BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal

Informacje na temat projektu

BlueBio4Future

Identyfikator umowy o grant: 952374

DOI

10.3030/952374

Projekt został zamknięty

Data podpisania przez KE 10 Czerwca 2020

Data rozpoczęcia 1 Października 2020

Data zakończenia 31 Marca 2026

Finansowanie w ramach

• Establishing ‚ERA Chairs’

Koszt całkowity

€ 2 494 032,50

Wkład UE

€ 2 494 032,50

Koordynowany przez

CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (3)

Webiste

Development of the project website together with the branding of the action

Report on implementation of the CIIMAR Bioengineering Lab

This deliverable focuses on offering the ERA Chair and the research team the opportunity to enhance the existing research labs with new equipment for world class HCI and design innovation research

International Conference on Marine Biotechnology Website

Development of the website for the conference giving access to the program invited speakers and their cv as well as a platform for online registration

Open Research Data Pilot (1)

At least 25 papers published in Open Access journals

It is expected that at least 25 Open Assess papers will be published in high raking journals such as Nature Methods, Trends in Biotechnology, Biotechnology Advances, Current Opinion in Biotechnology and other major journals with Open Access options in order to provide full free public access to these materials.

Publikacje

Peer reviewed articles (22)

Decoding Lusichelins A-E: An In-Depth Look at the Metallophores of Lusitaniella coriacea LEGE 07167 – Structure, Production, and Functionality

Autorzy: Maria Lígia Sousa, Leonor Ferreira, Dora Ferreira, Abel M Forero, Raquel Castelo-Branco, Nikoletta Szemerédi, Gabriella Spengler, Jaime Rodríguez, Carlos Jiménez, Pedro N Leão, Vitor Vasconcelos,
Opublikowane w: Journal Of Natural Products, 2025, ISSN 1520-6025
Wydawca: ACS Publications
DOI: 10.26434/chemrxiv-2025-63fgd

Biosynthesis of the unusual carbon skeleton of nocuolin A

Autorzy: Teresa Martins; Nathaniel Glasser; Duncan Kountz; Paulo Oliveira; Emily Balskus; Pedro Leão
Opublikowane w: ACS Chemical Biology, Numer 1, 2022, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.2c00464

Diversity of <scp>FAAL</scp> enzymes and prediction of their substrate specificity using <scp>FAALPred</scp>

Autorzy: Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão
Opublikowane w: Protein Science, Numer 35, 2026, ISSN 0961-8368
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70468

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Autorzy: Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho
Opublikowane w: Frontiers in Marine Science, Numer 13, 2026, ISSN 2296-7745
Wydawca: Frontiers Media SA
DOI: 10.3389/fmars.2026.1754764

Bioprocess optimization for nocuolin A production in Nodularia sp. LEGE 06071

Autorzy: Mariana M. Moutinho, Mariane Bittencourt Fagundes, Maria Lígia Sousa, Marco Preto, Pedro N. Leão
Opublikowane w: Algal Research, Numer 93, 2025, Strona(/y) 104448, ISSN 2211-9264
Wydawca: Elsevier BV
DOI: 10.1016/j.algal.2025.104448

Incorporation and modification of fatty acids in cyanobacterial natural products biosynthesis

Autorzy: Pedro N. Leão, Teresa P. Martins, Kathleen Abt, João P.A.Reis, Sandra Figueiredo, Raquel Castelo-Branco, Sara Freitas
Opublikowane w: Chemical Communications, 2023, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3cc00136a

The Cyanobacterial Oxadiazine Nocuolin A Shows Broad-Spectrum Toxicity Against Protozoans and the Nematode C. elegans

Autorzy: Ana R. Vieira, Francisco Camacho, Maria L. Sousa, Sara Luelmo, Nuno Santarém, Anabela Cordeiro-da-Silva, Pedro N. Leão
Opublikowane w: Microbial Ecology, Numer 88, 2025, ISSN 1432-184X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/s00248-025-02507-2

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

Autorzy: Anne Liong, Pedro N. Leão
Opublikowane w: Natural Product Reports, Numer 42, 2025, Strona(/y) 739-753, ISSN 0265-0568
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4np00073k

Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms

Autorzy: Jinyan Wang, Andrew R. J. Curson, Shun Zhou, Ornella Carrión, Ji Liu, Ana R. Vieira, Keanu S. Walsham, Serena Monaco, Chun-Yang Li, Qing-Yu Dong, Yu Wang, Peter Paolo L. Rivera, Xiao-Di Wang, Min Zha
Opublikowane w: Nature Microbiology, Numer 9, 2024, Strona(/y) 1979-1992, ISSN 2058-5276
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01715-9

LPS-Induced Mortality in Zebrafish: Preliminary Characterisation of Common Fish Pathogens

Autorzy: Rafaela A. Santos, Cláudia Cardoso, Neide Pedrosa, Gabriela Gonçalves, Jorge Matinha-Cardoso, Filipe Coutinho, António P. Carvalho, Paula Tamagnini, Aires Oliva-Teles, Paulo Oliveira, Cláudia R. S
Opublikowane w: Microorganisms, Numer 11, 2025, Strona(/y) 2205, ISSN 2076-2607
Wydawca: MDPI AG
DOI: 10.3390/microorganisms11092205

Fischerazoles A-C, cyanobacterial polychlorinated lipids featuring fatty acyl chain rearrangement

Autorzy: Sandra Figueiredo, Kathleen Abt, Teresa Martins, Iñaki Lacomba, Abel Forero, Carlos Jiménez, Jaime Rodríguez, Pedro Leão
Opublikowane w: Biological and Medicinal Chemistry, 2022, ISSN 2573-2293
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv-2022-v8zlp

Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341

Autorzy: Nádia Eusébio; Raquel Castelo-Branco; Diana Sousa; Marco Preto; Paul D’Agostino; Tobias A. M. Gulder; Pedro N. Leão
Opublikowane w: ACS Synthetic Biology, Numer 3, 2022, ISSN 2161-5063
Wydawca: American Chemical Society
DOI: 10.1021/acssynbio.2c00389

Evaluating Novel Direct Injection Liquid Chromatography–Mass Spectrometry Method and Extraction-Based Workflows for Untargeted Lipidomics of Extracellular Vesicles

Autorzy: Michał Młynarczyk, Felicja Gajdowska, Jorge Matinha-Cardoso, Paulo Oliveira, Paula Tamagnini, Mariusz Belka, Jagoda Mantej, Danuta Gutowska-Owsiak, Weronika Hewelt-Belka
Opublikowane w: Journal of Proteome Research, Numer 24, 2025, Strona(/y) 5412-5426, ISSN 1535-3893
Wydawca: American Chemical Society
DOI: 10.1021/acs.jproteome.5c00156

Thraustochytrium sp. and Aurantiochytrium sp.: Sustainable Alternatives for Squalene Production

Autorzy: Júnior Mendes Furlan, Graciela Salete Centenaro, Mariane Bittencourt Fagundes, Carlos Borges Filho, Irineu Batista, Narcisa Bandarra
Opublikowane w: Marine Drugs, Numer 23, 2025, Strona(/y) 132, ISSN 1660-3397
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23030132

Genome-informed Discovery of Monchicamides A–K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532

Autorzy: Raquel Castelo-Branco, João P. Pereira, Sara Freitas, Marco Preto, Ana R. Vieira, João Morais, Pedro N. Leão
Opublikowane w: Journal of Natural Products, Numer 88, 2025, Strona(/y) 86-93, ISSN 0163-3864
Wydawca: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01063

Incorporation, fate, and turnover of free fatty acids in cyanobacteria

Autorzy: Amaranta Kahn; Paulo Oliveira; Marine Cuau; Pedro N Leão
Opublikowane w: FEMS Microbiology Reviews, Numer 5, 2023, ISSN 0168-6445
Wydawca: Blackwell
DOI: 10.1093/femsre/fuad015

Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium <i>Desmonostoc muscorum</i> LEGE 12446

Autorzy: Sara Freitas; Raquel Castelo Branco; Arlette Wenzel-Storjohann; Vitor Vasconcelos; Deniz Tasdemir; Pedro Leão
Opublikowane w: Journal of Natural Products, Numer 4, 2022, ISSN 0163-3864
Wydawca: American Chemical Society
DOI: 10.1021/acs.jnatprod.2c00162

Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Autorzy: Raquel Castelo-Branco, Xiaodan Ouyang, João P. A. Reis, Sara Freitas, Diana Sousa, David P. Fewer, Pedro N. Leão
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-65184-2

Expanding the Diversity of the Cyanobacterial Dialkylresorcinol Bartoloside Family

Autorzy: João P. A. Reis, Sara Freitas, Tereza Procházková, Pedro N. Leão
Opublikowane w: Journal of Natural Products, Numer 87, 2025, Strona(/y) 2709-2715, ISSN 0163-3864
Wydawca: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00832

Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces

Autorzy: Mariana Girão, Sara Freitas, Teresa P. Martins, Ralph Urbatzka, Maria F. Carvalho, Pedro N. Leão
Opublikowane w: Frontiers in Pharmacology, Numer 15, 2024, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1347485

Cyanobacterial Extracellular Vesicles as Protein Carriers: Towards Fish Vaccination

Autorzy: Jorge Matinha‐Cardoso, Gabriela Gonçalves, Filipe Coutinho, Steeve Lima, Lourenço Bonneville, Mónica Serrano, Paula Tamagnini, Aires Oliva‐Teles, Ana Couto, Cláudia R. Serra, Paulo Oliveira
Opublikowane w: Microbial Biotechnology, Numer 19, 2026, ISSN 1751-7915
Wydawca: Wiley
DOI: 10.1111/1751-7915.70294

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium <i>Hyella patelloides</i> LEGE 07179

Autorzy: Ângela Brito, Teresa Martins, Sara Freitas, Raquel Castelo Branco, Adriana Rego, Vitor M. Vasconcelos, William H. Gerwick, Paula Tamagnini, Pedro N. Leão
Opublikowane w: Journal of Natural Products, Numer 88, 2025, Strona(/y) 850-856, ISSN 0163-3864
Wydawca: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00968

Other (2)

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

Autorzy: Amaranta Kahn, Cristina I.F. Sousa, João P. A. Reis, David A. Russo, Adriana Rego, Ricardo J.C.V Queirós, Marine Cuau, Julie A. Z. Zedler, Sandra A.C. Figueiredo, Paulo Oliveira, Pedro N. Leão
Opublikowane w: Preprint at openRxiv, 2026
Wydawca: openRxiv
DOI: 10.64898/2026.03.17.712404

A Wagner-Meerwein-like rearrangement shapes the structures of the fischerazoles, cyanobacterial polychlorinated lipopeptides

Autorzy: Pedro Leao, Sandra Figueiredo, Kathleen Abt, Konrad Viehrig, Peter Jervis, Teresa Martins, Inaki Lacomba, Daniele Castagnolo
Opublikowane w: Preprint at Research Square, 2026
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-8853700/v1

Book chapters (1)

Lipids, sterols, and fatty acids production in algal bioreactors

Autorzy: Mariane Bittencourt Fagundes, Mariana Miranda Moutinho, José Diogo Cruz
Opublikowane w: Algal Bioreactors, 2025, Strona(/y) 521-533
Wydawca: Elsevier
DOI: 10.1016/b978-0-443-14058-7.00049-x