Serotonin and BEYOND: Brain development research Excelling Young Ones in Neurotechnologies and Discoveries

Project Information

SEROTONIN and BEYOND

Grant agreement ID: 953327

DOI

10.3030/953327

Project closed

EC signature date 28 August 2020

Start date 1 January 2021

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 012 551,00

EU contribution

€ 4 012 551,00

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Website with advertised positions

Other (2)

Corporate Identity (Logo and Templates)
Press releases

Press releases, M24, 48

Publications

Peer reviewed articles (28)

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

Author(s): S. E. P. Bruzzone, B. Ozenne, P. M. Fisher, G. Ortega, P. S. Jensen, V. H. Dam, C. Svarer, G. M. Knudsen, K. P. Lesch, V. G. Frokjaer
Published in: Clinical Epigenetics, Issue 16, 2024, ISSN 1868-7083
Publisher: Springer/Nature
DOI: 10.1186/s13148-024-01678-y

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visuallytriggered locomotive enhancement in mice upon optogenetic stimulation

Author(s): N. Araragi, N. Alenina, M. Bader
Published in: Heliyon, Issue 8, 2022, Page(s) e08692, ISSN 2405-8440
Publisher: Cell press
DOI: 10.1016/j.heliyon.2021.e08692

Genetic contributions to brain serotonin transporter levels in healthy adults

Author(s): Silvia Elisabetta Portis Bruzzone; Arafat Nasser; Sagar Sanjay Aripaka; Marie Spies; Brice Ozenne; Peter Steen Jensen; Gitte Moos Knudsen; Vibe Gedsoe Frokjaer; Patrick MacDonald Fisher
Published in: Scientific Reports, Issue v 13, 2023, Page(s) no 16426, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-43690-x

Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission

Author(s): Giulia Gianni, Massimo Pasqualetti
Published in: ACS Chemical Neuroscience, Issue 14, 2023, Page(s) 4093-4104, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.3c00648

Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms.

Author(s): Paola, Brivio; Maria Teresa, Gallo; Peter, Karel; Giulia, Cogi; Fabio, Fumagalli; Judith R, Homberg; Francesca, Calabrese
Published in: Frontiers in Behavioral Neuroscience, Issue Vol 16, 2022, Page(s) 957702, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.957702

Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Author(s): Gabriel Ocana-Santero, Hannah Warming, Veronica Munday, Heather A. MacKay, Caius Gibeily, Christopher Hemingway, Jacqueline A. Stacey, Abhishek Saha, Ivan P. Lazarte, Anjali Bachetta, Fei Deng, Yulong Li, Adam M. Packer, Trevor Sharp, Simon. J. B. Butt
Published in: Nature Communications, Issue 16, 2025, Page(s) 5203, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-59659-5

Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Author(s): Olga Rivero; Olga Rivero; Judit Alhama-Riba; Hsing-Ping Ku; Matthias Fischer; Gabriela Ortega; Péter Álmos; David Diouf; Daniel van den Hove; Klaus-Peter Lesch; Klaus-Peter Lesch; Klaus-Peter Lesch
Published in: Frontiers in Genetics, Issue Vol 12, 2021, Page(s) article 668488, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.688488

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats

Author(s): Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader Fabio Fumagalli, Natalia Alenina, Judith R. Homberg and Francesca Calabrese
Published in: International Journal of Molecular Sciences, Issue 23, 2022, Page(s) 4941, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094941

Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring

Author(s): Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Published in: JAMA Network Open, Issue 8, 2025, Page(s) e2523978, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.23978

SSRIs in Pregnancy—What Offspring Brain Volumes Can and Cannot Tell Us—Reply

Author(s): Dogukan Koc, Henning Tiemeier, Hanan El Marroun
Published in: JAMA Psychiatry, Issue 81, 2024, Page(s) 317, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.5039

Effects of an Oral Contraceptive on Dynamic Brain States and Network Modularity in a Serial Single-Subject Study

Author(s): K.H.R. Jensen, D.E. McCulloch, A.S. Olsen, S.E.P. Bruzzone, S. V. Larsen, P.M. Fisher, V.G. Frokjaer
Published in: Frontiers in Neuroscience, Issue 16, 2022, Page(s) 855582, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2022.855582

DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

Author(s): Silvia Elisabetta Portis Bruzzone, Brice Ozenne, Patrick MacDonald Fisher, Gabriela Ortega, Martin Balslev Jørgensen, Gitte Moos Knudsen, Klaus-Peter Lesch, Vibe Gedsoe Frokjaer
Published in: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Issue 136, 2025, Page(s) 111160, ISSN 0278-5846
Publisher: Elsevier BV
DOI: 10.1016/j.pnpbp.2024.111160

Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory

Author(s): Dogukan Koc, Henning Tiemeier, MD, Bruno H. Stricker, Ryan L. Muetzel, Manon Hillegers, Hanan El Marroun.
Published in: JAMA Psychiatry, Issue August 30, 2023, 2023, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.3161

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Author(s): Nina Nitzan Soto, Patricia Gaspar, Alberto Bacci
Published in: ACS Chemical Neuroscience, Issue 15, 2024, Page(s) 1611-1618, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.3c00828

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice

Author(s): Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenina
Published in: Communications Biology, Issue 7, 2024, Page(s) 1641, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07360-6

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State

Author(s): Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina and Alexey N. Tomilin
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 4862, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054862

Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems

Author(s): Dogukan Koc, Martin Nørgaard, Melanie Ganz, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier, Vibe G. Frokjaer
Published in: NeuroImage: Clinical, Issue 48, 2025, Page(s) 103851, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2025.103851

Impact of Serotonin Deficiency on Circadian Dopaminergic Rhythms

Author(s): Giacomo Maddaloni, Noemi Barsotti, Sara Migliarini, Martina Giordano, Serena Nazzi, Marta Picchi, Francesco Errico, Alessandro Usiello, Massimo Pasqualetti
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 6475, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25126475

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Author(s): Anna Gorlova; Evgeniy Svirin; Dmitrii Pavlov; Raymond Cespuglio; Andrey Proshin; Careen A. Schroeter; Klaus-Peter Lesch; Tatyana Strekalova
Published in: Int. J. Mol. Sci., Issue Vol 24, 2023, Page(s) 915, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24020915

Reclaiming saliency: Rhythmic precision-modulated action and perception.

Author(s): Anil Meera, A., Novicky, F., Parr, T., Friston, K., Lanillos, P., & Sajid, N.
Published in: Frontiers in Neurorobotics, Issue Volume 16 - 2022, 2022, ISSN 1662-5218
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbot.2022.896229

Serotonin limits generation of chromaffin cells during adrenal organ development

Author(s): Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Published in: Nature Communications, Issue 13, 2022, Page(s) 2901, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence

Author(s): Dogukan Koc, Hanan El Marroun, Bruno H. Stricker, Ryan L. Muetzel, Henning Tiemeier
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Issue 9, 2024, Page(s) 217-226, ISSN 2451-9022
Publisher: Elsevier BV
DOI: 10.1016/j.bpsc.2023.10.009

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitiveabilities

Author(s): L. Alonso, P. Peeva, S. Stasko, M. Bader, N. Alenina, Y. Winter, M. Rivalan
Published in: iScience, Issue 26, 2023, Page(s) 105998, ISSN 2589-0042
Publisher: Cell Press Elsevier Inc.
DOI: 10.1016/j.isci.2023.105998

<i>In Vivo</i> Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex

Author(s): Gabriel Ocana-Santero, Adam M. Packer, Trevor Sharp, Simon J. B. Butt
Published in: ACS Chemical Neuroscience, Issue 15, 2024, Page(s) 456-461, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.3c00725

Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC)line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing

Author(s): D. Diouf, M.R. Vitale, J.E.M Zoller, A.-M. Pineau, E. Klopocki, C. Hamann, G.C. Ziegler, T. Vanmierlo, D. van den Hove, K.-P. Lesch
Published in: Stemm Cell Research, Issue Vol 63, 2023, Page(s) 103038, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2023.103038

Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits

Author(s): Tianhua Wang, Judith R. Homberg, Laura Boreggio, Marta C. F. Samina, Rogério C. R. Castro, Sharon M. Kolk, Natalia Alenina, Michael Bader, Jinye Dai, Markus Wöhr
Published in: Molecular Autism, Issue 15, 2024, Page(s) 50, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-024-00629-x

Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors

Author(s): Angela Michela De Stasi, Javier Zorrilla de San Martin, Nina Soto, Andrea Aguirre, Jimmy Olusakin, Joana Lourenço, Patricia Gaspar, Alberto Bacci
Published in: The Journal of Neuroscience, Issue 45, 2025, Page(s) e2393232024, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2393-23.2024

Tph2 Gene Expression Defines Ethanol Drinking Behavior in Mice

Author(s): Magdalena Zaniewska, Valentina Mosienko, Michael Bader, and Natalia Alenina
Published in: Cells, Issue 11, 2022, Page(s) 874, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11050874

Non-peer reviewed articles (1)

Maternal tryptophan hydroxylase 1 genotype defines offspring’s cognition and behaviour

Author(s): R. Rocha De Castro, M. Verheij, A.A. Vazquez, J. Buitelaar, J. Homberg
Published in: Neuroscience Applied, Issue 2, 2024, Page(s) 102608, ISSN 2772-4085
Publisher: Elsevier BV
DOI: 10.1016/j.nsa.2023.102608

Book chapters (1)

Robotic Active Tactile Sensing Inspired by Serotonergic Modulation Using Active Inference

Author(s): Filip Novicky, Joshua Offergeld, Simon Janssen, Pablo Lanillos
Published in: Lecture Notes in Computer Science, Biomimetic and Biohybrid Systems, 2023, Page(s) 33-55
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-38857-6_3