Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Deliverables

European centre collecting blood/tissue samples
Recruitment
European centre collecting clinical HT data

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Plan for dissemination strategy
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Publications

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Author(s): Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Published in: Volume 23, Issue 15, 2023, Page(s) 1209, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

present status and ongoing developments toward routine clinical use

Author(s): H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Published in: International journal of Hyperthermia, Issue 3, 2022, Page(s) 1126-1140, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Author(s): Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Published in: International Journal of Hyperthermia, 40(1), Issue 4, 2023, Page(s) 2207797, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Author(s): Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Published in: Cancers, Issue 14(19), 2022, Page(s) 4795, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Author(s): Scheidegger S, Mingo Barba S, Gaipl U.S.
Published in: Cancers, Issue 13, 2021, Page(s) 5764, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Author(s): Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Published in: Current Stem Cell Reports, 2022, ISSN 2198-7866
Publisher: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Author(s): Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Published in: Cancers, Issue 14(21), 2022, Page(s) 5349, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Author(s): Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Published in: Cancers, Issue 14(5), 2022, Page(s) 1175, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Author(s): Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Published in: Int J Hyperthermia. 2023;40(1):, Issue 6, 2023, Page(s) 2265590, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Author(s): Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Published in: International journal of Hyperthermia, Issue 6, 2023, Page(s) 2272578, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Author(s): H. P. Kok; T. D. Herrera; J. Crezee
Published in: Journal of Radiation Oncology, Biology, Physics, Issue Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Author(s): Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Published in: Cancers, Issue 15 (1), 2022, Page(s) 113, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Author(s): Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Published in: Cancers; Volume 14; Issue 9; Pages: 2050, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Author(s): Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Published in: International Journal of Hyperthermia, Issue 40 (1), 2023, Page(s) 2275540, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Author(s): Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Published in: International journal of hyperthermia, Issue 39(1), 2022, Page(s) 1078-1087, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Author(s): Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Published in: International Journal of Hyperthermia,, Issue 41:1,, 2024, Page(s) 2320852, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme.

Author(s): Thoralf Niendorf; Eva Oberacker; Pirus Ghadjar; Andre Kuehne
Published in: Cancers, Issue 13(8), 2021, Page(s) 1867, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Author(s): Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Published in: Cancers, Issue 14(3), 2022, Page(s) 625, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Author(s): Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Published in: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Author(s): Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Published in: Volume 15, Issue 4, 2023, Page(s) 1241, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Author(s): H Petra Kok, Timoteo D Herrera , Johannes Crezee
Published in: Int J Radiat Oncol Biol Phys ., Issue S0360-3016(22), 2022, Page(s) 03458-7, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Author(s): Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Published in: Front. Oncol.Volume 13, Issue 12, 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Author(s): Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Published in: Seminars in radiation Oncology, Issue 1, 2023, Page(s) 82-90, ISSN 1053-4296
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Author(s): Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Published in: arXiv Medical Physics, Issue 9, 2023, ISSN 2331-8422
Publisher: arXiv
DOI: 10.48550/arxiv.2310.01073

Deliverables

Publications

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