Epileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies

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Publicaciones

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Autores: Cláudia A. Valente; Francisco J Meda; Mafalda Carvalho; Ana M. Sebastião
Publicado en: Journal of Visualized Experiments, Edición 24, 2021, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/61330

miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex

Autores: Mirte Scheper, Alessia Romagnolo, Zein Mersini Besharat, Anand M. Iyer, Romina Moavero, Christoph Hertzberg, Bernhard Weschke, Kate Riney, Martha Feucht, Theresa Scholl, Borivoj Petrak, Alice Maulisova, Rima Nabbout, Anna C. Jansen, Floor E. Jansen, Lieven Lagae, Malgorzata Urbanska, Elisabetta Ferretti, Aleksandra Tempes, Magdalena Blazejczyk, Jacek Jaworski, David J. Kwiatkowski, Sergiusz Jozwia
Publicado en: Biomedicines, Edición 10, 2024, Página(s) 1838, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10081838

Lineage-specific changes in mitochondrial properties during neural stem cell differentiation

Autores: Rita Soares, Diogo M Lourenço, Isa F Mota, Ana M Sebastião, Sara Xapelli, Vanessa A Morais
Publicado en: Life Science Alliance, Edición 7, 2024, Página(s) e202302473, ISSN 2575-1077
Editor: Life Science Alliance LLC
DOI: 10.26508/lsa.202302473

Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy

Autores: Diogo M Lourenço, Leonor Ribeiro-Rodrigues, Ana M Sebastião, Maria J Diógenes, Sara Xapelli.
Publicado en: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197309

Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study

Autores: Pedro Coelho, João Madureira, Ana Franco, Ana Rita Peralta, Carla Bentes, Alexandre Rainha Campos, Jasper Anink, Eleonora Aronica, Rafael Roque, José Pimentel
Publicado en: European Journal of Neurology, Edición 30, 2023, Página(s) 2999-3007, ISSN 1351-5101
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ene.15963

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress

Autores: R. S. Rodrigues, J. B. Moreira, J. M. Mateus, A. Barateiro, S. L. Paulo, S. H. Vaz, D. M. Lourenço, F. F. Ribeiro, R. Soares, E. Loureiro-Campos, P. Bielefeld, A. M. Sebastião, A. Fernandes, L. Pinto, C. P. Fitzsimons, S. Xapelli
Publicado en: Translational Psychiatry, Edición 14, 2024, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-024-02877-0

Unexpected Effect of IL-1β on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia

Autores: Veronica Alfano, Alessia Romagnolo, James D. Mills, Pierangelo Cifelli, Alessandro Gaeta, Alessandra Morano, Angelika Mühlebner, Eleonora Aronica, Eleonora Palma, Gabriele Ruffolo
Publicado en: Brain Sciences, Edición 12, 2024, Página(s) 807, ISSN 2076-3425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci12060807

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

Autores: Mariana Van Zeller, Diogo Dias, Ana M. Sebastião, Cláudia A. Valente
Publicado en: Journal of Alzheimer's Disease, Edición 83, 2023, Página(s) 939-961, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-210268

Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology

Autores: Alessandra Morano, Emanuele Cerulli Irelli, Enrico Michele Salamone, Biagio Orlando, Martina Fanella, Emanuele Tinelli, Gabriele Ruffolo, Luigi Zuliani, Jinane Fattouch, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura
Publicado en: Frontiers in Neurology, Edición 13, 2022, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.924859

Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (<scp>CB1)</scp> receptor effect upon synaptic plasticity in the medial prefrontal cortex

Autores: Joana Gonçalves‐Ribeiro, Oksana K. Savchak, Sara Costa‐Pinto, Joana I. Gomes, Rafael Rivas‐Santisteban, Alejandro Lillo, Javier Sánchez Romero, Ana M. Sebastião, Marta Navarrete, Gemma Navarro, Rafael Franco, Sandra H. Vaz
Publicado en: Glia, Edición 72, 2024, Página(s) 1096-1116, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24518

Effective reduction in seizure severity and prevention of a fatty liver by a novel low ratio ketogenic diet composition in the rapid kindling rat model of epileptogenesis

Autores: Hester Meeusen, Rozemarijn S. Kalf, Diede W.M. Broekaart, Jose P. Silva, J. Martin Verkuyl, Ardy van Helvoort, Jan A. Gorter, Erwin A. van Vliet, Eleonora Aronica
Publicado en: Experimental Neurology, Edición 379, 2024, Página(s) 114861, ISSN 0014-4886
Editor: Academic Press
DOI: 10.1016/j.expneurol.2024.114861

Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine

Autores: Daniela Sofia Abreu, Joana I. Gomes, Filipa F. Ribeiro, Maria J. Diógenes, Ana M. Sebastião, Sandra H. Vaz
Publicado en: Frontiers in Cellular Neuroscience, Edición 17, 2023, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1282841

Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex

Autores: Biagio Orlando, Alessandra Morano, Valeria Manzini, Emanuele Cerulli Irelli, Maria S. Borioni, Caterina Veroni, Enrico Michele Salamone, Chiara D'Amelio, Elisa Moliterni, Sandra Giustini, Gabriele Ruffolo, Ivan Arisi, Mara D'Onofrio, Anna T. Giallonardo, Paola Piscopo, Carlo Di Bonaventura
Publicado en: Neurology, Edición 101, 2024, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000207799

Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome

Autores: Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Publicado en: Antioxidants, Edición 12, 2023, Página(s) 111, ISSN 2076-3921
Editor: MDPI
DOI: 10.3390/antiox12010111

Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy

Autores: Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Mühlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth François, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rüber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet, Eleonora Aro
Publicado en: Acta Neuropathologica, Edición 142, 2021, Página(s) 729-759, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-021-02348-6

Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

Autores: Ana M. Sebastião, Joaquim Alexandre Ribeiro
Publicado en: Neuropharmacology, Edición 236, 2023, Página(s) 109600, ISSN 0028-3908
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2023.109600

The Gelatinase Inhibitor ACT-03 Reduces Gliosis in the Rapid Kindling Rat Model of Epilepsy, and Attenuates Inflammation and Loss of Barrier Integrity In Vitro

Autores: Diede W. M. Broekaart, Till S. Zimmer, Sophie T. Cohen, Rianne Tessers, Jasper J. Anink, Helga E. de Vries, Jan A. Gorter, Roger Prades, Eleonora Aronica, Erwin A. van Vliet
Publicado en: Biomedicines, Edición 10, 2024, Página(s) 2117, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10092117

Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine

Autores: Nádia Rei, Cláudia A. Valente, Sandra H. Vaz, Miguel Farinha-Ferreira, Joaquim A. Ribeiro, Ana M. Sebastião
Publicado en: PLOS ONE, Edición 17, 2022, Página(s) e0272104, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0272104

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.

Autores: Anatoly Korotkov; Nam Suk Sim; Mark J. Luinenburg; Jasper J. Anink; Jackelien van Scheppingen; Jackelien van Scheppingen; Till S. Zimmer; Anika Bongaarts; Diede W. M. Broekaart; Caroline Mijnsbergen; Floor E. Jansen; Wim Van Hecke; Wim G.M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna Jansen;
Publicado en: VOLUME=47;ISSUE=6;STARTPAGE=796;ENDPAGE=811;ISSN=0305-1846;TITLE=Neuropathology and applied neurobiology, Edición 38, 2021, ISSN 1365-2990
Editor: Wiley Online Library
DOI: 10.1111/nan.12717

Manganese dioxide nanosheet-containing reactors as antioxidant support for neuroblastoma cells

Autores: Oksana K. Savchak, Nanying Wang, Miguel A. Ramos-Docampo, Paula de Dios Andres, Ana M. Sebastião, Filipa F. Ribeiro, Adam Armada-Moreira, Brigitte Städler, Sandra H. Vaz
Publicado en: Journal of Materials Chemistry B, Edición 10, 2024, Página(s) 4672-4683, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/d2tb00393g

Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy

Autores: Pierangelo Cifelli, Silvia Di Angelantonio, Veronica Alfano, Alessandra Morano, Eleonora De Felice, Eleonora Aronica, Gabriele Ruffolo, Eleonora Palma
Publicado en: Brain Sciences, 2021, ISSN 2076-3425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci11040441

Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors

Autores: Jody M. de Jong, Diede W. M. Broekaart, Anika Bongaarts, Angelika Mühlebner, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Publicado en: Biomedicines, Edición 10, 2024, Página(s) 2475, ISSN 2227-9059
Editor: Biomedicines
DOI: 10.3390/biomedicines10102475

mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment

Autores: Teresa Ravizza, Mirte Scheper, Rossella Di Sapia, Jan Gorter, Eleonora Aronica, Annamaria Vezzani
Publicado en: Nature Reviews Neuroscience, Edición 25, 2024, Página(s) 334-350, ISSN 1471-003X
Editor: Nature Publishing Group
DOI: 10.1038/s41583-024-00805-1

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

Autores: Gonçalo Costa, Filipa F. Ribeiro, Ana M. Sebastião, Elizabeth M. Muir, Sandra H. Vaz
Publicado en: Frontiers in Neuroscience, Edición 16, 2023, ISSN 1662-453X
Editor: Frontiers in Neuroscience
DOI: 10.3389/fnins.2022.1003145

Astrocytes in the initiation and progression of epilepsy

Autores: Annamaria Vezzani, Teresa Ravizza, Peter Bedner, Eleonora Aronica, Christian Steinhäuser, Detlev Boison
Publicado en: Nature Reviews Neurology, Edición 18, 2022, Página(s) 707-722, ISSN 1759-4758
Editor: Nature Publishing Group
DOI: 10.1038/s41582-022-00727-5

Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents

Autores: Frances S. Cho, Ilia D. Vainchtein, Yuliya Voskobiynyk, Allison R. Morningstar, Francisco Aparicio, Bryan Higashikubo, Agnieszka Ciesielska, Diede W. M. Broekaart, Jasper J. Anink, Erwin A. van Vliet, Xinzhu Yu, Baljit S. Khakh, Eleonora Aronica, Anna V. Molofsky, Jeanne T. Paz
Publicado en: Science Translational Medicine, Edición 14, 2024, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abj4310

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia 2B brain lesions.

Autores: Victoria-Elisabeth Gruber, Mark J. Luinenburg, Katrin Colleselli, Verena Endmayr, J. Anink, Till S. Zimmer, Floor Jansen, Peter Gosselaar, Roland Coras, Theresa Scholl, Jackelien van Scheppingen, Ingmar Blumcke, José Pimentel, Johannes A. Hainfellner, Romana Höftberger, Karl Rössler, Martha Feucht, Eleonora Aronica, and Angelika Mühlebner.
Publicado en: Epilepsia, 2021, ISSN 1528-1167
Editor: Wiley Online Library
DOI: 10.1111/epi.17139

CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy

Autores: Rossella Di Sapia, Till S. Zimmer, Valentina Kebede, Silvia Balosso, Teresa Ravizza, Diletta Sorrentino, Manuel Alejandro Montano Castillo, Luca Porcu, Franca Cattani, Anna Ruocco, Eleonora Aronica, Marcello Allegretti, Laura Brandolini, Annamaria Vezzani
Publicado en: Neurobiology of Disease, Edición 158, 2022, Página(s) 105468, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2021.105468

Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex

Autores: Mirte Scheper, Frederik N. F. Sørensen, Gabriele Ruffolo, Alessandro Gaeta, Lilian J. Lissner, Jasper J. Anink, Irina Korshunova, Floor E. Jansen, Kate Riney, Wim van Hecke, Angelika Mühlebner, Konstantin Khodosevich, Dirk Schubert, Eleonora Palma, James D. Mills, Eleonora Aronica
Publicado en: Acta Neuropathologica, Edición 147, 2024, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-024-02737-7

SIGAA: signaling automated analysis: a new tool for Ca2+ signaling quantification using ratiometric Ca2+ dyes

Autores: Rafael Faria Lopes, Joana Gonçalves-Ribeiro, Ana M. Sebastião, Carlos Meneses, Sandra H. Vaz
Publicado en: Signal, Image and Video Processing, Edición 18, 2024, Página(s) 1273-1284, ISSN 1863-1703
Editor: Springer Verlag
DOI: 10.1007/s11760-023-02821-7

GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol

Autores: Gabriele Ruffolo, Alessandro Gaeta, Beatrice Cannata, Camilla Pinzaglia, Eleonora Aronica, Alessandra Morano, Pierangelo Cifelli, Eleonora Palma
Publicado en: Life, Edición 12, 2024, Página(s) 2042, ISSN 2075-1729
Editor: MDPI
DOI: 10.3390/life12122042

Advances in the genetics and neuropathology of tuberous sclerosis complex: edging closer to targeted therapy

Autores: Paolo Curatolo, Nicola Specchio, Eleonora Aronica
Publicado en: The Lancet Neurology, Edición 21, 2023, Página(s) 843-856, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00213-7

Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Autores: Anatoly Korotkov; Mark J. Luinenburg; Alessia Romagnolo; Till S. Zimmer; Jackelien van Scheppingen; Anika Bongaarts; Diede W.M. Broekaart; Jasper J. Anink; Caroline Mijnsbergen; Floor E. Jansen; Wim van Hecke; Wim G. M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna C. Jansen; David J. Kwiatkow
Publicado en: Journal of Neurodevelopmental isorders, 2021, ISSN 1866-1947
Editor: Springer Verlag
DOI: 10.1186/s11689-022-09416-2

Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

Autores: Diogo M. Lourenço, Rita Soares, Sónia Sá-Santos, Joana M. Mateus, Rui S. Rodrigues, João B. Moreira, Sandra H. Vaz, Ana M. Sebastião, Susana Solá, Sara Xapelli
Publicado en: European Journal of Pharmacology, Edición 959, 2024, Página(s) 176079, ISSN 0014-2999
Editor: Elsevier BV
DOI: 10.1016/j.ejphar.2023.176079

Generalized Fast Discharges Along the Genetic Generalized Epilepsy Spectrum: Clinical and Prognostic Significance.

Autores: Placidi, Anna Teresa Giallonardo, Francesca Izzi and Carlo Di Bonaventura
Publicado en: rontiers in Neurology, 2022, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.844674

Cognitive comorbidities of experimental absence seizures are independent of anxiety

Autores: Mariana Neuparth-Sottomayor, Carolina C. Pina, Tatiana P. Morais, Miguel Farinha-Ferreira, Daniela Sofia Abreu, Filipa Solano, Francisco Mouro, Mark Good, Ana Maria Sebastião, Giuseppe Di Giovanni, Vincenzo Crunelli, Sandra H. Vaz
Publicado en: Neurobiology of Disease, Edición 186, 2023, Página(s) 106275, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2023.106275

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

Autores: Filipa F Ribeiro, Filipa Ferreira, Rui S Rodrigues, Rita Soares, Diogo M Pedro, Marta Duarte-Samartinho, Rita I Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Solá, Helena Mira, Ana M Sebastião, Sara Xapelli
Publicado en: Stem Cells, 2021, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1002/stem.3421

Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes

Autores: Mark J. Luinenburg, Mirte Scheper, Frederik N. F. Sørensen, Jasper J. Anink, Wim Van Hecke, Irina Korshunova, Floor E. Jansen, Kate Riney, Pieter van Eijsden, Peter Gosselaar, James D. Mills, Rozemarijn S. Kalf, Till S. Zimmer, Diede W. M. Broekaart, Konstantin Khodosevich, Eleonora Aronica, Angelika Mühlebner
Publicado en: Frontiers in Cellular Neuroscience, Edición 17, 2023, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1284394

Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

Autores: • Anika Bongaarts, Caroline Mijnsbergen, Jasper J. Anink, Floor E. Jansen, Wim G.M. Spliet, Wilfred F.A. den Dunnen, Roland Coras, Ingmar Blümcke, Werner Paulus, Victoria E. Gruber, Theresa Scholl, Johannes A. Hainfellner, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Wieslawa Grajkowska, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Figen Söylemezoğlu, J
Publicado en: Cellular and Molecular Neurobiology, 2021, ISSN 0272-4340
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10571-021-01157-5

Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females

Autores: Catarina Miranda-Lourenço, Jéssica Rosa, Nádia Rei, Rita F. Belo, Ana Luísa Lopes, Diogo Silva, Cátia Vieira, Teresa Magalhães-Cardoso, Ricardo Viais, Paulo Correia-de-Sá, Ana M. Sebastião, Maria J. Diógenes
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 16249, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242216249

Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder.

Autores: Joana Gomes; Miguel Farinha-Ferreira; Nádia Rei; Joana Gonçalves-Ribeiro; Joaquim A. Ribeiro; Ana M. Sebastião; Sandra H. Vaz
Publicado en: Pharmacological Research, Edición Volume 163, January 2021, 105363, 2020, ISSN 1043-6618
Editor: Academic Press
DOI: 10.1016/j.phrs.2020.105363

Traditional and Innovative Anti-seizure Medications Targeting Key PhysiopathologicalMechanisms: Focus on Neurodevelopment and Neurodegeneration

Autores: Miriam Sciaccaluga, Gabriele Ruffolo, Eleonora Palma, Cinzia Costa
Publicado en: Current Neuropharmacology, Edición 21, 2023, Página(s) 1736-1754, ISSN 1570-159X
Editor: Bentham Science Publishers
DOI: 10.2174/1570159x21666230504160948

Balloon cells promote immune system activation in focal cortical dysplasia type 2b.

Autores: Till S. Zimmer; Diede W. M. Broekaart; Mark J. Luinenburg; Caroline Mijnsbergen; Jasper J. Anink; Nam Suk Sim; Iliana Michailidou; Floor E. Jansen; Peter C. van Rijen; Jeong Ho Lee; Liesbeth François; Jonathan van Eyll; Stefanie Dedeurwaerdere; Stefanie Dedeurwaerdere; Erwin A. van Vliet; Angelika Mühlebner; Angelika Mühlebner; James D. Mills; Eleonora Aronica
Publicado en: Neuropathology and Applied Neurobiology, Edición 39, 2021, ISSN 1365-2990
Editor: Wiley Online Library
DOI: 10.1111/nan.12736

Astroglial calcium signaling and homeostasis in tuberous sclerosis complex

Autores: Alessia Romagnolo, Giulia Dematteis, Mirte Scheper, Mark J. Luinenburg, Angelika Mühlebner, Wim Van Hecke, Marcello Manfredi, Veronica De Giorgis, Simone Reano, Nicoletta Filigheddu, Valeria Bortolotto, Laura Tapella, Jasper J. Anink, Liesbeth François, Stefanie Dedeurwaerdere, James D. Mills, Armando A. Genazzani, Dmitry Lim, Eleonora Aronica
Publicado en: Acta Neuropathologica, Edición 147, 2024, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-024-02711-3

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

Autores: Till S. Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E. Jansen, Fried J. T. Zwartkruis, Nicholas R. Rensing, Michael Wong, Angelika Mühlebner, Erwin A. van Vliet, Eleonora Aronica, James D. Mills
Publicado en: Brain Pathology, 2021, ISSN 1750-3639
Editor: Wiley Online Library
DOI: 10.1111/bpa.12949

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats

Autores: Sara L. Paulo; Catarina Miranda-Lourenço; Rita F. Belo; Rui S. Rodrigues; João Fonseca-Gomes; Sara R. Tanqueiro; Vera Geraldes; Isabel Rocha; Ana M. Sebastião; Sara Xapelli; Maria J. Diógenes
Publicado en: Current Edicións in Molecular Biology, Vol 43, Iss 162, Pp 2305-2319 (2021), Edición 9, 2021, ISSN 1467-3045
Editor: MDPI
DOI: 10.3390/cimb43030162

GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β

Autores: Gabriele Ruffolo, Veronica Alfano, Alessia Romagnolo, Till Zimmer, James D. Mills, Pierangelo Cifelli, Alessandro Gaeta, Alessandra Morano, Jasper Anink, Angelika Mühlebner, Annamaria Vezzani, Eleonora Aronica, Eleonora Palma
Publicado en: Scientific Reports, Edición 12, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-22806-9

Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice

Autores: Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B. Relvas, Ana M. Sebastião, Sandra H. Vaz
Publicado en: Neurobiology of Disease, Edición 193, 2024, Página(s) 106435, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2024.106435

Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar‐Kyoto rat model of depression

Autores: Miguel Farinha‐Ferreira, Daniela M. Magalhães, Mariana Neuparth‐Sottomayor, Hugo Rafael, Catarina Miranda‐Lourenço, Ana M. Sebastião
Publicado en: Journal of Neurochemistry, 2024, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16083

Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice

Autores: Sara R Tanqueiro, Francisco M Mouro, Catarina B Ferreira, Céline F Freitas, João Fonseca-Gomes, Frederico Simões do Couto, Ana M Sebastião, Neil Dawson, Maria J Diógenes
Publicado en: Journal of Psychopharmacology, Edición 35, 2021, Página(s) 730-743, ISSN 0269-8811
Editor: SAGE Publications
DOI: 10.1177/02698811211008560

The sphingosine 1‐phosphate analogue, <scp>FTY720</scp>, modulates the lipidomic signature of the mouse hippocampus

Autores: Daniela M. Magalhães, Nicolas A. Stewart, Myrthe Mampay, Sara O. Rolle, Chloe M. Hall, Emad Moeendarbary, Melanie S. Flint, Ana M. Sebastião, Cláudia A. Valente, Marcus K. Dymond, Graham K. Sheridan
Publicado en: Journal of Neurochemistry, Edición 168, 2024, Página(s) 1113-1142, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16073

Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence.

Autores: Federica Avorio; Federica Avorio; Emanuele Cerulli Irelli; Alessandra Morano; Martina Fanella; Biagio Orlando; Mariarita Albini; Luca M. Basili; Gabriele Ruffolo; Jinane Fattouch; Mario Manfredi; Emilio Russo; Pasquale Striano; Marilia Carabotti; Anna Teresa Giallonardo; Carola Severi; Carlo Di Bonaventura
Publicado en: Frontiers in Neurology, Vol 12 (2021), Edición 23, 2021, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.705126

Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity

Autores: Stefania Scalise, Clara Zannino, Valeria Lucchino, Michela Lo Conte, Luana Scaramuzzino, Pierangelo Cifelli, Tiziano D’Andrea, Katiuscia Martinello, Sergio Fucile, Eleonora Palma, Antonio Gambardella, Gabriele Ruffolo, Giovanni Cuda, Elvira Immacolata Parrotta
Publicado en: Biomedicines, Edición 10, 2024, Página(s) 1075, ISSN 2227-9059
Editor: Frontiers
DOI: 10.3390/biomedicines10051075

Autores: Daniela M. Magalhães, Myrthe Mampay, Ana M. Sebastião, Graham K. Sheridan, Cláudia A. Valente
Publicado en: Neurochemistry International, Edición 174, 2024, Página(s) 105678, ISSN 0197-0186
Editor: Elsevier BV
DOI: 10.1016/j.neuint.2024.105678

Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior

Autores: Miguel Farinha-Ferreira, Nádia Rei, João Fonseca-Gomes, Catarina Miranda-Lourenço, Paula Serrão, Sandra H. Vaz, Joana I. Gomes, Valéria Martins, Beatriz de Alves Pereira, Ana M. Sebastião
Publicado en: Neuropharmacology, Edición 214, 2023, Página(s) 109155, ISSN 0028-3908
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2022.109155

Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging

Autores: Erwin A van Vliet, Nicola Marchi.
Publicado en: Epilepsy, 2022, ISSN 1528-1167
Editor: Wiley Online Library
DOI: 10.1111/epi.17210

Neuroprotective effects of platinum nanoparticle-based microreactors in bicuculline-induced seizures

Autores: Roberto N. Oliveira, Patrícia S. Carvalhinho-Lopes, Carolina P.F. Carvalho, Rafael Y.S. Hirata, Sandra H. Vaz, Ana Maria Sebastião, Adam Armada-Moreira, Bárbara A. Rosário, Jéssica A. Lemes, Beatriz Soares-Silva, José S. de Andrade, José Ronaldo Santos, Alessandra M. Ribeiro, Milena B. Viana
Publicado en: Behavioural Brain Research, Edición 465, 2024, Página(s) 114956, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2024.114956

Editorial: Cellular and molecular targets in epileptogenesis focusing on disease prevention

Autores: Diana Cunha-Reis, Sandra Henriques Vaz, Paulo Correia-de-Sá
Publicado en: Frontiers in Cellular Neuroscience, Edición 17, 2023, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1251038

Microglia Depletion from Primary Glial Cultures Enables to Accurately Address the Immune Response of Astrocytes

Autores: Mariana Van Zeller, Ana M. Sebastião, Cláudia A. Valente
Publicado en: Biomolecules, Edición 12, 2024, Página(s) 666, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom12050666

A maestro role of adenosine A

Autores: Sebastião, Ana M.
Publicado en: Purinergic Signal, Edición 6, 2022
Editor: Purinergic signalling

Astrocytes in Amyotrophic Lateral Sclerosis

Autores: Sandra H. Vaz, Sara Pinto, Ana M. Sebastião, and Dora Brites.
Publicado en: Amyotrophic Lateral Sclerosis., 2021, ISBN 978-0-6450017-7-8
Editor: Exon Publications
DOI: 10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021

An Overview of Adult Neurogenesis

Autores: Filipa F. Ribeiro, Sara Xapelli
Publicado en: Advances in Experimental Medicine and Biology, Recent Advances in NGF and Related Molecules, 2021, Página(s) 77-94
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-74046-7_7

Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis

Autores: Filipa F. Ribeiro, Sara Xapelli
Publicado en: Advances in Experimental Medicine and Biology, Recent Advances in NGF and Related Molecules, 2021, Página(s) 95-115
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-74046-7_8

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