INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS

Informations projet

INKplant

N° de convention de subvention: 953134

DOI

10.3030/953134

Projet clôturé

Date de signature de la CE 16 Decembre 2020

Date de début 1 Janvier 2021

Date de fin 30 Juin 2024

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coût total

€ 5 988 155,00

Contribution de l’UE

€ 5 988 155,00

Coordonné par

PROFACTOR GMBH
Austria

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Demonstrators, pilots, prototypes (3)

Open source collection of scaffolding structures with design maps

Collection of bioinspired lattice, porous and cellular structures according to Task 6.1 (MUW, UPM, JKU). The collection or library will be shared online as open source design files, blueprints & props.

Results of biomimetic structures (TS3 and TS4) from D5.3 for in-vivo testing

Test Structures 3 and 4 according to Task 5.4 for mechanical and for in vivo testing ready to be tested.

Final demonstrators using anonymized patient data for the use cases

Demonstrators for Use Case 1 (TTS, CHT, BMC) according to Task 8.2 and Use Case 2 (MUW, KUK, BTI, BMC) according to Task 8.3.

Websites, patent fillings, videos etc. (2)

Results from web-forums and Twitter data mining

Results from web-forums and Twitter data mining according to Task 9.1.

Launch of open online calls for use case ideas

Launch of open online calls according to Task 9.4. to open INKplant to external users and collect new ideas.

Documents, reports (1)

User acceptance study

User acceptance study.9.4 and 9.5 Results of User acceptance study according to Subtask 9.5.1 and organization of OI & stakeholder workshops (Chapter 2.2.2) according to Task 9.4 in different European countries during the project: UMC (2), CHT (1) and MUW (1), BTI (2). Results of “Intimate Implant: A public engagement project” (UMC).

Publications

Peer reviewed articles (24)

Personalized 3D printed scaffolds: The ethical aspects

Auteurs: Manon van Daal , Anne-Floor J. de Kanter , Annelien L. Bredenoord , Nienke de Graeff
Publié dans: New Biotechnology, Numéro Volume 78, 25 December 2023, 2023, Page(s) Pages 116-122, ISSN 1876-4347
Éditeur: Elsevier
DOI: 10.1016/j.nbt.2023.10.006

Assessment of geometrical variability in 3D printed ZrO2: Effects of printing and thermal post-processing

Auteurs: Erik Kornfellner, Filip Jelínek, Laszlo Jaksa, Anna Lebhard, Daniel Bomze, Martin Schwentenwein, Francesco Moscato
Publié dans: Open Ceramics, Numéro 19, 2024, Page(s) 100629, ISSN 2666-5395
Éditeur: Elsevier
DOI: 10.1016/j.oceram.2024.100629

3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review

Auteurs: Simon Enbergs; Jacob Spinnen; Tilo Dehne; Michael Sittinger
Publié dans: Journal of Tissue Engineering and Regenerative Medicine, 2023, ISSN 1932-6254
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1155/2023/3901448

A value hierarchy for inclusive design of heart valve implants in regenerative medicine1

Auteurs: Anne Johanna De Kanter, anon Van Daal, Callum J Gunn, Annelien L Bredenoord, Nienke DeGraeff, Karin R Jongsma,
Publié dans: Regenerative Medicine, 2024, ISSN 1746-076X
Éditeur: Taylor & Francis
DOI: 10.1080/17460751.2024.2357500

Hybrid design and prototyping of metamaterials and metasurfaces

Auteurs: Francisco Franco-Martínez; Christian Grasl; Erik Kornfellner; Matthias Vostatek; Adrián Martínez Cendrero; Francesco Moscato; Andrés Díaz Lantada
Publié dans: Virtual and Physical Prototyping, Numéro Volume 17, 2022 - Numéro 4, 2022, Page(s) 1031 - 1046, ISSN 1745-2759
Éditeur: Taylor & Francis
DOI: 10.1080/17452759.2022.2101009

Topology optimisation and lithography-based ceramic manufacturing of short-stem hip prostheses with enhanced biomechanical and mechanobiological performance

Auteurs: William Solórzano-Requejo, Adrián Martínez Cendrero, Altan Alpay Altun, Serkan Nohut, Carlos Ojeda, Javier García Molleja, Jon Molina-Aldareguia, Martin Schwentenwein, Andrés Díaz Lantada
Publié dans: Virtual and Physical Prototyping, Numéro 19, 2024, ISSN 1745-2759
Éditeur: Taylor & Francis
DOI: 10.1080/17452759.2024.2387280

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Auteurs: Michael Kainz; Stjepan Perak; Gerald Stubauer; Sonja Kopp; Sebastian Kauscheder; Julia Hemetzberger; Adrián Martínez Cendrero; Andrés Díaz Lantada; Disha Tupe; Zoltan Major; Dominik Hanetseder; Veronika Hruschka; Susanne Wolbank; Darja Marolt Presen; Michael Mühlberger; Elena Guillén
Publié dans: Polymers 2024, 2024, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym16050655

Fostering creativity in engineering design through constructive dialogues with generative artificial intelligence

Auteurs: William Solórzano Requejo, Francisco Franco Martínez, Carlos Aguilar Vega, Rodrigo Zapata Martínez, Adrián Martínez Cendrero, Andrés Díaz Lantada
Publié dans: Cell Reports Physical Science, Numéro 5, 2024, Page(s) 102157, ISSN 2666-3864
Éditeur: Cell Press
DOI: 10.1016/j.xcrp.2024.102157

Clinical performance of additively manufactured subperiosteal implants: a systematic review

Auteurs: Eduardo Anitua, Asier Eguia, Christoph Staudigl & Mohammad Hamdan Alkhraisat
Publié dans: International Journal of Implant Dentistry, 2024, ISSN 2198-4034
Éditeur: Springer Nature
DOI: 10.1186/s40729-024-00521-6

Preventing Bias in Medical Devices: IdentifyingMorally Significant Differences

Auteurs: Anne-Floor J. de Kanter, Manon van Daal, Nienke de Graeff & Karin R. Jongsma
Publié dans: The American Journal of Bioethics, Numéro 23:4, 2023, Page(s) 35-37, ISSN 1536-0075
Éditeur: Taylor & Francis
DOI: 10.1080/15265161.2023.2186516

Biodegradable resins for photochemical 3D printing via vinyl ester and vinyl carbonate functionalized amino acid-phosphoramidates

Auteurs: Stephan Haudum a, Berfin Demirdögen a, Laura Müller-Müchler b, Sophie Carolin Döttl b, Stefanie Monika Müller c, Christoph Naderer d, Oliver Brüggemann a, Thomas Griesser c, Jaroslaw Jacak d, Eleni Priglinger b, Ian Teasdale
Publié dans: European Polymer Journal, Numéro Volume 211, 15 May 2024, 113037, 2024, ISSN 1873-1945
Éditeur: Elsevier Ltd
DOI: 10.1016/j.eurpolymj.2024.113037

3D Inkjet Printing of Biomaterials with Solvent-Free, Thiol-Yne-Based Photocurable Inks

Auteurs: Michael Kainz,* Stephan Haudum, Elena Guillén, Oliver Brüggemann, Rita Höller, Heike Frommwald, Tilo Dehne, Michael Sittinger, Disha Tupe, Zoltan Major, Gerald Stubauer, Thomas Griesser,* and Ian Teasdale*
Publié dans: Macromolecular Materials and Engineering, Numéro Volume309, Numéro5, 2024, ISSN 1439-2054
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/mame.202400028

Quantitatively measuring the cytotoxicity of viscous hydrogels with direct cell sampling in a micro scale format “MicroDrop” and its comparison to CCK8

Auteurs: Anna Marie Margot, Andreas Engels, Michael Sittinger, Tilo Dehne, Shabnam Hemmati-Sadeghi
Publié dans: Journal of Materials Science: Materials in Medicine, Numéro 35, 2024, ISSN 1573-4838
Éditeur: Springer Nature
DOI: 10.1007/s10856-024-06800-3

Amino acid-based polyphosphorodiamidates with hydrolytically labile bonds for degradation-tuned photopolymers

Auteurs: Stephan Haudum; Stefan Lenhart; Stefanie M. Müller; Disha Tupe; Christoph Naderer; Tilo Dehne; Michael Sittinger; Zoltan Major; Thomas Griesser; Oliver Brüggemann; Jaroslaw Jacak; Ian Teasdale
Publié dans: ACS Macro Letters, Numéro Volume 12, Numéro 6, 2023, Page(s) 673-678, ISSN 2161-1653
Éditeur: American Chemical Society
DOI: 10.1021/acsmacrolett.3c00173

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Auteurs: Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro Volume 11 - 2023, 2023, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1214019

Mechanical properties of additively manufactured lattice structures composed of zirconia and hydroxyapatite ceramics

Auteurs: Erik Kornfellner, Stefan Reininger, Sebastian Geier, Martin Schwentenwein, Emir Benca, Stefan Scheiner, Francesco Moscato
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, Numéro 158, 2024, Page(s) 106644, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106644

Open-source library of tissue engineering scaffolds

Auteurs: Adrián Martínez Cendrero, Francisco Franco Martínez, William Gabriel Solórzano Requejo, Andrés Díaz Lantada
Publié dans: Materials & Design, Numéro 223, 2022, Page(s) 111154, ISSN 0264-1275
Éditeur: Elsevier BV
DOI: 10.1016/j.matdes.2022.111154

Design and optimization of a novel patient-specific subperiosteal implant additively manufactured in yttria-stabilized zirconia

Auteurs: Gunpreet Oberoi, Erik Kornfellner, Daniel Alexander Aigner, Ewald Unger, Martin Schwentenwein, Daniel Bomze, Christoph Staudigl, Dieter Pahr, Francesco Moscato
Publié dans: Dental Materials, Numéro 40, 2024, Page(s) 1568-1574, ISSN 0109-5641
Éditeur: Elsevier BV
DOI: 10.1016/j.dental.2024.07.008

Development of a five-axis printer for the fabrication of hybrid 3D scaffolds: From soft to hard phases and planar to curved surfaces

Auteurs: Michael Kainz1* , Isabel Caetano da Silva1 , Paula Schumann1 , Julia Kastner1 , Thomas Voglhuber1 , Lukas Hartung2 , Sandra Haas1 , Milan Rathod1 , Adrián Martínez Cendrero3 , Tilo Dehne4 , Daniel Seitz5 , Gunpreet Oberoi6,7 , Erik Kornfellner6 , Andrés Díaz Lantada3 , Francesco Moscato6,8,9 , Elena Guillén1*
Publié dans: International Journal of Bioprinting, 2024, ISSN 2424-8002
Éditeur: AccScience Publishing
DOI: 10.36922/ijb.3189

Embodiment and regenerative implants: a proposal for entanglement

Auteurs: Manon van Daal , Anne-Floor J de Kanter , Karin R Jongsma , Annelien L Bredenoord , Nienke de Graeff
Publié dans: Medicine, Health Care and Philosophy, 2024, ISSN 1572-8633
Éditeur: Springer
DOI: 10.1007/s11019-024-10199-7

Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study

Auteurs: Manon van Daal, Anne-Floor J de Kanter, Roel JH Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff
Publié dans: Regenerative Medicine, Numéro 19, 2024, Page(s) 393-406, ISSN 1746-0751
Éditeur: Future Medicine Ltd.
DOI: 10.1080/17460751.2024.2386214

Phosphorus and Silicon-Based Macromolecules as Degradable Biomedical Polymers

Auteurs: Stephan Haudum, Paul Strasser, Ian Teasdale
Publié dans: Macromolecular Bioscience, Numéro Volume23, Numéro11, 2023, ISSN 1616-5187
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202300127

Extracellular matrix from hiPSC-mesenchymal progenitors modulates the three-lineage differentiation of human bone marrow stromal cells

Auteurs: D Hanetseder, B Schaedl, H Redl, D Marolt Presen
Publié dans: eCM Journal - European Cells & Materials, Numéro Volume No 47, 2024, ISSN 1473-2262
Éditeur: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a08

Phosphoramide Hydrogels as Biodegradable Matrices for Inkjet Printing and Their Nano-Hydroxyapatite Composites

Auteurs: Mahsa Mostofizadeh, Michael Kainz, Farzaneh Alihosseini, Stephan Haudum, Mostafa Youssefi, Peter Bauer, Iurii Gnatiuk, Oliver Brüggemann, Katja Zembsch, Uwe Rinner, Catarina Coelho, Elena Guillén, Ian Teasdale
Publié dans: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.4c10532

Other (3)

Engineering Design-controlled Interwoven Multimaterial Scaffolds Combining Hard and Soft Phases

Auteurs: Adrián Martínez Cendrero, Tilo Dehne, Michael Sittinger, Andrés Díaz Lantada
Publié dans: 2023
Éditeur: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-2576924/v1

Open-source collection of tissue engineering scaffolds

Auteurs: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez William Gabriel Solórzano Requejo
Publié dans: 2022
Éditeur: ZENODO
DOI: 10.5281/zenodo.6387574

Open-source library of microtextured geometries for studying cell-material interactions

Auteurs: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez
Publié dans: 2022
Éditeur: ZENODO
DOI: 10.5281/zenodo.6387579

Thesis and dissertations (2)

Biomimetic design and additive manufacturing strategies for multi-scale and multi-material tissue engineering

Auteurs: null null, Adrián Martínez Cendrero
Publié dans: 2024
Éditeur: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.81612

Artificial intelligence aided design of microstructured surfaces for tribology and biointerfaces engineering

Auteurs: Francisco Franco Martínez
Publié dans: 2024
Éditeur: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.77158