Serotonin and BEYOND: Brain development research Excelling Young Ones in Neurotechnologies and Discoveries

Informazioni relative al progetto

SEROTONIN and BEYOND

ID dell’accordo di sovvenzione: 953327

DOI

10.3030/953327

Progetto chiuso

Data della firma CE 28 Agosto 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Aprile 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 012 551,00

Contributo UE

€ 4 012 551,00

Coordinato da

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Website with advertised positions

Other (2)

Corporate Identity (Logo and Templates)
Press releases

Press releases, M24, 48

Pubblicazioni

Peer reviewed articles (28)

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

Autori: S. E. P. Bruzzone, B. Ozenne, P. M. Fisher, G. Ortega, P. S. Jensen, V. H. Dam, C. Svarer, G. M. Knudsen, K. P. Lesch, V. G. Frokjaer
Pubblicato in: Clinical Epigenetics, Numero 16, 2024, ISSN 1868-7083
Editore: Springer/Nature
DOI: 10.1186/s13148-024-01678-y

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visuallytriggered locomotive enhancement in mice upon optogenetic stimulation

Autori: N. Araragi, N. Alenina, M. Bader
Pubblicato in: Heliyon, Numero 8, 2022, Pagina/e e08692, ISSN 2405-8440
Editore: Cell press
DOI: 10.1016/j.heliyon.2021.e08692

Genetic contributions to brain serotonin transporter levels in healthy adults

Autori: Silvia Elisabetta Portis Bruzzone; Arafat Nasser; Sagar Sanjay Aripaka; Marie Spies; Brice Ozenne; Peter Steen Jensen; Gitte Moos Knudsen; Vibe Gedsoe Frokjaer; Patrick MacDonald Fisher
Pubblicato in: Scientific Reports, Numero v 13, 2023, Pagina/e no 16426, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-43690-x

Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission

Autori: Giulia Gianni, Massimo Pasqualetti
Pubblicato in: ACS Chemical Neuroscience, Numero 14, 2023, Pagina/e 4093-4104, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.3c00648

Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms.

Autori: Paola, Brivio; Maria Teresa, Gallo; Peter, Karel; Giulia, Cogi; Fabio, Fumagalli; Judith R, Homberg; Francesca, Calabrese
Pubblicato in: Frontiers in Behavioral Neuroscience, Numero Vol 16, 2022, Pagina/e 957702, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.957702

Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Autori: Gabriel Ocana-Santero, Hannah Warming, Veronica Munday, Heather A. MacKay, Caius Gibeily, Christopher Hemingway, Jacqueline A. Stacey, Abhishek Saha, Ivan P. Lazarte, Anjali Bachetta, Fei Deng, Yulong Li, Adam M. Packer, Trevor Sharp, Simon. J. B. Butt
Pubblicato in: Nature Communications, Numero 16, 2025, Pagina/e 5203, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-59659-5

Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Autori: Olga Rivero; Olga Rivero; Judit Alhama-Riba; Hsing-Ping Ku; Matthias Fischer; Gabriela Ortega; Péter Álmos; David Diouf; Daniel van den Hove; Klaus-Peter Lesch; Klaus-Peter Lesch; Klaus-Peter Lesch
Pubblicato in: Frontiers in Genetics, Numero Vol 12, 2021, Pagina/e article 668488, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2021.688488

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats

Autori: Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader Fabio Fumagalli, Natalia Alenina, Judith R. Homberg and Francesca Calabrese
Pubblicato in: International Journal of Molecular Sciences, Numero 23, 2022, Pagina/e 4941, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094941

Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring

Autori: Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Pubblicato in: JAMA Network Open, Numero 8, 2025, Pagina/e e2523978, ISSN 2574-3805
Editore: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.23978

SSRIs in Pregnancy—What Offspring Brain Volumes Can and Cannot Tell Us—Reply

Autori: Dogukan Koc, Henning Tiemeier, Hanan El Marroun
Pubblicato in: JAMA Psychiatry, Numero 81, 2024, Pagina/e 317, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.5039

Effects of an Oral Contraceptive on Dynamic Brain States and Network Modularity in a Serial Single-Subject Study

Autori: K.H.R. Jensen, D.E. McCulloch, A.S. Olsen, S.E.P. Bruzzone, S. V. Larsen, P.M. Fisher, V.G. Frokjaer
Pubblicato in: Frontiers in Neuroscience, Numero 16, 2022, Pagina/e 855582, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fnins.2022.855582

DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

Autori: Silvia Elisabetta Portis Bruzzone, Brice Ozenne, Patrick MacDonald Fisher, Gabriela Ortega, Martin Balslev Jørgensen, Gitte Moos Knudsen, Klaus-Peter Lesch, Vibe Gedsoe Frokjaer
Pubblicato in: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Numero 136, 2025, Pagina/e 111160, ISSN 0278-5846
Editore: Elsevier BV
DOI: 10.1016/j.pnpbp.2024.111160

Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory

Autori: Dogukan Koc, Henning Tiemeier, MD, Bruno H. Stricker, Ryan L. Muetzel, Manon Hillegers, Hanan El Marroun.
Pubblicato in: JAMA Psychiatry, Numero August 30, 2023, 2023, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.3161

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Autori: Nina Nitzan Soto, Patricia Gaspar, Alberto Bacci
Pubblicato in: ACS Chemical Neuroscience, Numero 15, 2024, Pagina/e 1611-1618, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.3c00828

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice

Autori: Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenina
Pubblicato in: Communications Biology, Numero 7, 2024, Pagina/e 1641, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07360-6

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State

Autori: Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina and Alexey N. Tomilin
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 4862, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054862

Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems

Autori: Dogukan Koc, Martin Nørgaard, Melanie Ganz, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier, Vibe G. Frokjaer
Pubblicato in: NeuroImage: Clinical, Numero 48, 2025, Pagina/e 103851, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2025.103851

Impact of Serotonin Deficiency on Circadian Dopaminergic Rhythms

Autori: Giacomo Maddaloni, Noemi Barsotti, Sara Migliarini, Martina Giordano, Serena Nazzi, Marta Picchi, Francesco Errico, Alessandro Usiello, Massimo Pasqualetti
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 6475, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25126475

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Autori: Anna Gorlova; Evgeniy Svirin; Dmitrii Pavlov; Raymond Cespuglio; Andrey Proshin; Careen A. Schroeter; Klaus-Peter Lesch; Tatyana Strekalova
Pubblicato in: Int. J. Mol. Sci., Numero Vol 24, 2023, Pagina/e 915, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24020915

Reclaiming saliency: Rhythmic precision-modulated action and perception.

Autori: Anil Meera, A., Novicky, F., Parr, T., Friston, K., Lanillos, P., & Sajid, N.
Pubblicato in: Frontiers in Neurorobotics, Numero Volume 16 - 2022, 2022, ISSN 1662-5218
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbot.2022.896229

Serotonin limits generation of chromaffin cells during adrenal organ development

Autori: Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Pubblicato in: Nature Communications, Numero 13, 2022, Pagina/e 2901, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Intrauterine Exposure to Antidepressants or Maternal Depressive Symptoms and Offspring Brain White Matter Trajectories From Late Childhood to Adolescence

Autori: Dogukan Koc, Hanan El Marroun, Bruno H. Stricker, Ryan L. Muetzel, Henning Tiemeier
Pubblicato in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Numero 9, 2024, Pagina/e 217-226, ISSN 2451-9022
Editore: Elsevier BV
DOI: 10.1016/j.bpsc.2023.10.009

Constitutive depletion of brain serotonin differentially affects rats’ social and cognitiveabilities

Autori: L. Alonso, P. Peeva, S. Stasko, M. Bader, N. Alenina, Y. Winter, M. Rivalan
Pubblicato in: iScience, Numero 26, 2023, Pagina/e 105998, ISSN 2589-0042
Editore: Cell Press Elsevier Inc.
DOI: 10.1016/j.isci.2023.105998

<i>In Vivo</i> Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex

Autori: Gabriel Ocana-Santero, Adam M. Packer, Trevor Sharp, Simon J. B. Butt
Pubblicato in: ACS Chemical Neuroscience, Numero 15, 2024, Pagina/e 456-461, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.3c00725

Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC)line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing

Autori: D. Diouf, M.R. Vitale, J.E.M Zoller, A.-M. Pineau, E. Klopocki, C. Hamann, G.C. Ziegler, T. Vanmierlo, D. van den Hove, K.-P. Lesch
Pubblicato in: Stemm Cell Research, Numero Vol 63, 2023, Pagina/e 103038, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2023.103038

Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits

Autori: Tianhua Wang, Judith R. Homberg, Laura Boreggio, Marta C. F. Samina, Rogério C. R. Castro, Sharon M. Kolk, Natalia Alenina, Michael Bader, Jinye Dai, Markus Wöhr
Pubblicato in: Molecular Autism, Numero 15, 2024, Pagina/e 50, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-024-00629-x

Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors

Autori: Angela Michela De Stasi, Javier Zorrilla de San Martin, Nina Soto, Andrea Aguirre, Jimmy Olusakin, Joana Lourenço, Patricia Gaspar, Alberto Bacci
Pubblicato in: The Journal of Neuroscience, Numero 45, 2025, Pagina/e e2393232024, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.2393-23.2024

Tph2 Gene Expression Defines Ethanol Drinking Behavior in Mice

Autori: Magdalena Zaniewska, Valentina Mosienko, Michael Bader, and Natalia Alenina
Pubblicato in: Cells, Numero 11, 2022, Pagina/e 874, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11050874

Non-peer reviewed articles (1)

Maternal tryptophan hydroxylase 1 genotype defines offspring’s cognition and behaviour

Autori: R. Rocha De Castro, M. Verheij, A.A. Vazquez, J. Buitelaar, J. Homberg
Pubblicato in: Neuroscience Applied, Numero 2, 2024, Pagina/e 102608, ISSN 2772-4085
Editore: Elsevier BV
DOI: 10.1016/j.nsa.2023.102608

Book chapters (1)

Robotic Active Tactile Sensing Inspired by Serotonergic Modulation Using Active Inference

Autori: Filip Novicky, Joshua Offergeld, Simon Janssen, Pablo Lanillos
Pubblicato in: Lecture Notes in Computer Science, Biomimetic and Biohybrid Systems, 2023, Pagina/e 33-55
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-031-38857-6_3