Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Livrables

European centre collecting blood/tissue samples
Recruitment
European centre collecting clinical HT data

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Plan for dissemination strategy
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Publications

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Auteurs: Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Publié dans: Volume 23, Numéro 15, 2023, Page(s) 1209, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

present status and ongoing developments toward routine clinical use

Auteurs: H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Publié dans: International journal of Hyperthermia, Numéro 3, 2022, Page(s) 1126-1140, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Auteurs: Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Publié dans: International Journal of Hyperthermia, 40(1), Numéro 4, 2023, Page(s) 2207797, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Auteurs: Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Publié dans: Cancers, Numéro 14(19), 2022, Page(s) 4795, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Auteurs: Scheidegger S, Mingo Barba S, Gaipl U.S.
Publié dans: Cancers, Numéro 13, 2021, Page(s) 5764, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Auteurs: Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Publié dans: Current Stem Cell Reports, 2022, ISSN 2198-7866
Éditeur: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Auteurs: Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Publié dans: Cancers, Numéro 14(21), 2022, Page(s) 5349, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Auteurs: Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Publié dans: Cancers, Numéro 14(5), 2022, Page(s) 1175, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Auteurs: Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Publié dans: Int J Hyperthermia. 2023;40(1):, Numéro 6, 2023, Page(s) 2265590, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Auteurs: Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Publié dans: International journal of Hyperthermia, Numéro 6, 2023, Page(s) 2272578, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Auteurs: H. P. Kok; T. D. Herrera; J. Crezee
Publié dans: Journal of Radiation Oncology, Biology, Physics, Numéro Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Auteurs: Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Publié dans: Cancers, Numéro 15 (1), 2022, Page(s) 113, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Auteurs: Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Publié dans: Cancers; Volume 14; Numéro 9; Pages: 2050, Numéro 1, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Auteurs: Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Publié dans: International Journal of Hyperthermia, Numéro 40 (1), 2023, Page(s) 2275540, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Auteurs: Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Publié dans: International journal of hyperthermia, Numéro 39(1), 2022, Page(s) 1078-1087, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Auteurs: Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Publié dans: International Journal of Hyperthermia,, Numéro 41:1,, 2024, Page(s) 2320852, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme.

Auteurs: Thoralf Niendorf; Eva Oberacker; Pirus Ghadjar; Andre Kuehne
Publié dans: Cancers, Numéro 13(8), 2021, Page(s) 1867, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Auteurs: Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Publié dans: Cancers, Numéro 14(3), 2022, Page(s) 625, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Auteurs: Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Publié dans: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Éditeur: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Auteurs: Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Publié dans: Volume 15, Numéro 4, 2023, Page(s) 1241, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Auteurs: H Petra Kok, Timoteo D Herrera , Johannes Crezee
Publié dans: Int J Radiat Oncol Biol Phys ., Numéro S0360-3016(22), 2022, Page(s) 03458-7, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Auteurs: Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Publié dans: Front. Oncol.Volume 13, Numéro 12, 2023, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Auteurs: Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Publié dans: Seminars in radiation Oncology, Numéro 1, 2023, Page(s) 82-90, ISSN 1053-4296
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Auteurs: Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Publié dans: arXiv Medical Physics, Numéro 9, 2023, ISSN 2331-8422
Éditeur: arXiv
DOI: 10.48550/arxiv.2310.01073

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