Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

Oligonucleotides for Medical Applications

Descrizione del progetto

Tecnologie innovative basate sugli oligonucleotidi per trattare le malattie

Gli oligonucleotidi sintetici si stanno affermando come molecole terapeutiche promettenti per il trattamento di malattie genetiche. Le aziende farmaceutiche tendono ad autorizzare la produzione di tali molecole, sottolineando l’esigenza della collaborazione del mondo accademico e di quello industriale nello sviluppo della tecnologia basata sugli oligonucleotidi. Per affrontare questa limitazione, il progetto OLIGOMED, finanziato dall’UE, unirà esperti provenienti dai due settori e istituirà un programma di formazione per la nuova generazione di ricercatori nel campo. Inoltre, il progetto svilupperà tecnologie innovative basate sugli oligonucleotidi e le ottimizzerà per il trattamento di diverse patologie, quali le malattie cardiovascolari e il cancro.

Obiettivo

The use of synthetic oligonucleotides (ONs, short DNA or RNA strands) in the treatment of genetic diseases is a rapidly growing field, and the most promising alternative to gene therapy or small molecules. Most pharmaceutical companies shift from in-house platform development to product-specific licensing and co-development to get ON based therapies past clinical trials. Therefore there is a growing and currently unmet need for a combined academic and industry-based multidisciplinary research to further advance the field by bringing together the separated and fragmented R&D efforts of diverse ON technologies.

OLIGOMED will address these needs by:
- uniting world-class academic and private sector expertise in ON chemistry, bio-analysis and medical applications
- developing a next generation ON platform technology based on combining tailored synthetic ONs with smart delivery
- optimising ON therapies through testing in medicinal environments

We will use these novel ON technologies to develop innovative treatment options for high-impact genetic diseases, i.e. Huntington’s disease, cardiovascular diseases and cancer.

Our European intersectoral and multidisciplinary research and training network for 15 Early Stage Researchers (ESRs) will deliver:
-highly skilled scientific staff required to fully exploit ON therapeutics for personalised medicine
-top-class training in organic and chemoenzymatic synthesis, ON analysis, and biomedical/medicinal testing
-transferable skills courses, specific industry relevant workshops and public engagement activities

This combination makes OLIGOMED a truly exciting programme for ESRs. The platform will immediately benefit to both European citizens and commercial partners. In the long term, OLIGOMED`s flexible platform technology will be taken forward by our private sector and research institutions for exploitation and will thus strengthen the European innovation capacity in the field of ON therapies.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

È necessario effettuare l’accesso o registrarsi per utilizzare questa funzione

Coordinatore

UNIVERSITY OF SOUTHAMPTON
Contributo netto dell'UE
€ 606 345,12
Indirizzo
Highfield
SO17 1BJ Southampton
Regno Unito

Mostra sulla mappa

Regione
South East (England) Hampshire and Isle of Wight Southampton
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 606 345,12

Partecipanti (13)