BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal

Informations projet

BlueBio4Future

N° de convention de subvention: 952374

DOI

10.3030/952374

Projet clôturé

Date de signature de la CE 10 Juin 2020

Date de début 1 Octobre 2020

Date de fin 31 Mars 2026

Financé au titre de

• Establishing ‚ERA Chairs’

Coût total

€ 2 494 032,50

Contribution de l’UE

€ 2 494 032,50

Coordonné par

CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (3)

Webiste

Development of the project website together with the branding of the action

Report on implementation of the CIIMAR Bioengineering Lab

This deliverable focuses on offering the ERA Chair and the research team the opportunity to enhance the existing research labs with new equipment for world class HCI and design innovation research

International Conference on Marine Biotechnology Website

Development of the website for the conference giving access to the program invited speakers and their cv as well as a platform for online registration

Open Research Data Pilot (1)

At least 25 papers published in Open Access journals

It is expected that at least 25 Open Assess papers will be published in high raking journals such as Nature Methods, Trends in Biotechnology, Biotechnology Advances, Current Opinion in Biotechnology and other major journals with Open Access options in order to provide full free public access to these materials.

Publications

Peer reviewed articles (22)

Decoding Lusichelins A-E: An In-Depth Look at the Metallophores of Lusitaniella coriacea LEGE 07167 – Structure, Production, and Functionality

Auteurs: Maria Lígia Sousa, Leonor Ferreira, Dora Ferreira, Abel M Forero, Raquel Castelo-Branco, Nikoletta Szemerédi, Gabriella Spengler, Jaime Rodríguez, Carlos Jiménez, Pedro N Leão, Vitor Vasconcelos,
Publié dans: Journal Of Natural Products, 2025, ISSN 1520-6025
Éditeur: ACS Publications
DOI: 10.26434/chemrxiv-2025-63fgd

Biosynthesis of the unusual carbon skeleton of nocuolin A

Auteurs: Teresa Martins; Nathaniel Glasser; Duncan Kountz; Paulo Oliveira; Emily Balskus; Pedro Leão
Publié dans: ACS Chemical Biology, Numéro 1, 2022, ISSN 1554-8929
Éditeur: American Chemical Society
DOI: 10.1021/acschembio.2c00464

Diversity of <scp>FAAL</scp> enzymes and prediction of their substrate specificity using <scp>FAALPred</scp>

Auteurs: Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão
Publié dans: Protein Science, Numéro 35, 2026, ISSN 0961-8368
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70468

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Auteurs: Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho
Publié dans: Frontiers in Marine Science, Numéro 13, 2026, ISSN 2296-7745
Éditeur: Frontiers Media SA
DOI: 10.3389/fmars.2026.1754764

Bioprocess optimization for nocuolin A production in Nodularia sp. LEGE 06071

Auteurs: Mariana M. Moutinho, Mariane Bittencourt Fagundes, Maria Lígia Sousa, Marco Preto, Pedro N. Leão
Publié dans: Algal Research, Numéro 93, 2025, Page(s) 104448, ISSN 2211-9264
Éditeur: Elsevier BV
DOI: 10.1016/j.algal.2025.104448

Incorporation and modification of fatty acids in cyanobacterial natural products biosynthesis

Auteurs: Pedro N. Leão, Teresa P. Martins, Kathleen Abt, João P.A.Reis, Sandra Figueiredo, Raquel Castelo-Branco, Sara Freitas
Publié dans: Chemical Communications, 2023, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3cc00136a

The Cyanobacterial Oxadiazine Nocuolin A Shows Broad-Spectrum Toxicity Against Protozoans and the Nematode C. elegans

Auteurs: Ana R. Vieira, Francisco Camacho, Maria L. Sousa, Sara Luelmo, Nuno Santarém, Anabela Cordeiro-da-Silva, Pedro N. Leão
Publié dans: Microbial Ecology, Numéro 88, 2025, ISSN 1432-184X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s00248-025-02507-2

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

Auteurs: Anne Liong, Pedro N. Leão
Publié dans: Natural Product Reports, Numéro 42, 2025, Page(s) 739-753, ISSN 0265-0568
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4np00073k

Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms

Auteurs: Jinyan Wang, Andrew R. J. Curson, Shun Zhou, Ornella Carrión, Ji Liu, Ana R. Vieira, Keanu S. Walsham, Serena Monaco, Chun-Yang Li, Qing-Yu Dong, Yu Wang, Peter Paolo L. Rivera, Xiao-Di Wang, Min Zha
Publié dans: Nature Microbiology, Numéro 9, 2024, Page(s) 1979-1992, ISSN 2058-5276
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01715-9

LPS-Induced Mortality in Zebrafish: Preliminary Characterisation of Common Fish Pathogens

Auteurs: Rafaela A. Santos, Cláudia Cardoso, Neide Pedrosa, Gabriela Gonçalves, Jorge Matinha-Cardoso, Filipe Coutinho, António P. Carvalho, Paula Tamagnini, Aires Oliva-Teles, Paulo Oliveira, Cláudia R. S
Publié dans: Microorganisms, Numéro 11, 2025, Page(s) 2205, ISSN 2076-2607
Éditeur: MDPI AG
DOI: 10.3390/microorganisms11092205

Fischerazoles A-C, cyanobacterial polychlorinated lipids featuring fatty acyl chain rearrangement

Auteurs: Sandra Figueiredo, Kathleen Abt, Teresa Martins, Iñaki Lacomba, Abel Forero, Carlos Jiménez, Jaime Rodríguez, Pedro Leão
Publié dans: Biological and Medicinal Chemistry, 2022, ISSN 2573-2293
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv-2022-v8zlp

Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341

Auteurs: Nádia Eusébio; Raquel Castelo-Branco; Diana Sousa; Marco Preto; Paul D’Agostino; Tobias A. M. Gulder; Pedro N. Leão
Publié dans: ACS Synthetic Biology, Numéro 3, 2022, ISSN 2161-5063
Éditeur: American Chemical Society
DOI: 10.1021/acssynbio.2c00389

Evaluating Novel Direct Injection Liquid Chromatography–Mass Spectrometry Method and Extraction-Based Workflows for Untargeted Lipidomics of Extracellular Vesicles

Auteurs: Michał Młynarczyk, Felicja Gajdowska, Jorge Matinha-Cardoso, Paulo Oliveira, Paula Tamagnini, Mariusz Belka, Jagoda Mantej, Danuta Gutowska-Owsiak, Weronika Hewelt-Belka
Publié dans: Journal of Proteome Research, Numéro 24, 2025, Page(s) 5412-5426, ISSN 1535-3893
Éditeur: American Chemical Society
DOI: 10.1021/acs.jproteome.5c00156

Thraustochytrium sp. and Aurantiochytrium sp.: Sustainable Alternatives for Squalene Production

Auteurs: Júnior Mendes Furlan, Graciela Salete Centenaro, Mariane Bittencourt Fagundes, Carlos Borges Filho, Irineu Batista, Narcisa Bandarra
Publié dans: Marine Drugs, Numéro 23, 2025, Page(s) 132, ISSN 1660-3397
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23030132

Genome-informed Discovery of Monchicamides A–K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532

Auteurs: Raquel Castelo-Branco, João P. Pereira, Sara Freitas, Marco Preto, Ana R. Vieira, João Morais, Pedro N. Leão
Publié dans: Journal of Natural Products, Numéro 88, 2025, Page(s) 86-93, ISSN 0163-3864
Éditeur: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01063

Incorporation, fate, and turnover of free fatty acids in cyanobacteria

Auteurs: Amaranta Kahn; Paulo Oliveira; Marine Cuau; Pedro N Leão
Publié dans: FEMS Microbiology Reviews, Numéro 5, 2023, ISSN 0168-6445
Éditeur: Blackwell
DOI: 10.1093/femsre/fuad015

Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium <i>Desmonostoc muscorum</i> LEGE 12446

Auteurs: Sara Freitas; Raquel Castelo Branco; Arlette Wenzel-Storjohann; Vitor Vasconcelos; Deniz Tasdemir; Pedro Leão
Publié dans: Journal of Natural Products, Numéro 4, 2022, ISSN 0163-3864
Éditeur: American Chemical Society
DOI: 10.1021/acs.jnatprod.2c00162

Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Auteurs: Raquel Castelo-Branco, Xiaodan Ouyang, João P. A. Reis, Sara Freitas, Diana Sousa, David P. Fewer, Pedro N. Leão
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-65184-2

Expanding the Diversity of the Cyanobacterial Dialkylresorcinol Bartoloside Family

Auteurs: João P. A. Reis, Sara Freitas, Tereza Procházková, Pedro N. Leão
Publié dans: Journal of Natural Products, Numéro 87, 2025, Page(s) 2709-2715, ISSN 0163-3864
Éditeur: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00832

Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces

Auteurs: Mariana Girão, Sara Freitas, Teresa P. Martins, Ralph Urbatzka, Maria F. Carvalho, Pedro N. Leão
Publié dans: Frontiers in Pharmacology, Numéro 15, 2024, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1347485

Cyanobacterial Extracellular Vesicles as Protein Carriers: Towards Fish Vaccination

Auteurs: Jorge Matinha‐Cardoso, Gabriela Gonçalves, Filipe Coutinho, Steeve Lima, Lourenço Bonneville, Mónica Serrano, Paula Tamagnini, Aires Oliva‐Teles, Ana Couto, Cláudia R. Serra, Paulo Oliveira
Publié dans: Microbial Biotechnology, Numéro 19, 2026, ISSN 1751-7915
Éditeur: Wiley
DOI: 10.1111/1751-7915.70294

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium <i>Hyella patelloides</i> LEGE 07179

Auteurs: Ângela Brito, Teresa Martins, Sara Freitas, Raquel Castelo Branco, Adriana Rego, Vitor M. Vasconcelos, William H. Gerwick, Paula Tamagnini, Pedro N. Leão
Publié dans: Journal of Natural Products, Numéro 88, 2025, Page(s) 850-856, ISSN 0163-3864
Éditeur: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00968

Other (2)

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

Auteurs: Amaranta Kahn, Cristina I.F. Sousa, João P. A. Reis, David A. Russo, Adriana Rego, Ricardo J.C.V Queirós, Marine Cuau, Julie A. Z. Zedler, Sandra A.C. Figueiredo, Paulo Oliveira, Pedro N. Leão
Publié dans: Preprint at openRxiv, 2026
Éditeur: openRxiv
DOI: 10.64898/2026.03.17.712404

A Wagner-Meerwein-like rearrangement shapes the structures of the fischerazoles, cyanobacterial polychlorinated lipopeptides

Auteurs: Pedro Leao, Sandra Figueiredo, Kathleen Abt, Konrad Viehrig, Peter Jervis, Teresa Martins, Inaki Lacomba, Daniele Castagnolo
Publié dans: Preprint at Research Square, 2026
Éditeur: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-8853700/v1

Book chapters (1)

Lipids, sterols, and fatty acids production in algal bioreactors

Auteurs: Mariane Bittencourt Fagundes, Mariana Miranda Moutinho, José Diogo Cruz
Publié dans: Algal Bioreactors, 2025, Page(s) 521-533
Éditeur: Elsevier
DOI: 10.1016/b978-0-443-14058-7.00049-x