylation of recombinant tissue-type plasminogen activator

Autori: Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Król, Salvador Pané, Tessa Lühmann
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero Volume 192, 2023, Pagina/e 79-87, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2023.09.017

Powering and Fabrication of Small-Scale Robotics Systems

Autori: Salvador Pané; Pedro D. Wendel-García; Yonca Belce; Xiang-Zhong Chen; Josep Puigmartí-Luis
Pubblicato in: Current Robotics Reports, Numero 2, 2021, Pagina/e 1 - 14, ISSN 2662-4087
Editore: Springer
DOI: 10.1007/s43154-021-00066-1

Dexterous helical magnetic robot for improved endovascular access

Autori: Dreyfus R, Boehler Q, Lyttle S, Gruber P, Lussi J, Chautems C, Gervasoni S, Berberat J, Seibold D, Ochsenbein-Kölble N, Reinehr M, Weisskopf M, Remonda L, Nelson BJ. Dexterous helical magnetic robot for improved endovascular access.
Pubblicato in: Science Robotics, Numero Vol 9, Numero 87, 2024, ISSN 2470-9476
Editore: American Association for the Advancement of Science
DOI: 10.3929/ethz-b-000659728

Conference proceedings (8)

In Vitro Navigation of a Magnetic Sphere using a Model Predictive Controller for Neurovascular Targeted Drug Delivery Applications

Autori: null null, D Sivakumaran, F. C Landers, Q Boehler, C Chautems, S Pané, B. J Nelson, null null
Pubblicato in: Proceedings of The 14th Hamlyn Symposium on Medical Robotics 2022, 2022, Pagina/e 109-110
Editore: The Hamlyn Centre, Imperial College London London, UK
DOI: 10.31256/hsmr2022.54

Soft-hard magnetically driven microrobotic devices

Autori: F C Landers; C. J. Alcantara; Josep Puigmartí-Luis; Bradley J. Nelson; Salvador Pané
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.18332/pht/142296

Microfluidic technologies for chemistry, materials science and biotechnology

Autori: Josep Puigmartí-Luis
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.18332/pht/142301

Magnetic small-scale robots: Principles, applications and challenges

Autori: Salvador Pané; J. Puigmartí; M. Pinto; E. Mavromanolaki; A. Flouris; T. S. Mayor; Tessa Lühmann; D. Sargent; Bradley J. Nelson
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.3929/ethz-b-000526973

Evolution, gaps, and trends in the origins of innovation ecosystems

Autori: E. Mavromanolaki; G. Ntina; S. Karatsali; P. Smarianaki; M. Pinto; R. Moreira; S. Pané; T. S. Mayor, J; Puigmartí; A. D. Flouris
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.18332/pht/142303

In flow controlled synthesis of blood clots

Autori: R. S. Herrera-Restrepo; P. Martinez-Bulit; A. D. Flouris; M. Pinto; R. Moreira; E. Mavromanolaki; T. S. Mayor; S. Pané; J. Ignés; and J. Puigmartí-Luis
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.18332/pht/142302

3D interlocked metal-organic magnetic microrobots

Autori: F. Landers; S. Pané
Pubblicato in: International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2022
Editore: MARSS

Marrying inorganics and biologics: Opportunities and challenges

Autori: K. Meiners; M. Richter; F. Landers; S. Pané; T. Lühmann
Pubblicato in: Public Health and Toxicology, 2021
Editore: EU European Publishing
DOI: 10.18332/pht/142300

Monographic books (1)

Emerging Issues on Targeted Drug Delivery

Autori: Vliora Maria, Tsatsakis Aristidis, Kallinteri Paraskevi, Kallkach Aparicio Mariel
Pubblicato in: 2024, Pagina/e Scientific Research Publishing, ISBN 979-8-89507-901-0
Editore: Scientific Research Publishing
DOI: 10.5281/zenodo.14621049

Non-peer reviewed articles (1)

Clinically Ready Magnetic Microrobots for Targeted Therapies

Autori: Fabian C. Landers, Lukas Hertle, Vitaly Pustovalov, Derick Sivakumaran, Oliver Brinkmann, Kirstin Meiners, Pascal Theiler, Valentin Gantenbein, Andrea Veciana, Michael Mattmann, Silas Riss, Simone Gervasoni, Christophe Chautems, Hao Ye, Semih Sevim, Andreas D. Flouris, Josep Puigmartí-Luis, Tiago Sotto Mayor, Pedro Alves, Tessa Lühmann, Xiangzhong Chen, Nicole Ochsenbein, Ueli Moehrlen, Philipp
Pubblicato in: arXiv, 2025, ISSN 2331-8422
Editore: Cornell University
DOI: 10.48550/arxiv.2501.11553