Training experts in antigen processing to deliver new drug prototypes for cancer and autoimmune diseases

Informazioni relative al progetto

CAPSTONE

ID dell’accordo di sovvenzione: 954992

DOI

10.3030/954992

Progetto chiuso

Data della firma CE 3 Settembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 968 730,62

Contributo UE

€ 3 968 730,62

Coordinato da

UNIVERSITE DE LILLE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

ETN CAPSTONE website

Pubblicazioni

Peer reviewed articles (17)

ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights

Autori: Vasileios Fougiaxis, Ben He, Tuhina Khan, Rodolphe Vatinel, Nikoletta M. Koutroumpa, Antreas Afantitis, Laetitia Lesire, Pierre Sierocki, Benoit Deprez, Rebecca Deprez-Poulain
Pubblicato in: Journal of Medicinal Chemistry, Numero 67, 2024, Pagina/e 11597-11621, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00840

Immunogenic Cell Death Inducers in Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors

Autori: Valeria Lucarini, Ombretta Melaiu, Paula Gragera, Kamila Król, Valentina Scaldaferri, Verena Damiani, Adele De Ninno, Daniela Nardozi, Luca Businaro, Laura Masuelli, Roberto Bei, Loredana Cifaldi, Doriana Fruci
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, Pagina/e 1613, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26041613

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

Autori: Galateia Georgaki, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1415964

Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma

Autori: Patrizia Tempora, Silvia D’Amico, Paula Gragera, Verena Damiani, Kamila Krol, Valentina Scaldaferri, Kirti Pandey, Shanzou Chung, Valeria Lucarini, Ezio Giorda, Marco Scarsella, Gabriele Volpe, Marco Pezzullo, Cristiano De Stefanis, Valentina D’Oria, Lorenzo De Angelis, Roberto Giovannoni, Maria Antonietta De Ioris, Ombretta Melaiu, Anthony W. Purcell, Franco Locatelli, Doriana Fruci
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 43, 2024, ISSN 1756-9966
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s13046-024-03180-y

First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease

Autori: Vasileios Fougiaxis, Valentina Barcherini, Milena M. Petrovic, Pierre Sierocki, Sandrine Warenghem, Florence Leroux, Nour Bou Karroum, Fabien Petit-Cancelier, Vincent Rodeschini, Didier Roche, Benoit Deprez, Rebecca Deprez-Poulain
Pubblicato in: European Journal of Medicinal Chemistry, Numero 280, 2024, Pagina/e 116926, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2024.116926

Two bullets in the gun: combining immunotherapy with chemotherapy to defeat neuroblastoma by targeting adrenergic-mesenchymal plasticity

Autori: Silvia D’Amico, Patrizia Tempora, Paula Gragera, Kamila Król, Ombretta Melaiu, Maria Antonietta De Ioris, Franco Locatelli, Doriana Fruci
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1268645

Discovery of New Nanomolar Selective IRAP Inhibitors

Autori: Ben He, Nour Bou Karroum, Ronan Gealageas, François-Xavier Mauvais, Sandrine Warenghem, Matthieu Roignant, Nicolas Kraupner, Bao Vy Lam, Nathalie Azaroual, Vincent Ultré, Alexandre Rech, Laetitia Lesire, Cyril Couturier, Florence Leroux, Peter van Endert, Benoit Deprez, Rebecca Deprez-Poulain
Pubblicato in: Journal of Medicinal Chemistry, Numero 68, 2025, Pagina/e 4168-4195, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c01744

A Systematic Review of Deep Learning Methodologies Used in the Drug Discovery Process with Emphasis on In Vivo Validation

Autori: Nikoletta-Maria Koutroumpa, Konstantinos D. Papavasileiou, Anastasios G. Papadiamantis, Georgia Melagraki, Antreas Afantitis
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 6573, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076573

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor

Autori: Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D. Findlay, Jonathan S. Foot, Francois‐Xavier Mauvais, Peter van Endert, Petros Giastas, Dieter W. Hamprecht, Efstratios Stratikos
Pubblicato in: Protein Science, Numero 33, 2024, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.5151

Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)

Autori: Aroosha Raja, Jonas J. W. Kuiper
Pubblicato in: Genes & Immunity, Numero 24, 2023, Pagina/e 295-302, ISSN 1476-5470
Editore: Nature
DOI: 10.1038/s41435-023-00225-8

Discovery of Novel Allosteric Inhibitor Hits for Insulin-Regulated Aminopeptidase Provides Insights on Enzymatic Mechanism

Autori: Galateia Georgaki, Nikoletta-Maria Koutroumpa, Panagiotis Lagarias, Antreas Afantitis, Athanasios Papakyriakou, Efstratios Stratikos
Pubblicato in: ACS Omega, Numero 10, 2025, Pagina/e 17960-17972, ISSN 2470-1343
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsomega.5c01169

ERAP1 Activity Modulates the Immunopeptidome but Also Affects the Proteome, Metabolism, and Stress Responses in Cancer Cells

Autori: Martha Nikopaschou, Martina Samiotaki, Elli-Anna Stylianaki, Kamila Król, Paula Gragera, Aroosha Raja, Vassilis Aidinis, Angeliki Chroni, Doriana Fruci, George Panayotou, Efstratios Stratikos
Pubblicato in: Molecular & Cellular Proteomics, Numero 24, 2025, Pagina/e 100964, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2025.100964

Titania: an integrated tool for in silico molecular property prediction and NAM-based modeling

Autori: Nikoletta-Maria Koutroumpa, Maria Antoniou, Dimitra-Danai Varsou, Konstantinos D. Papavasileiou, Nikolaos K. Sidiropoulos, Christoforos Kyprianou, Andreas Tsoumanis, Haralambos Sarimveis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis
Pubblicato in: Molecular Diversity, 2025, ISSN 1381-1991
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11030-025-11196-5

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

Autori: Paolo Romania, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Doriana Fruci
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1537876

Prediction of blood–brain barrier and Caco-2 permeability through the Enalos Cloud Platform: combining contrastive learning and atom-attention message passing neural networks

Autori: Nikoletta-Maria Koutroumpa, Andreas Tsoumanis, Haralambos Sarimveis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis
Pubblicato in: Journal of Cheminformatics, Numero 17, 2025, ISSN 1758-2946
Editore: Chemistry Central
DOI: 10.1186/s13321-025-01007-2

An untargeted metabolomic study using MALDI-mass spectrometry imaging reveals region-specific biomarkers associated with bowel inflammation

Autori: Adele Ponzoni, Silvia Speca, Matthew Hartle, Amandine Gerstenberg, Aurore Tomezyk, Victor Senechal, Shane Karnik, Laurent Dubuquoy, David Launay, Rebecca Deprez-Poulain, Mathieu Gaudin, Corinne Ramos, Benoit Deprez
Pubblicato in: Metabolomics, Numero 21, 2025, ISSN 1573-3890
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11306-024-02200-4

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1

Autori: Ioannis Temponeras, Martina Samiotaki, Despoina Koumantou, Martha Nikopaschou, Jonas J.W. Kuiper, George Panayotou, Efstratios Stratikos
Pubblicato in: European Journal of Immunology, Numero 53, 2023, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350449

Other (1)

ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes

Autori: Martha Nikopaschou, Martina Samiotaki, Anna Kanavou, Nikos Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos
Pubblicato in: bioRxiv - The preprint server for biology, 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.08.652898