European Network Linking Informatics and Genomics of Helper T cells in Tissues

Projektinformationen

ENLIGHT-TENplus

ID Finanzhilfevereinbarung: 955321

DOI

10.3030/955321

Projekt abgeschlossen

EK-Unterschriftsdatum 19 August 2020

Startdatum 1 März 2021

Enddatum 28 Februar 2025

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 4 067 526,24

EU-Beitrag

€ 4 067 526,24

Koordiniert durch

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Other (13)

Vacancy widely advertised (incl. Euraxess, Naturejobs)

Vacancy of ESR positions widely advertised; detailed information on ESR projects provided via website

3rd Network Meeting

Organisation and implementation of 3rd Network Meeting including specific training events

1st Summer School Key concepts and innovative methods in immunology

Organisation and implementation of a Summer School on the understanding and communication of key concepts and innovative methods in immunology

Symposium How -omics & artificial intelligence advance T cell immunology

"Organisation and implementation of a 2-day International Symposium on the topic ""How -omics and artificial intelligence can advance T cell immunology""; ESR will take the lead"

Researcher Declaration (submitted within 20 days after recruitment)

Researcher Declaration submitted within 20 days after recruitment for each ESR

4th Summer School What to do with a PhD?

"Organisation and implementation of a Summer School on the topic ""What to do with a PhD – a hands-on workshop for job hunters"""

Art exhibition

Organisation and implementation of an art exhibition by internationally renowned artists in parallel with the International Symposium

2nd Summer School Bioinformatics and machine-learning for immunologists

Organisation and implementation of a Summer School on data resources and machine-learning tools for T cell immunologists

Awarding of PhD degrees

Awarding of PhD degrees to ESRs documented

2nd Network Meeting

Organisation and implementation of 2nd Network Meeting including specific training events

3rd Summer School Translational research and medicine development

Organisation and implementation of a Summer School on translational research and medicine development

1st Network Meeting

Organisation and implementation of 1st Network Meeting including specific training events

PCDP created (and yearly updates by the Training Committee to the SB)

PCDPs jointly drafted by the ESR and the responsible supervisor, updated and reviewed by the co-supervisor and the Training Committee, and submitted yearly to SBDue dates: months 12, 24 and 36

Documents, reports (3)

Dissemination & Exploitation Plan, annual updates

Establishment of Dissemination & Exploitation Plan, and annual updatesDue dates: months 6, 18, 30, and 42

Press release about ENLIGHT-TEN+ start

Press release about ENLIGHT-TEN+ start published

Communication Plan, biannual updates

Establishment of Communication Plan, and biannual updatesDue dates: months 6, 12, 18, 24, 30, 36, and 42

Veröffentlichungen

Peer reviewed articles (16)

Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children

Autoren: Zhenguang Zhang, Iain R. L. Kean, Lisa M. Dratva, John A. Clark, Eleni Syrimi, Naeem Khan, Esther Daubney, Deborah White, Lauran O’Neill, Catherine Chisholm, Caroline Payne, Sarah Benkenstein, Klaudia Kupiec, Rachel Galassini, Victoria Wright, Helen Winmill, Ceri Robbins, Katherine Brown, Padmanabhan Ramnarayan, Barnaby Scholefield, Mark Peters, Nigel Klein, Hugh Montgomery, Kerstin B. Meyer, Sa
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-48699-y

PIM kinases regulate early human Th17 cell differentiation

Autoren: Tanja Buchacher, Ankitha Shetty, Saara A. Koskela, Johannes Smolander, Riina Kaukonen, António G.G. Sousa, Sini Junttila, Asta Laiho, Olof Rundquist, Tapio Lönnberg, Alexander Marson, Omid Rasool, Laura L. Elo, Riitta Lahesmaa
Veröffentlicht in: Cell Reports, Ausgabe 42, 2024, Seite(n) 113469, ISSN 2211-1247
Herausgeber: Cell Press
DOI: 10.1016/j.celrep.2023.113469

Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration

Autoren: António G.G. Sousa, Johannes Smolander, Sini Junttila, Laura L. Elo
Veröffentlicht in: bioRxiv, 2025, ISSN 0000-0000
Herausgeber: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.07.637023

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

Autoren: Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Lorenz Kretschmer, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline M. Boccacino, Waradon Sungnak, Rasa Elmentaite, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killing
Veröffentlicht in: Nature, 2024, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-024-07575-x

The dark side of Tregs during aging

Autoren: Martina Palatella Stephane M. Guillaume Michelle A. Linterman Jochen Huehn
Veröffentlicht in: Frontiers in Immunology, 2022, ISSN 1664-3224
Herausgeber: International Union of Immunological Societies
DOI: 10.3389/fimmu.2022.940705

A comprehensive genetic map of cytokine responses in Lyme borreliosis

Autoren: Javier Botey-Bataller, Hedwig D. Vrijmoeth, Jeanine Ursinus, Bart-Jan Kullberg, Cees C. van den Wijngaard, Hadewych ter Hofstede, Ahmed Alaswad, Manoj K. Gupta, Lennart M. Roesner, Jochen Huehn, Thomas Werfel, Thomas F. Schulz, Cheng-Jian Xu, Mihai G. Netea, Joppe W. Hovius, Leo A. B. Joosten, Yang Li
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-47505-z

Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoder

Autoren: Alice Driessen, Susanne Unger, An-phi Nguyen, Rhonda E Ries, Soheil Meshinchi, Stefanie Kreutmair, Chiara Alberti, Pavel Sumazin, Richard Aplenc, Michele S Redell, Burkhard Becher, María Rodríguez Martínez
Veröffentlicht in: Life Science Alliance, Ausgabe 7, 2024, Seite(n) e202402674, ISSN 2575-1077
Herausgeber: Life Science Alliance LLC
DOI: 10.26508/lsa.202402674

A new method to measure cell metabolism of rare cells <i>in vivo</i> reveals a high oxidative phosphorylation dependence of lung T cells

Autoren: Aristeidis Roubanis, Morgane Hilaire, Morgane Le Teuff, Odile Devergne, Tim Sparwasser, Luciana Berod, Benoît L Salomon
Veröffentlicht in: Immunology &amp; Cell Biology, 2025, ISSN 0818-9641
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/imcb.70018

Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1

Autoren: Thea Sjøgren, Shahinul Islam, Igor Filippov, Adrianna Jebrzycka, André Sulen, Lars E. Breivik, Alexander Hellesen, Anders P. Jørgensen, Kari Lima, Liina Tserel, Kai Kisand, Pärt Peterson, Annamari Ranki, Eystein S. Husebye, Bergithe E. Oftedal, Anette S.B. Wolff
Veröffentlicht in: iScience, Ausgabe 27, 2024, Seite(n) 109610, ISSN 2589-0042
Herausgeber: Elsevier
DOI: 10.1016/j.isci.2024.109610

An integrated single-cell atlas of blood immune cells in aging

Autoren: Igor Filippov, Leif Schauser, Pärt Peterson
Veröffentlicht in: npj Aging, Ausgabe 10, 2024, ISSN 2731-6068
Herausgeber: Nature Portfolio
DOI: 10.1038/s41514-024-00185-x

MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells

Autoren: Rutger J. Röring, Priya A. Debisarun, Javier Botey-Bataller, Tsz Kin Suen, Özlem Bulut, Gizem Kilic, Valerie A.C.M. Koeken, Andrei Sarlea, Harsh Bahrar, Helga Dijkstra, Heidi Lemmers, Katharina L. Gössling, Nadine Rüchel, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Yavuz Ariyurek, Emile J. de Meijer, Susan L. Kloet, Jaap ten Oever, Katarzyna Placek, Yang L
Veröffentlicht in: Journal of Clinical Investigation, Ausgabe 134, 2024, ISSN 1558-8238
Herausgeber: American Society for Clinical Investigation
DOI: 10.1172/jci170848

Cytotoxic CD8+ Temra cells show loss of chromatin accessibility at genes associated with T cell activation

Autoren: Lehte Türk, Igor Filippov, Christian Arnold, Judith Zaugg, Liina Tserel, Kai Kisand, Pärt Peterson
Veröffentlicht in: Frontiers in Immunology, Ausgabe 15, 2024, ISSN 1664-3224
Herausgeber: Frontiers
DOI: 10.3389/fimmu.2024.1285798

Temporal multi-omics analysis of COVID-19 in end-stage kidney disease

Autoren: Emily Stephenson, Erin Macdonald-Dunlop, Lisa M. Dratva, Rik G.H. Lindeboom, Zewen Kelvin Tuong, Win Min Tun, Lorenz Kretschmer, Norzawani B. Buang, Stephane Ballereau, Mia Cabantaus, Ana Peñalver, Elena Prigmore, John R. Ferdinand, Benjamin J. Stewart, Jack Gisby, Talat H. Malik, Candice L. Clarke, Nicholas Medjeral-Thomas, Maria Prendecki, Stephen McAdoo, Anais Portet, Michelle Willicombe, Elea
Veröffentlicht in: Cell Genomics, Ausgabe 5, 2025, Seite(n) 100918, ISSN 2666-979X
Herausgeber: Elsevier BV
DOI: 10.1016/j.xgen.2025.100918

Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population

Autoren: Saumya Kumar, Martijn Zoodsma, Nhan Nguyen, Rodrigo Pedroso, Stephanie Trittel, Peggy Riese, Javier Botey-Bataller, Liang Zhou, Ahmed Alaswad, Haroon Arshad, Mihai G. Netea, Cheng-Jian Xu, Frank Pessler, Carlos A. Guzmán, Luis Graca, Yang Li
Veröffentlicht in: Science Advances, Ausgabe 10, 2024, ISSN 2375-2548
Herausgeber: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adq7006

Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data

Autoren: Felix Drost, Yang An, Irene Bonafonte-Pardàs, Lisa M. Dratva, Rik G. H. Lindeboom, Muzlifah Haniffa, Sarah A. Teichmann, Fabian Theis, Mohammad Lotfollahi, Benjamin Schubert
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-49806-9

Comparative transcriptomic analyses of thymocytes using 10x Genomics and Parse scRNA-seq technologies

Autoren: Igor Filippov, Chinna Susan Philip, Leif Schauser, Pärt Peterson
Veröffentlicht in: BMC Genomics, Ausgabe 25, 2024, ISSN 1471-2164
Herausgeber: BioMed Central
DOI: 10.1186/s12864-024-10976-x

Book chapters (1)

Inferring Tree-Shaped Single-Cell Trajectories with Totem

Autoren: António G. G. Sousa, Johannes Smolander, Sini Junttila, Laura L. Elo
Veröffentlicht in: Methods in Molecular Biology, Transcriptome Data Analysis, 2024, Seite(n) 169-191
Herausgeber: Springer US
DOI: 10.1007/978-1-0716-3886-6_9

Non-peer reviewed articles (2)

Crafting an MSCA PhD Masterpiece: Guiding Students on the Verge of Discovery

Autoren: Lisa Dratva, Alice Driessen, Igor Filippov, Stéphane Guillaume, Lisa Hoenicke, Jean‐Christophe Lone
Veröffentlicht in: European Journal of Immunology, 2024, ISSN 0014-2980
Herausgeber: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202451659

Temporal multi-omic analysis of COVID-19 in end-stage kidney disease

Autoren: Emily Stephenson, Erin Macdonald-Dunlop, Lisa M Dratva, Rik G.H. Lindeboom, Zewen Kelvin Tuong, Win Min Tun, Norzawani B Buang, Stephane Ballereau, Mia Cabantaus, Ana Peñalver, Elena Prigmore, John R Ferdinand, Benjamin J Stewart, Jack Gisby, Talat Malik, Candice L Clarke, Nicholas Medjeral-Thomas, Maria Prendecki, Stephen McAdoo, Anais Portet, Michelle Willicombe, Eleanor Sandhu, Matthew C. Pick
Veröffentlicht in: medRxiv, 2024, ISSN 0000-0000
Herausgeber: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.20.24309228