Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Información del proyecto

HYPERBOOST

Identificador del acuerdo de subvención: 955625

DOI

10.3030/955625

Proyecto cerrado

Fecha de la firma de la CE 13 Agosto 2020

Fecha de inicio 1 Diciembre 2020

Fecha de finalización 30 Noviembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 761 881,56

Aportación de la UE

€ 3 761 881,56

Coordinado por

STICHTING AMSTERDAM UMC
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (22)

Normal tissue response after RT±HT-update
Report on HYPERBOOST training finalized
QA guidelines for clinical HT treatments-update
Dissemination report based on dissemination strategy

Dissemination report based on D6.1

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Heat shock and tumor response after RT±HT-update

heat shock and tumor response after RT±HT-update

Plan for dissemination strategy
HYPERBOOST international conference conducted
Progress PhD theses according to PCDP
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Data reporting formats for RT+HT treatments-update

data reporting formats for RT+HT treatments -update

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Immune system effects after RT±HT-update
Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Optimisation strategies based on biological modelling-update

optimisation strategies based on biological modelling-update

RT+HT dose predictors for incorporation in planning
Blood flow and hypoxia after RT±HT-update
Mathematical model representing effect RT±HT-update

mathematical model representing effect RT±HT-update

Other (5)

European centre collecting blood/tissue samples
Multicentre clinical registration study
ESR training certificates provided
Recruitment
European centre collecting clinical HT data

Demonstrators, pilots, prototypes (2)

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Imaging technique to monitor effect of RT+HT therapy-update

imaging technique to monitor effect of RT+HT therapy-update

Open Research Data Pilot (2)

Scientific and education material available on the website
Paper best practice hyperthermia planning published

Publicaciones

Peer reviewed articles (31)

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Autores: Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Publicado en: Volume 23, Edición 15, 2023, Página(s) 1209, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Autores: Enzo M. Scutigliani, Jons van Hattum, Fernando Lobo-Cerna, Joanne Kruyswijk, Maja Myrcha, Frederique E. G. A. Dekkers, Ron A. Hoebe, Finn Edwards, Jetta J. Oppelaar, Liffert Vogt, Sanne Bootsma, Maarten F. Bijlsma, Daisy I. Picavet, Johannes Crezee, Jorg R. Oddens, Theo M. de Reijke, Przemek M. Krawczyk
Publicado en: International Journal of Molecular Sciences, Edición 25, 2023, Página(s) 423, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25010423

Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors

Autores: Faezeh Rahimi, Bilguun Nurzed, Thomas W. Eigentler, Mostafa Berangi, Eva Oberacker, Andre Kuehne, Pirus Ghadjar, Jason M. Millward, Rolf Schuhmann, Thoralf Niendorf
Publicado en: Bioengineering, Edición 11, 2024, Página(s) 733, ISSN 2306-5354
Editor: MDPI
DOI: 10.3390/bioengineering11070733

present status and ongoing developments toward routine clinical use

Autores: H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Publicado en: International journal of Hyperthermia, Edición 3, 2022, Página(s) 1126-1140, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Autores: Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Publicado en: International Journal of Hyperthermia, 40(1), Edición 4, 2023, Página(s) 2207797, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Autores: Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Publicado en: Cancers, Edición 14(19), 2022, Página(s) 4795, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Autores: Scheidegger S, Mingo Barba S, Gaipl U.S.
Publicado en: Cancers, Edición 13, 2021, Página(s) 5764, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers

Autores: Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips,
Publicado en: International Journal of Hyperthermia, Edición 41, 2024, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2024.2342348

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme

Autores: Eva Oberacker, Cecilia Diesch, Jacek Nadobny, Andre Kuehne, Peter Wust, Pirus Ghadjar, Thoralf Niendorf
Publicado en: Cancers, Edición 13, 2024, Página(s) 1867, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Autores: Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Publicado en: Current Stem Cell Reports, 2022, ISSN 2198-7866
Editor: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Robust stochastic optimisation strategies for locoregional hyperthermia treatment planning using polynomial chaos expansion

Autores: Jort Groen, Timoteo Daniel Herrera, Johannes Crezee, H Petra Kok
Publicado en: Physics in Medicine & Biology, 2025, ISSN 0031-9155
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ada685

Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties

Autores: Timoteo D. Herrera, Jakob Ödén, Andrea Lorenzo Polo, Johannes Crezee, H. Petra Kok
Publicado en: International Journal of Radiation Oncology*Biology*Physics, Edición 120, 2024, Página(s) 1435-1447, ISSN 0360-3016
Editor: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.07.2146

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Autores: Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Publicado en: Cancers, Edición 14(21), 2022, Página(s) 5349, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Autores: Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Publicado en: Cancers, Edición 14(5), 2022, Página(s) 1175, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Autores: Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Publicado en: Int J Hyperthermia. 2023;40(1):, Edición 6, 2023, Página(s) 2265590, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Autores: Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Publicado en: International journal of Hyperthermia, Edición 6, 2023, Página(s) 2272578, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Autores: H. P. Kok; T. D. Herrera; J. Crezee
Publicado en: Journal of Radiation Oncology, Biology, Physics, Edición Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Editor: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Autores: Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Publicado en: Cancers, Edición 15 (1), 2022, Página(s) 113, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis

Autores: Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides
Publicado en: International Journal of Hyperthermia, Edición 41, 2024, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2024.2405105

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Autores: Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Publicado en: Cancers; Volume 14; Edición 9; Pages: 2050, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Autores: Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Publicado en: International Journal of Hyperthermia, Edición 40 (1), 2023, Página(s) 2275540, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

Autores: Mattia De Lazzari, Carolina Carrapiço-Seabra, Dietmar Marder, Gerard C. van Rhoon, Sergio Curto, Hana Dobšíček Trefná
Publicado en: International Journal of Hyperthermia, Edición 41, 2025, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2024.2436005

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Autores: Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Publicado en: International journal of hyperthermia, Edición 39(1), 2022, Página(s) 1078-1087, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Autores: Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Publicado en: International Journal of Hyperthermia,, Edición 41:1,, 2024, Página(s) 2320852, ISSN 0265-6736
Editor: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis

Autores: Adela Ademaj, Sonja Stieb, Cihan Gani, Oliver J. Ott, Dietmar Marder, Roger A. Hälg, Susanne Rogers, Pirus Ghadjar, Rainer Fietkau, Hans Crezee, Oliver Riesterer
Publicado en: Strahlentherapie und Onkologie, 2024, ISSN 0179-7158
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-024-02312-9

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Autores: Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Publicado en: Cancers, Edición 14(3), 2022, Página(s) 625, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Autores: Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Publicado en: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for <i>In-Silico</i> Dynamic Radiobiological Models

Autores: Sergio Mingo Barba, Fernando Lobo-Cerna, Przemek M. Krawczyk, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger
Publicado en: Dose-Response, Edición 22, 2024, ISSN 1559-3258
Editor: International Dose-Response Society
DOI: 10.1177/15593258241279906

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Autores: Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Publicado en: Volume 15, Edición 4, 2023, Página(s) 1241, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Autores: H Petra Kok, Timoteo D Herrera , Johannes Crezee
Publicado en: Int J Radiat Oncol Biol Phys ., Edición S0360-3016(22), 2022, Página(s) 03458-7, ISSN 0360-3016
Editor: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Autores: Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Publicado en: Front. Oncol.Volume 13, Edición 12, 2023, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

Non-peer reviewed articles (2)

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Autores: Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Publicado en: Seminars in radiation Oncology, Edición 1, 2023, Página(s) 82-90, ISSN 1053-4296
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Autores: Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Publicado en: arXiv Medical Physics, Edición 9, 2023, ISSN 2331-8422
Editor: arXiv
DOI: 10.48550/arxiv.2310.01073