RESEarch for healThy AGEING

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Repository of RESETageing complementary advanced PhD courses

A repository of complementary RESETageing PhD advanced courses derived from existing programs UC UNEW UM will be prepared

Project flyer/poster and webinar communication system

A flyerposter of the RESETageing project will be elaborated for public dissemination and a webinar communication system within the consortium will be implemented

Report of RESETageing in strengthening research management and administration

A report with the specific activities developed during the project regarding the strengthening research management and administration of the staff of the coordinating institution will be created.

Report about the workshop in innovation and Business Ignition program

It will be elaborated a report about the workshop that RESETageing project will organize regarding Innovation in Ageing and about the Business Ignition program in Ageing that will be launched.

Report in advanced PhD courses

At the end of RESEtageing project a report regarding the advanced PhD courses will be delivered.

Participation in the 10th annual alliance for healthy ageing conference

A report about the participation of the RESETageing consortium in the Annual Alliance for Healthy Ageing Conference will be elaborated.

Report of RESETageing early stage researcher's involvement in the coordinating institution

A report of the involvement of early stage researchers in the coordination institution will be created.

Submission of Go to Market plans to the Business Ignition Program

It is expected that at least 1 Go to Market Plan will be submitted to the Business Ignition Program (see WP5) based in technologies that have been developed in a multi-institutional context.

Kick off meeting

Representatives of the four partners of the RESETageing consortium UC UNEM LIA and UM will gather to discuss all the details regarding the implementation of the RESETageing project such as the action plan the role of each partner the deliverables for the coming months the forthcoming meetings among other topics

RESETageing meeting conferences book

A book with all the RESETageing meeting conferences will be elaborated at the end of RESETageing project.

Repository of scientific achievements - result of three years of RESETageing project

At the end of the project it will be created a repository of the scientific achievements of the three years of RESETageing project of all partners of the consortium

Submission of a Marie Curie ITN and of Marie Curie European fellowship applications

A report with the submissions of a Marie Curie ITN and Marie Curie European fellowships applications will be delivered.

Repository of scientific achievements - last three years before project starts

It will be created a repository of the scientific achievements within the scope of the project of all partners of the consortium UC UNEW LIA and UM in the three years before the initiation of the RESETageing project

Data management plan

A Data Management Plan with the description for the life cycle for the data to be collected processed andor generated by the RESETageing project will be elaborated and will be deposited in a research data repository

Web site

A dedicated web site for the RESETageing project will be launched where information regarding the project will be disseminated

Publikacje

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Autorzy: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Opublikowane w: BMC Biology, Numer 16/1, 2018, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-018-0547-y

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Autorzy: Vitor Francisco, Catarina Rebelo, Artur Filipe Rodrigues, Josephine Blersch, Hugo Fernandes, Lino Ferreira
Opublikowane w: Methods, 2020, ISSN 1046-2023
Wydawca: Academic Press
DOI: 10.1016/j.ymeth.2020.12.002

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Autorzy: Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual
Opublikowane w: The EMBO Journal, Numer 38/5, 2019, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.2018100492

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Autorzy: Andrea Raso, Ellen Dirkx, Leonne E. Philippen, Amaya Fernandez-Celis, Federica De Majo, Vasco Sampaio-Pinto, Marida Sansonetti, Rio Juni, Hamid el Azzouzi, Martina Calore, Nicole Bitsch, Servé Olieslagers, Martinus I.F.J. Oerlemans, Manon M. Huibers, Roel A. de Weger, Yolan J. Reckman, Yigal M. Pinto, Lorena Zentilin, Serena Zacchigna, Mauro Giacca, Paula A. da Costa Martins, Natalia López-Andr
Opublikowane w: Molecular Therapy, Numer 27/3, 2019, Strona(/y) 584-599, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.011

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Autorzy: Anna Walaszczyk, Emily Dookun, Rachael Redgrave, Simon Tual‐Chalot, Stella Victorelli, Ioakim Spyridopoulos, Andrew Owens, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Opublikowane w: Aging Cell, Numer 18/3, 2019, Strona(/y) e12945, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.12945

The crosstalk of NAD, ROS and autophagy in cellular health and ageing

Autorzy: Lucia Sedlackova, Viktor I. Korolchuk
Opublikowane w: Biogerontology, Numer 21/3, 2020, Strona(/y) 381-397, ISSN 1389-5729
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09864-0

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Autorzy: Tianhong Su, Doug Turnbull, Laura Greaves
Opublikowane w: Genes, Numer 9/4, 2018, Strona(/y) 182, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9040182

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Autorzy: Zhiyang Chen, Elias Moris Amro, Friedrich Becker, Martin Hölzer, Seyed Mohammad Mahdi Rasa, Sospeter Ngoci Njeru, Bing Han, Simone Di Sanzo, Yulin Chen, Duozhuang Tang, Si Tao, Ronny Haenold, Marco Groth, Vasily S. Romanov, Joanna M. Kirkpatrick, Johann M. Kraus, Hans A. Kestler, Manja Marz, Alessandro Ori, Francesco Neri, Yohei Morita, K. Lenhard Rudolph
Opublikowane w: Journal of Experimental Medicine, Numer 216/1, 2019, Strona(/y) 152-175, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20181505

Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells

Autorzy: Andreia Vilaça Carlos Jesus Miguel Lino Danika Hayman Costanza Emanueli Cesare M. Terracciano Hugo Fernandes Leon J. de Windt Lino Ferreira Show less Show footnotes
Opublikowane w: Molecular Therapy - Nucleic Acids, 2024, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102233

Stem cells as vehicles and targets of nanoparticles

Autorzy: Sonia Pinho, Maria H. Macedo, Catarina Rebelo, Bruno Sarmento, Lino Ferreira
Opublikowane w: Drug Discovery Today, Numer 23/5, 2018, Strona(/y) 1071-1078, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.030

A nanomedicine-based therapeutic strategy to fight senescence

Autorzy: Aires H, Sofia, Domingues N, Raimundo N, Francisco V, Pitrez PR, Ferreira L.
Opublikowane w: Journal of Nanobiotechnology, Numer (in preparation), 2024, ISSN 1477-3155
Wydawca: BioMed Central

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Autorzy: Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho & Lino Ferreira
Opublikowane w: Nature Communications, Numer 13, 4135, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-31791-6

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Autorzy: João Sargento-Freitas, Anabela Pereira, André Gomes, Paula Amorim, Teresa Matos, Carla M. P. Cardoso, Fernando Silva, Gustavo Cordeiro Santo, César Nunes, Orlando Galego, José Carda, João Branco, Víctor Lourenço, Luís Cunha, Lino Ferreira
Opublikowane w: Frontiers in Neurology, Numer 9, 2018, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00302

Integrated multi-omics analysis of the cellular and molecular cardiac senescent phenotype in Progeria and its partial reversion by lonafarnib

Autorzy: Monteiro LM, Pitrez PR*, Santos SC, Dark N, Santinha D, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Soares CS, Ribeiro R, Logarinho E, Ori A, Smith JC, Bernardo A*, Ferreira L*
Opublikowane w: Nature Cardiovascular Research, Numer (in preparation), 2024, ISSN 2731-0590
Wydawca: Springer Nature Limited

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Autorzy: Helena Henriques-Antunes, Renato M. S. Cardoso, Alessandra Zonari, Joana Correia, Ermelindo C. Leal, Adrián Jiménez-Balsa, Miguel M. Lino, Ana Barradas, Ivana Kostic, Célia Gomes, Jeffrey M. Karp, Eugénia Carvalho, Lino Ferreira
Opublikowane w: ACS Nano, Numer 13/8, 2019, Strona(/y) 8694-8707, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.9b00376

Circulating blood cells and extracellular vesicles in acute cardioprotection

Autorzy: Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Opublikowane w: Cardiovascular Research, Numer 115/7, 2018, Strona(/y) 1156-1166, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy314

MicroRNA-216a is essential for cardiac angiogenesis

Autorzy: Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins
Opublikowane w: Molecular Therapy, Numer 31, 2023, Strona(/y) 1807-1828, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2023.04.007

Exogenous loading of miRNAs into small extracellular vesicles

Autorzy: Ricardo Abreu, Cristiana V Ramos, Clarissa Becher, Miguel Lino, Carlos Jesus, Pauça da Costa Martins, Patrícia A T, Martins, Maria João Moreno, Hugo Fernandes, Lino Ferreira
Opublikowane w: Journal of Extracellular Vesicles, Numer 10/10, 2021, Strona(/y) e12111, ISSN 2001-3078
Wydawca: WILEY
DOI: 10.1002/jev2.12111

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Autorzy: Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Opublikowane w: Neurobiology of Aging, Numer 92, 2020, Strona(/y) 98-113, ISSN 0197-4580
Wydawca: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Nutrient sensing, growth and senescence

Autorzy: Bernadette Carroll, Viktor I. Korolchuk
Opublikowane w: The FEBS Journal, Numer 285/11, 2018, Strona(/y) 1948-1958, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.14400

Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential

Autorzy: Rachel Oldershaw, W. Andrew Owens, Rachel Sutherland, Martin Linney, Rachel Liddle, Lissette Magana, Gendie E. Lash, Jason H. Gill, Gavin Richardson, Annette Meeson
Opublikowane w: Stem Cells and Development, Numer 28/9, 2019, Strona(/y) 593-607, ISSN 1547-3287
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2018.0170

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Autorzy: Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Opublikowane w: Molecular Systems Biology, Numer 16/6, 2020, ISSN 1744-4292
Wydawca: Nature Publishing Group
DOI: 10.15252/msb.20209596

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Autorzy: Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-68566-2

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Autorzy: Despoina Kesidou, Paula A. da Costa Martins, Leon J. de Windt, Mairi Brittan, Abdelaziz Beqqali, Andrew Howard Baker
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Autorzy: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, Helena Antunes, Carlo Gonzato, Sandra Pinto, Susana Simões, Klaus Liedl, Karsten Haupt, Lino Ferreira
Opublikowane w: Angewandte Chemie International Edition, Numer 59/5, 2020, Strona(/y) 1985-1991, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911398

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Autorzy: Akash Srivastava, Emanuel Barth, Maria A. Ermolaeva, Madlen Guenther, Christiane Frahm, Manja Marz, Otto W. Witte
Opublikowane w: Genomics, Proteomics & Bioinformatics, 2020, ISSN 1672-0229
Wydawca: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2020.12.001

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Autorzy: Emily Dookun, Anna Walaszczyk, Rachael Redgrave, Pawel Palmowski, Simon Tual‐Chalot, Averina Suwana, James Chapman, Eduard Jirkovsky, Leticia Donastorg Sosa, Eleanor Gill, Oliver E Yausep, Yohan Santin, Jeanne Mialet‐Perez, W Andrew Owens, David Grieve, Ioakim Spyridopoulos, Michael Taggart, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Opublikowane w: Aging Cell, Numer 19/10, 2020, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13249

Pharmacological clearance of senescent cells with Navitoclax reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis

Autorzy: "Silva ED*, Tomé I*, Vasques-Nóvoa F, Conceição G, Silva A, Barros A, Gonçalves A, Caetano C, Sousa D, Silva D, Nádia, Pinto VP, Alexandre, Moreira AL, Pires IF, Pitrez P, Pinto-do-Ó P, Santos SG, Ferreira L#, Nascimento DS#"
Opublikowane w: Cardiovascular Research, Numer (under revision), 2024, ISSN 1755-3245
Wydawca: Oxford University Press

Non-coding RNAs in Cardiac Intercellular Communication

Autorzy: Raquel Figuinha Videira, Paula A. da Costa Martins
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00738

Cx43 modulates the sorting of miRNA intro extracellular vesicles

Autorzy: T Martins-Marques, MC Costa, S Catarino, I Simoes, T Aasen, FJ Enguita, H Girão
Opublikowane w: EMBO Reports, Numer May 20, 2022, Strona(/y) e54312, ISSN 1469-3178
Wydawca: EMBO press
DOI: 10.15252/embr.202154312

The pROS of Autophagy in Neuronal Health

Autorzy: Lucia Sedlackova, George Kelly, Viktor I. Korolchuk
Opublikowane w: Journal of Molecular Biology, Numer 432/8, 2020, Strona(/y) 2546-2559, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2020.01.020

The mTORC1-autophagy pathway is a target for senescent cell elimination

Autorzy: Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I. Korolchuk, Bernadette Carroll
Opublikowane w: Biogerontology, Numer 20/3, 2019, Strona(/y) 331-335, ISSN 1389-5729
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09802-9

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autorzy: Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17901-2

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Autorzy: Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Opublikowane w: Nanoscale, Numer 11/28, 2019, Strona(/y) 13243-13248, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9nr02512j

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Autorzy: H Fernandes, A Zonnari, R Abreu, S Aday, M Barão, I Albino, M Lino, A Branco,C Seabra, T Barata, E Leal, G Tralhão, L Gonçalves, A Jon, H Peters, M Vries, PC Martins, P Quax, L Ferreira
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 28, 2022, Strona(/y) P307-327, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.03.018

Targeted anti-senescence formulations

Autorzy: Rita Ferreira, Patricia Pitrez, Joana Padrão, Carolina Guímaro, Marta Barão, Emanuel Barth, Manja Marz, Lino Ferreira
Opublikowane w: Molecular Therapy, Numer (in preparation), 2024, ISSN 1525-0024
Wydawca: Cell Press

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Autorzy: Miguel M. Lino, Susana Simões, Andreia Vilaça, Helena Antunes, Alessandra Zonari, Lino Ferreira
Opublikowane w: ACS Nano, Numer 12/6, 2018, Strona(/y) 5207-5220, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.7b07538

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy

Autorzy: Silva J, da Costa Martins PA.
Opublikowane w: Cells, Numer May 31;11(11):1805, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11111805

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac 2 endothelial cells

Autorzy: L. Ottaviani, R. P. Juni, R. C. de Abreu, M. Sansonetti, V. Sampaio-Pinto, J. Halkein, J. C. Hegenbarth, N. Ring, K. Knoops, J. M. M. Kocken, C. Jesus, A. C, Ernault, H. el Azzouzi, F. Rühle, S, Olieslagers, H. Fernandes, L. Ferreira, L. Braga, M. Stoll, D. S. Nascimento, L. J. de Windt, P. A. da Costa Martins
Opublikowane w: Molecular Therapy, Numer 30/6, 2022, Strona(/y) 2257-2273, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.03.002

Light-triggerable formulations for the intracellular controlled release of biomolecules

Autorzy: Miguel M. Lino, Lino Ferreira
Opublikowane w: Drug Discovery Today, Numer 23/5, 2018, Strona(/y) 1062-1070, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.019

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Autorzy: Lígia Fão, Sandra I. Mota, A. Cristina Rego
Opublikowane w: Ageing Research Reviews, Numer 54, 2019, Strona(/y) 100942, ISSN 1568-1637
Wydawca: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

Autorzy: Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI.
Opublikowane w: Developmental Cell, 2024, ISSN 1878-1551
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2024.04.020

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Autorzy: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez-Balsa, Helena Antunes, Sandra Pinto, Susana Simões, Akhilesh Rai, Lino Ferreira
Opublikowane w: Nanoscale, Numer 12/18, 2020, Strona(/y) 9935-9942, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9nr10503d

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Autorzy: Tengfei Wan, Emma J. Weir, Mary Johnson, Viktor I. Korolchuk, Gabriele C. Saretzki
Opublikowane w: Progress in Neurobiology, 2020, Strona(/y) 101953, ISSN 0301-0082
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101953

The extracellular matrix of senescent cells induces a senescence program in non-senescent cells by the TGF-β pathway

Autorzy: Rita Sá Ferreira, Patricia Pitrez, Helena Aires, Alessandro Ori, Lino Ferreira
Opublikowane w: Molecular Therapy, Numer (in preparation), 2024, ISSN 1525-0024
Wydawca: Cell Press

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Autorzy: Tania Martins-Marques, Derek J. Hausenloy, Joost P.G. Sluijter, Luc Leybaert, Henrique Girao
Opublikowane w: Trends in Molecular Medicine, 2020, ISSN 1471-4914
Wydawca: Elsevier BV
DOI: 10.1016/j.molmed.2020.10.002

Cellular reprogramming as a tool to model human aging in a dish

Autorzy: Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-46004-5

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Autorzy: João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
Opublikowane w: Journal of the Neurological Sciences, Numer 385, 2018, Strona(/y) 119-125, ISSN 0022-510X
Wydawca: Elsevier BV
DOI: 10.1016/j.jns.2017.12.028

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

Autorzy: Clara Correia-Melo, Jodie Birch, Edward Fielder, Dina Rahmatika, Jennifer Taylor, James Chapman, Anthony Lagnado, Bernadette M. Carroll, Satomi Miwa, Gavin Richardson, Diana Jurk, Fiona Oakley, Jelena Mann, Derek A. Mann, Viktor I. Korolchuk, João F. Passos
Opublikowane w: Aging Cell, Numer 18/1, 2019, Strona(/y) e12882, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.12882

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Autorzy: S. Rosa, C. Praça, P. R. Pitrez, P. José Gouveia, X. L. Aranguren, L. Ricotti, L. Silva Ferreira
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-40417-9

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