Exploring cell-to-cell heterogeneity and exploiting epigenetic regulation for the interception of myeloid disease cells.

Project Information

INTERCEPT-MDS

Grant agreement ID: 953407

DOI

10.3030/953407

Project closed

EC signature date 13 August 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 120 455,88

EU contribution

€ 3 120 455,88

Coordinated by

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Initial online presence

Online presence with twitter account and website with links to a published layman video and links to social media profiles of ESRs

Publications

Peer reviewed articles (12)

Topic: AS04-MDS Biology and Pathogenesis/AS04f-Gene expression profiling: MUTATION-SPECIFIC HSPC ENRICHMENT PATTERNS UNDERLIE PROGNOSTICALLY SIGNIFICANT TRANSCRIPTOMIC SUBGROUPS OF MDS PATIENTS

Author(s): M. Sakuma, M. Meggendorfer, W. Kern, C. Haferlach, T. Haferlach, W. Walter
Published in: Leukemia Research, Issue 128, 2023, Page(s) 107199, ISSN 0145-2126
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2023.107199

UBA1 Non-M41 Variants Are More Aggressive than UBA1 M41 Variants in Their Haematological Manifestations

Author(s): Maki Sakuma, Constance Baer, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Wencke Walter
Published in: EMJ Hematology, 2023, Page(s) 37-38, ISSN 2053-6631
Publisher: European Medical Journal
DOI: 10.33590/emjhematol/10308258.

Flow cytometric analysis of erythroid precursors and mutational signatures of lower risk myelodysplastic syndromes identify responders to erythroid stimulating agents

Author(s): Marco G. Raddi, Sara Bencini, Benedetta Peruzzi, Giorgio Mattiuz, Sven De Pourcq, Michele Tanturli, Nicolas Chapuis, Angela Consagra, Luca Rigodanza, Cristina Amato, Alessandro Sanna, Elena Tofacchi, Enrico Attardi, Sophie Park, Olivier Kosmider, Francesco Annunziato, Michaela Fontenay, Valeria Santini
Published in: Blood Cancer Journal, Issue 14, 2024, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/s41408-024-01112-9

Histone Variants and Their Chaperones in Hematological Malignancies

Author(s): Ecem Kirkiz, Oliver Meers, Florian Grebien, Marcus Buschbeck
Published in: HemaSphere, Issue 7, 2024, Page(s) e927, ISSN 2572-9241
Publisher: Hague
DOI: 10.1097/hs9.0000000000000927

Novel causative variants of VEXAS in UBA1 detected through whole genome transcriptome sequencing in a large cohort of hematological malignancies

Author(s): Maki Sakuma, Piers Blombery, Manja Meggendorfer, Claudia Haferlach, Markus Lindauer, Uwe M. Martens, Wolfgang Kern, Torsten Haferlach, Wencke Walter
Published in: Leukemia, Issue 37, 2023, Page(s) 1080-1091, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-023-01857-5

EHA2024 Hybrid Congress

Author(s): Maki Sakuma, Wencke Walter, Manja Meggendorfer, Shubhra Bhattacharya, Marcus Buschbeck, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach
Published in: HemaSphere, Issue 8, 2024, ISSN 2572-9241
Publisher: European Hematology Association
DOI: 10.1002/hem3.104

The consequences of cohesin mutations in myeloid malignancies

Author(s): Shubhra Ashish Bhattacharya, Eve Dias,Andrea Nieto-Aliseda and Marcus Buschbeck
Published in: Frontiers in Molecular Biosciences, 2023, ISSN 2296-889X
Publisher: University of California, Davis
DOI: 10.3389/fmolb.2023.1319804

scMaSigPro: Differential Expression Analysis along Single-Cell Trajectories

Author(s): Priyansh Srivastava, Marta Benegas Coll, Stefan Götz, María José Nueda, Ana Conesa
Published in: Bioinformatics, 2024, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btae443

S161: UBA1 NON-M41 VARIANTS ARE MORE AGGRESSIVE THAN UBA1 M41 VARIANTS IN THEIR HEMATOLOGICAL MANIFESTATIONS.

Author(s): Maki Sakuma, Constance Baer, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Wencke Walter
Published in: HemaSphere, Issue 7, 2023, Page(s) e3306813, ISSN 2572-9241
Publisher: European Hematology Association
DOI: 10.1097/01.hs9.0000967556.33068.13

<i>UBA1</i> dysfunction in VEXAS and cancer

Author(s): Maki Sakuma, Torsten Haferlach, Wencke Walter
Published in: Oncotarget, Issue 15, 2024, Page(s) 644-658, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.28646

Identification of novel <i>NUP98</i> fusion partners and comutations in acute myeloid leukemia: an adult cohort study

Author(s): James S. Heald, Aleix Méndez López, Miguel L. Pato, Neus Ruiz-Xivillé, Marta Cabezón, Lurdes Zamora, Susana Vives, Rosa Coll, Clara Maluquer, Isabel Granada, Francesc Solé, Manel Esteller, María Berdasco
Published in: Blood Advances, Issue 8, 2024, Page(s) 2691-2694, ISSN 2473-9529
Publisher: American Society of Hematology,
DOI: 10.1182/bloodadvances.2023012479

P690: IDENTIFICATION OF CLINICALLY RELEVANT VARIANT-LEVEL SEX-BIAS IN SF3B1 K700/K666 AND IDH2 R140/R172

Author(s): Maki Sakuma, Constance Baer, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Wencke Walter
Published in: HemaSphere, Issue 7, 2023, Page(s) e13393b9, ISSN 2572-9241
Publisher: European Hematology Association
DOI: 10.1097/01.hs9.0000969664.13393.b9

Non-peer reviewed articles (1)

Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays

Author(s): Sven De Pourcq, Pei-Lun Kuo, Ann Zenobia Moore, Stefania Bandinelli, Steve Horvath, Luigi Ferrucci, Valeria Santini
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.17.618672