Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Project Information

HYPERBOOST

Grant agreement ID: 955625

DOI

10.3030/955625

Project closed

EC signature date 13 August 2020

Start date 1 December 2020

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 761 881,56

EU contribution

€ 3 761 881,56

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (22)

Normal tissue response after RT±HT-update
Report on HYPERBOOST training finalized
QA guidelines for clinical HT treatments-update
Dissemination report based on dissemination strategy

Dissemination report based on D6.1

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Heat shock and tumor response after RT±HT-update

heat shock and tumor response after RT±HT-update

Plan for dissemination strategy
HYPERBOOST international conference conducted
Progress PhD theses according to PCDP
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Data reporting formats for RT+HT treatments-update

data reporting formats for RT+HT treatments -update

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Immune system effects after RT±HT-update
Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Optimisation strategies based on biological modelling-update

optimisation strategies based on biological modelling-update

RT+HT dose predictors for incorporation in planning
Blood flow and hypoxia after RT±HT-update
Mathematical model representing effect RT±HT-update

mathematical model representing effect RT±HT-update

Other (5)

European centre collecting blood/tissue samples
Multicentre clinical registration study
ESR training certificates provided
Recruitment
European centre collecting clinical HT data

Demonstrators, pilots, prototypes (2)

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Imaging technique to monitor effect of RT+HT therapy-update

imaging technique to monitor effect of RT+HT therapy-update

Open Research Data Pilot (2)

Scientific and education material available on the website
Paper best practice hyperthermia planning published

Publications

Peer reviewed articles (31)

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Author(s): Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Published in: Volume 23, Issue 15, 2023, Page(s) 1209, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Author(s): Enzo M. Scutigliani, Jons van Hattum, Fernando Lobo-Cerna, Joanne Kruyswijk, Maja Myrcha, Frederique E. G. A. Dekkers, Ron A. Hoebe, Finn Edwards, Jetta J. Oppelaar, Liffert Vogt, Sanne Bootsma, Maarten F. Bijlsma, Daisy I. Picavet, Johannes Crezee, Jorg R. Oddens, Theo M. de Reijke, Przemek M. Krawczyk
Published in: International Journal of Molecular Sciences, Issue 25, 2023, Page(s) 423, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25010423

Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors

Author(s): Faezeh Rahimi, Bilguun Nurzed, Thomas W. Eigentler, Mostafa Berangi, Eva Oberacker, Andre Kuehne, Pirus Ghadjar, Jason M. Millward, Rolf Schuhmann, Thoralf Niendorf
Published in: Bioengineering, Issue 11, 2024, Page(s) 733, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering11070733

present status and ongoing developments toward routine clinical use

Author(s): H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Published in: International journal of Hyperthermia, Issue 3, 2022, Page(s) 1126-1140, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Author(s): Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Published in: International Journal of Hyperthermia, 40(1), Issue 4, 2023, Page(s) 2207797, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Author(s): Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Published in: Cancers, Issue 14(19), 2022, Page(s) 4795, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Author(s): Scheidegger S, Mingo Barba S, Gaipl U.S.
Published in: Cancers, Issue 13, 2021, Page(s) 5764, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers

Author(s): Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips,
Published in: International Journal of Hyperthermia, Issue 41, 2024, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2024.2342348

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme

Author(s): Eva Oberacker, Cecilia Diesch, Jacek Nadobny, Andre Kuehne, Peter Wust, Pirus Ghadjar, Thoralf Niendorf
Published in: Cancers, Issue 13, 2024, Page(s) 1867, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Author(s): Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Published in: Current Stem Cell Reports, 2022, ISSN 2198-7866
Publisher: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Robust stochastic optimisation strategies for locoregional hyperthermia treatment planning using polynomial chaos expansion

Author(s): Jort Groen, Timoteo Daniel Herrera, Johannes Crezee, H Petra Kok
Published in: Physics in Medicine & Biology, 2025, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ada685

Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties

Author(s): Timoteo D. Herrera, Jakob Ödén, Andrea Lorenzo Polo, Johannes Crezee, H. Petra Kok
Published in: International Journal of Radiation Oncology*Biology*Physics, Issue 120, 2024, Page(s) 1435-1447, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.07.2146

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Author(s): Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Published in: Cancers, Issue 14(21), 2022, Page(s) 5349, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Author(s): Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Published in: Cancers, Issue 14(5), 2022, Page(s) 1175, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Author(s): Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Published in: Int J Hyperthermia. 2023;40(1):, Issue 6, 2023, Page(s) 2265590, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Author(s): Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Published in: International journal of Hyperthermia, Issue 6, 2023, Page(s) 2272578, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Author(s): H. P. Kok; T. D. Herrera; J. Crezee
Published in: Journal of Radiation Oncology, Biology, Physics, Issue Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Author(s): Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Published in: Cancers, Issue 15 (1), 2022, Page(s) 113, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis

Author(s): Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides
Published in: International Journal of Hyperthermia, Issue 41, 2024, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2024.2405105

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Author(s): Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Published in: Cancers; Volume 14; Issue 9; Pages: 2050, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Author(s): Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Published in: International Journal of Hyperthermia, Issue 40 (1), 2023, Page(s) 2275540, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

Author(s): Mattia De Lazzari, Carolina Carrapiço-Seabra, Dietmar Marder, Gerard C. van Rhoon, Sergio Curto, Hana Dobšíček Trefná
Published in: International Journal of Hyperthermia, Issue 41, 2025, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2024.2436005

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Author(s): Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Published in: International journal of hyperthermia, Issue 39(1), 2022, Page(s) 1078-1087, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Author(s): Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Published in: International Journal of Hyperthermia,, Issue 41:1,, 2024, Page(s) 2320852, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis

Author(s): Adela Ademaj, Sonja Stieb, Cihan Gani, Oliver J. Ott, Dietmar Marder, Roger A. Hälg, Susanne Rogers, Pirus Ghadjar, Rainer Fietkau, Hans Crezee, Oliver Riesterer
Published in: Strahlentherapie und Onkologie, 2024, ISSN 0179-7158
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-024-02312-9

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Author(s): Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Published in: Cancers, Issue 14(3), 2022, Page(s) 625, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Author(s): Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Published in: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for <i>In-Silico</i> Dynamic Radiobiological Models

Author(s): Sergio Mingo Barba, Fernando Lobo-Cerna, Przemek M. Krawczyk, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger
Published in: Dose-Response, Issue 22, 2024, ISSN 1559-3258
Publisher: International Dose-Response Society
DOI: 10.1177/15593258241279906

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Author(s): Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Published in: Volume 15, Issue 4, 2023, Page(s) 1241, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Author(s): H Petra Kok, Timoteo D Herrera , Johannes Crezee
Published in: Int J Radiat Oncol Biol Phys ., Issue S0360-3016(22), 2022, Page(s) 03458-7, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Author(s): Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Published in: Front. Oncol.Volume 13, Issue 12, 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

Non-peer reviewed articles (2)

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Author(s): Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Published in: Seminars in radiation Oncology, Issue 1, 2023, Page(s) 82-90, ISSN 1053-4296
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Author(s): Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Published in: arXiv Medical Physics, Issue 9, 2023, ISSN 2331-8422
Publisher: arXiv
DOI: 10.48550/arxiv.2310.01073