Epileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies

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Publications

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Author(s): Cláudia A. Valente; Francisco J Meda; Mafalda Carvalho; Ana M. Sebastião
Published in: Journal of Visualized Experiments, Issue 24, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/61330

Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy

Author(s): Diogo M Lourenço, Leonor Ribeiro-Rodrigues, Ana M Sebastião, Maria J Diógenes, Sara Xapelli.
Published in: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197309

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.

Author(s): Anatoly Korotkov; Nam Suk Sim; Mark J. Luinenburg; Jasper J. Anink; Jackelien van Scheppingen; Jackelien van Scheppingen; Till S. Zimmer; Anika Bongaarts; Diede W. M. Broekaart; Caroline Mijnsbergen; Floor E. Jansen; Wim Van Hecke; Wim G.M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna Jansen;
Published in: VOLUME=47;ISSUE=6;STARTPAGE=796;ENDPAGE=811;ISSN=0305-1846;TITLE=Neuropathology and applied neurobiology, Issue 38, 2021, ISSN 1365-2990
Publisher: Wiley Online Library
DOI: 10.1111/nan.12717

Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy

Author(s): Pierangelo Cifelli, Silvia Di Angelantonio, Veronica Alfano, Alessandra Morano, Eleonora De Felice, Eleonora Aronica, Gabriele Ruffolo, Eleonora Palma
Published in: Brain Sciences, 2021, ISSN 2076-3425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci11040441

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia 2B brain lesions.

Author(s): Victoria-Elisabeth Gruber, Mark J. Luinenburg, Katrin Colleselli, Verena Endmayr, J. Anink, Till S. Zimmer, Floor Jansen, Peter Gosselaar, Roland Coras, Theresa Scholl, Jackelien van Scheppingen, Ingmar Blumcke, José Pimentel, Johannes A. Hainfellner, Romana Höftberger, Karl Rössler, Martha Feucht, Eleonora Aronica, and Angelika Mühlebner.
Published in: Epilepsia, 2021, ISSN 1528-1167
Publisher: Wiley Online Library
DOI: 10.1111/epi.17139

Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Author(s): Anatoly Korotkov; Mark J. Luinenburg; Alessia Romagnolo; Till S. Zimmer; Jackelien van Scheppingen; Anika Bongaarts; Diede W.M. Broekaart; Jasper J. Anink; Caroline Mijnsbergen; Floor E. Jansen; Wim van Hecke; Wim G. M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna C. Jansen; David J. Kwiatkow
Published in: Journal of Neurodevelopmental isorders, 2021, ISSN 1866-1947
Publisher: Springer Verlag
DOI: 10.1186/s11689-022-09416-2

Generalized Fast Discharges Along the Genetic Generalized Epilepsy Spectrum: Clinical and Prognostic Significance.

Author(s): Placidi, Anna Teresa Giallonardo, Francesca Izzi and Carlo Di Bonaventura
Published in: rontiers in Neurology, 2022, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.844674

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

Author(s): Filipa F Ribeiro, Filipa Ferreira, Rui S Rodrigues, Rita Soares, Diogo M Pedro, Marta Duarte-Samartinho, Rita I Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Solá, Helena Mira, Ana M Sebastião, Sara Xapelli
Published in: Stem Cells, 2021, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3421

Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

Author(s): • Anika Bongaarts, Caroline Mijnsbergen, Jasper J. Anink, Floor E. Jansen, Wim G.M. Spliet, Wilfred F.A. den Dunnen, Roland Coras, Ingmar Blümcke, Werner Paulus, Victoria E. Gruber, Theresa Scholl, Johannes A. Hainfellner, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Wieslawa Grajkowska, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Figen Söylemezoğlu, J
Published in: Cellular and Molecular Neurobiology, 2021, ISSN 0272-4340
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10571-021-01157-5

Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder.

Author(s): Joana Gomes; Miguel Farinha-Ferreira; Nádia Rei; Joana Gonçalves-Ribeiro; Joaquim A. Ribeiro; Ana M. Sebastião; Sandra H. Vaz
Published in: Pharmacological Research, Issue Volume 163, January 2021, 105363, 2020, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2020.105363

Balloon cells promote immune system activation in focal cortical dysplasia type 2b.

Author(s): Till S. Zimmer; Diede W. M. Broekaart; Mark J. Luinenburg; Caroline Mijnsbergen; Jasper J. Anink; Nam Suk Sim; Iliana Michailidou; Floor E. Jansen; Peter C. van Rijen; Jeong Ho Lee; Liesbeth François; Jonathan van Eyll; Stefanie Dedeurwaerdere; Stefanie Dedeurwaerdere; Erwin A. van Vliet; Angelika Mühlebner; Angelika Mühlebner; James D. Mills; Eleonora Aronica
Published in: Neuropathology and Applied Neurobiology, Issue 39, 2021, ISSN 1365-2990
Publisher: Wiley Online Library
DOI: 10.1111/nan.12736

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

Author(s): Till S. Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E. Jansen, Fried J. T. Zwartkruis, Nicholas R. Rensing, Michael Wong, Angelika Mühlebner, Erwin A. van Vliet, Eleonora Aronica, James D. Mills
Published in: Brain Pathology, 2021, ISSN 1750-3639
Publisher: Wiley Online Library
DOI: 10.1111/bpa.12949

Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Author(s): Catarina Miranda-Lourenço, Sofia T. Duarte, Cátia Palminha, Cláudia Gaspar, Tiago M. Rodrigues, Teresa Magalhães-Cardoso, Nádia Rei, Mariana Colino-Oliveira, Rui Gomes, Sara Ferreira, Jéssica Rosa, Sara Xapelli, Judith Armstrong, Àngels García-Cazorla, Paulo Correia-de-Sá, Ana M. Sebastião, Maria José Diógenes
Published in: Neurobiology of Disease, Issue 145, 2020, Page(s) 105043, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2020.105043

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats

Author(s): Sara L. Paulo; Catarina Miranda-Lourenço; Rita F. Belo; Rui S. Rodrigues; João Fonseca-Gomes; Sara R. Tanqueiro; Vera Geraldes; Isabel Rocha; Ana M. Sebastião; Sara Xapelli; Maria J. Diógenes
Published in: Current Issues in Molecular Biology, Vol 43, Iss 162, Pp 2305-2319 (2021), Issue 9, 2021, ISSN 1467-3045
Publisher: MDPI
DOI: 10.3390/cimb43030162

Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence.

Author(s): Federica Avorio; Federica Avorio; Emanuele Cerulli Irelli; Alessandra Morano; Martina Fanella; Biagio Orlando; Mariarita Albini; Luca M. Basili; Gabriele Ruffolo; Jinane Fattouch; Mario Manfredi; Emilio Russo; Pasquale Striano; Marilia Carabotti; Anna Teresa Giallonardo; Carola Severi; Carlo Di Bonaventura
Published in: Frontiers in Neurology, Vol 12 (2021), Issue 23, 2021, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.705126

Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging

Author(s): Erwin A van Vliet, Nicola Marchi.
Published in: Epilepsy, 2022, ISSN 1528-1167
Publisher: Wiley Online Library
DOI: 10.1111/epi.17210

Astrocytes in Amyotrophic Lateral Sclerosis

Author(s): Sandra H. Vaz, Sara Pinto, Ana M. Sebastião, and Dora Brites.
Published in: Amyotrophic Lateral Sclerosis., 2021, ISBN 978-0-6450017-7-8
Publisher: Exon Publications
DOI: 10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021

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