INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS

Informazioni relative al progetto

INKplant

ID dell’accordo di sovvenzione: 953134

DOI

10.3030/953134

Progetto chiuso

Data della firma CE 16 Dicembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2024

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Costo totale

€ 5 988 155,00

Contributo UE

€ 5 988 155,00

Coordinato da

PROFACTOR GMBH
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (3)

Open source collection of scaffolding structures with design maps

Collection of bioinspired lattice, porous and cellular structures according to Task 6.1 (MUW, UPM, JKU). The collection or library will be shared online as open source design files, blueprints & props.

Results of biomimetic structures (TS3 and TS4) from D5.3 for in-vivo testing

Test Structures 3 and 4 according to Task 5.4 for mechanical and for in vivo testing ready to be tested.

Final demonstrators using anonymized patient data for the use cases

Demonstrators for Use Case 1 (TTS, CHT, BMC) according to Task 8.2 and Use Case 2 (MUW, KUK, BTI, BMC) according to Task 8.3.

Websites, patent fillings, videos etc. (2)

Results from web-forums and Twitter data mining

Results from web-forums and Twitter data mining according to Task 9.1.

Launch of open online calls for use case ideas

Launch of open online calls according to Task 9.4. to open INKplant to external users and collect new ideas.

Documents, reports (1)

User acceptance study

User acceptance study.9.4 and 9.5 Results of User acceptance study according to Subtask 9.5.1 and organization of OI & stakeholder workshops (Chapter 2.2.2) according to Task 9.4 in different European countries during the project: UMC (2), CHT (1) and MUW (1), BTI (2). Results of “Intimate Implant: A public engagement project” (UMC).

Pubblicazioni

Peer reviewed articles (24)

Personalized 3D printed scaffolds: The ethical aspects

Autori: Manon van Daal , Anne-Floor J. de Kanter , Annelien L. Bredenoord , Nienke de Graeff
Pubblicato in: New Biotechnology, Numero Volume 78, 25 December 2023, 2023, Pagina/e Pages 116-122, ISSN 1876-4347
Editore: Elsevier
DOI: 10.1016/j.nbt.2023.10.006

Assessment of geometrical variability in 3D printed ZrO2: Effects of printing and thermal post-processing

Autori: Erik Kornfellner, Filip Jelínek, Laszlo Jaksa, Anna Lebhard, Daniel Bomze, Martin Schwentenwein, Francesco Moscato
Pubblicato in: Open Ceramics, Numero 19, 2024, Pagina/e 100629, ISSN 2666-5395
Editore: Elsevier
DOI: 10.1016/j.oceram.2024.100629

3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review

Autori: Simon Enbergs; Jacob Spinnen; Tilo Dehne; Michael Sittinger
Pubblicato in: Journal of Tissue Engineering and Regenerative Medicine, 2023, ISSN 1932-6254
Editore: John Wiley & Sons Ltd.
DOI: 10.1155/2023/3901448

A value hierarchy for inclusive design of heart valve implants in regenerative medicine1

Autori: Anne Johanna De Kanter, anon Van Daal, Callum J Gunn, Annelien L Bredenoord, Nienke DeGraeff, Karin R Jongsma,
Pubblicato in: Regenerative Medicine, 2024, ISSN 1746-076X
Editore: Taylor & Francis
DOI: 10.1080/17460751.2024.2357500

Hybrid design and prototyping of metamaterials and metasurfaces

Autori: Francisco Franco-Martínez; Christian Grasl; Erik Kornfellner; Matthias Vostatek; Adrián Martínez Cendrero; Francesco Moscato; Andrés Díaz Lantada
Pubblicato in: Virtual and Physical Prototyping, Numero Volume 17, 2022 - Numero 4, 2022, Pagina/e 1031 - 1046, ISSN 1745-2759
Editore: Taylor & Francis
DOI: 10.1080/17452759.2022.2101009

Topology optimisation and lithography-based ceramic manufacturing of short-stem hip prostheses with enhanced biomechanical and mechanobiological performance

Autori: William Solórzano-Requejo, Adrián Martínez Cendrero, Altan Alpay Altun, Serkan Nohut, Carlos Ojeda, Javier García Molleja, Jon Molina-Aldareguia, Martin Schwentenwein, Andrés Díaz Lantada
Pubblicato in: Virtual and Physical Prototyping, Numero 19, 2024, ISSN 1745-2759
Editore: Taylor & Francis
DOI: 10.1080/17452759.2024.2387280

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Autori: Michael Kainz; Stjepan Perak; Gerald Stubauer; Sonja Kopp; Sebastian Kauscheder; Julia Hemetzberger; Adrián Martínez Cendrero; Andrés Díaz Lantada; Disha Tupe; Zoltan Major; Dominik Hanetseder; Veronika Hruschka; Susanne Wolbank; Darja Marolt Presen; Michael Mühlberger; Elena Guillén
Pubblicato in: Polymers 2024, 2024, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym16050655

Fostering creativity in engineering design through constructive dialogues with generative artificial intelligence

Autori: William Solórzano Requejo, Francisco Franco Martínez, Carlos Aguilar Vega, Rodrigo Zapata Martínez, Adrián Martínez Cendrero, Andrés Díaz Lantada
Pubblicato in: Cell Reports Physical Science, Numero 5, 2024, Pagina/e 102157, ISSN 2666-3864
Editore: Cell Press
DOI: 10.1016/j.xcrp.2024.102157

Clinical performance of additively manufactured subperiosteal implants: a systematic review

Autori: Eduardo Anitua, Asier Eguia, Christoph Staudigl & Mohammad Hamdan Alkhraisat
Pubblicato in: International Journal of Implant Dentistry, 2024, ISSN 2198-4034
Editore: Springer Nature
DOI: 10.1186/s40729-024-00521-6

Preventing Bias in Medical Devices: IdentifyingMorally Significant Differences

Autori: Anne-Floor J. de Kanter, Manon van Daal, Nienke de Graeff & Karin R. Jongsma
Pubblicato in: The American Journal of Bioethics, Numero 23:4, 2023, Pagina/e 35-37, ISSN 1536-0075
Editore: Taylor & Francis
DOI: 10.1080/15265161.2023.2186516

Biodegradable resins for photochemical 3D printing via vinyl ester and vinyl carbonate functionalized amino acid-phosphoramidates

Autori: Stephan Haudum a, Berfin Demirdögen a, Laura Müller-Müchler b, Sophie Carolin Döttl b, Stefanie Monika Müller c, Christoph Naderer d, Oliver Brüggemann a, Thomas Griesser c, Jaroslaw Jacak d, Eleni Priglinger b, Ian Teasdale
Pubblicato in: European Polymer Journal, Numero Volume 211, 15 May 2024, 113037, 2024, ISSN 1873-1945
Editore: Elsevier Ltd
DOI: 10.1016/j.eurpolymj.2024.113037

3D Inkjet Printing of Biomaterials with Solvent-Free, Thiol-Yne-Based Photocurable Inks

Autori: Michael Kainz,* Stephan Haudum, Elena Guillén, Oliver Brüggemann, Rita Höller, Heike Frommwald, Tilo Dehne, Michael Sittinger, Disha Tupe, Zoltan Major, Gerald Stubauer, Thomas Griesser,* and Ian Teasdale*
Pubblicato in: Macromolecular Materials and Engineering, Numero Volume309, Numero5, 2024, ISSN 1439-2054
Editore: Wiley-VCH GmbH
DOI: 10.1002/mame.202400028

Quantitatively measuring the cytotoxicity of viscous hydrogels with direct cell sampling in a micro scale format “MicroDrop” and its comparison to CCK8

Autori: Anna Marie Margot, Andreas Engels, Michael Sittinger, Tilo Dehne, Shabnam Hemmati-Sadeghi
Pubblicato in: Journal of Materials Science: Materials in Medicine, Numero 35, 2024, ISSN 1573-4838
Editore: Springer Nature
DOI: 10.1007/s10856-024-06800-3

Amino acid-based polyphosphorodiamidates with hydrolytically labile bonds for degradation-tuned photopolymers

Autori: Stephan Haudum; Stefan Lenhart; Stefanie M. Müller; Disha Tupe; Christoph Naderer; Tilo Dehne; Michael Sittinger; Zoltan Major; Thomas Griesser; Oliver Brüggemann; Jaroslaw Jacak; Ian Teasdale
Pubblicato in: ACS Macro Letters, Numero Volume 12, Numero 6, 2023, Pagina/e 673-678, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.3c00173

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Autori: Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero Volume 11 - 2023, 2023, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1214019

Mechanical properties of additively manufactured lattice structures composed of zirconia and hydroxyapatite ceramics

Autori: Erik Kornfellner, Stefan Reininger, Sebastian Geier, Martin Schwentenwein, Emir Benca, Stefan Scheiner, Francesco Moscato
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, Numero 158, 2024, Pagina/e 106644, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106644

Open-source library of tissue engineering scaffolds

Autori: Adrián Martínez Cendrero, Francisco Franco Martínez, William Gabriel Solórzano Requejo, Andrés Díaz Lantada
Pubblicato in: Materials & Design, Numero 223, 2022, Pagina/e 111154, ISSN 0264-1275
Editore: Elsevier BV
DOI: 10.1016/j.matdes.2022.111154

Design and optimization of a novel patient-specific subperiosteal implant additively manufactured in yttria-stabilized zirconia

Autori: Gunpreet Oberoi, Erik Kornfellner, Daniel Alexander Aigner, Ewald Unger, Martin Schwentenwein, Daniel Bomze, Christoph Staudigl, Dieter Pahr, Francesco Moscato
Pubblicato in: Dental Materials, Numero 40, 2024, Pagina/e 1568-1574, ISSN 0109-5641
Editore: Elsevier BV
DOI: 10.1016/j.dental.2024.07.008

Development of a five-axis printer for the fabrication of hybrid 3D scaffolds: From soft to hard phases and planar to curved surfaces

Autori: Michael Kainz1* , Isabel Caetano da Silva1 , Paula Schumann1 , Julia Kastner1 , Thomas Voglhuber1 , Lukas Hartung2 , Sandra Haas1 , Milan Rathod1 , Adrián Martínez Cendrero3 , Tilo Dehne4 , Daniel Seitz5 , Gunpreet Oberoi6,7 , Erik Kornfellner6 , Andrés Díaz Lantada3 , Francesco Moscato6,8,9 , Elena Guillén1*
Pubblicato in: International Journal of Bioprinting, 2024, ISSN 2424-8002
Editore: AccScience Publishing
DOI: 10.36922/ijb.3189

Embodiment and regenerative implants: a proposal for entanglement

Autori: Manon van Daal , Anne-Floor J de Kanter , Karin R Jongsma , Annelien L Bredenoord , Nienke de Graeff
Pubblicato in: Medicine, Health Care and Philosophy, 2024, ISSN 1572-8633
Editore: Springer
DOI: 10.1007/s11019-024-10199-7

Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study

Autori: Manon van Daal, Anne-Floor J de Kanter, Roel JH Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff
Pubblicato in: Regenerative Medicine, Numero 19, 2024, Pagina/e 393-406, ISSN 1746-0751
Editore: Future Medicine Ltd.
DOI: 10.1080/17460751.2024.2386214

Phosphorus and Silicon-Based Macromolecules as Degradable Biomedical Polymers

Autori: Stephan Haudum, Paul Strasser, Ian Teasdale
Pubblicato in: Macromolecular Bioscience, Numero Volume23, Numero11, 2023, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202300127

Extracellular matrix from hiPSC-mesenchymal progenitors modulates the three-lineage differentiation of human bone marrow stromal cells

Autori: D Hanetseder, B Schaedl, H Redl, D Marolt Presen
Pubblicato in: eCM Journal - European Cells & Materials, Numero Volume No 47, 2024, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a08

Phosphoramide Hydrogels as Biodegradable Matrices for Inkjet Printing and Their Nano-Hydroxyapatite Composites

Autori: Mahsa Mostofizadeh, Michael Kainz, Farzaneh Alihosseini, Stephan Haudum, Mostafa Youssefi, Peter Bauer, Iurii Gnatiuk, Oliver Brüggemann, Katja Zembsch, Uwe Rinner, Catarina Coelho, Elena Guillén, Ian Teasdale
Pubblicato in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.4c10532

Other (3)

Engineering Design-controlled Interwoven Multimaterial Scaffolds Combining Hard and Soft Phases

Autori: Adrián Martínez Cendrero, Tilo Dehne, Michael Sittinger, Andrés Díaz Lantada
Pubblicato in: 2023
Editore: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-2576924/v1

Open-source collection of tissue engineering scaffolds

Autori: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez William Gabriel Solórzano Requejo
Pubblicato in: 2022
Editore: ZENODO
DOI: 10.5281/zenodo.6387574

Open-source library of microtextured geometries for studying cell-material interactions

Autori: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez
Pubblicato in: 2022
Editore: ZENODO
DOI: 10.5281/zenodo.6387579

Thesis and dissertations (2)

Biomimetic design and additive manufacturing strategies for multi-scale and multi-material tissue engineering

Autori: null null, Adrián Martínez Cendrero
Pubblicato in: 2024
Editore: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.81612

Artificial intelligence aided design of microstructured surfaces for tribology and biointerfaces engineering

Autori: Francisco Franco Martínez
Pubblicato in: 2024
Editore: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.77158