RESEarch for healThy AGEING

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Repository of RESETageing complementary advanced PhD courses

A repository of complementary RESETageing PhD advanced courses derived from existing programs UC UNEW UM will be prepared

Project flyer/poster and webinar communication system

A flyerposter of the RESETageing project will be elaborated for public dissemination and a webinar communication system within the consortium will be implemented

Report of RESETageing in strengthening research management and administration

A report with the specific activities developed during the project regarding the strengthening research management and administration of the staff of the coordinating institution will be created.

Report about the workshop in innovation and Business Ignition program

It will be elaborated a report about the workshop that RESETageing project will organize regarding Innovation in Ageing and about the Business Ignition program in Ageing that will be launched.

Report in advanced PhD courses

At the end of RESEtageing project a report regarding the advanced PhD courses will be delivered.

Participation in the 10th annual alliance for healthy ageing conference

A report about the participation of the RESETageing consortium in the Annual Alliance for Healthy Ageing Conference will be elaborated.

Report of RESETageing early stage researcher's involvement in the coordinating institution

A report of the involvement of early stage researchers in the coordination institution will be created.

Submission of Go to Market plans to the Business Ignition Program

It is expected that at least 1 Go to Market Plan will be submitted to the Business Ignition Program (see WP5) based in technologies that have been developed in a multi-institutional context.

Kick off meeting

Representatives of the four partners of the RESETageing consortium UC UNEM LIA and UM will gather to discuss all the details regarding the implementation of the RESETageing project such as the action plan the role of each partner the deliverables for the coming months the forthcoming meetings among other topics

RESETageing meeting conferences book

A book with all the RESETageing meeting conferences will be elaborated at the end of RESETageing project.

Repository of scientific achievements - result of three years of RESETageing project

At the end of the project it will be created a repository of the scientific achievements of the three years of RESETageing project of all partners of the consortium

Submission of a Marie Curie ITN and of Marie Curie European fellowship applications

A report with the submissions of a Marie Curie ITN and Marie Curie European fellowships applications will be delivered.

Repository of scientific achievements - last three years before project starts

It will be created a repository of the scientific achievements within the scope of the project of all partners of the consortium UC UNEW LIA and UM in the three years before the initiation of the RESETageing project

Data management plan

A Data Management Plan with the description for the life cycle for the data to be collected processed andor generated by the RESETageing project will be elaborated and will be deposited in a research data repository

Web site

A dedicated web site for the RESETageing project will be launched where information regarding the project will be disseminated

Publicaciones

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Autores: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Publicado en: BMC Biology, Edición 16/1, 2018, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-018-0547-y

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Autores: Vitor Francisco, Catarina Rebelo, Artur Filipe Rodrigues, Josephine Blersch, Hugo Fernandes, Lino Ferreira
Publicado en: Methods, 2020, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2020.12.002

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Autores: Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual
Publicado en: The EMBO Journal, Edición 38/5, 2019, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2018100492

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Autores: Andrea Raso, Ellen Dirkx, Leonne E. Philippen, Amaya Fernandez-Celis, Federica De Majo, Vasco Sampaio-Pinto, Marida Sansonetti, Rio Juni, Hamid el Azzouzi, Martina Calore, Nicole Bitsch, Servé Olieslagers, Martinus I.F.J. Oerlemans, Manon M. Huibers, Roel A. de Weger, Yolan J. Reckman, Yigal M. Pinto, Lorena Zentilin, Serena Zacchigna, Mauro Giacca, Paula A. da Costa Martins, Natalia López-Andr
Publicado en: Molecular Therapy, Edición 27/3, 2019, Página(s) 584-599, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.011

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Autores: Anna Walaszczyk, Emily Dookun, Rachael Redgrave, Simon Tual‐Chalot, Stella Victorelli, Ioakim Spyridopoulos, Andrew Owens, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Publicado en: Aging Cell, Edición 18/3, 2019, Página(s) e12945, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.12945

The crosstalk of NAD, ROS and autophagy in cellular health and ageing

Autores: Lucia Sedlackova, Viktor I. Korolchuk
Publicado en: Biogerontology, Edición 21/3, 2020, Página(s) 381-397, ISSN 1389-5729
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09864-0

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Autores: Tianhong Su, Doug Turnbull, Laura Greaves
Publicado en: Genes, Edición 9/4, 2018, Página(s) 182, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9040182

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Autores: Zhiyang Chen, Elias Moris Amro, Friedrich Becker, Martin Hölzer, Seyed Mohammad Mahdi Rasa, Sospeter Ngoci Njeru, Bing Han, Simone Di Sanzo, Yulin Chen, Duozhuang Tang, Si Tao, Ronny Haenold, Marco Groth, Vasily S. Romanov, Joanna M. Kirkpatrick, Johann M. Kraus, Hans A. Kestler, Manja Marz, Alessandro Ori, Francesco Neri, Yohei Morita, K. Lenhard Rudolph
Publicado en: Journal of Experimental Medicine, Edición 216/1, 2019, Página(s) 152-175, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20181505

Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells

Autores: Andreia Vilaça Carlos Jesus Miguel Lino Danika Hayman Costanza Emanueli Cesare M. Terracciano Hugo Fernandes Leon J. de Windt Lino Ferreira Show less Show footnotes
Publicado en: Molecular Therapy - Nucleic Acids, 2024, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102233

Stem cells as vehicles and targets of nanoparticles

Autores: Sonia Pinho, Maria H. Macedo, Catarina Rebelo, Bruno Sarmento, Lino Ferreira
Publicado en: Drug Discovery Today, Edición 23/5, 2018, Página(s) 1071-1078, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.030

A nanomedicine-based therapeutic strategy to fight senescence

Autores: Aires H, Sofia, Domingues N, Raimundo N, Francisco V, Pitrez PR, Ferreira L.
Publicado en: Journal of Nanobiotechnology, Edición (in preparation), 2024, ISSN 1477-3155
Editor: BioMed Central

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Autores: Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho & Lino Ferreira
Publicado en: Nature Communications, Edición 13, 4135, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-31791-6

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Autores: João Sargento-Freitas, Anabela Pereira, André Gomes, Paula Amorim, Teresa Matos, Carla M. P. Cardoso, Fernando Silva, Gustavo Cordeiro Santo, César Nunes, Orlando Galego, José Carda, João Branco, Víctor Lourenço, Luís Cunha, Lino Ferreira
Publicado en: Frontiers in Neurology, Edición 9, 2018, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00302

Integrated multi-omics analysis of the cellular and molecular cardiac senescent phenotype in Progeria and its partial reversion by lonafarnib

Autores: Monteiro LM, Pitrez PR*, Santos SC, Dark N, Santinha D, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Soares CS, Ribeiro R, Logarinho E, Ori A, Smith JC, Bernardo A*, Ferreira L*
Publicado en: Nature Cardiovascular Research, Edición (in preparation), 2024, ISSN 2731-0590
Editor: Springer Nature Limited

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Autores: Helena Henriques-Antunes, Renato M. S. Cardoso, Alessandra Zonari, Joana Correia, Ermelindo C. Leal, Adrián Jiménez-Balsa, Miguel M. Lino, Ana Barradas, Ivana Kostic, Célia Gomes, Jeffrey M. Karp, Eugénia Carvalho, Lino Ferreira
Publicado en: ACS Nano, Edición 13/8, 2019, Página(s) 8694-8707, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.9b00376

Circulating blood cells and extracellular vesicles in acute cardioprotection

Autores: Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Publicado en: Cardiovascular Research, Edición 115/7, 2018, Página(s) 1156-1166, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvy314

MicroRNA-216a is essential for cardiac angiogenesis

Autores: Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins
Publicado en: Molecular Therapy, Edición 31, 2023, Página(s) 1807-1828, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2023.04.007

Exogenous loading of miRNAs into small extracellular vesicles

Autores: Ricardo Abreu, Cristiana V Ramos, Clarissa Becher, Miguel Lino, Carlos Jesus, Pauça da Costa Martins, Patrícia A T, Martins, Maria João Moreno, Hugo Fernandes, Lino Ferreira
Publicado en: Journal of Extracellular Vesicles, Edición 10/10, 2021, Página(s) e12111, ISSN 2001-3078
Editor: WILEY
DOI: 10.1002/jev2.12111

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Autores: Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Publicado en: Neurobiology of Aging, Edición 92, 2020, Página(s) 98-113, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Nutrient sensing, growth and senescence

Autores: Bernadette Carroll, Viktor I. Korolchuk
Publicado en: The FEBS Journal, Edición 285/11, 2018, Página(s) 1948-1958, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.14400

Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential

Autores: Rachel Oldershaw, W. Andrew Owens, Rachel Sutherland, Martin Linney, Rachel Liddle, Lissette Magana, Gendie E. Lash, Jason H. Gill, Gavin Richardson, Annette Meeson
Publicado en: Stem Cells and Development, Edición 28/9, 2019, Página(s) 593-607, ISSN 1547-3287
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2018.0170

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Autores: Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Publicado en: Molecular Systems Biology, Edición 16/6, 2020, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20209596

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Autores: Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-68566-2

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Autores: Despoina Kesidou, Paula A. da Costa Martins, Leon J. de Windt, Mairi Brittan, Abdelaziz Beqqali, Andrew Howard Baker
Publicado en: Frontiers in Physiology, Edición 11, 2020, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Autores: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, Helena Antunes, Carlo Gonzato, Sandra Pinto, Susana Simões, Klaus Liedl, Karsten Haupt, Lino Ferreira
Publicado en: Angewandte Chemie International Edition, Edición 59/5, 2020, Página(s) 1985-1991, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911398

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Autores: Akash Srivastava, Emanuel Barth, Maria A. Ermolaeva, Madlen Guenther, Christiane Frahm, Manja Marz, Otto W. Witte
Publicado en: Genomics, Proteomics & Bioinformatics, 2020, ISSN 1672-0229
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2020.12.001

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Autores: Emily Dookun, Anna Walaszczyk, Rachael Redgrave, Pawel Palmowski, Simon Tual‐Chalot, Averina Suwana, James Chapman, Eduard Jirkovsky, Leticia Donastorg Sosa, Eleanor Gill, Oliver E Yausep, Yohan Santin, Jeanne Mialet‐Perez, W Andrew Owens, David Grieve, Ioakim Spyridopoulos, Michael Taggart, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Publicado en: Aging Cell, Edición 19/10, 2020, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13249

Pharmacological clearance of senescent cells with Navitoclax reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis

Autores: "Silva ED*, Tomé I*, Vasques-Nóvoa F, Conceição G, Silva A, Barros A, Gonçalves A, Caetano C, Sousa D, Silva D, Nádia, Pinto VP, Alexandre, Moreira AL, Pires IF, Pitrez P, Pinto-do-Ó P, Santos SG, Ferreira L#, Nascimento DS#"
Publicado en: Cardiovascular Research, Edición (under revision), 2024, ISSN 1755-3245
Editor: Oxford University Press

Non-coding RNAs in Cardiac Intercellular Communication

Autores: Raquel Figuinha Videira, Paula A. da Costa Martins
Publicado en: Frontiers in Physiology, Edición 11, 2020, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00738

Cx43 modulates the sorting of miRNA intro extracellular vesicles

Autores: T Martins-Marques, MC Costa, S Catarino, I Simoes, T Aasen, FJ Enguita, H Girão
Publicado en: EMBO Reports, Edición May 20, 2022, Página(s) e54312, ISSN 1469-3178
Editor: EMBO press
DOI: 10.15252/embr.202154312

The pROS of Autophagy in Neuronal Health

Autores: Lucia Sedlackova, George Kelly, Viktor I. Korolchuk
Publicado en: Journal of Molecular Biology, Edición 432/8, 2020, Página(s) 2546-2559, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2020.01.020

The mTORC1-autophagy pathway is a target for senescent cell elimination

Autores: Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I. Korolchuk, Bernadette Carroll
Publicado en: Biogerontology, Edición 20/3, 2019, Página(s) 331-335, ISSN 1389-5729
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09802-9

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autores: Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17901-2

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Autores: Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Publicado en: Nanoscale, Edición 11/28, 2019, Página(s) 13243-13248, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c9nr02512j

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Autores: H Fernandes, A Zonnari, R Abreu, S Aday, M Barão, I Albino, M Lino, A Branco,C Seabra, T Barata, E Leal, G Tralhão, L Gonçalves, A Jon, H Peters, M Vries, PC Martins, P Quax, L Ferreira
Publicado en: Molecular Therapy - Nucleic Acids, Edición 28, 2022, Página(s) P307-327, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.03.018

Targeted anti-senescence formulations

Autores: Rita Ferreira, Patricia Pitrez, Joana Padrão, Carolina Guímaro, Marta Barão, Emanuel Barth, Manja Marz, Lino Ferreira
Publicado en: Molecular Therapy, Edición (in preparation), 2024, ISSN 1525-0024
Editor: Cell Press

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Autores: Miguel M. Lino, Susana Simões, Andreia Vilaça, Helena Antunes, Alessandra Zonari, Lino Ferreira
Publicado en: ACS Nano, Edición 12/6, 2018, Página(s) 5207-5220, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.7b07538

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy

Autores: Silva J, da Costa Martins PA.
Publicado en: Cells, Edición May 31;11(11):1805, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11111805

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac 2 endothelial cells

Autores: L. Ottaviani, R. P. Juni, R. C. de Abreu, M. Sansonetti, V. Sampaio-Pinto, J. Halkein, J. C. Hegenbarth, N. Ring, K. Knoops, J. M. M. Kocken, C. Jesus, A. C, Ernault, H. el Azzouzi, F. Rühle, S, Olieslagers, H. Fernandes, L. Ferreira, L. Braga, M. Stoll, D. S. Nascimento, L. J. de Windt, P. A. da Costa Martins
Publicado en: Molecular Therapy, Edición 30/6, 2022, Página(s) 2257-2273, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.03.002

Light-triggerable formulations for the intracellular controlled release of biomolecules

Autores: Miguel M. Lino, Lino Ferreira
Publicado en: Drug Discovery Today, Edición 23/5, 2018, Página(s) 1062-1070, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.019

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Autores: Lígia Fão, Sandra I. Mota, A. Cristina Rego
Publicado en: Ageing Research Reviews, Edición 54, 2019, Página(s) 100942, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

Autores: Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI.
Publicado en: Developmental Cell, 2024, ISSN 1878-1551
Editor: Cell Press
DOI: 10.1016/j.devcel.2024.04.020

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Autores: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez-Balsa, Helena Antunes, Sandra Pinto, Susana Simões, Akhilesh Rai, Lino Ferreira
Publicado en: Nanoscale, Edición 12/18, 2020, Página(s) 9935-9942, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c9nr10503d

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Autores: Tengfei Wan, Emma J. Weir, Mary Johnson, Viktor I. Korolchuk, Gabriele C. Saretzki
Publicado en: Progress in Neurobiology, 2020, Página(s) 101953, ISSN 0301-0082
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101953

The extracellular matrix of senescent cells induces a senescence program in non-senescent cells by the TGF-β pathway

Autores: Rita Sá Ferreira, Patricia Pitrez, Helena Aires, Alessandro Ori, Lino Ferreira
Publicado en: Molecular Therapy, Edición (in preparation), 2024, ISSN 1525-0024
Editor: Cell Press

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Autores: Tania Martins-Marques, Derek J. Hausenloy, Joost P.G. Sluijter, Luc Leybaert, Henrique Girao
Publicado en: Trends in Molecular Medicine, 2020, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2020.10.002

Cellular reprogramming as a tool to model human aging in a dish

Autores: Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46004-5

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Autores: João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
Publicado en: Journal of the Neurological Sciences, Edición 385, 2018, Página(s) 119-125, ISSN 0022-510X
Editor: Elsevier BV
DOI: 10.1016/j.jns.2017.12.028

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

Autores: Clara Correia-Melo, Jodie Birch, Edward Fielder, Dina Rahmatika, Jennifer Taylor, James Chapman, Anthony Lagnado, Bernadette M. Carroll, Satomi Miwa, Gavin Richardson, Diana Jurk, Fiona Oakley, Jelena Mann, Derek A. Mann, Viktor I. Korolchuk, João F. Passos
Publicado en: Aging Cell, Edición 18/1, 2019, Página(s) e12882, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.12882

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Autores: S. Rosa, C. Praça, P. R. Pitrez, P. José Gouveia, X. L. Aranguren, L. Ricotti, L. Silva Ferreira
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-40417-9

Engineering extracellular vesicles to permeabilize the blood-brain barrier

Autores: Tomatis, F, Rosa, S, Simões, S, Barão, M, Barth, E, Marz, M, Ferreira, L.
Publicado en: Journal of Nanobiotechnology, Edición (under revision), 2024, ISSN 1477-3155
Editor: BioMed Central

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Autores: Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Publicado en: The EMBO Journal, 2024, ISSN 1460-2075
Editor: EMBO PRESS
DOI: 10.1038/s44318-024-00177-3

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Autores: C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio
Publicado en: Cells, Edición 9/5, 2020, Página(s) 1217, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9051217

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Autores: Vitor Francisco, Miguel Lino, Lino Ferreira
Publicado en: Journal of Nanobiotechnology, Edición 17/1, 2019, ISSN 1477-3155
Editor: BioMed Central
DOI: 10.1186/s12951-019-0530-y

Redox signalling in physiology, ageing and disease

Autores: Viktor I. Korolchuk, Katarzyna Goljanek-Whysall
Publicado en: Biogerontology, Edición 21/4, 2020, Página(s) 411-414, ISSN 1389-5729
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09885-9

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

Autores: Huaize Liu, Jie Ding, Karl Köhnlein, Nadine Urban, Alessandro Ori, Pablo Villavicencio-Lorini, Peter Walentek, Lars-Oliver Klotz, Thomas Hollemann, Thorsten Pfirrmann
Publicado en: Autophagy, Edición 16/9, 2020, Página(s) 1618-1634, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2019.1695399

Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing

Autores: Simoes, S, Lino, M, Barrera, A, Rebelo, C, Tomatis, F, Vilaça, A, Breunig, C, Neuner, A, Peça, J, Gonzalez, R, Carvalho, A, Stricker, S, Ferreira, L.
Publicado en: Angewandte Chemie, 2024, ISSN 1521-3773
Editor: wiley
DOI: 10.1002/anie.202401004

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Autores: Ricardo Cerqueira de Abreu, Hugo Fernandes, Paula A. da Costa Martins, Susmita Sahoo, Costanza Emanueli, Lino Ferreira
Publicado en: Nature Reviews Cardiology, Edición 17/11, 2020, Página(s) 685-697, ISSN 1759-5002
Editor: Nature Publishing Group
DOI: 10.1038/s41569-020-0389-5

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

Autores: Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, João F. Passos, Gavin D. Richardson
Publicado en: npj Aging, 2023, ISSN 2731-6068
Editor: Springer Nature
DOI: 10.1038/s41514-023-00113-5

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease

Autores: Daniela Marinho, Ildete Luísa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Publicado en: Aging Cell, 2023, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13895

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autores: Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori
Publicado en: Cell Reports, Edición 31/4, 2020, Página(s) 107565, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107565

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Autores: Raquel Figuinha Videira, Paula A. da Costa Martins, Inês Falcão-Pires
Publicado en: International Journal of Molecular Sciences, Edición 21/23, 2020, Página(s) 9285, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239285

Histone deacetylase inhibitors rescue senescence markers in human fibroblasts after prolonged exposure to amyloid-beta oligomers

Autores: Marinho D, Ferreira IL, Kelly G, Lovat P, Korolchuk V, Rego AC
Publicado en: Aging Celll, Edición (in preparation), 2024, ISSN 1474-9718
Editor: Blackwell Publishing Inc.

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Autores: João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Publicado en: Aging Cell, Edición 23, 2024, Página(s) e14270, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Autores: Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira
Publicado en: Stem Cell Reports, Edición 13/4, 2019, Página(s) 599-611, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.08.002

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

Autores: Gavin David Richardson, Andrew Sage, Karim Bennaceur, Nayef Al Zhrany, Jose Coelho-Lima, Emily Dookun, Lilia Draganova, Gabriele Saretzki, David T. Breault, Ziad Mallat, Ioakim Spyridopoulos
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 38/6, 2018, Página(s) 1283-1296, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.309940

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

Autores: Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao
Publicado en: Life Science Alliance, Edición 3/12, 2020, Página(s) e202000821, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202000821

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Autores: Deolinda Santinha; Andreia Vilaça; Luís Estronca; Svenja C. Schüler; Catherine Bartoli; Annachiara De Sandre-Giovannoli; Arnaldo Figueiredo; Maximillian Quaas; Tilo Pompe; Alessandro Ori; Lino Ferreira
Publicado en: Molecular & Cellular Proteomics, Edición Vol. 23, Edición 1, 2024, Página(s) 100706, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100706

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Autores: Luísa Cortes, João Malva, Ana Cristina Rego, Cláudia F. Pereira
Publicado en: International Journal of Molecular Sciences, Edición 21/3, 2020, Página(s) 1125, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21031125

Myocardial cell-to-cell communication via microRNAs

Autores: Lara Ottaviani, Marida Sansonetti, Paula A. da Costa Martins
Publicado en: Non-coding RNA Research, Edición 3/3, 2018, Página(s) 144-153, ISSN 2468-0540
Editor: KeAi Publishing Communications Ltd
DOI: 10.1016/j.ncrna.2018.05.004

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Autores: Emanuel Barth, Akash Srivastava, Milan Stojiljkovic, Christiane Frahm, Hubertus Axer, Otto W. Witte, Manja Marz
Publicado en: Aging, Edición 11/19, 2019, Página(s) 8556-8572, ISSN 1945-4589
Editor: Impact Journals, LLC
DOI: 10.18632/aging.102345

Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains

Autores: Frieder Simon, Kaya Bork, Vinayaga S. Gnanapragassam, Tim Baldensperger, Marcus A. Glomb, Simone Di Sanzo, Alessandro Ori, Rüdiger Horstkorte
Publicado en: International Journal of Molecular Sciences, Edición 20/24, 2019, Página(s) 6118, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246118

A nanoformulation for the preferential accumulation in adult neurogenic niches

Autores: Catarina Praça, Akhilesh Rai, Tiago Santos, Ana C. Cristovão, Sonia L. Pinho, Romeo Cecchelli, Marie-Pierre Dehouck, Liliana Bernardino, Lino S. Ferreira
Publicado en: Journal of Controlled Release, Edición 284, 2018, Página(s) 57-72, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2018.06.013

Stem cell aging: The upcoming era of proteins and metabolites

Autores: Svenja C. Schüler, Nadja Gebert, Alessandro Ori
Publicado en: Mechanisms of Ageing and Development, Edición 190, 2020, Página(s) 111288, ISSN 0047-6374
Editor: Elsevier BV
DOI: 10.1016/j.mad.2020.111288

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Autores: Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-65115-9

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