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Training Network for Optimizing Adoptive T cell Therapy of Cancer

Descripción del proyecto

Optimización del tratamiento con linfocitos T

El tratamiento con linfocitos T adoptivos, que utiliza las células del propio enfermo como un arma, constituye un gran paso adelante en el tratamiento del cáncer. Sin embargo, la elaboración de tales productos inmunoterapéuticos no ha sido armonizada mediante estudios clínicos. El proyecto T-OP, financiado con fondos europeos, se propone cubrir esta laguna reuniendo equipos interdisciplinares de científicos que trabajan en terapia celular, inmunología, ingeniería de proteínas y bioinformática, con grandes y medianas empresas. El trabajo científico se centrará en las citocinas y su función en los resultados terapéuticos del tratamiento con células adoptivas con el fin de determinar la combinación óptima. Los resultados del proyecto conducirán al desarrollo de inmunoterapias mejores y más seguras.

Objetivo

Over the last years, immunotherapy – using a patient’s own immune system to fight tumours – has emerged as an important complement to standard treatments. The clinical implementation of immunotherapeutics has established T cells as efficient anti-cancer weapons if targeted by specific drugs. Their therapeutic utilization has recently come to a breakthrough: adoptive T cell therapy (ACT), collecting and transforming the patient’s own T cells to treat cancer. An estimated 753 different cell therapies are currently in development, of which 375 are in clinical trials worldwide. The global cell therapy market was valued at $2.70 billion in 2018 and is expected to reach $8.21 billion in 2025. While European pharmaceutical companies and research institutions rank amongst the world leaders in basic and preclinical aspects of immunity including cell therapy development, clinical innovations and approvals in this field have largely been pioneered in other countries, especially in the USA and in China. The generation of such ACT products is a complex but ill-defined process with limited harmonization across production and clinical studies, even for the same indication. Cytokines are proteins responsible for the growth and differentiation of T cells. They are central to the generation procedure, whilst also playing a key role in the efficacy and safety of the cellular product. There is however a limited understanding as to which cytokines might lead to the best outcome on any of these steps. T-OP targets a pioneering research question: how do cytokines influence the therapeutic outcome of ACT products? T-OP brings together interdisciplinary and cross-sectorial teams spanning large and small-sized companies as well as experts in different aspects of cell therapy, immunology, protein engineering and bioinformatics. T-OP will train by research 15 ESR, enabling them to develop efficient therapeutic solutions and to tackle economic opportunities.

Coordinador

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Aportación neta de la UEn
€ 758 365,20
Dirección
GESCHWISTER SCHOLL PLATZ 1
80539 Muenchen
Alemania

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Región
Bayern Oberbayern München, Kreisfreie Stadt
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 758 365,20

Participantes (11)