BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal

Información del proyecto

BlueBio4Future

Identificador del acuerdo de subvención: 952374

DOI

10.3030/952374

Proyecto cerrado

Fecha de la firma de la CE 10 Junio 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• Establishing ‚ERA Chairs’

Coste total

€ 2 494 032,50

Aportación de la UE

€ 2 494 032,50

Coordinado por

CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

Webiste

Development of the project website together with the branding of the action

Report on implementation of the CIIMAR Bioengineering Lab

This deliverable focuses on offering the ERA Chair and the research team the opportunity to enhance the existing research labs with new equipment for world class HCI and design innovation research

International Conference on Marine Biotechnology Website

Development of the website for the conference giving access to the program invited speakers and their cv as well as a platform for online registration

Open Research Data Pilot (1)

At least 25 papers published in Open Access journals

It is expected that at least 25 Open Assess papers will be published in high raking journals such as Nature Methods, Trends in Biotechnology, Biotechnology Advances, Current Opinion in Biotechnology and other major journals with Open Access options in order to provide full free public access to these materials.

Publicaciones

Peer reviewed articles (22)

Decoding Lusichelins A-E: An In-Depth Look at the Metallophores of Lusitaniella coriacea LEGE 07167 – Structure, Production, and Functionality

Autores: Maria Lígia Sousa, Leonor Ferreira, Dora Ferreira, Abel M Forero, Raquel Castelo-Branco, Nikoletta Szemerédi, Gabriella Spengler, Jaime Rodríguez, Carlos Jiménez, Pedro N Leão, Vitor Vasconcelos,
Publicado en: Journal Of Natural Products, 2025, ISSN 1520-6025
Editor: ACS Publications
DOI: 10.26434/chemrxiv-2025-63fgd

Biosynthesis of the unusual carbon skeleton of nocuolin A

Autores: Teresa Martins; Nathaniel Glasser; Duncan Kountz; Paulo Oliveira; Emily Balskus; Pedro Leão
Publicado en: ACS Chemical Biology, Edición 1, 2022, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.2c00464

Diversity of <scp>FAAL</scp> enzymes and prediction of their substrate specificity using <scp>FAALPred</scp>

Autores: Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão
Publicado en: Protein Science, Edición 35, 2026, ISSN 0961-8368
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70468

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Autores: Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho
Publicado en: Frontiers in Marine Science, Edición 13, 2026, ISSN 2296-7745
Editor: Frontiers Media SA
DOI: 10.3389/fmars.2026.1754764

Bioprocess optimization for nocuolin A production in Nodularia sp. LEGE 06071

Autores: Mariana M. Moutinho, Mariane Bittencourt Fagundes, Maria Lígia Sousa, Marco Preto, Pedro N. Leão
Publicado en: Algal Research, Edición 93, 2025, Página(s) 104448, ISSN 2211-9264
Editor: Elsevier BV
DOI: 10.1016/j.algal.2025.104448

Incorporation and modification of fatty acids in cyanobacterial natural products biosynthesis

Autores: Pedro N. Leão, Teresa P. Martins, Kathleen Abt, João P.A.Reis, Sandra Figueiredo, Raquel Castelo-Branco, Sara Freitas
Publicado en: Chemical Communications, 2023, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d3cc00136a

The Cyanobacterial Oxadiazine Nocuolin A Shows Broad-Spectrum Toxicity Against Protozoans and the Nematode C. elegans

Autores: Ana R. Vieira, Francisco Camacho, Maria L. Sousa, Sara Luelmo, Nuno Santarém, Anabela Cordeiro-da-Silva, Pedro N. Leão
Publicado en: Microbial Ecology, Edición 88, 2025, ISSN 1432-184X
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00248-025-02507-2

Fatty acyl-AMP ligases in bacterial natural product biosynthesis

Autores: Anne Liong, Pedro N. Leão
Publicado en: Natural Product Reports, Edición 42, 2025, Página(s) 739-753, ISSN 0265-0568
Editor: Royal Society of Chemistry
DOI: 10.1039/d4np00073k

Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms

Autores: Jinyan Wang, Andrew R. J. Curson, Shun Zhou, Ornella Carrión, Ji Liu, Ana R. Vieira, Keanu S. Walsham, Serena Monaco, Chun-Yang Li, Qing-Yu Dong, Yu Wang, Peter Paolo L. Rivera, Xiao-Di Wang, Min Zha
Publicado en: Nature Microbiology, Edición 9, 2024, Página(s) 1979-1992, ISSN 2058-5276
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01715-9

LPS-Induced Mortality in Zebrafish: Preliminary Characterisation of Common Fish Pathogens

Autores: Rafaela A. Santos, Cláudia Cardoso, Neide Pedrosa, Gabriela Gonçalves, Jorge Matinha-Cardoso, Filipe Coutinho, António P. Carvalho, Paula Tamagnini, Aires Oliva-Teles, Paulo Oliveira, Cláudia R. S
Publicado en: Microorganisms, Edición 11, 2025, Página(s) 2205, ISSN 2076-2607
Editor: MDPI AG
DOI: 10.3390/microorganisms11092205

Fischerazoles A-C, cyanobacterial polychlorinated lipids featuring fatty acyl chain rearrangement

Autores: Sandra Figueiredo, Kathleen Abt, Teresa Martins, Iñaki Lacomba, Abel Forero, Carlos Jiménez, Jaime Rodríguez, Pedro Leão
Publicado en: Biological and Medicinal Chemistry, 2022, ISSN 2573-2293
Editor: ChemRxiv
DOI: 10.26434/chemrxiv-2022-v8zlp

Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341

Autores: Nádia Eusébio; Raquel Castelo-Branco; Diana Sousa; Marco Preto; Paul D’Agostino; Tobias A. M. Gulder; Pedro N. Leão
Publicado en: ACS Synthetic Biology, Edición 3, 2022, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.2c00389

Evaluating Novel Direct Injection Liquid Chromatography–Mass Spectrometry Method and Extraction-Based Workflows for Untargeted Lipidomics of Extracellular Vesicles

Autores: Michał Młynarczyk, Felicja Gajdowska, Jorge Matinha-Cardoso, Paulo Oliveira, Paula Tamagnini, Mariusz Belka, Jagoda Mantej, Danuta Gutowska-Owsiak, Weronika Hewelt-Belka
Publicado en: Journal of Proteome Research, Edición 24, 2025, Página(s) 5412-5426, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.5c00156

Thraustochytrium sp. and Aurantiochytrium sp.: Sustainable Alternatives for Squalene Production

Autores: Júnior Mendes Furlan, Graciela Salete Centenaro, Mariane Bittencourt Fagundes, Carlos Borges Filho, Irineu Batista, Narcisa Bandarra
Publicado en: Marine Drugs, Edición 23, 2025, Página(s) 132, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23030132

Genome-informed Discovery of Monchicamides A–K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532

Autores: Raquel Castelo-Branco, João P. Pereira, Sara Freitas, Marco Preto, Ana R. Vieira, João Morais, Pedro N. Leão
Publicado en: Journal of Natural Products, Edición 88, 2025, Página(s) 86-93, ISSN 0163-3864
Editor: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c01063

Incorporation, fate, and turnover of free fatty acids in cyanobacteria

Autores: Amaranta Kahn; Paulo Oliveira; Marine Cuau; Pedro N Leão
Publicado en: FEMS Microbiology Reviews, Edición 5, 2023, ISSN 0168-6445
Editor: Blackwell
DOI: 10.1093/femsre/fuad015

Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium <i>Desmonostoc muscorum</i> LEGE 12446

Autores: Sara Freitas; Raquel Castelo Branco; Arlette Wenzel-Storjohann; Vitor Vasconcelos; Deniz Tasdemir; Pedro Leão
Publicado en: Journal of Natural Products, Edición 4, 2022, ISSN 0163-3864
Editor: American Chemical Society
DOI: 10.1021/acs.jnatprod.2c00162

Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Autores: Raquel Castelo-Branco, Xiaodan Ouyang, João P. A. Reis, Sara Freitas, Diana Sousa, David P. Fewer, Pedro N. Leão
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-65184-2

Expanding the Diversity of the Cyanobacterial Dialkylresorcinol Bartoloside Family

Autores: João P. A. Reis, Sara Freitas, Tereza Procházková, Pedro N. Leão
Publicado en: Journal of Natural Products, Edición 87, 2025, Página(s) 2709-2715, ISSN 0163-3864
Editor: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00832

Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces

Autores: Mariana Girão, Sara Freitas, Teresa P. Martins, Ralph Urbatzka, Maria F. Carvalho, Pedro N. Leão
Publicado en: Frontiers in Pharmacology, Edición 15, 2024, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1347485

Cyanobacterial Extracellular Vesicles as Protein Carriers: Towards Fish Vaccination

Autores: Jorge Matinha‐Cardoso, Gabriela Gonçalves, Filipe Coutinho, Steeve Lima, Lourenço Bonneville, Mónica Serrano, Paula Tamagnini, Aires Oliva‐Teles, Ana Couto, Cláudia R. Serra, Paulo Oliveira
Publicado en: Microbial Biotechnology, Edición 19, 2026, ISSN 1751-7915
Editor: Wiley
DOI: 10.1111/1751-7915.70294

Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium <i>Hyella patelloides</i> LEGE 07179

Autores: Ângela Brito, Teresa Martins, Sara Freitas, Raquel Castelo Branco, Adriana Rego, Vitor M. Vasconcelos, William H. Gerwick, Paula Tamagnini, Pedro N. Leão
Publicado en: Journal of Natural Products, Edición 88, 2025, Página(s) 850-856, ISSN 0163-3864
Editor: American Chemical Society
DOI: 10.1021/acs.jnatprod.4c00968

Other (2)

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

Autores: Amaranta Kahn, Cristina I.F. Sousa, João P. A. Reis, David A. Russo, Adriana Rego, Ricardo J.C.V Queirós, Marine Cuau, Julie A. Z. Zedler, Sandra A.C. Figueiredo, Paulo Oliveira, Pedro N. Leão
Publicado en: Preprint at openRxiv, 2026
Editor: openRxiv
DOI: 10.64898/2026.03.17.712404

A Wagner-Meerwein-like rearrangement shapes the structures of the fischerazoles, cyanobacterial polychlorinated lipopeptides

Autores: Pedro Leao, Sandra Figueiredo, Kathleen Abt, Konrad Viehrig, Peter Jervis, Teresa Martins, Inaki Lacomba, Daniele Castagnolo
Publicado en: Preprint at Research Square, 2026
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-8853700/v1

Book chapters (1)

Lipids, sterols, and fatty acids production in algal bioreactors

Autores: Mariane Bittencourt Fagundes, Mariana Miranda Moutinho, José Diogo Cruz
Publicado en: Algal Bioreactors, 2025, Página(s) 521-533
Editor: Elsevier
DOI: 10.1016/b978-0-443-14058-7.00049-x