INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS

Project Information

INKplant

Grant agreement ID: 953134

DOI

10.3030/953134

Project closed

EC signature date 16 December 2020

Start date 1 January 2021

End date 30 June 2024

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Total cost

€ 5 988 155,00

EU contribution

€ 5 988 155,00

Coordinated by

PROFACTOR GMBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (3)

Open source collection of scaffolding structures with design maps

Collection of bioinspired lattice, porous and cellular structures according to Task 6.1 (MUW, UPM, JKU). The collection or library will be shared online as open source design files, blueprints & props.

Results of biomimetic structures (TS3 and TS4) from D5.3 for in-vivo testing

Test Structures 3 and 4 according to Task 5.4 for mechanical and for in vivo testing ready to be tested.

Final demonstrators using anonymized patient data for the use cases

Demonstrators for Use Case 1 (TTS, CHT, BMC) according to Task 8.2 and Use Case 2 (MUW, KUK, BTI, BMC) according to Task 8.3.

Websites, patent fillings, videos etc. (2)

Results from web-forums and Twitter data mining

Results from web-forums and Twitter data mining according to Task 9.1.

Launch of open online calls for use case ideas

Launch of open online calls according to Task 9.4. to open INKplant to external users and collect new ideas.

Documents, reports (1)

User acceptance study

User acceptance study.9.4 and 9.5 Results of User acceptance study according to Subtask 9.5.1 and organization of OI & stakeholder workshops (Chapter 2.2.2) according to Task 9.4 in different European countries during the project: UMC (2), CHT (1) and MUW (1), BTI (2). Results of “Intimate Implant: A public engagement project” (UMC).

Publications

Peer reviewed articles (24)

Personalized 3D printed scaffolds: The ethical aspects

Author(s): Manon van Daal , Anne-Floor J. de Kanter , Annelien L. Bredenoord , Nienke de Graeff
Published in: New Biotechnology, Issue Volume 78, 25 December 2023, 2023, Page(s) Pages 116-122, ISSN 1876-4347
Publisher: Elsevier
DOI: 10.1016/j.nbt.2023.10.006

Assessment of geometrical variability in 3D printed ZrO2: Effects of printing and thermal post-processing

Author(s): Erik Kornfellner, Filip Jelínek, Laszlo Jaksa, Anna Lebhard, Daniel Bomze, Martin Schwentenwein, Francesco Moscato
Published in: Open Ceramics, Issue 19, 2024, Page(s) 100629, ISSN 2666-5395
Publisher: Elsevier
DOI: 10.1016/j.oceram.2024.100629

3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review

Author(s): Simon Enbergs; Jacob Spinnen; Tilo Dehne; Michael Sittinger
Published in: Journal of Tissue Engineering and Regenerative Medicine, 2023, ISSN 1932-6254
Publisher: John Wiley & Sons Ltd.
DOI: 10.1155/2023/3901448

A value hierarchy for inclusive design of heart valve implants in regenerative medicine1

Author(s): Anne Johanna De Kanter, anon Van Daal, Callum J Gunn, Annelien L Bredenoord, Nienke DeGraeff, Karin R Jongsma,
Published in: Regenerative Medicine, 2024, ISSN 1746-076X
Publisher: Taylor & Francis
DOI: 10.1080/17460751.2024.2357500

Hybrid design and prototyping of metamaterials and metasurfaces

Author(s): Francisco Franco-Martínez; Christian Grasl; Erik Kornfellner; Matthias Vostatek; Adrián Martínez Cendrero; Francesco Moscato; Andrés Díaz Lantada
Published in: Virtual and Physical Prototyping, Issue Volume 17, 2022 - Issue 4, 2022, Page(s) 1031 - 1046, ISSN 1745-2759
Publisher: Taylor & Francis
DOI: 10.1080/17452759.2022.2101009

Topology optimisation and lithography-based ceramic manufacturing of short-stem hip prostheses with enhanced biomechanical and mechanobiological performance

Author(s): William Solórzano-Requejo, Adrián Martínez Cendrero, Altan Alpay Altun, Serkan Nohut, Carlos Ojeda, Javier García Molleja, Jon Molina-Aldareguia, Martin Schwentenwein, Andrés Díaz Lantada
Published in: Virtual and Physical Prototyping, Issue 19, 2024, ISSN 1745-2759
Publisher: Taylor & Francis
DOI: 10.1080/17452759.2024.2387280

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Author(s): Michael Kainz; Stjepan Perak; Gerald Stubauer; Sonja Kopp; Sebastian Kauscheder; Julia Hemetzberger; Adrián Martínez Cendrero; Andrés Díaz Lantada; Disha Tupe; Zoltan Major; Dominik Hanetseder; Veronika Hruschka; Susanne Wolbank; Darja Marolt Presen; Michael Mühlberger; Elena Guillén
Published in: Polymers 2024, 2024, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym16050655

Fostering creativity in engineering design through constructive dialogues with generative artificial intelligence

Author(s): William Solórzano Requejo, Francisco Franco Martínez, Carlos Aguilar Vega, Rodrigo Zapata Martínez, Adrián Martínez Cendrero, Andrés Díaz Lantada
Published in: Cell Reports Physical Science, Issue 5, 2024, Page(s) 102157, ISSN 2666-3864
Publisher: Cell Press
DOI: 10.1016/j.xcrp.2024.102157

Clinical performance of additively manufactured subperiosteal implants: a systematic review

Author(s): Eduardo Anitua, Asier Eguia, Christoph Staudigl & Mohammad Hamdan Alkhraisat
Published in: International Journal of Implant Dentistry, 2024, ISSN 2198-4034
Publisher: Springer Nature
DOI: 10.1186/s40729-024-00521-6

Preventing Bias in Medical Devices: IdentifyingMorally Significant Differences

Author(s): Anne-Floor J. de Kanter, Manon van Daal, Nienke de Graeff & Karin R. Jongsma
Published in: The American Journal of Bioethics, Issue 23:4, 2023, Page(s) 35-37, ISSN 1536-0075
Publisher: Taylor & Francis
DOI: 10.1080/15265161.2023.2186516

Biodegradable resins for photochemical 3D printing via vinyl ester and vinyl carbonate functionalized amino acid-phosphoramidates

Author(s): Stephan Haudum a, Berfin Demirdögen a, Laura Müller-Müchler b, Sophie Carolin Döttl b, Stefanie Monika Müller c, Christoph Naderer d, Oliver Brüggemann a, Thomas Griesser c, Jaroslaw Jacak d, Eleni Priglinger b, Ian Teasdale
Published in: European Polymer Journal, Issue Volume 211, 15 May 2024, 113037, 2024, ISSN 1873-1945
Publisher: Elsevier Ltd
DOI: 10.1016/j.eurpolymj.2024.113037

3D Inkjet Printing of Biomaterials with Solvent-Free, Thiol-Yne-Based Photocurable Inks

Author(s): Michael Kainz,* Stephan Haudum, Elena Guillén, Oliver Brüggemann, Rita Höller, Heike Frommwald, Tilo Dehne, Michael Sittinger, Disha Tupe, Zoltan Major, Gerald Stubauer, Thomas Griesser,* and Ian Teasdale*
Published in: Macromolecular Materials and Engineering, Issue Volume309, Issue5, 2024, ISSN 1439-2054
Publisher: Wiley-VCH GmbH
DOI: 10.1002/mame.202400028

Quantitatively measuring the cytotoxicity of viscous hydrogels with direct cell sampling in a micro scale format “MicroDrop” and its comparison to CCK8

Author(s): Anna Marie Margot, Andreas Engels, Michael Sittinger, Tilo Dehne, Shabnam Hemmati-Sadeghi
Published in: Journal of Materials Science: Materials in Medicine, Issue 35, 2024, ISSN 1573-4838
Publisher: Springer Nature
DOI: 10.1007/s10856-024-06800-3

Amino acid-based polyphosphorodiamidates with hydrolytically labile bonds for degradation-tuned photopolymers

Author(s): Stephan Haudum; Stefan Lenhart; Stefanie M. Müller; Disha Tupe; Christoph Naderer; Tilo Dehne; Michael Sittinger; Zoltan Major; Thomas Griesser; Oliver Brüggemann; Jaroslaw Jacak; Ian Teasdale
Published in: ACS Macro Letters, Issue Volume 12, Issue 6, 2023, Page(s) 673-678, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.3c00173

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Author(s): Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Published in: Frontiers in Bioengineering and Biotechnology, Issue Volume 11 - 2023, 2023, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1214019

Mechanical properties of additively manufactured lattice structures composed of zirconia and hydroxyapatite ceramics

Author(s): Erik Kornfellner, Stefan Reininger, Sebastian Geier, Martin Schwentenwein, Emir Benca, Stefan Scheiner, Francesco Moscato
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 158, 2024, Page(s) 106644, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106644

Open-source library of tissue engineering scaffolds

Author(s): Adrián Martínez Cendrero, Francisco Franco Martínez, William Gabriel Solórzano Requejo, Andrés Díaz Lantada
Published in: Materials & Design, Issue 223, 2022, Page(s) 111154, ISSN 0264-1275
Publisher: Elsevier BV
DOI: 10.1016/j.matdes.2022.111154

Design and optimization of a novel patient-specific subperiosteal implant additively manufactured in yttria-stabilized zirconia

Author(s): Gunpreet Oberoi, Erik Kornfellner, Daniel Alexander Aigner, Ewald Unger, Martin Schwentenwein, Daniel Bomze, Christoph Staudigl, Dieter Pahr, Francesco Moscato
Published in: Dental Materials, Issue 40, 2024, Page(s) 1568-1574, ISSN 0109-5641
Publisher: Elsevier BV
DOI: 10.1016/j.dental.2024.07.008

Development of a five-axis printer for the fabrication of hybrid 3D scaffolds: From soft to hard phases and planar to curved surfaces

Author(s): Michael Kainz1* , Isabel Caetano da Silva1 , Paula Schumann1 , Julia Kastner1 , Thomas Voglhuber1 , Lukas Hartung2 , Sandra Haas1 , Milan Rathod1 , Adrián Martínez Cendrero3 , Tilo Dehne4 , Daniel Seitz5 , Gunpreet Oberoi6,7 , Erik Kornfellner6 , Andrés Díaz Lantada3 , Francesco Moscato6,8,9 , Elena Guillén1*
Published in: International Journal of Bioprinting, 2024, ISSN 2424-8002
Publisher: AccScience Publishing
DOI: 10.36922/ijb.3189

Embodiment and regenerative implants: a proposal for entanglement

Author(s): Manon van Daal , Anne-Floor J de Kanter , Karin R Jongsma , Annelien L Bredenoord , Nienke de Graeff
Published in: Medicine, Health Care and Philosophy, 2024, ISSN 1572-8633
Publisher: Springer
DOI: 10.1007/s11019-024-10199-7

Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study

Author(s): Manon van Daal, Anne-Floor J de Kanter, Roel JH Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff
Published in: Regenerative Medicine, Issue 19, 2024, Page(s) 393-406, ISSN 1746-0751
Publisher: Future Medicine Ltd.
DOI: 10.1080/17460751.2024.2386214

Phosphorus and Silicon-Based Macromolecules as Degradable Biomedical Polymers

Author(s): Stephan Haudum, Paul Strasser, Ian Teasdale
Published in: Macromolecular Bioscience, Issue Volume23, Issue11, 2023, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202300127

Extracellular matrix from hiPSC-mesenchymal progenitors modulates the three-lineage differentiation of human bone marrow stromal cells

Author(s): D Hanetseder, B Schaedl, H Redl, D Marolt Presen
Published in: eCM Journal - European Cells & Materials, Issue Volume No 47, 2024, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a08

Phosphoramide Hydrogels as Biodegradable Matrices for Inkjet Printing and Their Nano-Hydroxyapatite Composites

Author(s): Mahsa Mostofizadeh, Michael Kainz, Farzaneh Alihosseini, Stephan Haudum, Mostafa Youssefi, Peter Bauer, Iurii Gnatiuk, Oliver Brüggemann, Katja Zembsch, Uwe Rinner, Catarina Coelho, Elena Guillén, Ian Teasdale
Published in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c10532

Other (3)

Engineering Design-controlled Interwoven Multimaterial Scaffolds Combining Hard and Soft Phases

Author(s): Adrián Martínez Cendrero, Tilo Dehne, Michael Sittinger, Andrés Díaz Lantada
Published in: 2023
Publisher: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-2576924/v1

Open-source collection of tissue engineering scaffolds

Author(s): Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez William Gabriel Solórzano Requejo
Published in: 2022
Publisher: ZENODO
DOI: 10.5281/zenodo.6387574

Open-source library of microtextured geometries for studying cell-material interactions

Author(s): Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez
Published in: 2022
Publisher: ZENODO
DOI: 10.5281/zenodo.6387579

Thesis and dissertations (2)

Biomimetic design and additive manufacturing strategies for multi-scale and multi-material tissue engineering

Author(s): null null, Adrián Martínez Cendrero
Published in: 2024
Publisher: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.81612

Artificial intelligence aided design of microstructured surfaces for tribology and biointerfaces engineering

Author(s): Francisco Franco Martínez
Published in: 2024
Publisher: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.77158