RESEarch for healThy AGEING

Rezultaty

Repository of RESETageing complementary advanced PhD courses

A repository of complementary RESETageing PhD advanced courses derived from existing programs UC UNEW UM will be prepared

Project flyer/poster and webinar communication system

A flyerposter of the RESETageing project will be elaborated for public dissemination and a webinar communication system within the consortium will be implemented

Kick off meeting

Representatives of the four partners of the RESETageing consortium UC UNEM LIA and UM will gather to discuss all the details regarding the implementation of the RESETageing project such as the action plan the role of each partner the deliverables for the coming months the forthcoming meetings among other topics

Repository of scientific achievements - last three years before project starts

It will be created a repository of the scientific achievements within the scope of the project of all partners of the consortium UC UNEW LIA and UM in the three years before the initiation of the RESETageing project

Data management plan

A Data Management Plan with the description for the life cycle for the data to be collected processed andor generated by the RESETageing project will be elaborated and will be deposited in a research data repository

Web site

A dedicated web site for the RESETageing project will be launched where information regarding the project will be disseminated

Publikacje

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Autorzy: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Opublikowane w: BMC Biology, Numer 16/1, 2018, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-018-0547-y

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Autorzy: Vitor Francisco, Catarina Rebelo, Artur Filipe Rodrigues, Josephine Blersch, Hugo Fernandes, Lino Ferreira
Opublikowane w: Methods, 2020, ISSN 1046-2023
Wydawca: Academic Press
DOI: 10.1016/j.ymeth.2020.12.002

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Autorzy: Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual
Opublikowane w: The EMBO Journal, Numer 38/5, 2019, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.2018100492

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Autorzy: Andrea Raso, Ellen Dirkx, Leonne E. Philippen, Amaya Fernandez-Celis, Federica De Majo, Vasco Sampaio-Pinto, Marida Sansonetti, Rio Juni, Hamid el Azzouzi, Martina Calore, Nicole Bitsch, Servé Olieslagers, Martinus I.F.J. Oerlemans, Manon M. Huibers, Roel A. de Weger, Yolan J. Reckman, Yigal M. Pinto, Lorena Zentilin, Serena Zacchigna, Mauro Giacca, Paula A. da Costa Martins, Natalia López-Andr
Opublikowane w: Molecular Therapy, Numer 27/3, 2019, Strona(/y) 584-599, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.011

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Autorzy: Anna Walaszczyk, Emily Dookun, Rachael Redgrave, Simon Tual‐Chalot, Stella Victorelli, Ioakim Spyridopoulos, Andrew Owens, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Opublikowane w: Aging Cell, Numer 18/3, 2019, Strona(/y) e12945, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.12945

The crosstalk of NAD, ROS and autophagy in cellular health and ageing

Autorzy: Lucia Sedlackova, Viktor I. Korolchuk
Opublikowane w: Biogerontology, Numer 21/3, 2020, Strona(/y) 381-397, ISSN 1389-5729
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09864-0

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Autorzy: Tianhong Su, Doug Turnbull, Laura Greaves
Opublikowane w: Genes, Numer 9/4, 2018, Strona(/y) 182, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9040182

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Autorzy: Zhiyang Chen, Elias Moris Amro, Friedrich Becker, Martin Hölzer, Seyed Mohammad Mahdi Rasa, Sospeter Ngoci Njeru, Bing Han, Simone Di Sanzo, Yulin Chen, Duozhuang Tang, Si Tao, Ronny Haenold, Marco Groth, Vasily S. Romanov, Joanna M. Kirkpatrick, Johann M. Kraus, Hans A. Kestler, Manja Marz, Alessandro Ori, Francesco Neri, Yohei Morita, K. Lenhard Rudolph
Opublikowane w: Journal of Experimental Medicine, Numer 216/1, 2019, Strona(/y) 152-175, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20181505

Stem cells as vehicles and targets of nanoparticles

Autorzy: Sonia Pinho, Maria H. Macedo, Catarina Rebelo, Bruno Sarmento, Lino Ferreira
Opublikowane w: Drug Discovery Today, Numer 23/5, 2018, Strona(/y) 1071-1078, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.030

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Autorzy: Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho & Lino Ferreira
Opublikowane w: Nature Communications, Numer 20411723, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-31791-6

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Autorzy: João Sargento-Freitas, Anabela Pereira, André Gomes, Paula Amorim, Teresa Matos, Carla M. P. Cardoso, Fernando Silva, Gustavo Cordeiro Santo, César Nunes, Orlando Galego, José Carda, João Branco, Víctor Lourenço, Luís Cunha, Lino Ferreira
Opublikowane w: Frontiers in Neurology, Numer 9, 2018, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00302

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Autorzy: Helena Henriques-Antunes, Renato M. S. Cardoso, Alessandra Zonari, Joana Correia, Ermelindo C. Leal, Adrián Jiménez-Balsa, Miguel M. Lino, Ana Barradas, Ivana Kostic, Célia Gomes, Jeffrey M. Karp, Eugénia Carvalho, Lino Ferreira
Opublikowane w: ACS Nano, Numer 13/8, 2019, Strona(/y) 8694-8707, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.9b00376

Circulating blood cells and extracellular vesicles in acute cardioprotection

Autorzy: Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Opublikowane w: Cardiovascular Research, Numer 115/7, 2018, Strona(/y) 1156-1166, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy314

Exogenous loading of miRNAs into small extracellular vesicles

Autorzy: Ricardo Abreu, Cristiana V Ramos, Clarissa Becher, Miguel Lino, Carlos Jesus, Pauça da Costa Martins, Patrícia A T, Martins, Maria João Moreno, Hugo Fernandes, Lino Ferreira
Opublikowane w: Journal of Extracellular Vesicles, Numer 10/10, 2021, Strona(/y) e12111, ISSN 2001-3078
Wydawca: WILEY
DOI: 10.1002/jev2.12111

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Autorzy: Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Opublikowane w: Neurobiology of Aging, Numer 92, 2020, Strona(/y) 98-113, ISSN 0197-4580
Wydawca: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Nutrient sensing, growth and senescence

Autorzy: Bernadette Carroll, Viktor I. Korolchuk
Opublikowane w: The FEBS Journal, Numer 285/11, 2018, Strona(/y) 1948-1958, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.14400

Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential

Autorzy: Rachel Oldershaw, W. Andrew Owens, Rachel Sutherland, Martin Linney, Rachel Liddle, Lissette Magana, Gendie E. Lash, Jason H. Gill, Gavin Richardson, Annette Meeson
Opublikowane w: Stem Cells and Development, Numer 28/9, 2019, Strona(/y) 593-607, ISSN 1547-3287
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2018.0170

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Autorzy: Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Opublikowane w: Molecular Systems Biology, Numer 16/6, 2020, ISSN 1744-4292
Wydawca: Nature Publishing Group
DOI: 10.15252/msb.20209596

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Autorzy: Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-68566-2

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Autorzy: Despoina Kesidou, Paula A. da Costa Martins, Leon J. de Windt, Mairi Brittan, Abdelaziz Beqqali, Andrew Howard Baker
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Autorzy: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, Helena Antunes, Carlo Gonzato, Sandra Pinto, Susana Simões, Klaus Liedl, Karsten Haupt, Lino Ferreira
Opublikowane w: Angewandte Chemie International Edition, Numer 59/5, 2020, Strona(/y) 1985-1991, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911398

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Autorzy: Akash Srivastava, Emanuel Barth, Maria A. Ermolaeva, Madlen Guenther, Christiane Frahm, Manja Marz, Otto W. Witte
Opublikowane w: Genomics, Proteomics & Bioinformatics, 2020, ISSN 1672-0229
Wydawca: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2020.12.001

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Autorzy: Emily Dookun, Anna Walaszczyk, Rachael Redgrave, Pawel Palmowski, Simon Tual‐Chalot, Averina Suwana, James Chapman, Eduard Jirkovsky, Leticia Donastorg Sosa, Eleanor Gill, Oliver E Yausep, Yohan Santin, Jeanne Mialet‐Perez, W Andrew Owens, David Grieve, Ioakim Spyridopoulos, Michael Taggart, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Opublikowane w: Aging Cell, Numer 19/10, 2020, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13249

Non-coding RNAs in Cardiac Intercellular Communication

Autorzy: Raquel Figuinha Videira, Paula A. da Costa Martins
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00738

Cx43 modulates the sorting of miRNA intro extracellular vesicles

Autorzy: T Martins-Marques, MC Costa, S Catarino, I Simoes, T Aasen, FJ Enguita, H Girão
Opublikowane w: EMBO Reports, Numer May 20, 2022, Strona(/y) e54312, ISSN 1469-3178
Wydawca: EMBO press
DOI: 10.15252/embr.202154312

The pROS of Autophagy in Neuronal Health

Autorzy: Lucia Sedlackova, George Kelly, Viktor I. Korolchuk
Opublikowane w: Journal of Molecular Biology, Numer 432/8, 2020, Strona(/y) 2546-2559, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/j.jmb.2020.01.020

The mTORC1-autophagy pathway is a target for senescent cell elimination

Autorzy: Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I. Korolchuk, Bernadette Carroll
Opublikowane w: Biogerontology, Numer 20/3, 2019, Strona(/y) 331-335, ISSN 1389-5729
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09802-9

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autorzy: Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17901-2

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Autorzy: Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Opublikowane w: Nanoscale, Numer 11/28, 2019, Strona(/y) 13243-13248, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9nr02512j

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Autorzy: H Fernandes, A Zonnari, R Abreu, S Aday, M Barão, I Albino, M Lino, A Branco,C Seabra, T Barata, E Leal, G Tralhão, L Gonçalves, A Jon, H Peters, M Vries, PC Martins, P Quax, L Ferreira
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 28, 2022, Strona(/y) P307-327, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.03.018

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Autorzy: Miguel M. Lino, Susana Simões, Andreia Vilaça, Helena Antunes, Alessandra Zonari, Lino Ferreira
Opublikowane w: ACS Nano, Numer 12/6, 2018, Strona(/y) 5207-5220, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.7b07538

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy

Autorzy: Silva J, da Costa Martins PA.
Opublikowane w: Cells, Numer May 31;11(11):1805, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11111805

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac 2 endothelial cells

Autorzy: L. Ottaviani, R. P. Juni, R. C. de Abreu, M. Sansonetti, V. Sampaio-Pinto, J. Halkein, J. C. Hegenbarth, N. Ring, K. Knoops, J. M. M. Kocken, C. Jesus, A. C, Ernault, H. el Azzouzi, F. Rühle, S, Olieslagers, H. Fernandes, L. Ferreira, L. Braga, M. Stoll, D. S. Nascimento, L. J. de Windt, P. A. da Costa Martins
Opublikowane w: Molecular Therapy, Numer 30/6, 2022, Strona(/y) 2257-2273, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.03.002

Light-triggerable formulations for the intracellular controlled release of biomolecules

Autorzy: Miguel M. Lino, Lino Ferreira
Opublikowane w: Drug Discovery Today, Numer 23/5, 2018, Strona(/y) 1062-1070, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.019

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Autorzy: Lígia Fão, Sandra I. Mota, A. Cristina Rego
Opublikowane w: Ageing Research Reviews, Numer 54, 2019, Strona(/y) 100942, ISSN 1568-1637
Wydawca: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Autorzy: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez-Balsa, Helena Antunes, Sandra Pinto, Susana Simões, Akhilesh Rai, Lino Ferreira
Opublikowane w: Nanoscale, Numer 12/18, 2020, Strona(/y) 9935-9942, ISSN 2040-3364
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9nr10503d

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Autorzy: Tengfei Wan, Emma J. Weir, Mary Johnson, Viktor I. Korolchuk, Gabriele C. Saretzki
Opublikowane w: Progress in Neurobiology, 2020, Strona(/y) 101953, ISSN 0301-0082
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101953

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Autorzy: Tania Martins-Marques, Derek J. Hausenloy, Joost P.G. Sluijter, Luc Leybaert, Henrique Girao
Opublikowane w: Trends in Molecular Medicine, 2020, ISSN 1471-4914
Wydawca: Elsevier BV
DOI: 10.1016/j.molmed.2020.10.002

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Autorzy: João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
Opublikowane w: Journal of the Neurological Sciences, Numer 385, 2018, Strona(/y) 119-125, ISSN 0022-510X
Wydawca: Elsevier BV
DOI: 10.1016/j.jns.2017.12.028

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

Autorzy: Clara Correia-Melo, Jodie Birch, Edward Fielder, Dina Rahmatika, Jennifer Taylor, James Chapman, Anthony Lagnado, Bernadette M. Carroll, Satomi Miwa, Gavin Richardson, Diana Jurk, Fiona Oakley, Jelena Mann, Derek A. Mann, Viktor I. Korolchuk, João F. Passos
Opublikowane w: Aging Cell, Numer 18/1, 2019, Strona(/y) e12882, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.12882

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Autorzy: S. Rosa, C. Praça, P. R. Pitrez, P. José Gouveia, X. L. Aranguren, L. Ricotti, L. Silva Ferreira
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-40417-9

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Autorzy: C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio
Opublikowane w: Cells, Numer 9/5, 2020, Strona(/y) 1217, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells9051217

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Autorzy: Vitor Francisco, Miguel Lino, Lino Ferreira
Opublikowane w: Journal of Nanobiotechnology, Numer 17/1, 2019, ISSN 1477-3155
Wydawca: BioMed Central
DOI: 10.1186/s12951-019-0530-y

Redox signalling in physiology, ageing and disease

Autorzy: Viktor I. Korolchuk, Katarzyna Goljanek-Whysall
Opublikowane w: Biogerontology, Numer 21/4, 2020, Strona(/y) 411-414, ISSN 1389-5729
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09885-9

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

Autorzy: Huaize Liu, Jie Ding, Karl Köhnlein, Nadine Urban, Alessandro Ori, Pablo Villavicencio-Lorini, Peter Walentek, Lars-Oliver Klotz, Thomas Hollemann, Thorsten Pfirrmann
Opublikowane w: Autophagy, Numer 16/9, 2020, Strona(/y) 1618-1634, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2019.1695399

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Autorzy: Ricardo Cerqueira de Abreu, Hugo Fernandes, Paula A. da Costa Martins, Susmita Sahoo, Costanza Emanueli, Lino Ferreira
Opublikowane w: Nature Reviews Cardiology, Numer 17/11, 2020, Strona(/y) 685-697, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-020-0389-5

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

Autorzy: Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, João F. Passos, Gavin D. Richardson
Opublikowane w: npj Aging, 2023, ISSN 2731-6068
Wydawca: Springer Nature
DOI: 10.1038/s41514-023-00113-5

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease

Autorzy: Daniela Marinho, Ildete Luísa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Opublikowane w: Aging Cell, 2023, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13895

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autorzy: Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori
Opublikowane w: Cell Reports, Numer 31/4, 2020, Strona(/y) 107565, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107565

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Autorzy: Raquel Figuinha Videira, Paula A. da Costa Martins, Inês Falcão-Pires
Opublikowane w: International Journal of Molecular Sciences, Numer 21/23, 2020, Strona(/y) 9285, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239285

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Autorzy: Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira
Opublikowane w: Stem Cell Reports, Numer 13/4, 2019, Strona(/y) 599-611, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2019.08.002

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

Autorzy: Gavin David Richardson, Andrew Sage, Karim Bennaceur, Nayef Al Zhrany, Jose Coelho-Lima, Emily Dookun, Lilia Draganova, Gabriele Saretzki, David T. Breault, Ziad Mallat, Ioakim Spyridopoulos
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 38/6, 2018, Strona(/y) 1283-1296, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.309940

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

Autorzy: Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao
Opublikowane w: Life Science Alliance, Numer 3/12, 2020, Strona(/y) e202000821, ISSN 2575-1077
Wydawca: Life Science Alliance
DOI: 10.26508/lsa.202000821

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Autorzy: Deolinda Santinha; Andreia Vilaça; Luís Estronca; Svenja C. Schüler; Catherine Bartoli; Annachiara De Sandre-Giovannoli; Arnaldo Figueiredo; Maximillian Quaas; Tilo Pompe; Alessandro Ori; Lino Ferreira
Opublikowane w: Molecular & Cellular Proteomics, Numer Vol. 23, Numer 1, 2024, Strona(/y) 100706, ISSN 1535-9476
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
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