The major work was done before and after hiring all the 15 ESRs, according to the workpackages (WPs) of the P4 FIT project. In WP1 we have coordinated and management of the project, which deal with the organization of different meetings, internal communication, website preparation and maintenance, finances, administration, advice to all network, etc. To mention a few, we have organized the P4 FIT Welcome Week, the 1st P4 FIT progress meeting, the P4 FIT Mid-Term Meeting, and the 1st P4 FIT Annual Meeting+Summer School. In WP 2, all ESRs have been acquired a large set of training in soft and hard skills/knowledge at their host institutions and partner organizations, aiming to receive general and specific interdisciplinary knowledge. These activities ranged from career development activities, dissemination scientific and to a lay audience (for societal outreach), general knowledge in a research field, intellectual property rights or regulatory affairs, project management, research ethics and integrity, technical research skills, commercialisation of research outputs, entrepreneurship, language courses, scientific communications (e.g. oral and poster presentations in conferences and public meetings), project management, computational skills, journal clubs, to scientific writing, etc. Altogether this P4 FIT skills and knowledge activities acquired by the ESRs has led to the accomplishment of 160.5 ECTS and 177*ESRs attendances. In WP3-5, the research activities of all ESRs have led to master soft and hard skills for their research work. The research results so far have demonstrated:(i) a unknown role of dendritic cells in the regulation of proliferation and collagen production in human fibroblasts and tenocytes;(ii) treated dendritic cells have the capacity to activate diseased tenocytes;(iii) some factors may contribute to the immuno-modulatory function of human amniotic mesenchymal cells;(iv) hybrid lipid nanoparticles co-loaded with an anti-inflammatory drug and siRNA can tackle complex conditions of macrophage dysregulation;(v) a synergistic anti-inflammatory and anti-fibrotic activity was achieved with a nanosystem developed for the inflammatory disease;(vi) different mesenchymal-related lineages led to specific teno-inductive signals;(vii); specific hydrogel microspheres showed high-protein loading capacity and cell encapsulation possibility;(viii) fabrication of polymer-based electrospun tendon biomimetic scaffolds;(xi) immuno-modulatory factors strengthen the phagocytic cell system in tendinopathy;(x) spontaneous healing does not provide a complete tendon healing, and thus, a complete recovery of the biomechanics;(xi) a method was developed to generate new and realistic samples of human motion and forces based on a new sensor, which can be used invasively to directly measure strain and strain rates or used directly on skin to non-invasively monitor motion and estimate biomechanics. In WP6, the Communication and Dissemination Strategy/Plan was achieved throughout the enhanced visibility of the P4 FIT network via the website of the project, social media (e.g. Twitter, YouTube and Facebook), multimedia content, and press releases. In WP7, the Dissemination and exploitation was achieved by sharing the obtained research results with peers in the field, industry and other commercial players and policymakers to maximize the potential applications (both social and economic), via conferences, technical and industry meetings, workshops and joint contacts/interactions with other (EU) networks/projects in topics related to P4 FIT.
