Colonization resistance: training and research towards microbiome derived solutions to foodborne disease

Informazioni relative al progetto

COL_RES

ID dell’accordo di sovvenzione: 956279

DOI

10.3030/956279

Progetto chiuso

Data della firma CE 27 Luglio 2020

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 2 186 997,48

Contributo UE

€ 2 186 997,48

Coordinato da

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (2)

A metabolomics protocol for metabolite annotation

A metabolomics protocol for large-scale and high-throughput metabolite annotation

A computational tool to unravel metabolic interactions among microbiota

A computational tool to unravel metabolic interactions among microbiota combining metaproteomics and metabolomics

Documents, reports (7)

Final report on probiotics in infectious disease

A final report outlining the success or otherwise of using probiotics to impede infectious disease in the models outlined above

Paper on use of phage to prevent infection

Scientific paper outlining potential for phage therapies and preventative measures

Paper on role of diet in Colonization Resistance

Scientific paper outlining the specific effects of dietary factors on individual pathogens

Report describing a meta-analytical workflow

Report outlining a reliable meta-analytic workflow for integration of ‘omics’ datasets

Paper on phage dynamics during infection

Scientific paper outlining the dynamics of phage communities in an infection model

Scientific Paper on Colonization Resistance

Scientific paper outlining the role of specific commensals in colonisation resistance

Report outlining integration of COL_RES data

Report outlining integration and comparison of datasets from infectious disease models in COL_RES

Pubblicazioni

Peer reviewed articles (15)

Metabolomic signatures of intestinal colonization resistance against Campylobacter jejuni in mice

Autori: Nizar W. Shayya, Rasmus Bandick, Lia V. Busmann, Soraya Mousavi, Stefan Bereswill, Markus M. Heimesaat
Pubblicato in: Frontiers in Microbiology, Numero 14, 2023, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2023.1331114

From microbiome composition to functional engineering, one step at a time

Autori: Burz, Sebastian Dan; Causevic, Senka; Dal Co, Alma; id_orcid0000-0001-8816-7670; Dmitrijeva, Marija; Engel, Philipp; Garrido-Sanz, Daniel; Greub, Gilbert; Hapfelmeier, Siegfried; Hardt, Wolf-Dietrich; id_orcid0000-0002-9892-6420; Hatzimanikatis, Vassily; Heiman, Clara Margot; Herzog, Mathias Klaus-Maria; id_orcid0000-0002-0097-2526; Hockenberry, Alyson; id_orcid0000-0003-0828-1428; Keel, Christoph
Pubblicato in: Microbiology and Molecular Biology Reviews, 87 (4), Numero 1, 2023, ISSN 1092-2172
Editore: American Society for Microbiology
DOI: 10.1128/mmbr.00063-23

Predicting the Predicted: A Comparison of Machine Learning-Based Collision Cross-Section Prediction Models for Small Molecules

Autori: Sara M. de Cripan, Trisha Arora, Adrià Olomí, Núria Canela, Gary Siuzdak, Xavier Domingo-Almenara
Pubblicato in: Analytical Chemistry, Numero 96, 2024, Pagina/e 9088-9096, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.4c00630

<i>Akkermansia muciniphila</i> in infectious disease: A new target for this next-generation probiotic?

Autori: Jonathan M. Keane, Monica Cazzaniga, Cormac G.M. Gahan
Pubblicato in: Science Progress, Numero 107, 2025, ISSN 0036-8504
Editore: Science Reviews Ltd.
DOI: 10.1177/00368504241231159

Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut

Autori: Yassine Cherrak, Miguel Angel Salazar, Nicolas Näpflin, Lukas Malfertheiner, Mathias K.-M. Herzog, Christopher Schubert, Christian von Mering, Wolf-Dietrich Hardt
Pubblicato in: Nature Microbiology, 2024, ISSN 2058-5276
Editore: Springer Nature
DOI: 10.1038/s41564-024-01775-x

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Autori: Sanne Kroon, Dejan Malcic, Lena Weidert, Lea Bircher, Leonardo Boldt, Philipp Christen, Patrick Kiefer, Anna Sintsova, Bidong D. Nguyen, Manja Barthel, Yves Steiger, Melanie Clerc, Mathias K.-M. Herzog, Carmen Chen, Ersin Gül, Benoit Guery, Emma Slack, Shinichi Sunagawa, Julia A. Vorholt, Lisa Maier, Christophe Lacroix, Annika Hausmann, Wolf-Dietrich Hardt
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-57979-0

Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification

Autori: Abhishek Jain, Montana T. Morris, Domenica Berardi, Trisha Arora, Xavier Domingo-Almenara, Philip B. Paty, Nicholas J. W. Rattray, Daniel Kerekes, Lingeng Lu, Sajid A. Khan, Caroline H. Johnson
Pubblicato in: Molecular Cancer, Numero 23, 2024, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-024-02133-5

Comparing <i>Campylobacter jejuni</i> to three other enteric pathogens in OligoMM ¹² mice reveals pathogen-specific host and microbiota responses

Autori: Mathias K.-M. Herzog, Audrey Peters, Nizar Shayya, Monica Cazzaniga, Kardokh Kaka Bra, Trisha Arora, Manja Barthel, Ersin Gül, Luca Maurer, Patrick Kiefer, Philipp Christen, Katharina Endhardt, Julia A. Vorholt, Gad Frankel, Markus M. Heimesaat, Stefan Bereswill, Cormac G. M. Gahan, Marcus J. Claesson, Xavier Domingo-Almenara, Wolf-Dietrich Hardt
Pubblicato in: Gut Microbes, Numero 17, 2025, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2024.2447832

Differential antibiosis predisposes mice to Campylobacter jejuni infection: Deeper insights into the impact of the gut microbiota composition in colonization resistance

Autori: Nizar W. Shayya, Soraya Mousavi, Kerstin Stingl, Stefan Bereswill, Markus M. Heimesaat
Pubblicato in: European Journal of Microbiology and Immunology, 2025, ISSN 2062-509X
Editore: AKjournals
DOI: 10.1556/1886.2024.00140

Mouse models for bacterial enteropathogen infections: insights into the role of colonization resistance.

Autori: Herzog, Mathias K-M; Cazzaniga, Monica; Peters, Audrey; Shayya, Nizar; Beldi, Luca; Hapfelmeier, Siegfried Hektor; Heimesaat, Markus M; Bereswill, Stefan; Frankel, Gad; Gahan, Cormac G M; Hardt, Wolf-Dietrich
Pubblicato in: Gut Microbes, 15 (1), Numero 2, 2023, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2023.2172667

Impact of Western Diet on Enterohemorrhagic Escherichia coli Colonization in the Human In Vitro Mucosal Artificial Colon as Mediated by Gut Microbiota

Autori: Deborah O’Sullivan, Trisha Arora, Claude Durif, Ophélie Uriot, Morgane Brun, Marc Riu, Elisabet Foguet-Romero, Iris Samarra, Xavier Domingo-Almenara, Cormac G. M. Gahan, Lucie Etienne-Mesmin, Stéphanie Blanquet-Diot
Pubblicato in: Nutrients, Numero 16, 2024, Pagina/e 2046, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16132046

The gut virome in health and disease: new insights and associations

Autori: Hiba Shareefdeen, Colin Hill
Pubblicato in: Current Opinion in Gastroenterology, 2024, ISSN 0267-1379
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mog.0000000000000885

The Mobilizable Plasmid P3 of Salmonella enterica Serovar Typhimurium SL1344 Depends on the P2 Plasmid for Conjugative Transfer into a Broad Range of Bacteria In Vitro and In Vivo

Autori: Gaissmaier, Marla Sofie; Laganenka, Leanid; Herzog, Mathias Klaus-Maria; Bakkeren, Erik; Hardt, Wolf-Dietrich
Pubblicato in: Journal of Bacteriology, 204 (12), Numero 1, 2022, ISSN 0021-9193
Editore: American Society for Microbiology
DOI: 10.1128/jb.00347-22

Nano in Micro: Novel Concepts in Foodborne Pathogen Transmission and Pathogenesis

Autori: Yue Liu, Xuchuan Ma, Monica Cazzaniga, Cormac G.M. Gahan, Heidy M.W. den Besten, Tjakko Abee
Pubblicato in: Annual Review of Food Science and Technology, 2024, ISSN 1941-1413
Editore: Annual Reviews Inc.
DOI: 10.1146/annurev-food-111523-121811

Microbiota and metabolome dynamics induced by Shiga toxin-producing E. coli in an in vitro model of an infant’s colon

Autori: Mariana Izquierdo, Deborah O’Sullivan, Ophélie Uriot, Morgane Brun, Claude Durif, Sylvain Denis, Pablo Gallardo, Cormac G M Gahan, Lucie Etienne-Mesmin, Stéphanie Blanquet-Diot, Mauricio J. Farfan
Pubblicato in: Microbial Cell, Numero 12, 2025, Pagina/e 76-92, ISSN 2311-2638
Editore: Shared Science Publishers OG
DOI: 10.15698/mic2025.04.847