Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor.

Informazioni relative al progetto

HYPERBOOST

ID dell’accordo di sovvenzione: 955625

DOI

10.3030/955625

Progetto chiuso

Data della firma CE 13 Agosto 2020

Data di avvio 1 Dicembre 2020

Data di completamento 30 Novembre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 761 881,56

Contributo UE

€ 3 761 881,56

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (22)

Normal tissue response after RT±HT-update
Report on HYPERBOOST training finalized
QA guidelines for clinical HT treatments-update
Dissemination report based on dissemination strategy

Dissemination report based on D6.1

Immune system effects after RT±HT (publ/OA)

Immune system effects after RTHT publOA

Heat shock and tumor response after RT±HT-update

heat shock and tumor response after RT±HT-update

Plan for dissemination strategy
HYPERBOOST international conference conducted
Progress PhD theses according to PCDP
QA guidelines for clinical HT treatments (publ/OA)

QA guidelines for clinical HT treatments publOA

Data reporting formats for RT+HT treatments-update

data reporting formats for RT+HT treatments -update

Normal tissue response after RT±HT (publ/OA)

Normal tissue response after RTHT publOA

Immune system effects after RT±HT-update
Optimisation strategies based on biological modelling

optimisation strategies based on biological modelling

Mathematical model representing effect RT±HT (publ)

mathematical model representing effect RTHT publ

Blood flow and hypoxia after RT±HT (publ/OA)

Blood flow and hypoxia after RTHT publOA

Data reporting formats for RT+HT treatments (publ/OA)

data reporting formats for RTHT treatments publOA

Heat shock and tumor response after RT±HT (publ/OA)

heat shock and tumor response after RTHT publOA

Optimisation strategies based on biological modelling-update

optimisation strategies based on biological modelling-update

RT+HT dose predictors for incorporation in planning
Blood flow and hypoxia after RT±HT-update
Mathematical model representing effect RT±HT-update

mathematical model representing effect RT±HT-update

Other (5)

European centre collecting blood/tissue samples
Multicentre clinical registration study
ESR training certificates provided
Recruitment
European centre collecting clinical HT data

Demonstrators, pilots, prototypes (2)

Imaging technique to monitor effect of RT+HT therapy

imaging technique to monitor effect of RT+HT therapy

Imaging technique to monitor effect of RT+HT therapy-update

imaging technique to monitor effect of RT+HT therapy-update

Open Research Data Pilot (2)

Scientific and education material available on the website
Paper best practice hyperthermia planning published

Pubblicazioni

Peer reviewed articles (31)

High-Fidelity 3D Stray Magnetic Field Mapping of Smartphones to Address Safety Considerations with Active Implantable Electronic Medical Devices

Autori: Nandita Saha; Jason M. Millward; Carl J. J. Herrmann; Faezeh Rahimi; Haopeng Han; Philipp Lacour; Florian Blaschke; Thoralf Niendorf
Pubblicato in: Volume 23, Numero 15, 2023, Pagina/e 1209, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23031209

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Autori: Enzo M. Scutigliani, Jons van Hattum, Fernando Lobo-Cerna, Joanne Kruyswijk, Maja Myrcha, Frederique E. G. A. Dekkers, Ron A. Hoebe, Finn Edwards, Jetta J. Oppelaar, Liffert Vogt, Sanne Bootsma, Maarten F. Bijlsma, Daisy I. Picavet, Johannes Crezee, Jorg R. Oddens, Theo M. de Reijke, Przemek M. Krawczyk
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2023, Pagina/e 423, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25010423

Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors

Autori: Faezeh Rahimi, Bilguun Nurzed, Thomas W. Eigentler, Mostafa Berangi, Eva Oberacker, Andre Kuehne, Pirus Ghadjar, Jason M. Millward, Rolf Schuhmann, Thoralf Niendorf
Pubblicato in: Bioengineering, Numero 11, 2024, Pagina/e 733, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering11070733

present status and ongoing developments toward routine clinical use

Autori: H. P. Kok; G. C. van Rhoon; T. D. Herrera; J. Overgaard; J. Crezee
Pubblicato in: International journal of Hyperthermia, Numero 3, 2022, Pagina/e 1126-1140, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2022.2113826

Ethylcellulose-stabilized fat-tissue phantom for quality assurance in clinical hyperthermia

Autori: Mattia De Lazzari; Anna Ström; Laura Farina; Nuno P. Silva; Sergio Curto; Hana Dobšíček Trefná
Pubblicato in: International Journal of Hyperthermia, 40(1), Numero 4, 2023, Pagina/e 2207797, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2023.2207797

Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

Autori: Carolina Carrapiço-Seabra, Sergio Curto, Martine Franckena, Gerard C Van Rhoon
Pubblicato in: Cancers, Numero 14(19), 2022, Pagina/e 4795, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194795

Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem.

Autori: Scheidegger S, Mingo Barba S, Gaipl U.S.
Pubblicato in: Cancers, Numero 13, 2021, Pagina/e 5764, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13225764

Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers

Autori: Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips,
Pubblicato in: International Journal of Hyperthermia, Numero 41, 2024, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2024.2342348

Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme

Autori: Eva Oberacker, Cecilia Diesch, Jacek Nadobny, Andre Kuehne, Peter Wust, Pirus Ghadjar, Thoralf Niendorf
Pubblicato in: Cancers, Numero 13, 2024, Pagina/e 1867, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081867

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

Autori: Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl & Michael Rückert
Pubblicato in: Current Stem Cell Reports, 2022, ISSN 2198-7866
Editore: Springer International Publishing AG
DOI: 10.1007/s40778-022-00215-y

Robust stochastic optimisation strategies for locoregional hyperthermia treatment planning using polynomial chaos expansion

Autori: Jort Groen, Timoteo Daniel Herrera, Johannes Crezee, H Petra Kok
Pubblicato in: Physics in Medicine & Biology, 2025, ISSN 0031-9155
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ada685

Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties

Autori: Timoteo D. Herrera, Jakob Ödén, Andrea Lorenzo Polo, Johannes Crezee, H. Petra Kok
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 120, 2024, Pagina/e 1435-1447, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.07.2146

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Autori: Wust P, Veltsista PD, Oberacker E, Yavvari P, Walther W, Bengtsson O, Sterner-Kock A, Weinhart M, Heyd F, Grabowski P, Stintzing S, Heinrich W, Stein U, Ghadjar P.
Pubblicato in: Cancers, Numero 14(21), 2022, Pagina/e 5349, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14215349

Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Autori: Stutz, E., Puric, E., Ademaj, A., Künzi, A., Krcek, R., Timm, O., Marder, D., Notter, M., Rogers, S., Bodis, S., & Riesterer, O.
Pubblicato in: Cancers, Numero 14(5), 2022, Pagina/e 1175, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051175

Broadband microwave spiral applicator (105–125 MHz) for <i>in vitro</i> examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells

Autori: Jannik Walter; Michael Hader; Azzaya Sengedorj; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl
Pubblicato in: Int J Hyperthermia. 2023;40(1):, Numero 6, 2023, Pagina/e 2265590, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2023.2265590

Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Autori: Carolina Carrapiço-Seabra; Mattia De Lazzari; Abdelali Ameziane; Gerard C. van Rhoon; Hana Dobšícek Trefná; Sergio Curto
Pubblicato in: International journal of Hyperthermia, Numero 6, 2023, Pagina/e 2272578, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2023.2272578

Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Autori: H. P. Kok; T. D. Herrera; J. Crezee
Pubblicato in: Journal of Radiation Oncology, Biology, Physics, Numero Volume 200, pages 512–522, (2024), 2024, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1007/s00066-023-02185-4

The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis

Autori: Scutigliani, Enzo M., Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, and Przemek M. Krawczyk
Pubblicato in: Cancers, Numero 15 (1), 2022, Pagina/e 113, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010113

Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis

Autori: Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides
Pubblicato in: International Journal of Hyperthermia, Numero 41, 2024, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2024.2405105

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

Autori: Azzaya Sengedorj; Michael Hader; Lukas Heger; Benjamin Frey; Diana Dudziak; Rainer Fietkau; Oliver J. Ott; Stephan Scheidegger; Sergio Mingo Barba; Udo S. Gaipl; Michael Rückert
Pubblicato in: Cancers; Volume 14; Numero 9; Pages: 2050, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092050

Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Autori: Ademaj ,Adela, Puric ,Emsad, Marder ,Dietmar, Timm ,Olaf, Kern ,Thomas, Hälg ,Roger A., Rogers ,Susanne, Riesterer ,Oliver
Pubblicato in: International Journal of Hyperthermia, Numero 40 (1), 2023, Pagina/e 2275540, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2023.2275540

Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

Autori: Mattia De Lazzari, Carolina Carrapiço-Seabra, Dietmar Marder, Gerard C. van Rhoon, Sergio Curto, Hana Dobšíček Trefná
Pubblicato in: International Journal of Hyperthermia, Numero 41, 2025, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2024.2436005

Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Autori: Oliver Riesterer; Adela Ademaj; Emsad Puric; Brigitte Eberle; Marcus Beck; Silvia Gomez; Dietmar Marder; Eva Oberacker; Susanne Rogers; Roger A. Hälg; Thomas Kern; Sonja Schwenne; Jürgen Stein; Emanuel Stutz; Olaf Timm; Sebastian Zschaeck; Mathias S. Weyland; Paraskevi D. Veltsista; Stephen Wyler; Peter Wust; Stephan Scheidegger; Stephan Bodis; Pirus Ghadjar
Pubblicato in: International journal of hyperthermia, Numero 39(1), 2022, Pagina/e 1078-1087, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2022.2109763

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Autori: Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink & Stephan Scheidegger
Pubblicato in: International Journal of Hyperthermia,, Numero 41:1,, 2024, Pagina/e 2320852, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2024.2320852

Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis

Autori: Adela Ademaj, Sonja Stieb, Cihan Gani, Oliver J. Ott, Dietmar Marder, Roger A. Hälg, Susanne Rogers, Pirus Ghadjar, Rainer Fietkau, Hans Crezee, Oliver Riesterer
Pubblicato in: Strahlentherapie und Onkologie, 2024, ISSN 0179-7158
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-024-02312-9

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Autori: Ademaj A, Veltsista DP, Ghadjar P, Marder D, Oberacker E, Ott OJ, Wust P, Puric E, Hälg RA, Rogers S, Bodis S, Fietkau R, Crezee H, Riesterer O.
Pubblicato in: Cancers, Numero 14(3), 2022, Pagina/e 625, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030625

A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Autori: Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Hälg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar & Oliver Rie
Pubblicato in: Strahlentherapie und Onkologie, 2022, ISSN 0179-7158
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s00066-022-01980-9

The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for <i>In-Silico</i> Dynamic Radiobiological Models

Autori: Sergio Mingo Barba, Fernando Lobo-Cerna, Przemek M. Krawczyk, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger
Pubblicato in: Dose-Response, Numero 22, 2024, ISSN 1559-3258
Editore: International Dose-Response Society
DOI: 10.1177/15593258241279906

Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Autori: Adela Ademaj; Emsad Puric; Olaf Timm; David Kurti; Dietmar Marder; Thomas Kern; Roger A. Hälg; Susanne Rogers; Oliver Riesterer
Pubblicato in: Volume 15, Numero 4, 2023, Pagina/e 1241, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15041241

The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose

Autori: H Petra Kok, Timoteo D Herrera , Johannes Crezee
Pubblicato in: Int J Radiat Oncol Biol Phys ., Numero S0360-3016(22), 2022, Pagina/e 03458-7, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2022.10.023

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer cells

Autori: Simon Gehre; Felix Meyer; Azzaya Sengedorj; Fridolin Grottker; Clara M. Reichardt; Jannik Alomo; Kerstin Borgmann; Benjamin Frey; Rainer Fietkau; Michael Rückert; Udo S. Gaipl
Pubblicato in: Front. Oncol.Volume 13, Numero 12, 2023, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.981239

Non-peer reviewed articles (2)

The Emerging Evidence Supporting Integration of Deep Regional Hyperthermia With Chemoradiation in Bladder Cancer.

Autori: Oliver J. Ott; Udo S. Gaipl; Allison Lamrani; Rainer Fietkau
Pubblicato in: Seminars in radiation Oncology, Numero 1, 2023, Pagina/e 82-90, ISSN 1053-4296
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2022.10.011

Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hypterthermia

Autori: Khatun, Rupali; Chatterjee, Soumick; Bert, Christoph; Wadepohl, Martin; Schmidt, Manfred; Ott, Oliver J.; Fietkau, Rainer; Nürnberger, Andreas; Gaipl, Udo S.; Frey, Benjamin
Pubblicato in: arXiv Medical Physics, Numero 9, 2023, ISSN 2331-8422
Editore: arXiv
DOI: 10.48550/arxiv.2310.01073