Epileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies

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A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Auteurs: Cláudia A. Valente; Francisco J Meda; Mafalda Carvalho; Ana M. Sebastião
Publié dans: Journal of Visualized Experiments, Numéro 24, 2021, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/61330

Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy

Auteurs: Diogo M Lourenço, Leonor Ribeiro-Rodrigues, Ana M Sebastião, Maria J Diógenes, Sara Xapelli.
Publié dans: International Journal of Molecular Sciences, 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197309

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.

Auteurs: Anatoly Korotkov; Nam Suk Sim; Mark J. Luinenburg; Jasper J. Anink; Jackelien van Scheppingen; Jackelien van Scheppingen; Till S. Zimmer; Anika Bongaarts; Diede W. M. Broekaart; Caroline Mijnsbergen; Floor E. Jansen; Wim Van Hecke; Wim G.M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna Jansen;
Publié dans: VOLUME=47;ISSUE=6;STARTPAGE=796;ENDPAGE=811;ISSN=0305-1846;TITLE=Neuropathology and applied neurobiology, Numéro 38, 2021, ISSN 1365-2990
Éditeur: Wiley Online Library
DOI: 10.1111/nan.12717

Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy

Auteurs: Pierangelo Cifelli, Silvia Di Angelantonio, Veronica Alfano, Alessandra Morano, Eleonora De Felice, Eleonora Aronica, Gabriele Ruffolo, Eleonora Palma
Publié dans: Brain Sciences, 2021, ISSN 2076-3425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci11040441

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia 2B brain lesions.

Auteurs: Victoria-Elisabeth Gruber, Mark J. Luinenburg, Katrin Colleselli, Verena Endmayr, J. Anink, Till S. Zimmer, Floor Jansen, Peter Gosselaar, Roland Coras, Theresa Scholl, Jackelien van Scheppingen, Ingmar Blumcke, José Pimentel, Johannes A. Hainfellner, Romana Höftberger, Karl Rössler, Martha Feucht, Eleonora Aronica, and Angelika Mühlebner.
Publié dans: Epilepsia, 2021, ISSN 1528-1167
Éditeur: Wiley Online Library
DOI: 10.1111/epi.17139

Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Auteurs: Anatoly Korotkov; Mark J. Luinenburg; Alessia Romagnolo; Till S. Zimmer; Jackelien van Scheppingen; Anika Bongaarts; Diede W.M. Broekaart; Jasper J. Anink; Caroline Mijnsbergen; Floor E. Jansen; Wim van Hecke; Wim G. M. Spliet; Peter C. van Rijen; Martha Feucht; Johannes A. Hainfellner; Pavel Krsek; Josef Zamecnik; Peter B. Crino; Katarzyna Kotulska; Lieven Lagae; Anna C. Jansen; David J. Kwiatkow
Publié dans: Journal of Neurodevelopmental isorders, 2021, ISSN 1866-1947
Éditeur: Springer Verlag
DOI: 10.1186/s11689-022-09416-2

Generalized Fast Discharges Along the Genetic Generalized Epilepsy Spectrum: Clinical and Prognostic Significance.

Auteurs: Placidi, Anna Teresa Giallonardo, Francesca Izzi and Carlo Di Bonaventura
Publié dans: rontiers in Neurology, 2022, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.844674

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

Auteurs: Filipa F Ribeiro, Filipa Ferreira, Rui S Rodrigues, Rita Soares, Diogo M Pedro, Marta Duarte-Samartinho, Rita I Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Solá, Helena Mira, Ana M Sebastião, Sara Xapelli
Publié dans: Stem Cells, 2021, ISSN 1066-5099
Éditeur: AlphaMed Press Inc
DOI: 10.1002/stem.3421

Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

Auteurs: • Anika Bongaarts, Caroline Mijnsbergen, Jasper J. Anink, Floor E. Jansen, Wim G.M. Spliet, Wilfred F.A. den Dunnen, Roland Coras, Ingmar Blümcke, Werner Paulus, Victoria E. Gruber, Theresa Scholl, Johannes A. Hainfellner, Martha Feucht, Katarzyna Kotulska, Sergiusz Jozwiak, Wieslawa Grajkowska, Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Lorenzo Genitori, Figen Söylemezoğlu, J
Publié dans: Cellular and Molecular Neurobiology, 2021, ISSN 0272-4340
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10571-021-01157-5

Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder.

Auteurs: Joana Gomes; Miguel Farinha-Ferreira; Nádia Rei; Joana Gonçalves-Ribeiro; Joaquim A. Ribeiro; Ana M. Sebastião; Sandra H. Vaz
Publié dans: Pharmacological Research, Numéro Volume 163, January 2021, 105363, 2020, ISSN 1043-6618
Éditeur: Academic Press
DOI: 10.1016/j.phrs.2020.105363

Balloon cells promote immune system activation in focal cortical dysplasia type 2b.

Auteurs: Till S. Zimmer; Diede W. M. Broekaart; Mark J. Luinenburg; Caroline Mijnsbergen; Jasper J. Anink; Nam Suk Sim; Iliana Michailidou; Floor E. Jansen; Peter C. van Rijen; Jeong Ho Lee; Liesbeth François; Jonathan van Eyll; Stefanie Dedeurwaerdere; Stefanie Dedeurwaerdere; Erwin A. van Vliet; Angelika Mühlebner; Angelika Mühlebner; James D. Mills; Eleonora Aronica
Publié dans: Neuropathology and Applied Neurobiology, Numéro 39, 2021, ISSN 1365-2990
Éditeur: Wiley Online Library
DOI: 10.1111/nan.12736

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

Auteurs: Till S. Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E. Jansen, Fried J. T. Zwartkruis, Nicholas R. Rensing, Michael Wong, Angelika Mühlebner, Erwin A. van Vliet, Eleonora Aronica, James D. Mills
Publié dans: Brain Pathology, 2021, ISSN 1750-3639
Éditeur: Wiley Online Library
DOI: 10.1111/bpa.12949

Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Auteurs: Catarina Miranda-Lourenço, Sofia T. Duarte, Cátia Palminha, Cláudia Gaspar, Tiago M. Rodrigues, Teresa Magalhães-Cardoso, Nádia Rei, Mariana Colino-Oliveira, Rui Gomes, Sara Ferreira, Jéssica Rosa, Sara Xapelli, Judith Armstrong, Àngels García-Cazorla, Paulo Correia-de-Sá, Ana M. Sebastião, Maria José Diógenes
Publié dans: Neurobiology of Disease, Numéro 145, 2020, Page(s) 105043, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.nbd.2020.105043

High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats

Auteurs: Sara L. Paulo; Catarina Miranda-Lourenço; Rita F. Belo; Rui S. Rodrigues; João Fonseca-Gomes; Sara R. Tanqueiro; Vera Geraldes; Isabel Rocha; Ana M. Sebastião; Sara Xapelli; Maria J. Diógenes
Publié dans: Current Numéros in Molecular Biology, Vol 43, Iss 162, Pp 2305-2319 (2021), Numéro 9, 2021, ISSN 1467-3045
Éditeur: MDPI
DOI: 10.3390/cimb43030162

Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence.

Auteurs: Federica Avorio; Federica Avorio; Emanuele Cerulli Irelli; Alessandra Morano; Martina Fanella; Biagio Orlando; Mariarita Albini; Luca M. Basili; Gabriele Ruffolo; Jinane Fattouch; Mario Manfredi; Emilio Russo; Pasquale Striano; Marilia Carabotti; Anna Teresa Giallonardo; Carola Severi; Carlo Di Bonaventura
Publié dans: Frontiers in Neurology, Vol 12 (2021), Numéro 23, 2021, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.705126

Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging

Auteurs: Erwin A van Vliet, Nicola Marchi.
Publié dans: Epilepsy, 2022, ISSN 1528-1167
Éditeur: Wiley Online Library
DOI: 10.1111/epi.17210

Astrocytes in Amyotrophic Lateral Sclerosis

Auteurs: Sandra H. Vaz, Sara Pinto, Ana M. Sebastião, and Dora Brites.
Publié dans: Amyotrophic Lateral Sclerosis., 2021, ISBN 978-0-6450017-7-8
Éditeur: Exon Publications
DOI: 10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021

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