INK-BASED HYBRID MULTI-MATERIAL FABRICATION OF NEXT GENERATION IMPLANTS

Información del proyecto

INKplant

Identificador del acuerdo de subvención: 953134

DOI

10.3030/953134

Proyecto cerrado

Fecha de la firma de la CE 16 Diciembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coste total

€ 5 988 155,00

Aportación de la UE

€ 5 988 155,00

Coordinado por

PROFACTOR GMBH
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (3)

Open source collection of scaffolding structures with design maps

Collection of bioinspired lattice, porous and cellular structures according to Task 6.1 (MUW, UPM, JKU). The collection or library will be shared online as open source design files, blueprints & props.

Results of biomimetic structures (TS3 and TS4) from D5.3 for in-vivo testing

Test Structures 3 and 4 according to Task 5.4 for mechanical and for in vivo testing ready to be tested.

Final demonstrators using anonymized patient data for the use cases

Demonstrators for Use Case 1 (TTS, CHT, BMC) according to Task 8.2 and Use Case 2 (MUW, KUK, BTI, BMC) according to Task 8.3.

Websites, patent fillings, videos etc. (2)

Results from web-forums and Twitter data mining

Results from web-forums and Twitter data mining according to Task 9.1.

Launch of open online calls for use case ideas

Launch of open online calls according to Task 9.4. to open INKplant to external users and collect new ideas.

Documents, reports (1)

User acceptance study

User acceptance study.9.4 and 9.5 Results of User acceptance study according to Subtask 9.5.1 and organization of OI & stakeholder workshops (Chapter 2.2.2) according to Task 9.4 in different European countries during the project: UMC (2), CHT (1) and MUW (1), BTI (2). Results of “Intimate Implant: A public engagement project” (UMC).

Publicaciones

Peer reviewed articles (24)

Personalized 3D printed scaffolds: The ethical aspects

Autores: Manon van Daal , Anne-Floor J. de Kanter , Annelien L. Bredenoord , Nienke de Graeff
Publicado en: New Biotechnology, Edición Volume 78, 25 December 2023, 2023, Página(s) Pages 116-122, ISSN 1876-4347
Editor: Elsevier
DOI: 10.1016/j.nbt.2023.10.006

Assessment of geometrical variability in 3D printed ZrO2: Effects of printing and thermal post-processing

Autores: Erik Kornfellner, Filip Jelínek, Laszlo Jaksa, Anna Lebhard, Daniel Bomze, Martin Schwentenwein, Francesco Moscato
Publicado en: Open Ceramics, Edición 19, 2024, Página(s) 100629, ISSN 2666-5395
Editor: Elsevier
DOI: 10.1016/j.oceram.2024.100629

3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review

Autores: Simon Enbergs; Jacob Spinnen; Tilo Dehne; Michael Sittinger
Publicado en: Journal of Tissue Engineering and Regenerative Medicine, 2023, ISSN 1932-6254
Editor: John Wiley & Sons Ltd.
DOI: 10.1155/2023/3901448

A value hierarchy for inclusive design of heart valve implants in regenerative medicine1

Autores: Anne Johanna De Kanter, anon Van Daal, Callum J Gunn, Annelien L Bredenoord, Nienke DeGraeff, Karin R Jongsma,
Publicado en: Regenerative Medicine, 2024, ISSN 1746-076X
Editor: Taylor & Francis
DOI: 10.1080/17460751.2024.2357500

Hybrid design and prototyping of metamaterials and metasurfaces

Autores: Francisco Franco-Martínez; Christian Grasl; Erik Kornfellner; Matthias Vostatek; Adrián Martínez Cendrero; Francesco Moscato; Andrés Díaz Lantada
Publicado en: Virtual and Physical Prototyping, Edición Volume 17, 2022 - Edición 4, 2022, Página(s) 1031 - 1046, ISSN 1745-2759
Editor: Taylor & Francis
DOI: 10.1080/17452759.2022.2101009

Topology optimisation and lithography-based ceramic manufacturing of short-stem hip prostheses with enhanced biomechanical and mechanobiological performance

Autores: William Solórzano-Requejo, Adrián Martínez Cendrero, Altan Alpay Altun, Serkan Nohut, Carlos Ojeda, Javier García Molleja, Jon Molina-Aldareguia, Martin Schwentenwein, Andrés Díaz Lantada
Publicado en: Virtual and Physical Prototyping, Edición 19, 2024, ISSN 1745-2759
Editor: Taylor & Francis
DOI: 10.1080/17452759.2024.2387280

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Autores: Michael Kainz; Stjepan Perak; Gerald Stubauer; Sonja Kopp; Sebastian Kauscheder; Julia Hemetzberger; Adrián Martínez Cendrero; Andrés Díaz Lantada; Disha Tupe; Zoltan Major; Dominik Hanetseder; Veronika Hruschka; Susanne Wolbank; Darja Marolt Presen; Michael Mühlberger; Elena Guillén
Publicado en: Polymers 2024, 2024, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym16050655

Fostering creativity in engineering design through constructive dialogues with generative artificial intelligence

Autores: William Solórzano Requejo, Francisco Franco Martínez, Carlos Aguilar Vega, Rodrigo Zapata Martínez, Adrián Martínez Cendrero, Andrés Díaz Lantada
Publicado en: Cell Reports Physical Science, Edición 5, 2024, Página(s) 102157, ISSN 2666-3864
Editor: Cell Press
DOI: 10.1016/j.xcrp.2024.102157

Clinical performance of additively manufactured subperiosteal implants: a systematic review

Autores: Eduardo Anitua, Asier Eguia, Christoph Staudigl & Mohammad Hamdan Alkhraisat
Publicado en: International Journal of Implant Dentistry, 2024, ISSN 2198-4034
Editor: Springer Nature
DOI: 10.1186/s40729-024-00521-6

Preventing Bias in Medical Devices: IdentifyingMorally Significant Differences

Autores: Anne-Floor J. de Kanter, Manon van Daal, Nienke de Graeff & Karin R. Jongsma
Publicado en: The American Journal of Bioethics, Edición 23:4, 2023, Página(s) 35-37, ISSN 1536-0075
Editor: Taylor & Francis
DOI: 10.1080/15265161.2023.2186516

Biodegradable resins for photochemical 3D printing via vinyl ester and vinyl carbonate functionalized amino acid-phosphoramidates

Autores: Stephan Haudum a, Berfin Demirdögen a, Laura Müller-Müchler b, Sophie Carolin Döttl b, Stefanie Monika Müller c, Christoph Naderer d, Oliver Brüggemann a, Thomas Griesser c, Jaroslaw Jacak d, Eleni Priglinger b, Ian Teasdale
Publicado en: European Polymer Journal, Edición Volume 211, 15 May 2024, 113037, 2024, ISSN 1873-1945
Editor: Elsevier Ltd
DOI: 10.1016/j.eurpolymj.2024.113037

3D Inkjet Printing of Biomaterials with Solvent-Free, Thiol-Yne-Based Photocurable Inks

Autores: Michael Kainz,* Stephan Haudum, Elena Guillén, Oliver Brüggemann, Rita Höller, Heike Frommwald, Tilo Dehne, Michael Sittinger, Disha Tupe, Zoltan Major, Gerald Stubauer, Thomas Griesser,* and Ian Teasdale*
Publicado en: Macromolecular Materials and Engineering, Edición Volume309, Edición5, 2024, ISSN 1439-2054
Editor: Wiley-VCH GmbH
DOI: 10.1002/mame.202400028

Quantitatively measuring the cytotoxicity of viscous hydrogels with direct cell sampling in a micro scale format “MicroDrop” and its comparison to CCK8

Autores: Anna Marie Margot, Andreas Engels, Michael Sittinger, Tilo Dehne, Shabnam Hemmati-Sadeghi
Publicado en: Journal of Materials Science: Materials in Medicine, Edición 35, 2024, ISSN 1573-4838
Editor: Springer Nature
DOI: 10.1007/s10856-024-06800-3

Amino acid-based polyphosphorodiamidates with hydrolytically labile bonds for degradation-tuned photopolymers

Autores: Stephan Haudum; Stefan Lenhart; Stefanie M. Müller; Disha Tupe; Christoph Naderer; Tilo Dehne; Michael Sittinger; Zoltan Major; Thomas Griesser; Oliver Brüggemann; Jaroslaw Jacak; Ian Teasdale
Publicado en: ACS Macro Letters, Edición Volume 12, Edición 6, 2023, Página(s) 673-678, ISSN 2161-1653
Editor: American Chemical Society
DOI: 10.1021/acsmacrolett.3c00173

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Autores: Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición Volume 11 - 2023, 2023, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1214019

Mechanical properties of additively manufactured lattice structures composed of zirconia and hydroxyapatite ceramics

Autores: Erik Kornfellner, Stefan Reininger, Sebastian Geier, Martin Schwentenwein, Emir Benca, Stefan Scheiner, Francesco Moscato
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials, Edición 158, 2024, Página(s) 106644, ISSN 1751-6161
Editor: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106644

Open-source library of tissue engineering scaffolds

Autores: Adrián Martínez Cendrero, Francisco Franco Martínez, William Gabriel Solórzano Requejo, Andrés Díaz Lantada
Publicado en: Materials & Design, Edición 223, 2022, Página(s) 111154, ISSN 0264-1275
Editor: Elsevier BV
DOI: 10.1016/j.matdes.2022.111154

Design and optimization of a novel patient-specific subperiosteal implant additively manufactured in yttria-stabilized zirconia

Autores: Gunpreet Oberoi, Erik Kornfellner, Daniel Alexander Aigner, Ewald Unger, Martin Schwentenwein, Daniel Bomze, Christoph Staudigl, Dieter Pahr, Francesco Moscato
Publicado en: Dental Materials, Edición 40, 2024, Página(s) 1568-1574, ISSN 0109-5641
Editor: Elsevier BV
DOI: 10.1016/j.dental.2024.07.008

Development of a five-axis printer for the fabrication of hybrid 3D scaffolds: From soft to hard phases and planar to curved surfaces

Autores: Michael Kainz1* , Isabel Caetano da Silva1 , Paula Schumann1 , Julia Kastner1 , Thomas Voglhuber1 , Lukas Hartung2 , Sandra Haas1 , Milan Rathod1 , Adrián Martínez Cendrero3 , Tilo Dehne4 , Daniel Seitz5 , Gunpreet Oberoi6,7 , Erik Kornfellner6 , Andrés Díaz Lantada3 , Francesco Moscato6,8,9 , Elena Guillén1*
Publicado en: International Journal of Bioprinting, 2024, ISSN 2424-8002
Editor: AccScience Publishing
DOI: 10.36922/ijb.3189

Embodiment and regenerative implants: a proposal for entanglement

Autores: Manon van Daal , Anne-Floor J de Kanter , Karin R Jongsma , Annelien L Bredenoord , Nienke de Graeff
Publicado en: Medicine, Health Care and Philosophy, 2024, ISSN 1572-8633
Editor: Springer
DOI: 10.1007/s11019-024-10199-7

Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study

Autores: Manon van Daal, Anne-Floor J de Kanter, Roel JH Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff
Publicado en: Regenerative Medicine, Edición 19, 2024, Página(s) 393-406, ISSN 1746-0751
Editor: Future Medicine Ltd.
DOI: 10.1080/17460751.2024.2386214

Phosphorus and Silicon-Based Macromolecules as Degradable Biomedical Polymers

Autores: Stephan Haudum, Paul Strasser, Ian Teasdale
Publicado en: Macromolecular Bioscience, Edición Volume23, Edición11, 2023, ISSN 1616-5187
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202300127

Extracellular matrix from hiPSC-mesenchymal progenitors modulates the three-lineage differentiation of human bone marrow stromal cells

Autores: D Hanetseder, B Schaedl, H Redl, D Marolt Presen
Publicado en: eCM Journal - European Cells & Materials, Edición Volume No 47, 2024, ISSN 1473-2262
Editor: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a08

Phosphoramide Hydrogels as Biodegradable Matrices for Inkjet Printing and Their Nano-Hydroxyapatite Composites

Autores: Mahsa Mostofizadeh, Michael Kainz, Farzaneh Alihosseini, Stephan Haudum, Mostafa Youssefi, Peter Bauer, Iurii Gnatiuk, Oliver Brüggemann, Katja Zembsch, Uwe Rinner, Catarina Coelho, Elena Guillén, Ian Teasdale
Publicado en: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c10532

Other (3)

Engineering Design-controlled Interwoven Multimaterial Scaffolds Combining Hard and Soft Phases

Autores: Adrián Martínez Cendrero, Tilo Dehne, Michael Sittinger, Andrés Díaz Lantada
Publicado en: 2023
Editor: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-2576924/v1

Open-source collection of tissue engineering scaffolds

Autores: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez William Gabriel Solórzano Requejo
Publicado en: 2022
Editor: ZENODO
DOI: 10.5281/zenodo.6387574

Open-source library of microtextured geometries for studying cell-material interactions

Autores: Andrés Díaz Lantada Adrián Martínez Cendrero Francisco Franco Martínez
Publicado en: 2022
Editor: ZENODO
DOI: 10.5281/zenodo.6387579

Thesis and dissertations (2)

Biomimetic design and additive manufacturing strategies for multi-scale and multi-material tissue engineering

Autores: null null, Adrián Martínez Cendrero
Publicado en: 2024
Editor: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.81612

Artificial intelligence aided design of microstructured surfaces for tribology and biointerfaces engineering

Autores: Francisco Franco Martínez
Publicado en: 2024
Editor: Universidad Politecnica de Madrid - University Library
DOI: 10.20868/upm.thesis.77158