RESEarch for healThy AGEING

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Repository of RESETageing complementary advanced PhD courses

A repository of complementary RESETageing PhD advanced courses derived from existing programs UC UNEW UM will be prepared

Project flyer/poster and webinar communication system

A flyerposter of the RESETageing project will be elaborated for public dissemination and a webinar communication system within the consortium will be implemented

Report of RESETageing in strengthening research management and administration

A report with the specific activities developed during the project regarding the strengthening research management and administration of the staff of the coordinating institution will be created.

Report about the workshop in innovation and Business Ignition program

It will be elaborated a report about the workshop that RESETageing project will organize regarding Innovation in Ageing and about the Business Ignition program in Ageing that will be launched.

Report in advanced PhD courses

At the end of RESEtageing project a report regarding the advanced PhD courses will be delivered.

Participation in the 10th annual alliance for healthy ageing conference

A report about the participation of the RESETageing consortium in the Annual Alliance for Healthy Ageing Conference will be elaborated.

Report of RESETageing early stage researcher's involvement in the coordinating institution

A report of the involvement of early stage researchers in the coordination institution will be created.

Submission of Go to Market plans to the Business Ignition Program

It is expected that at least 1 Go to Market Plan will be submitted to the Business Ignition Program (see WP5) based in technologies that have been developed in a multi-institutional context.

Kick off meeting

Representatives of the four partners of the RESETageing consortium UC UNEM LIA and UM will gather to discuss all the details regarding the implementation of the RESETageing project such as the action plan the role of each partner the deliverables for the coming months the forthcoming meetings among other topics

RESETageing meeting conferences book

A book with all the RESETageing meeting conferences will be elaborated at the end of RESETageing project.

Repository of scientific achievements - result of three years of RESETageing project

At the end of the project it will be created a repository of the scientific achievements of the three years of RESETageing project of all partners of the consortium

Submission of a Marie Curie ITN and of Marie Curie European fellowship applications

A report with the submissions of a Marie Curie ITN and Marie Curie European fellowships applications will be delivered.

Repository of scientific achievements - last three years before project starts

It will be created a repository of the scientific achievements within the scope of the project of all partners of the consortium UC UNEW LIA and UM in the three years before the initiation of the RESETageing project

Data management plan

A Data Management Plan with the description for the life cycle for the data to be collected processed andor generated by the RESETageing project will be elaborated and will be deposited in a research data repository

Web site

A dedicated web site for the RESETageing project will be launched where information regarding the project will be disseminated

Pubblicazioni

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

Autori: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt, Alessandro Ori
Pubblicato in: BMC Biology, Numero 16/1, 2018, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-018-0547-y

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Autori: Vitor Francisco, Catarina Rebelo, Artur Filipe Rodrigues, Josephine Blersch, Hugo Fernandes, Lino Ferreira
Pubblicato in: Methods, 2020, ISSN 1046-2023
Editore: Academic Press
DOI: 10.1016/j.ymeth.2020.12.002

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Autori: Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual
Pubblicato in: The EMBO Journal, Numero 38/5, 2019, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2018100492

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Autori: Andrea Raso, Ellen Dirkx, Leonne E. Philippen, Amaya Fernandez-Celis, Federica De Majo, Vasco Sampaio-Pinto, Marida Sansonetti, Rio Juni, Hamid el Azzouzi, Martina Calore, Nicole Bitsch, Servé Olieslagers, Martinus I.F.J. Oerlemans, Manon M. Huibers, Roel A. de Weger, Yolan J. Reckman, Yigal M. Pinto, Lorena Zentilin, Serena Zacchigna, Mauro Giacca, Paula A. da Costa Martins, Natalia López-Andr
Pubblicato in: Molecular Therapy, Numero 27/3, 2019, Pagina/e 584-599, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.11.011

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Autori: Anna Walaszczyk, Emily Dookun, Rachael Redgrave, Simon Tual‐Chalot, Stella Victorelli, Ioakim Spyridopoulos, Andrew Owens, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Pubblicato in: Aging Cell, Numero 18/3, 2019, Pagina/e e12945, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.12945

The crosstalk of NAD, ROS and autophagy in cellular health and ageing

Autori: Lucia Sedlackova, Viktor I. Korolchuk
Pubblicato in: Biogerontology, Numero 21/3, 2020, Pagina/e 381-397, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09864-0

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Autori: Tianhong Su, Doug Turnbull, Laura Greaves
Pubblicato in: Genes, Numero 9/4, 2018, Pagina/e 182, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9040182

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Autori: Zhiyang Chen, Elias Moris Amro, Friedrich Becker, Martin Hölzer, Seyed Mohammad Mahdi Rasa, Sospeter Ngoci Njeru, Bing Han, Simone Di Sanzo, Yulin Chen, Duozhuang Tang, Si Tao, Ronny Haenold, Marco Groth, Vasily S. Romanov, Joanna M. Kirkpatrick, Johann M. Kraus, Hans A. Kestler, Manja Marz, Alessandro Ori, Francesco Neri, Yohei Morita, K. Lenhard Rudolph
Pubblicato in: Journal of Experimental Medicine, Numero 216/1, 2019, Pagina/e 152-175, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20181505

Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells

Autori: Andreia Vilaça Carlos Jesus Miguel Lino Danika Hayman Costanza Emanueli Cesare M. Terracciano Hugo Fernandes Leon J. de Windt Lino Ferreira Show less Show footnotes
Pubblicato in: Molecular Therapy - Nucleic Acids, 2024, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102233

Stem cells as vehicles and targets of nanoparticles

Autori: Sonia Pinho, Maria H. Macedo, Catarina Rebelo, Bruno Sarmento, Lino Ferreira
Pubblicato in: Drug Discovery Today, Numero 23/5, 2018, Pagina/e 1071-1078, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.030

A nanomedicine-based therapeutic strategy to fight senescence

Autori: Aires H, Sofia, Domingues N, Raimundo N, Francisco V, Pitrez PR, Ferreira L.
Pubblicato in: Journal of Nanobiotechnology, Numero (in preparation), 2024, ISSN 1477-3155
Editore: BioMed Central

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Autori: Catarina Rebelo, Tiago Reis, Joana Guedes, Cláudia Saraiva, Artur Filipe Rodrigues, Susana Simões, Liliana Bernardino, João Peça, Sónia L. C. Pinho & Lino Ferreira
Pubblicato in: Nature Communications, Numero 13, 4135, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31791-6

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Autori: João Sargento-Freitas, Anabela Pereira, André Gomes, Paula Amorim, Teresa Matos, Carla M. P. Cardoso, Fernando Silva, Gustavo Cordeiro Santo, César Nunes, Orlando Galego, José Carda, João Branco, Víctor Lourenço, Luís Cunha, Lino Ferreira
Pubblicato in: Frontiers in Neurology, Numero 9, 2018, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00302

Integrated multi-omics analysis of the cellular and molecular cardiac senescent phenotype in Progeria and its partial reversion by lonafarnib

Autori: Monteiro LM, Pitrez PR*, Santos SC, Dark N, Santinha D, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Soares CS, Ribeiro R, Logarinho E, Ori A, Smith JC, Bernardo A*, Ferreira L*
Pubblicato in: Nature Cardiovascular Research, Numero (in preparation), 2024, ISSN 2731-0590
Editore: Springer Nature Limited

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Autori: Helena Henriques-Antunes, Renato M. S. Cardoso, Alessandra Zonari, Joana Correia, Ermelindo C. Leal, Adrián Jiménez-Balsa, Miguel M. Lino, Ana Barradas, Ivana Kostic, Célia Gomes, Jeffrey M. Karp, Eugénia Carvalho, Lino Ferreira
Pubblicato in: ACS Nano, Numero 13/8, 2019, Pagina/e 8694-8707, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.9b00376

Circulating blood cells and extracellular vesicles in acute cardioprotection

Autori: Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Pubblicato in: Cardiovascular Research, Numero 115/7, 2018, Pagina/e 1156-1166, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy314

MicroRNA-216a is essential for cardiac angiogenesis

Autori: Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins
Pubblicato in: Molecular Therapy, Numero 31, 2023, Pagina/e 1807-1828, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2023.04.007

Exogenous loading of miRNAs into small extracellular vesicles

Autori: Ricardo Abreu, Cristiana V Ramos, Clarissa Becher, Miguel Lino, Carlos Jesus, Pauça da Costa Martins, Patrícia A T, Martins, Maria João Moreno, Hugo Fernandes, Lino Ferreira
Pubblicato in: Journal of Extracellular Vesicles, Numero 10/10, 2021, Pagina/e e12111, ISSN 2001-3078
Editore: WILEY
DOI: 10.1002/jev2.12111

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Autori: Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Pubblicato in: Neurobiology of Aging, Numero 92, 2020, Pagina/e 98-113, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Nutrient sensing, growth and senescence

Autori: Bernadette Carroll, Viktor I. Korolchuk
Pubblicato in: The FEBS Journal, Numero 285/11, 2018, Pagina/e 1948-1958, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.14400

Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential

Autori: Rachel Oldershaw, W. Andrew Owens, Rachel Sutherland, Martin Linney, Rachel Liddle, Lissette Magana, Gendie E. Lash, Jason H. Gill, Gavin Richardson, Annette Meeson
Pubblicato in: Stem Cells and Development, Numero 28/9, 2019, Pagina/e 593-607, ISSN 1547-3287
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2018.0170

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Autori: Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Pubblicato in: Molecular Systems Biology, Numero 16/6, 2020, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.20209596

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Autori: Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-68566-2

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Autori: Despoina Kesidou, Paula A. da Costa Martins, Leon J. de Windt, Mairi Brittan, Abdelaziz Beqqali, Andrew Howard Baker
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Autori: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, Helena Antunes, Carlo Gonzato, Sandra Pinto, Susana Simões, Klaus Liedl, Karsten Haupt, Lino Ferreira
Pubblicato in: Angewandte Chemie International Edition, Numero 59/5, 2020, Pagina/e 1985-1991, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911398

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

Autori: Akash Srivastava, Emanuel Barth, Maria A. Ermolaeva, Madlen Guenther, Christiane Frahm, Manja Marz, Otto W. Witte
Pubblicato in: Genomics, Proteomics & Bioinformatics, 2020, ISSN 1672-0229
Editore: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2020.12.001

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Autori: Emily Dookun, Anna Walaszczyk, Rachael Redgrave, Pawel Palmowski, Simon Tual‐Chalot, Averina Suwana, James Chapman, Eduard Jirkovsky, Leticia Donastorg Sosa, Eleanor Gill, Oliver E Yausep, Yohan Santin, Jeanne Mialet‐Perez, W Andrew Owens, David Grieve, Ioakim Spyridopoulos, Michael Taggart, Helen M. Arthur, João F. Passos, Gavin D. Richardson
Pubblicato in: Aging Cell, Numero 19/10, 2020, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13249

Pharmacological clearance of senescent cells with Navitoclax reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis

Autori: "Silva ED*, Tomé I*, Vasques-Nóvoa F, Conceição G, Silva A, Barros A, Gonçalves A, Caetano C, Sousa D, Silva D, Nádia, Pinto VP, Alexandre, Moreira AL, Pires IF, Pitrez P, Pinto-do-Ó P, Santos SG, Ferreira L#, Nascimento DS#"
Pubblicato in: Cardiovascular Research, Numero (under revision), 2024, ISSN 1755-3245
Editore: Oxford University Press

Non-coding RNAs in Cardiac Intercellular Communication

Autori: Raquel Figuinha Videira, Paula A. da Costa Martins
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00738

Cx43 modulates the sorting of miRNA intro extracellular vesicles

Autori: T Martins-Marques, MC Costa, S Catarino, I Simoes, T Aasen, FJ Enguita, H Girão
Pubblicato in: EMBO Reports, Numero May 20, 2022, Pagina/e e54312, ISSN 1469-3178
Editore: EMBO press
DOI: 10.15252/embr.202154312

The pROS of Autophagy in Neuronal Health

Autori: Lucia Sedlackova, George Kelly, Viktor I. Korolchuk
Pubblicato in: Journal of Molecular Biology, Numero 432/8, 2020, Pagina/e 2546-2559, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2020.01.020

The mTORC1-autophagy pathway is a target for senescent cell elimination

Autori: Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I. Korolchuk, Bernadette Carroll
Pubblicato in: Biogerontology, Numero 20/3, 2019, Pagina/e 331-335, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-019-09802-9

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Autori: Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17901-2

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Autori: Arnab Banerjee, Vitor Alves, Tiago Rondão, José Sereno, Ângela Neves, Miguel Lino, Andreia Ribeiro, Antero J. Abrunhosa, Lino S. Ferreira
Pubblicato in: Nanoscale, Numero 11/28, 2019, Pagina/e 13243-13248, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c9nr02512j

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Autori: H Fernandes, A Zonnari, R Abreu, S Aday, M Barão, I Albino, M Lino, A Branco,C Seabra, T Barata, E Leal, G Tralhão, L Gonçalves, A Jon, H Peters, M Vries, PC Martins, P Quax, L Ferreira
Pubblicato in: Molecular Therapy - Nucleic Acids, Numero 28, 2022, Pagina/e P307-327, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2022.03.018

Targeted anti-senescence formulations

Autori: Rita Ferreira, Patricia Pitrez, Joana Padrão, Carolina Guímaro, Marta Barão, Emanuel Barth, Manja Marz, Lino Ferreira
Pubblicato in: Molecular Therapy, Numero (in preparation), 2024, ISSN 1525-0024
Editore: Cell Press

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Autori: Miguel M. Lino, Susana Simões, Andreia Vilaça, Helena Antunes, Alessandra Zonari, Lino Ferreira
Pubblicato in: ACS Nano, Numero 12/6, 2018, Pagina/e 5207-5220, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.7b07538

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy

Autori: Silva J, da Costa Martins PA.
Pubblicato in: Cells, Numero May 31;11(11):1805, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11111805

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac 2 endothelial cells

Autori: L. Ottaviani, R. P. Juni, R. C. de Abreu, M. Sansonetti, V. Sampaio-Pinto, J. Halkein, J. C. Hegenbarth, N. Ring, K. Knoops, J. M. M. Kocken, C. Jesus, A. C, Ernault, H. el Azzouzi, F. Rühle, S, Olieslagers, H. Fernandes, L. Ferreira, L. Braga, M. Stoll, D. S. Nascimento, L. J. de Windt, P. A. da Costa Martins
Pubblicato in: Molecular Therapy, Numero 30/6, 2022, Pagina/e 2257-2273, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.03.002

Light-triggerable formulations for the intracellular controlled release of biomolecules

Autori: Miguel M. Lino, Lino Ferreira
Pubblicato in: Drug Discovery Today, Numero 23/5, 2018, Pagina/e 1062-1070, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2018.01.019

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Autori: Lígia Fão, Sandra I. Mota, A. Cristina Rego
Pubblicato in: Ageing Research Reviews, Numero 54, 2019, Pagina/e 100942, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

Autori: Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI.
Pubblicato in: Developmental Cell, 2024, ISSN 1878-1551
Editore: Cell Press
DOI: 10.1016/j.devcel.2024.04.020

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Autori: Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez-Balsa, Helena Antunes, Sandra Pinto, Susana Simões, Akhilesh Rai, Lino Ferreira
Pubblicato in: Nanoscale, Numero 12/18, 2020, Pagina/e 9935-9942, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c9nr10503d

Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy

Autori: Tengfei Wan, Emma J. Weir, Mary Johnson, Viktor I. Korolchuk, Gabriele C. Saretzki
Pubblicato in: Progress in Neurobiology, 2020, Pagina/e 101953, ISSN 0301-0082
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.pneurobio.2020.101953

The extracellular matrix of senescent cells induces a senescence program in non-senescent cells by the TGF-β pathway

Autori: Rita Sá Ferreira, Patricia Pitrez, Helena Aires, Alessandro Ori, Lino Ferreira
Pubblicato in: Molecular Therapy, Numero (in preparation), 2024, ISSN 1525-0024
Editore: Cell Press

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

Autori: Tania Martins-Marques, Derek J. Hausenloy, Joost P.G. Sluijter, Luc Leybaert, Henrique Girao
Pubblicato in: Trends in Molecular Medicine, 2020, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2020.10.002

Cellular reprogramming as a tool to model human aging in a dish

Autori: Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46004-5

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Autori: João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
Pubblicato in: Journal of the Neurological Sciences, Numero 385, 2018, Pagina/e 119-125, ISSN 0022-510X
Editore: Elsevier BV
DOI: 10.1016/j.jns.2017.12.028

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

Autori: Clara Correia-Melo, Jodie Birch, Edward Fielder, Dina Rahmatika, Jennifer Taylor, James Chapman, Anthony Lagnado, Bernadette M. Carroll, Satomi Miwa, Gavin Richardson, Diana Jurk, Fiona Oakley, Jelena Mann, Derek A. Mann, Viktor I. Korolchuk, João F. Passos
Pubblicato in: Aging Cell, Numero 18/1, 2019, Pagina/e e12882, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.12882

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Autori: S. Rosa, C. Praça, P. R. Pitrez, P. José Gouveia, X. L. Aranguren, L. Ricotti, L. Silva Ferreira
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-40417-9

Engineering extracellular vesicles to permeabilize the blood-brain barrier

Autori: Tomatis, F, Rosa, S, Simões, S, Barão, M, Barth, E, Marz, M, Ferreira, L.
Pubblicato in: Journal of Nanobiotechnology, Numero (under revision), 2024, ISSN 1477-3155
Editore: BioMed Central

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Autori: Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Pubblicato in: The EMBO Journal, 2024, ISSN 1460-2075
Editore: EMBO PRESS
DOI: 10.1038/s44318-024-00177-3

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Autori: C. Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósio
Pubblicato in: Cells, Numero 9/5, 2020, Pagina/e 1217, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9051217

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

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Pubblicato in: Journal of Nanobiotechnology, Numero 17/1, 2019, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-019-0530-y

Redox signalling in physiology, ageing and disease

Autori: Viktor I. Korolchuk, Katarzyna Goljanek-Whysall
Pubblicato in: Biogerontology, Numero 21/4, 2020, Pagina/e 411-414, ISSN 1389-5729
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10522-020-09885-9

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

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Pubblicato in: Autophagy, Numero 16/9, 2020, Pagina/e 1618-1634, ISSN 1554-8627
Editore: Landes Bioscience
DOI: 10.1080/15548627.2019.1695399

Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing

Autori: Simoes, S, Lino, M, Barrera, A, Rebelo, C, Tomatis, F, Vilaça, A, Breunig, C, Neuner, A, Peça, J, Gonzalez, R, Carvalho, A, Stricker, S, Ferreira, L.
Pubblicato in: Angewandte Chemie, 2024, ISSN 1521-3773
Editore: wiley
DOI: 10.1002/anie.202401004

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Autori: Ricardo Cerqueira de Abreu, Hugo Fernandes, Paula A. da Costa Martins, Susmita Sahoo, Costanza Emanueli, Lino Ferreira
Pubblicato in: Nature Reviews Cardiology, Numero 17/11, 2020, Pagina/e 685-697, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-020-0389-5

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

Autori: Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, João F. Passos, Gavin D. Richardson
Pubblicato in: npj Aging, 2023, ISSN 2731-6068
Editore: Springer Nature
DOI: 10.1038/s41514-023-00113-5

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease

Autori: Daniela Marinho, Ildete Luísa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Pubblicato in: Aging Cell, 2023, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13895

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autori: Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori
Pubblicato in: Cell Reports, Numero 31/4, 2020, Pagina/e 107565, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107565

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Autori: Raquel Figuinha Videira, Paula A. da Costa Martins, Inês Falcão-Pires
Pubblicato in: International Journal of Molecular Sciences, Numero 21/23, 2020, Pagina/e 9285, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239285

Histone deacetylase inhibitors rescue senescence markers in human fibroblasts after prolonged exposure to amyloid-beta oligomers

Autori: Marinho D, Ferreira IL, Kelly G, Lovat P, Korolchuk V, Rego AC
Pubblicato in: Aging Celll, Numero (in preparation), 2024, ISSN 1474-9718
Editore: Blackwell Publishing Inc.

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Autori: João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Pubblicato in: Aging Cell, Numero 23, 2024, Pagina/e e14270, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Autori: Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira
Pubblicato in: Stem Cell Reports, Numero 13/4, 2019, Pagina/e 599-611, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2019.08.002

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

Autori: Gavin David Richardson, Andrew Sage, Karim Bennaceur, Nayef Al Zhrany, Jose Coelho-Lima, Emily Dookun, Lilia Draganova, Gabriele Saretzki, David T. Breault, Ziad Mallat, Ioakim Spyridopoulos
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 38/6, 2018, Pagina/e 1283-1296, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.117.309940

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

Autori: Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao
Pubblicato in: Life Science Alliance, Numero 3/12, 2020, Pagina/e e202000821, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.202000821

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Autori: Deolinda Santinha; Andreia Vilaça; Luís Estronca; Svenja C. Schüler; Catherine Bartoli; Annachiara De Sandre-Giovannoli; Arnaldo Figueiredo; Maximillian Quaas; Tilo Pompe; Alessandro Ori; Lino Ferreira
Pubblicato in: Molecular & Cellular Proteomics, Numero Vol. 23, Numero 1, 2024, Pagina/e 100706, ISSN 1535-9476
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Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Autori: Luísa Cortes, João Malva, Ana Cristina Rego, Cláudia F. Pereira
Pubblicato in: International Journal of Molecular Sciences, Numero 21/3, 2020, Pagina/e 1125, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Myocardial cell-to-cell communication via microRNAs

Autori: Lara Ottaviani, Marida Sansonetti, Paula A. da Costa Martins
Pubblicato in: Non-coding RNA Research, Numero 3/3, 2018, Pagina/e 144-153, ISSN 2468-0540
Editore: KeAi Publishing Communications Ltd
DOI: 10.1016/j.ncrna.2018.05.004

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Autori: Emanuel Barth, Akash Srivastava, Milan Stojiljkovic, Christiane Frahm, Hubertus Axer, Otto W. Witte, Manja Marz
Pubblicato in: Aging, Numero 11/19, 2019, Pagina/e 8556-8572, ISSN 1945-4589
Editore: Impact Journals, LLC
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Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains

Autori: Frieder Simon, Kaya Bork, Vinayaga S. Gnanapragassam, Tim Baldensperger, Marcus A. Glomb, Simone Di Sanzo, Alessandro Ori, Rüdiger Horstkorte
Pubblicato in: International Journal of Molecular Sciences, Numero 20/24, 2019, Pagina/e 6118, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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A nanoformulation for the preferential accumulation in adult neurogenic niches

Autori: Catarina Praça, Akhilesh Rai, Tiago Santos, Ana C. Cristovão, Sonia L. Pinho, Romeo Cecchelli, Marie-Pierre Dehouck, Liliana Bernardino, Lino S. Ferreira
Pubblicato in: Journal of Controlled Release, Numero 284, 2018, Pagina/e 57-72, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2018.06.013

Stem cell aging: The upcoming era of proteins and metabolites

Autori: Svenja C. Schüler, Nadja Gebert, Alessandro Ori
Pubblicato in: Mechanisms of Ageing and Development, Numero 190, 2020, Pagina/e 111288, ISSN 0047-6374
Editore: Elsevier BV
DOI: 10.1016/j.mad.2020.111288

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Autori: Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-65115-9

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