RESEarch for healThy AGEING

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Repository of RESETageing complementary advanced PhD courses

A repository of complementary RESETageing PhD advanced courses derived from existing programs UC UNEW UM will be prepared

Project flyer/poster and webinar communication system

A flyerposter of the RESETageing project will be elaborated for public dissemination and a webinar communication system within the consortium will be implemented

Report of RESETageing in strengthening research management and administration

A report with the specific activities developed during the project regarding the strengthening research management and administration of the staff of the coordinating institution will be created.

Report about the workshop in innovation and Business Ignition program

It will be elaborated a report about the workshop that RESETageing project will organize regarding Innovation in Ageing and about the Business Ignition program in Ageing that will be launched.

Report in advanced PhD courses

At the end of RESEtageing project a report regarding the advanced PhD courses will be delivered.

Participation in the 10th annual alliance for healthy ageing conference

A report about the participation of the RESETageing consortium in the Annual Alliance for Healthy Ageing Conference will be elaborated.

Report of RESETageing early stage researcher's involvement in the coordinating institution

A report of the involvement of early stage researchers in the coordination institution will be created.

Submission of Go to Market plans to the Business Ignition Program

It is expected that at least 1 Go to Market Plan will be submitted to the Business Ignition Program (see WP5) based in technologies that have been developed in a multi-institutional context.

Kick off meeting

Representatives of the four partners of the RESETageing consortium UC UNEM LIA and UM will gather to discuss all the details regarding the implementation of the RESETageing project such as the action plan the role of each partner the deliverables for the coming months the forthcoming meetings among other topics

RESETageing meeting conferences book

A book with all the RESETageing meeting conferences will be elaborated at the end of RESETageing project.

Repository of scientific achievements - result of three years of RESETageing project

At the end of the project it will be created a repository of the scientific achievements of the three years of RESETageing project of all partners of the consortium

Submission of a Marie Curie ITN and of Marie Curie European fellowship applications

A report with the submissions of a Marie Curie ITN and Marie Curie European fellowships applications will be delivered.

Repository of scientific achievements - last three years before project starts

It will be created a repository of the scientific achievements within the scope of the project of all partners of the consortium UC UNEW LIA and UM in the three years before the initiation of the RESETageing project

Data management plan

A Data Management Plan with the description for the life cycle for the data to be collected processed andor generated by the RESETageing project will be elaborated and will be deposited in a research data repository

Web site

A dedicated web site for the RESETageing project will be launched where information regarding the project will be disseminated

Publications

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Author(s): Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Published in: BMC Biology, Issue 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-018-0547-y

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Author(s): Vitor Francisco, Catarina Rebelo, Artur Filipe Rodrigues, Josephine Blersch, Hugo Fernandes, Lino Ferreira
Published in: Methods, 2020, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2020.12.002

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Author(s): Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual
Published in: The EMBO Journal, Issue 38/5, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100492

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Author(s): Andrea Raso, Ellen Dirkx, Leonne E. Philippen, Amaya Fernandez-Celis, Federica De Majo, Vasco Sampaio-Pinto, Marida Sansonetti, Rio Juni, Hamid el Azzouzi, Martina Calore, Nicole Bitsch, Servé Olieslagers, Martinus I.F.J. Oerlemans, Manon M. Huibers, Roel A. de Weger, Yolan J. Reckman, Yigal M. Pinto, Lorena Zentilin, Serena Zacchigna, Mauro Giacca, Paula A. da Costa Martins, Natalia López-Andr
Published in: Molecular Therapy, Issue 27/3, 2019, Page(s) 584-599, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.011

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Author(s): Anna Walaszczyk, Emily Dookun, Rachael Redgrave, Simon Tual‐Chalot, Stella Victorelli, Ioakim Spyridopoulos, Andrew Owens, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Published in: Aging Cell, Issue 18/3, 2019, Page(s) e12945, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12945

The crosstalk of NAD, ROS and autophagy in cellular health and ageing

Author(s): Lucia Sedlackova, Viktor I. Korolchuk
Published in: Biogerontology, Issue 21/3, 2020, Page(s) 381-397, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09864-0

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Author(s): Tianhong Su, Doug Turnbull, Laura Greaves
Published in: Genes, Issue 9/4, 2018, Page(s) 182, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9040182

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Author(s): Zhiyang Chen, Elias Moris Amro, Friedrich Becker, Martin Hölzer, Seyed Mohammad Mahdi Rasa, Sospeter Ngoci Njeru, Bing Han, Simone Di Sanzo, Yulin Chen, Duozhuang Tang, Si Tao, Ronny Haenold, Marco Groth, Vasily S. Romanov, Joanna M. Kirkpatrick, Johann M. Kraus, Hans A. Kestler, Manja Marz, Alessandro Ori, Francesco Neri, Yohei Morita, K. Lenhard Rudolph
Published in: Journal of Experimental Medicine, Issue 216/1, 2019, Page(s) 152-175, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20181505

Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells

Author(s): Andreia Vilaça Carlos Jesus Miguel Lino Danika Hayman Costanza Emanueli Cesare M. Terracciano Hugo Fernandes Leon J. de Windt Lino Ferreira Show less Show footnotes
Published in: Molecular Therapy - Nucleic Acids, 2024, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102233

Stem cells as vehicles and targets of nanoparticles

Author(s): Sonia Pinho, Maria H. Macedo, Catarina Rebelo, Bruno Sarmento, Lino Ferreira
Published in: Drug Discovery Today, Issue 23/5, 2018, Page(s) 1071-1078, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.030

A nanomedicine-based therapeutic strategy to fight senescence

Author(s): Aires H, Sofia, Domingues N, Raimundo N, Francisco V, Pitrez PR, Ferreira L.
Published in: Journal of Nanobiotechnology, Issue (in preparation), 2024, ISSN 1477-3155
Publisher: BioMed Central

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Author(s): Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho & Lino Ferreira
Published in: Nature Communications, Issue 13, 4135, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31791-6

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Author(s): João Sargento-Freitas, Anabela Pereira, André Gomes, Paula Amorim, Teresa Matos, Carla M. P. Cardoso, Fernando Silva, Gustavo Cordeiro Santo, César Nunes, Orlando Galego, José Carda, João Branco, Víctor Lourenço, Luís Cunha, Lino Ferreira
Published in: Frontiers in Neurology, Issue 9, 2018, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00302

Integrated multi-omics analysis of the cellular and molecular cardiac senescent phenotype in Progeria and its partial reversion by lonafarnib

Author(s): Monteiro LM, Pitrez PR*, Santos SC, Dark N, Santinha D, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Soares CS, Ribeiro R, Logarinho E, Ori A, Smith JC, Bernardo A*, Ferreira L*
Published in: Nature Cardiovascular Research, Issue (in preparation), 2024, ISSN 2731-0590
Publisher: Springer Nature Limited

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Author(s): Helena Henriques-Antunes, Renato M. S. Cardoso, Alessandra Zonari, Joana Correia, Ermelindo C. Leal, Adrián Jiménez-Balsa, Miguel M. Lino, Ana Barradas, Ivana Kostic, Célia Gomes, Jeffrey M. Karp, Eugénia Carvalho, Lino Ferreira
Published in: ACS Nano, Issue 13/8, 2019, Page(s) 8694-8707, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b00376

Circulating blood cells and extracellular vesicles in acute cardioprotection

Author(s): Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Published in: Cardiovascular Research, Issue 115/7, 2018, Page(s) 1156-1166, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy314

MicroRNA-216a is essential for cardiac angiogenesis

Author(s): Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins
Published in: Molecular Therapy, Issue 31, 2023, Page(s) 1807-1828, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2023.04.007

Exogenous loading of miRNAs into small extracellular vesicles

Author(s): Ricardo Abreu, Cristiana V Ramos, Clarissa Becher, Miguel Lino, Carlos Jesus, Pauça da Costa Martins, Patrícia A T, Martins, Maria João Moreno, Hugo Fernandes, Lino Ferreira
Published in: Journal of Extracellular Vesicles, Issue 10/10, 2021, Page(s) e12111, ISSN 2001-3078
Publisher: WILEY
DOI: 10.1002/jev2.12111

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Author(s): Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Published in: Neurobiology of Aging, Issue 92, 2020, Page(s) 98-113, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Nutrient sensing, growth and senescence

Author(s): Bernadette Carroll, Viktor I. Korolchuk
Published in: The FEBS Journal, Issue 285/11, 2018, Page(s) 1948-1958, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.14400

Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential

Author(s): Rachel Oldershaw, W. Andrew Owens, Rachel Sutherland, Martin Linney, Rachel Liddle, Lissette Magana, Gendie E. Lash, Jason H. Gill, Gavin Richardson, Annette Meeson
Published in: Stem Cells and Development, Issue 28/9, 2019, Page(s) 593-607, ISSN 1547-3287
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2018.0170

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Author(s): Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Published in: Molecular Systems Biology, Issue 16/6, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209596

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Author(s): Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-68566-2

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Author(s): Despoina Kesidou, Paula A. da Costa Martins, Leon J. de Windt, Mairi Brittan, Abdelaziz Beqqali, Andrew Howard Baker
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Author(s): Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, Helena Antunes, Carlo Gonzato, Sandra Pinto, Susana Simões, Klaus Liedl, Karsten Haupt, Lino Ferreira
Published in: Angewandte Chemie International Edition, Issue 59/5, 2020, Page(s) 1985-1991, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911398

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Author(s): Akash Srivastava, Emanuel Barth, Maria A. Ermolaeva, Madlen Guenther, Christiane Frahm, Manja Marz, Otto W. Witte
Published in: Genomics, Proteomics & Bioinformatics, 2020, ISSN 1672-0229
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2020.12.001

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Author(s): Emily Dookun, Anna Walaszczyk, Rachael Redgrave, Pawel Palmowski, Simon Tual‐Chalot, Averina Suwana, James Chapman, Eduard Jirkovsky, Leticia Donastorg Sosa, Eleanor Gill, Oliver E Yausep, Yohan Santin, Jeanne Mialet‐Perez, W Andrew Owens, David Grieve, Ioakim Spyridopoulos, Michael Taggart, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Published in: Aging Cell, Issue 19/10, 2020, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13249

Pharmacological clearance of senescent cells with Navitoclax reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis

Author(s): "Silva ED*, Tomé I*, Vasques-Nóvoa F, Conceição G, Silva A, Barros A, Gonçalves A, Caetano C, Sousa D, Silva D, Nádia, Pinto VP, Alexandre, Moreira AL, Pires IF, Pitrez P, Pinto-do-Ó P, Santos SG, Ferreira L#, Nascimento DS#"
Published in: Cardiovascular Research, Issue (under revision), 2024, ISSN 1755-3245
Publisher: Oxford University Press

Non-coding RNAs in Cardiac Intercellular Communication

Author(s): Raquel Figuinha Videira, Paula A. da Costa Martins
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00738

Cx43 modulates the sorting of miRNA intro extracellular vesicles

Author(s): T Martins-Marques, MC Costa, S Catarino, I Simoes, T Aasen, FJ Enguita, H Girão
Published in: EMBO Reports, Issue May 20, 2022, Page(s) e54312, ISSN 1469-3178
Publisher: EMBO press
DOI: 10.15252/embr.202154312

The pROS of Autophagy in Neuronal Health

Author(s): Lucia Sedlackova, George Kelly, Viktor I. Korolchuk
Published in: Journal of Molecular Biology, Issue 432/8, 2020, Page(s) 2546-2559, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2020.01.020

The mTORC1-autophagy pathway is a target for senescent cell elimination

Author(s): Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I. Korolchuk, Bernadette Carroll
Published in: Biogerontology, Issue 20/3, 2019, Page(s) 331-335, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09802-9

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Author(s): Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17901-2

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Author(s): Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Published in: Nanoscale, Issue 11/28, 2019, Page(s) 13243-13248, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr02512j

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Author(s): H Fernandes, A Zonnari, R Abreu, S Aday, M Barão, I Albino, M Lino, A Branco,C Seabra, T Barata, E Leal, G Tralhão, L Gonçalves, A Jon, H Peters, M Vries, PC Martins, P Quax, L Ferreira
Published in: Molecular Therapy - Nucleic Acids, Issue 28, 2022, Page(s) P307-327, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.03.018

Targeted anti-senescence formulations

Author(s): Rita Ferreira, Patricia Pitrez, Joana Padrão, Carolina Guímaro, Marta Barão, Emanuel Barth, Manja Marz, Lino Ferreira
Published in: Molecular Therapy, Issue (in preparation), 2024, ISSN 1525-0024
Publisher: Cell Press

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Author(s): Miguel M. Lino, Susana Simões, Andreia Vilaça, Helena Antunes, Alessandra Zonari, Lino Ferreira
Published in: ACS Nano, Issue 12/6, 2018, Page(s) 5207-5220, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b07538

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy

Author(s): Silva J, da Costa Martins PA.
Published in: Cells, Issue May 31;11(11):1805, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11111805

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac 2 endothelial cells

Author(s): L. Ottaviani, R. P. Juni, R. C. de Abreu, M. Sansonetti, V. Sampaio-Pinto, J. Halkein, J. C. Hegenbarth, N. Ring, K. Knoops, J. M. M. Kocken, C. Jesus, A. C, Ernault, H. el Azzouzi, F. Rühle, S, Olieslagers, H. Fernandes, L. Ferreira, L. Braga, M. Stoll, D. S. Nascimento, L. J. de Windt, P. A. da Costa Martins
Published in: Molecular Therapy, Issue 30/6, 2022, Page(s) 2257-2273, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.03.002

Light-triggerable formulations for the intracellular controlled release of biomolecules

Author(s): Miguel M. Lino, Lino Ferreira
Published in: Drug Discovery Today, Issue 23/5, 2018, Page(s) 1062-1070, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.019

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Author(s): Lígia Fão, Sandra I. Mota, A. Cristina Rego
Published in: Ageing Research Reviews, Issue 54, 2019, Page(s) 100942, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

Author(s): Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI.
Published in: Developmental Cell, 2024, ISSN 1878-1551
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.04.020

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Author(s): Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez-Balsa, Helena Antunes, Sandra Pinto, Susana Simões, Akhilesh Rai, Lino Ferreira
Published in: Nanoscale, Issue 12/18, 2020, Page(s) 9935-9942, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr10503d

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Author(s): Tengfei Wan, Emma J. Weir, Mary Johnson, Viktor I. Korolchuk, Gabriele C. Saretzki
Published in: Progress in Neurobiology, 2020, Page(s) 101953, ISSN 0301-0082
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101953

The extracellular matrix of senescent cells induces a senescence program in non-senescent cells by the TGF-β pathway

Author(s): Rita Sá Ferreira, Patricia Pitrez, Helena Aires, Alessandro Ori, Lino Ferreira
Published in: Molecular Therapy, Issue (in preparation), 2024, ISSN 1525-0024
Publisher: Cell Press

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Author(s): Tania Martins-Marques, Derek J. Hausenloy, Joost P.G. Sluijter, Luc Leybaert, Henrique Girao
Published in: Trends in Molecular Medicine, 2020, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2020.10.002

Cellular reprogramming as a tool to model human aging in a dish

Author(s): Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46004-5

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Author(s): João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
Published in: Journal of the Neurological Sciences, Issue 385, 2018, Page(s) 119-125, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2017.12.028

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

Author(s): Clara Correia-Melo, Jodie Birch, Edward Fielder, Dina Rahmatika, Jennifer Taylor, James Chapman, Anthony Lagnado, Bernadette M. Carroll, Satomi Miwa, Gavin Richardson, Diana Jurk, Fiona Oakley, Jelena Mann, Derek A. Mann, Viktor I. Korolchuk, João F. Passos
Published in: Aging Cell, Issue 18/1, 2019, Page(s) e12882, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12882

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Author(s): S. Rosa, C. Praça, P. R. Pitrez, P. José Gouveia, X. L. Aranguren, L. Ricotti, L. Silva Ferreira
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-40417-9

Engineering extracellular vesicles to permeabilize the blood-brain barrier

Author(s): Tomatis, F, Rosa, S, Simões, S, Barão, M, Barth, E, Marz, M, Ferreira, L.
Published in: Journal of Nanobiotechnology, Issue (under revision), 2024, ISSN 1477-3155
Publisher: BioMed Central

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Author(s): Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Published in: The EMBO Journal, 2024, ISSN 1460-2075
Publisher: EMBO PRESS
DOI: 10.1038/s44318-024-00177-3

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Author(s): C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio
Published in: Cells, Issue 9/5, 2020, Page(s) 1217, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9051217

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Author(s): Vitor Francisco, Miguel Lino, Lino Ferreira
Published in: Journal of Nanobiotechnology, Issue 17/1, 2019, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-019-0530-y

Redox signalling in physiology, ageing and disease

Author(s): Viktor I. Korolchuk, Katarzyna Goljanek-Whysall
Published in: Biogerontology, Issue 21/4, 2020, Page(s) 411-414, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09885-9

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

Author(s): Huaize Liu, Jie Ding, Karl Köhnlein, Nadine Urban, Alessandro Ori, Pablo Villavicencio-Lorini, Peter Walentek, Lars-Oliver Klotz, Thomas Hollemann, Thorsten Pfirrmann
Published in: Autophagy, Issue 16/9, 2020, Page(s) 1618-1634, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2019.1695399

Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing

Author(s): Simoes, S, Lino, M, Barrera, A, Rebelo, C, Tomatis, F, Vilaça, A, Breunig, C, Neuner, A, Peça, J, Gonzalez, R, Carvalho, A, Stricker, S, Ferreira, L.
Published in: Angewandte Chemie, 2024, ISSN 1521-3773
Publisher: wiley
DOI: 10.1002/anie.202401004

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Author(s): Ricardo Cerqueira de Abreu, Hugo Fernandes, Paula A. da Costa Martins, Susmita Sahoo, Costanza Emanueli, Lino Ferreira
Published in: Nature Reviews Cardiology, Issue 17/11, 2020, Page(s) 685-697, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-020-0389-5

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

Author(s): Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, João F. Passos, Gavin D. Richardson
Published in: npj Aging, 2023, ISSN 2731-6068
Publisher: Springer Nature
DOI: 10.1038/s41514-023-00113-5

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease

Author(s): Daniela Marinho, Ildete Luísa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Published in: Aging Cell, 2023, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13895

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Author(s): Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori
Published in: Cell Reports, Issue 31/4, 2020, Page(s) 107565, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107565

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Author(s): Raquel Figuinha Videira, Paula A. da Costa Martins, Inês Falcão-Pires
Published in: International Journal of Molecular Sciences, Issue 21/23, 2020, Page(s) 9285, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239285

Histone deacetylase inhibitors rescue senescence markers in human fibroblasts after prolonged exposure to amyloid-beta oligomers

Author(s): Marinho D, Ferreira IL, Kelly G, Lovat P, Korolchuk V, Rego AC
Published in: Aging Celll, Issue (in preparation), 2024, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Author(s): João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Published in: Aging Cell, Issue 23, 2024, Page(s) e14270, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Author(s): Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira
Published in: Stem Cell Reports, Issue 13/4, 2019, Page(s) 599-611, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.08.002

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

Author(s): Gavin David Richardson, Andrew Sage, Karim Bennaceur, Nayef Al Zhrany, Jose Coelho-Lima, Emily Dookun, Lilia Draganova, Gabriele Saretzki, David T. Breault, Ziad Mallat, Ioakim Spyridopoulos
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 38/6, 2018, Page(s) 1283-1296, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.309940

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

Author(s): Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao
Published in: Life Science Alliance, Issue 3/12, 2020, Page(s) e202000821, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202000821

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Author(s): Deolinda Santinha; Andreia Vilaça; Luís Estronca; Svenja C. Schüler; Catherine Bartoli; Annachiara De Sandre-Giovannoli; Arnaldo Figueiredo; Maximillian Quaas; Tilo Pompe; Alessandro Ori; Lino Ferreira
Published in: Molecular & Cellular Proteomics, Issue Vol. 23, Issue 1, 2024, Page(s) 100706, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100706

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Author(s): Luísa Cortes, João Malva, Ana Cristina Rego, Cláudia F. Pereira
Published in: International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 1125, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21031125

Myocardial cell-to-cell communication via microRNAs

Author(s): Lara Ottaviani, Marida Sansonetti, Paula A. da Costa Martins
Published in: Non-coding RNA Research, Issue 3/3, 2018, Page(s) 144-153, ISSN 2468-0540
Publisher: KeAi Publishing Communications Ltd
DOI: 10.1016/j.ncrna.2018.05.004

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Author(s): Emanuel Barth, Akash Srivastava, Milan Stojiljkovic, Christiane Frahm, Hubertus Axer, Otto W. Witte, Manja Marz
Published in: Aging, Issue 11/19, 2019, Page(s) 8556-8572, ISSN 1945-4589
Publisher: Impact Journals, LLC
DOI: 10.18632/aging.102345

Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains

Author(s): Frieder Simon, Kaya Bork, Vinayaga S. Gnanapragassam, Tim Baldensperger, Marcus A. Glomb, Simone Di Sanzo, Alessandro Ori, Rüdiger Horstkorte
Published in: International Journal of Molecular Sciences, Issue 20/24, 2019, Page(s) 6118, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246118

A nanoformulation for the preferential accumulation in adult neurogenic niches

Author(s): Catarina Praça, Akhilesh Rai, Tiago Santos, Ana C. Cristovão, Sonia L. Pinho, Romeo Cecchelli, Marie-Pierre Dehouck, Liliana Bernardino, Lino S. Ferreira
Published in: Journal of Controlled Release, Issue 284, 2018, Page(s) 57-72, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.06.013

Stem cell aging: The upcoming era of proteins and metabolites

Author(s): Svenja C. Schüler, Nadja Gebert, Alessandro Ori
Published in: Mechanisms of Ageing and Development, Issue 190, 2020, Page(s) 111288, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111288

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Author(s): Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65115-9

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