BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal

Informazioni relative al progetto

BlueBio4Future

ID dell’accordo di sovvenzione: 952374

DOI

10.3030/952374

Progetto chiuso

Data della firma CE 10 Giugno 2020

Data di avvio 1 Ottobre 2020

Data di completamento 31 Marzo 2026

Finanziato da

• Establishing ‚ERA Chairs’

Costo totale

€ 2 494 032,50

Contributo UE

€ 2 494 032,50

Coordinato da

CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (3)

Webiste

Development of the project website together with the branding of the action

Report on implementation of the CIIMAR Bioengineering Lab

This deliverable focuses on offering the ERA Chair and the research team the opportunity to enhance the existing research labs with new equipment for world class HCI and design innovation research

International Conference on Marine Biotechnology Website

Development of the website for the conference giving access to the program invited speakers and their cv as well as a platform for online registration

Open Research Data Pilot (1)

At least 25 papers published in Open Access journals

It is expected that at least 25 Open Assess papers will be published in high raking journals such as Nature Methods, Trends in Biotechnology, Biotechnology Advances, Current Opinion in Biotechnology and other major journals with Open Access options in order to provide full free public access to these materials.

Pubblicazioni

Peer reviewed articles (22)

Decoding Lusichelins A-E: An In-Depth Look at the Metallophores of Lusitaniella coriacea LEGE 07167 – Structure, Production, and Functionality

Autori: Maria Lígia Sousa, Leonor Ferreira, Dora Ferreira, Abel M Forero, Raquel Castelo-Branco, Nikoletta Szemerédi, Gabriella Spengler, Jaime Rodríguez, Carlos Jiménez, Pedro N Leão, Vitor Vasconcelos,
Pubblicato in: Journal Of Natural Products, 2025, ISSN 1520-6025
Editore: ACS Publications
DOI: 10.26434/chemrxiv-2025-63fgd

Biosynthesis of the unusual carbon skeleton of nocuolin A

Autori: Teresa Martins; Nathaniel Glasser; Duncan Kountz; Paulo Oliveira; Emily Balskus; Pedro Leão
Pubblicato in: ACS Chemical Biology, Numero 1, 2022, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.2c00464

Diversity of <scp>FAAL</scp> enzymes and prediction of their substrate specificity using <scp>FAALPred</scp>

Autori: Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão
Pubblicato in: Protein Science, Numero 35, 2026, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70468

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Autori: Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho
Pubblicato in: Frontiers in Marine Science, Numero 13, 2026, ISSN 2296-7745
Editore: Frontiers Media SA
DOI: 10.3389/fmars.2026.1754764

Bioprocess optimization for nocuolin A production in Nodularia sp. LEGE 06071

Autori: Mariana M. Moutinho, Mariane Bittencourt Fagundes, Maria Lígia Sousa, Marco Preto, Pedro N. Leão
Pubblicato in: Algal Research, Numero 93, 2025, Pagina/e 104448, ISSN 2211-9264
Editore: Elsevier BV
DOI: 10.1016/j.algal.2025.104448

Incorporation and modification of fatty acids in cyanobacterial natural products biosynthesis

Autori: Pedro N. Leão, Teresa P. Martins, Kathleen Abt, João P.A.Reis, Sandra Figueiredo, Raquel Castelo-Branco, Sara Freitas
Pubblicato in: Chemical Communications, 2023, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cc00136a

The Cyanobacterial Oxadiazine Nocuolin A Shows Broad-Spectrum Toxicity Against Protozoans and the Nematode C. elegans

Autori: Ana R. Vieira, Francisco Camacho, Maria L. Sousa, Sara Luelmo, Nuno Santarém, Anabela Cordeiro-da-Silva, Pedro N. Leão
Pubblicato in: Microbial Ecology, Numero 88, 2025, ISSN 1432-184X
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00248-025-02507-2

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

Autori: Anne Liong, Pedro N. Leão
Pubblicato in: Natural Product Reports, Numero 42, 2025, Pagina/e 739-753, ISSN 0265-0568
Editore: Royal Society of Chemistry
DOI: 10.1039/d4np00073k

Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms

Autori: Jinyan Wang, Andrew R. J. Curson, Shun Zhou, Ornella Carrión, Ji Liu, Ana R. Vieira, Keanu S. Walsham, Serena Monaco, Chun-Yang Li, Qing-Yu Dong, Yu Wang, Peter Paolo L. Rivera, Xiao-Di Wang, Min Zha
Pubblicato in: Nature Microbiology, Numero 9, 2024, Pagina/e 1979-1992, ISSN 2058-5276
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01715-9

LPS-Induced Mortality in Zebrafish: Preliminary Characterisation of Common Fish Pathogens

Autori: Rafaela A. Santos, Cláudia Cardoso, Neide Pedrosa, Gabriela Gonçalves, Jorge Matinha-Cardoso, Filipe Coutinho, António P. Carvalho, Paula Tamagnini, Aires Oliva-Teles, Paulo Oliveira, Cláudia R. S
Pubblicato in: Microorganisms, Numero 11, 2025, Pagina/e 2205, ISSN 2076-2607
Editore: MDPI AG
DOI: 10.3390/microorganisms11092205

Fischerazoles A-C, cyanobacterial polychlorinated lipids featuring fatty acyl chain rearrangement

Autori: Sandra Figueiredo, Kathleen Abt, Teresa Martins, Iñaki Lacomba, Abel Forero, Carlos Jiménez, Jaime Rodríguez, Pedro Leão
Pubblicato in: Biological and Medicinal Chemistry, 2022, ISSN 2573-2293
Editore: ChemRxiv
DOI: 10.26434/chemrxiv-2022-v8zlp

Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341

Autori: Nádia Eusébio; Raquel Castelo-Branco; Diana Sousa; Marco Preto; Paul D’Agostino; Tobias A. M. Gulder; Pedro N. Leão
Pubblicato in: ACS Synthetic Biology, Numero 3, 2022, ISSN 2161-5063
Editore: American Chemical Society
DOI: 10.1021/acssynbio.2c00389

Evaluating Novel Direct Injection Liquid Chromatography–Mass Spectrometry Method and Extraction-Based Workflows for Untargeted Lipidomics of Extracellular Vesicles

Autori: Michał Młynarczyk, Felicja Gajdowska, Jorge Matinha-Cardoso, Paulo Oliveira, Paula Tamagnini, Mariusz Belka, Jagoda Mantej, Danuta Gutowska-Owsiak, Weronika Hewelt-Belka
Pubblicato in: Journal of Proteome Research, Numero 24, 2025, Pagina/e 5412-5426, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.5c00156

Thraustochytrium sp. and Aurantiochytrium sp.: Sustainable Alternatives for Squalene Production

Autori: Júnior Mendes Furlan, Graciela Salete Centenaro, Mariane Bittencourt Fagundes, Carlos Borges Filho, Irineu Batista, Narcisa Bandarra
Pubblicato in: Marine Drugs, Numero 23, 2025, Pagina/e 132, ISSN 1660-3397
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23030132

Genome-informed Discovery of Monchicamides A–K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532

Autori: Raquel Castelo-Branco, João P. Pereira, Sara Freitas, Marco Preto, Ana R. Vieira, João Morais, Pedro N. Leão
Pubblicato in: Journal of Natural Products, Numero 88, 2025, Pagina/e 86-93, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01063

Incorporation, fate, and turnover of free fatty acids in cyanobacteria

Autori: Amaranta Kahn; Paulo Oliveira; Marine Cuau; Pedro N Leão
Pubblicato in: FEMS Microbiology Reviews, Numero 5, 2023, ISSN 0168-6445
Editore: Blackwell
DOI: 10.1093/femsre/fuad015

Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium <i>Desmonostoc muscorum</i> LEGE 12446

Autori: Sara Freitas; Raquel Castelo Branco; Arlette Wenzel-Storjohann; Vitor Vasconcelos; Deniz Tasdemir; Pedro Leão
Pubblicato in: Journal of Natural Products, Numero 4, 2022, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.2c00162

Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Autori: Raquel Castelo-Branco, Xiaodan Ouyang, João P. A. Reis, Sara Freitas, Diana Sousa, David P. Fewer, Pedro N. Leão
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-65184-2

Expanding the Diversity of the Cyanobacterial Dialkylresorcinol Bartoloside Family

Autori: João P. A. Reis, Sara Freitas, Tereza Procházková, Pedro N. Leão
Pubblicato in: Journal of Natural Products, Numero 87, 2025, Pagina/e 2709-2715, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00832

Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces

Autori: Mariana Girão, Sara Freitas, Teresa P. Martins, Ralph Urbatzka, Maria F. Carvalho, Pedro N. Leão
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1347485

Cyanobacterial Extracellular Vesicles as Protein Carriers: Towards Fish Vaccination

Autori: Jorge Matinha‐Cardoso, Gabriela Gonçalves, Filipe Coutinho, Steeve Lima, Lourenço Bonneville, Mónica Serrano, Paula Tamagnini, Aires Oliva‐Teles, Ana Couto, Cláudia R. Serra, Paulo Oliveira
Pubblicato in: Microbial Biotechnology, Numero 19, 2026, ISSN 1751-7915
Editore: Wiley
DOI: 10.1111/1751-7915.70294

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium <i>Hyella patelloides</i> LEGE 07179

Autori: Ângela Brito, Teresa Martins, Sara Freitas, Raquel Castelo Branco, Adriana Rego, Vitor M. Vasconcelos, William H. Gerwick, Paula Tamagnini, Pedro N. Leão
Pubblicato in: Journal of Natural Products, Numero 88, 2025, Pagina/e 850-856, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00968

Other (2)

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

Autori: Amaranta Kahn, Cristina I.F. Sousa, João P. A. Reis, David A. Russo, Adriana Rego, Ricardo J.C.V Queirós, Marine Cuau, Julie A. Z. Zedler, Sandra A.C. Figueiredo, Paulo Oliveira, Pedro N. Leão
Pubblicato in: Preprint at openRxiv, 2026
Editore: openRxiv
DOI: 10.64898/2026.03.17.712404

A Wagner-Meerwein-like rearrangement shapes the structures of the fischerazoles, cyanobacterial polychlorinated lipopeptides

Autori: Pedro Leao, Sandra Figueiredo, Kathleen Abt, Konrad Viehrig, Peter Jervis, Teresa Martins, Inaki Lacomba, Daniele Castagnolo
Pubblicato in: Preprint at Research Square, 2026
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-8853700/v1

Book chapters (1)

Lipids, sterols, and fatty acids production in algal bioreactors

Autori: Mariane Bittencourt Fagundes, Mariana Miranda Moutinho, José Diogo Cruz
Pubblicato in: Algal Bioreactors, 2025, Pagina/e 521-533
Editore: Elsevier
DOI: 10.1016/b978-0-443-14058-7.00049-x