Serotonin and BEYOND: Brain development research Excelling Young Ones in Neurotechnologies and Discoveries

Información del proyecto

SEROTONIN and BEYOND

Identificador del acuerdo de subvención: 953327

DOI

10.3030/953327

Proyecto cerrado

Fecha de la firma de la CE 28 Agosto 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Abril 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 012 551,00

Aportación de la UE

€ 4 012 551,00

Coordinado por

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Website with advertised positions

Other (2)

Corporate Identity (Logo and Templates)
Press releases

Press releases, M24, 48

Publicaciones

Peer reviewed articles (28)

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

Autores: S. E. P. Bruzzone, B. Ozenne, P. M. Fisher, G. Ortega, P. S. Jensen, V. H. Dam, C. Svarer, G. M. Knudsen, K. P. Lesch, V. G. Frokjaer
Publicado en: Clinical Epigenetics, Edición 16, 2024, ISSN 1868-7083
Editor: Springer/Nature
DOI: 10.1186/s13148-024-01678-y

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visuallytriggered locomotive enhancement in mice upon optogenetic stimulation

Autores: N. Araragi, N. Alenina, M. Bader
Publicado en: Heliyon, Edición 8, 2022, Página(s) e08692, ISSN 2405-8440
Editor: Cell press
DOI: 10.1016/j.heliyon.2021.e08692

Genetic contributions to brain serotonin transporter levels in healthy adults

Autores: Silvia Elisabetta Portis Bruzzone; Arafat Nasser; Sagar Sanjay Aripaka; Marie Spies; Brice Ozenne; Peter Steen Jensen; Gitte Moos Knudsen; Vibe Gedsoe Frokjaer; Patrick MacDonald Fisher
Publicado en: Scientific Reports, Edición v 13, 2023, Página(s) no 16426, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-43690-x

Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission

Autores: Giulia Gianni, Massimo Pasqualetti
Publicado en: ACS Chemical Neuroscience, Edición 14, 2023, Página(s) 4093-4104, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.3c00648

Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms.

Autores: Paola, Brivio; Maria Teresa, Gallo; Peter, Karel; Giulia, Cogi; Fabio, Fumagalli; Judith R, Homberg; Francesca, Calabrese
Publicado en: Frontiers in Behavioral Neuroscience, Edición Vol 16, 2022, Página(s) 957702, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.957702

Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Autores: Gabriel Ocana-Santero, Hannah Warming, Veronica Munday, Heather A. MacKay, Caius Gibeily, Christopher Hemingway, Jacqueline A. Stacey, Abhishek Saha, Ivan P. Lazarte, Anjali Bachetta, Fei Deng, Yulong Li, Adam M. Packer, Trevor Sharp, Simon. J. B. Butt
Publicado en: Nature Communications, Edición 16, 2025, Página(s) 5203, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-59659-5

Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Autores: Olga Rivero; Olga Rivero; Judit Alhama-Riba; Hsing-Ping Ku; Matthias Fischer; Gabriela Ortega; Péter Álmos; David Diouf; Daniel van den Hove; Klaus-Peter Lesch; Klaus-Peter Lesch; Klaus-Peter Lesch
Publicado en: Frontiers in Genetics, Edición Vol 12, 2021, Página(s) article 668488, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2021.688488

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats

Autores: Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader Fabio Fumagalli, Natalia Alenina, Judith R. Homberg and Francesca Calabrese
Publicado en: International Journal of Molecular Sciences, Edición 23, 2022, Página(s) 4941, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094941

Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring

Autores: Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Publicado en: JAMA Network Open, Edición 8, 2025, Página(s) e2523978, ISSN 2574-3805
Editor: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.23978

SSRIs in Pregnancy—What Offspring Brain Volumes Can and Cannot Tell Us—Reply

Autores: Dogukan Koc, Henning Tiemeier, Hanan El Marroun
Publicado en: JAMA Psychiatry, Edición 81, 2024, Página(s) 317, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.5039

Effects of an Oral Contraceptive on Dynamic Brain States and Network Modularity in a Serial Single-Subject Study

Autores: K.H.R. Jensen, D.E. McCulloch, A.S. Olsen, S.E.P. Bruzzone, S. V. Larsen, P.M. Fisher, V.G. Frokjaer
Publicado en: Frontiers in Neuroscience, Edición 16, 2022, Página(s) 855582, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2022.855582

DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

Autores: Silvia Elisabetta Portis Bruzzone, Brice Ozenne, Patrick MacDonald Fisher, Gabriela Ortega, Martin Balslev Jørgensen, Gitte Moos Knudsen, Klaus-Peter Lesch, Vibe Gedsoe Frokjaer
Publicado en: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Edición 136, 2025, Página(s) 111160, ISSN 0278-5846
Editor: Elsevier BV
DOI: 10.1016/j.pnpbp.2024.111160

Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory

Autores: Dogukan Koc, Henning Tiemeier, MD, Bruno H. Stricker, Ryan L. Muetzel, Manon Hillegers, Hanan El Marroun.
Publicado en: JAMA Psychiatry, Edición August 30, 2023, 2023, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.3161

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Autores: Nina Nitzan Soto, Patricia Gaspar, Alberto Bacci
Publicado en: ACS Chemical Neuroscience, Edición 15, 2024, Página(s) 1611-1618, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.3c00828

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice

Autores: Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenina
Publicado en: Communications Biology, Edición 7, 2024, Página(s) 1641, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07360-6

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State

Autores: Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina and Alexey N. Tomilin
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 4862, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054862

Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems

Autores: Dogukan Koc, Martin Nørgaard, Melanie Ganz, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier, Vibe G. Frokjaer
Publicado en: NeuroImage: Clinical, Edición 48, 2025, Página(s) 103851, ISSN 2213-1582
Editor: Elsevier BV
DOI: 10.1016/j.nicl.2025.103851

Impact of Serotonin Deficiency on Circadian Dopaminergic Rhythms

Autores: Giacomo Maddaloni, Noemi Barsotti, Sara Migliarini, Martina Giordano, Serena Nazzi, Marta Picchi, Francesco Errico, Alessandro Usiello, Massimo Pasqualetti
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 6475, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25126475

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Autores: Anna Gorlova; Evgeniy Svirin; Dmitrii Pavlov; Raymond Cespuglio; Andrey Proshin; Careen A. Schroeter; Klaus-Peter Lesch; Tatyana Strekalova
Publicado en: Int. J. Mol. Sci., Edición Vol 24, 2023, Página(s) 915, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24020915

Reclaiming saliency: Rhythmic precision-modulated action and perception.

Autores: Anil Meera, A., Novicky, F., Parr, T., Friston, K., Lanillos, P., & Sajid, N.
Publicado en: Frontiers in Neurorobotics, Edición Volume 16 - 2022, 2022, ISSN 1662-5218
Editor: Frontiers Research Foundation
DOI: 10.3389/fnbot.2022.896229

Serotonin limits generation of chromaffin cells during adrenal organ development

Autores: Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Publicado en: Nature Communications, Edición 13, 2022, Página(s) 2901, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence

Autores: Dogukan Koc, Hanan El Marroun, Bruno H. Stricker, Ryan L. Muetzel, Henning Tiemeier
Publicado en: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Edición 9, 2024, Página(s) 217-226, ISSN 2451-9022
Editor: Elsevier BV
DOI: 10.1016/j.bpsc.2023.10.009

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitiveabilities

Autores: L. Alonso, P. Peeva, S. Stasko, M. Bader, N. Alenina, Y. Winter, M. Rivalan
Publicado en: iScience, Edición 26, 2023, Página(s) 105998, ISSN 2589-0042
Editor: Cell Press Elsevier Inc.
DOI: 10.1016/j.isci.2023.105998

<i>In Vivo</i> Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex

Autores: Gabriel Ocana-Santero, Adam M. Packer, Trevor Sharp, Simon J. B. Butt
Publicado en: ACS Chemical Neuroscience, Edición 15, 2024, Página(s) 456-461, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.3c00725

Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC)line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing

Autores: D. Diouf, M.R. Vitale, J.E.M Zoller, A.-M. Pineau, E. Klopocki, C. Hamann, G.C. Ziegler, T. Vanmierlo, D. van den Hove, K.-P. Lesch
Publicado en: Stemm Cell Research, Edición Vol 63, 2023, Página(s) 103038, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2023.103038

Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits

Autores: Tianhua Wang, Judith R. Homberg, Laura Boreggio, Marta C. F. Samina, Rogério C. R. Castro, Sharon M. Kolk, Natalia Alenina, Michael Bader, Jinye Dai, Markus Wöhr
Publicado en: Molecular Autism, Edición 15, 2024, Página(s) 50, ISSN 2040-2392
Editor: BioMed Central
DOI: 10.1186/s13229-024-00629-x

Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors

Autores: Angela Michela De Stasi, Javier Zorrilla de San Martin, Nina Soto, Andrea Aguirre, Jimmy Olusakin, Joana Lourenço, Patricia Gaspar, Alberto Bacci
Publicado en: The Journal of Neuroscience, Edición 45, 2025, Página(s) e2393232024, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.2393-23.2024

Tph2 Gene Expression Defines Ethanol Drinking Behavior in Mice

Autores: Magdalena Zaniewska, Valentina Mosienko, Michael Bader, and Natalia Alenina
Publicado en: Cells, Edición 11, 2022, Página(s) 874, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11050874

Non-peer reviewed articles (1)

Maternal tryptophan hydroxylase 1 genotype defines offspring’s cognition and behaviour

Autores: R. Rocha De Castro, M. Verheij, A.A. Vazquez, J. Buitelaar, J. Homberg
Publicado en: Neuroscience Applied, Edición 2, 2024, Página(s) 102608, ISSN 2772-4085
Editor: Elsevier BV
DOI: 10.1016/j.nsa.2023.102608

Book chapters (1)

Robotic Active Tactile Sensing Inspired by Serotonergic Modulation Using Active Inference

Autores: Filip Novicky, Joshua Offergeld, Simon Janssen, Pablo Lanillos
Publicado en: Lecture Notes in Computer Science, Biomimetic and Biohybrid Systems, 2023, Página(s) 33-55
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-38857-6_3