Projektbeschreibung
Wichtige Aspekte des Prozesses der Metastasenbildung beleuchten
Die Metastasenbildung ist ein komplexer Prozess, bei dem Krebszellen wichtige zelluläre Funktionen überschreiben und ihre Wechselwirkung mit dem Immunsystem und dem angrenzenden Mikromilieu verändern. Ungeachtet der Tatsache, dass die Metastasenbildung ein Kennzeichen von Krebserkrankungen ist, werden ihre kinetischen und regulatorischen Mechanismen kaum verstanden. Im Fokus des EU-finanzierten Projekts Evomet steht die Sezierung der metastatischen Kaskade und ihrer Entwicklung sowie die Ermittlung von Zielmechanismen für die Therapie und Arzneimittelentwicklung. Das Projekt offeriert zudem ein multidisziplinäres Ausbildungsprogramm für Nachwuchsforschende in der modernsten Methodik und in übertragbaren Fähigkeiten für eine zukünftige Karriere in diesem Gebiet.
Ziel
Evomet aims to create a high-level training programme on the various aspects of metastasis evolution in order to provide young researchers with skills to become future leaders in the field. To this end, it is imperative to have a solid mentoring and training strategy, a state-of-the-art scientific approach, and a broad range of complementary soft skills. Collectively, these skills will be provided to each ESR through a series of events (local and network-wide) and initiatives that will allow ESRs to ensure smooth progress of their research projects and a successful career.
Scientifically, Evomet has been designed to address an unmet medical need through leverage of basic science to impact drug development and, ultimately, improve how patients are managed. Scientific WPs tackling metastasis from a functional perspective have been defined. To metastasize, cancer cells must orchestrate diverse cellular functions to overcome the challenges inherent in the metastatic cascade (Cell Fate – WP1). These functions are also highly dependent on the interactions of the metastatic cell with the host immune system and tissue stroma (Environment – WP2). However, the kinetics of metastasis and, in particular, the mechanisms that regulate metastasis latency remain poorly understood (Latency – WP3). Mapping this complexity, examining patterns of clonal evolution, mechanisms of therapy failure, and pathways for expansion is central to defining new targets (Expansion – WP4). In summary, we are facing a fast-growing multidisciplinary area created from the aggregation of different fields that have problems communicating with each other. Evomet’s success builds on the strong relations between partners, the open exchange of ideas, state-of-the-art methodology, tools and equipment as well as the exploitation of synergistic opportunities between the network members, covering different perspectives and filling the gap between them, thus breaking the isolation between disciplines.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Koordinator
08028 Barcelona
Spanien