Skip to main content
françaisFR
European Commission logo print header

Deconstructing the evolution of metastasis

Description du projet

DEENESFRITPL

Dévoiler les aspects clés du processus métastatique

La métastase est un processus complexe qui exige des cellules cancéreuses qu’elles supplantent des fonctions cellulaires clés et modifient leurs interactions avec le système immunitaire et leur microenvironnement. Malgré le fait que la métastase soit l’un des signes distinctifs du cancer, sa cinétique et ses mécanismes de régulation sont mal compris. Le projet Evomet, financé par l’UE, a pour objectif de disséquer la cascade métastatique et son évolution, ainsi que d’identifier les mécanismes cibles pour la thérapie et le développement de médicaments. Le projet proposera également un programme de formation pluridisciplinaire aux chercheurs en début de carrière sur la méthodologie de pointe qui leur permettra d’acquérir les compétences transférables nécessaires pour une future carrière dans ce domaine.

Objectif

Evomet aims to create a high-level training programme on the various aspects of metastasis evolution in order to provide young researchers with skills to become future leaders in the field. To this end, it is imperative to have a solid mentoring and training strategy, a state-of-the-art scientific approach, and a broad range of complementary soft skills. Collectively, these skills will be provided to each ESR through a series of events (local and network-wide) and initiatives that will allow ESRs to ensure smooth progress of their research projects and a successful career.
Scientifically, Evomet has been designed to address an unmet medical need through leverage of basic science to impact drug development and, ultimately, improve how patients are managed. Scientific WPs tackling metastasis from a functional perspective have been defined. To metastasize, cancer cells must orchestrate diverse cellular functions to overcome the challenges inherent in the metastatic cascade (Cell Fate – WP1). These functions are also highly dependent on the interactions of the metastatic cell with the host immune system and tissue stroma (Environment – WP2). However, the kinetics of metastasis and, in particular, the mechanisms that regulate metastasis latency remain poorly understood (Latency – WP3). Mapping this complexity, examining patterns of clonal evolution, mechanisms of therapy failure, and pathways for expansion is central to defining new targets (Expansion – WP4). In summary, we are facing a fast-growing multidisciplinary area created from the aggregation of different fields that have problems communicating with each other. Evomet’s success builds on the strong relations between partners, the open exchange of ideas, state-of-the-art methodology, tools and equipment as well as the exploitation of synergistic opportunities between the network members, covering different perspectives and filling the gap between them, thus breaking the isolation between disciplines.

Champ scientifique

Mots‑clés

Programme(s)

Thème(s)

Appel à propositions

H2020-MSCA-ITN-2020

Voir d’autres projets de cet appel

Régime de financement

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinateur

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Contribution nette de l'UE
€ 501 809,76
Adresse
CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA
08028 Barcelona
Espagne

Voir sur la carte
Région
Este Cataluña Barcelona
Type d’activité
Research Organisations
Liens
Coût total
€ 501 809,76

Participants (14)

Partager cette page

Télécharger

Dernière mise à jour: 2 Mai 2024

Mon livret

Permalink: https://cordis.europa.eu/project/id/955951/fr

European Union, 2024