Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Informations projet

HYPERBOOST

N° de convention de subvention: 955625

DOI

10.3030/955625

Projet clôturé

Date de signature de la CE 13 Août 2020

Date de début 1 Decembre 2020

Date de fin 30 Novembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 761 881,56

Contribution de l’UE

€ 3 761 881,56

Coordonné par

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (22)

Normal tissue response after RT±HT-update
Report on HYPERBOOST training finalized
QA guidelines for clinical HT treatments-update
Dissemination report based on dissemination strategy

Dissemination report based on D6.1

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Heat shock and tumor response after RT±HT-update

heat shock and tumor response after RT±HT-update

Plan for dissemination strategy
HYPERBOOST international conference conducted
Progress PhD theses according to PCDP
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Data reporting formats for RT+HT treatments-update

data reporting formats for RT+HT treatments -update

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Immune system effects after RT±HT-update
Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Optimisation strategies based on biological modelling-update

optimisation strategies based on biological modelling-update

RT+HT dose predictors for incorporation in planning
Blood flow and hypoxia after RT±HT-update
Mathematical model representing effect RT±HT-update

mathematical model representing effect RT±HT-update

Other (5)

European centre collecting blood/tissue samples
Multicentre clinical registration study
ESR training certificates provided
Recruitment
European centre collecting clinical HT data

Demonstrators, pilots, prototypes (2)

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Imaging technique to monitor effect of RT+HT therapy-update

imaging technique to monitor effect of RT+HT therapy-update

Open Research Data Pilot (2)

Scientific and education material available on the website
Paper best practice hyperthermia planning published

Publications

Peer reviewed articles (31)

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Auteurs: Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Publié dans: Volume 23, Numéro 15, 2023, Page(s) 1209, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Auteurs: Enzo M. Scutigliani, Jons van Hattum, Fernando Lobo-Cerna, Joanne Kruyswijk, Maja Myrcha, Frederique E. G. A. Dekkers, Ron A. Hoebe, Finn Edwards, Jetta J. Oppelaar, Liffert Vogt, Sanne Bootsma, Maarten F. Bijlsma, Daisy I. Picavet, Johannes Crezee, Jorg R. Oddens, Theo M. de Reijke, Przemek M. Krawczyk
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2023, Page(s) 423, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25010423

Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors

Auteurs: Faezeh Rahimi, Bilguun Nurzed, Thomas W. Eigentler, Mostafa Berangi, Eva Oberacker, Andre Kuehne, Pirus Ghadjar, Jason M. Millward, Rolf Schuhmann, Thoralf Niendorf
Publié dans: Bioengineering, Numéro 11, 2024, Page(s) 733, ISSN 2306-5354
Éditeur: MDPI
DOI: 10.3390/bioengineering11070733

present status and ongoing developments toward routine clinical use

Auteurs: H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Publié dans: International journal of Hyperthermia, Numéro 3, 2022, Page(s) 1126-1140, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Auteurs: Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Publié dans: International Journal of Hyperthermia, 40(1), Numéro 4, 2023, Page(s) 2207797, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Auteurs: Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Publié dans: Cancers, Numéro 14(19), 2022, Page(s) 4795, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Auteurs: Scheidegger S, Mingo Barba S, Gaipl U.S.
Publié dans: Cancers, Numéro 13, 2021, Page(s) 5764, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers

Auteurs: Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips,
Publié dans: International Journal of Hyperthermia, Numéro 41, 2024, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2024.2342348

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme

Auteurs: Eva Oberacker, Cecilia Diesch, Jacek Nadobny, Andre Kuehne, Peter Wust, Pirus Ghadjar, Thoralf Niendorf
Publié dans: Cancers, Numéro 13, 2024, Page(s) 1867, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Auteurs: Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Publié dans: Current Stem Cell Reports, 2022, ISSN 2198-7866
Éditeur: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Robust stochastic optimisation strategies for locoregional hyperthermia treatment planning using polynomial chaos expansion

Auteurs: Jort Groen, Timoteo Daniel Herrera, Johannes Crezee, H Petra Kok
Publié dans: Physics in Medicine & Biology, 2025, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ada685

Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties

Auteurs: Timoteo D. Herrera, Jakob Ödén, Andrea Lorenzo Polo, Johannes Crezee, H. Petra Kok
Publié dans: International Journal of Radiation Oncology*Biology*Physics, Numéro 120, 2024, Page(s) 1435-1447, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.07.2146

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Auteurs: Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Publié dans: Cancers, Numéro 14(21), 2022, Page(s) 5349, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Auteurs: Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Publié dans: Cancers, Numéro 14(5), 2022, Page(s) 1175, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Auteurs: Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Publié dans: Int J Hyperthermia. 2023;40(1):, Numéro 6, 2023, Page(s) 2265590, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Auteurs: Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Publié dans: International journal of Hyperthermia, Numéro 6, 2023, Page(s) 2272578, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Auteurs: H. P. Kok; T. D. Herrera; J. Crezee
Publié dans: Journal of Radiation Oncology, Biology, Physics, Numéro Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Auteurs: Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Publié dans: Cancers, Numéro 15 (1), 2022, Page(s) 113, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis

Auteurs: Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides
Publié dans: International Journal of Hyperthermia, Numéro 41, 2024, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2024.2405105

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Auteurs: Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Publié dans: Cancers; Volume 14; Numéro 9; Pages: 2050, Numéro 1, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Auteurs: Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Publié dans: International Journal of Hyperthermia, Numéro 40 (1), 2023, Page(s) 2275540, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

Auteurs: Mattia De Lazzari, Carolina Carrapiço-Seabra, Dietmar Marder, Gerard C. van Rhoon, Sergio Curto, Hana Dobšíček Trefná
Publié dans: International Journal of Hyperthermia, Numéro 41, 2025, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2024.2436005

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Auteurs: Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Publié dans: International journal of hyperthermia, Numéro 39(1), 2022, Page(s) 1078-1087, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Auteurs: Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Publié dans: International Journal of Hyperthermia,, Numéro 41:1,, 2024, Page(s) 2320852, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis

Auteurs: Adela Ademaj, Sonja Stieb, Cihan Gani, Oliver J. Ott, Dietmar Marder, Roger A. Hälg, Susanne Rogers, Pirus Ghadjar, Rainer Fietkau, Hans Crezee, Oliver Riesterer
Publié dans: Strahlentherapie und Onkologie, 2024, ISSN 0179-7158
Éditeur: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-024-02312-9

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Auteurs: Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Publié dans: Cancers, Numéro 14(3), 2022, Page(s) 625, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Auteurs: Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Publié dans: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Éditeur: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for <i>In-Silico</i> Dynamic Radiobiological Models

Auteurs: Sergio Mingo Barba, Fernando Lobo-Cerna, Przemek M. Krawczyk, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger
Publié dans: Dose-Response, Numéro 22, 2024, ISSN 1559-3258
Éditeur: International Dose-Response Society
DOI: 10.1177/15593258241279906

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Auteurs: Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Publié dans: Volume 15, Numéro 4, 2023, Page(s) 1241, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Auteurs: H Petra Kok, Timoteo D Herrera , Johannes Crezee
Publié dans: Int J Radiat Oncol Biol Phys ., Numéro S0360-3016(22), 2022, Page(s) 03458-7, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Auteurs: Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Publié dans: Front. Oncol.Volume 13, Numéro 12, 2023, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

Non-peer reviewed articles (2)

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Auteurs: Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Publié dans: Seminars in radiation Oncology, Numéro 1, 2023, Page(s) 82-90, ISSN 1053-4296
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Auteurs: Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Publié dans: arXiv Medical Physics, Numéro 9, 2023, ISSN 2331-8422
Éditeur: arXiv
DOI: 10.48550/arxiv.2310.01073