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CORDIS - Risultati della ricerca dell’UE
CORDIS

Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate students

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Annual report 2 on exploitation, dissemination and outreach (si apre in una nuova finestra)

Annual report 2 on exploitation dissemination and outreach activities

Manuscript on validation of epigenetic drug targets in rhabdomyosarcoma (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript on novel targets of Ewing sarcoma EMT (si apre in una nuova finestra)

A manuscript on novel targets of Ewing sarcoma EMT will at least be drafted, aiming to eventually be published in a peer-reviewed journal.The manuscript itself will have to remain confidential until it is published, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript describing (i) the landscape of the surfaceome in Medullo, (ii) from this data: functional validation of a novel target (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript on in vitro testing of gdTcells in paediatric cancer (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Annual report 3 on exploitation, dissemination and outreach (si apre in una nuova finestra)

Annual report 3 on exploitation, dissemination and outreach activities

Annual report 1 on exploitation, dissemination and outreach (si apre in una nuova finestra)

Annual report 1 on exploitation dissemination and outreach activities

Manuscript on evidence-based recommendation for efficacious precision medicine/ conventional chemotherapeutic drug combinations in drug development programs for children with leukemia (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript on validation of one targeted immune intervention based on in silico and in vitro analysis (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript on role of chromatin remodeling in neuroblastoma (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Annual report 4 on exploitation, dissemination and outreach (si apre in una nuova finestra)

Annual report 4 on exploitation, dissemination and outreach activities

Manuscript on epigenetic processes driving SMARCB1 /SMARCB4 deficient paediatric tumours (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Manuscript on the diagnostic/prognostic value of exosome-associated miRNAs in sarcomas (si apre in una nuova finestra)

The manuscript itself will have to remain confidential until it is published or shared on bioRxiv, but the deliverable is achieved in the form of a report (on this manuscript). That report can be made public if it does not contain any sensitive information.

Pubblicazioni

Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma (si apre in una nuova finestra)

Autori: Salih Demir, Negin Razizadeh, Emilie Indersie, Sophie Branchereau, Stefano Cairo, Roland Kappler
Pubblicato in: Hepatology Communications, Numero 8, 2024, ISSN 2471-254X
Editore: Hepatology Communications
DOI: 10.1097/hc9.0000000000000378

Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions (si apre in una nuova finestra)

Autori: Joaquín J. Maqueda, Alessandra De Feo, Katia Scotlandi
Pubblicato in: Biomolecules, Numero 14, 2025, Pagina/e 1306, ISSN 2218-273X
Editore: Cancers
DOI: 10.3390/biom14101306

CD99 Modulates the Proteomic Landscape of Ewing Sarcoma Cells and Related Extracellular Vesicles (si apre in una nuova finestra)

Autori: Alessandra De Feo, Marcello Manfredi, Caterina Mancarella, Joaquín J. Maqueda, Veronica De Giorgis, Ymera Pignochino, Marika Sciandra, Camilla Cristalli, Massimo Donadelli, Katia Scotlandi
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, Pagina/e 1588, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031588

Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma (si apre in una nuova finestra)

Autori: Muhammad Rishfi, Simon Krols, Fien Martens, Sarah-Lee Bekaert, Ellen Sanders, Aline Eggermont, Fanny De Vloed, Joshua Robert Goulding, Martijn Risseeuw, Jan Molenaar, Bram De Wilde, Serge Van Calenbergh, Kaat Durinck
Pubblicato in: European Journal of Medicinal Chemistry, Numero 247, 2023, Pagina/e 115033, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2022.115033

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy (si apre in una nuova finestra)

Autori: Judith Wienke, Lindy L. Visser, Waleed M. Kholosy, Kaylee M. Keller, Marta Barisa, Evon Poon, Sophie Munnings-Tomes, Courtney Himsworth, Elizabeth Calton, Ana Rodriguez, Ronald Bernardi, Femke van den Ham, Sander R. van Hooff, Yvette A.H. Matser, Michelle L. Tas, Karin P.S. Langenberg, Philip Lijnzaad, Anne L. Borst, Elisa Zappa, Francisca J. Bergsma, Josephine G.M. Strijker, Bronte M. Verhoeven,
Pubblicato in: Cancer Cell, 2024, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2023.12.008

Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges (si apre in una nuova finestra)

Autori: Elisa Zappa, Alice Vitali, Kathleen Anders, Jan J. Molenaar, Judith Wienke, Annette Künkele
Pubblicato in: European Journal of Cancer, Numero 194, 2024, Pagina/e 113347, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2023.113347

Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy (si apre in una nuova finestra)

Autori: Charles Bobin, Yasmine Iddir, Charlotte Butterworth, Julien Masliah-Planchon, Alexandra Saint-Charles, Angela Bellini, Jaydutt Bhalshankar, Gaelle Pierron, Valérie Combaret, Valéry Attignon, Nicolas André, Nadège Corradini, Benoit Dumont, Ludovic Mansuy, Camille Khanfar, Sebastien Klein, Claire Briandet, Dominique Plantaz, Frederic Millot, Sandrine Thouvenin, Isabelle Aerts, Lee Aymar Ndounga-
Pubblicato in: Clinical Cancer Research, Numero 30, 2024, Pagina/e 3316-3328, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0753

Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression (si apre in una nuova finestra)

Autori: Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, Maki Jami, Kayo Nishitani, Yukimi Arai, Zhize Xiao, Hua Yu, Valentina Lo Re, Véronique Marsaud, Julie Talbot, Bérangère Lombard, Damarys Loew, Maho Jingu, Konstantin Okonechnikov, Masaki Sone, Norio Motohashi, Yoshitsugu Ao
Pubblicato in: Developmental Cell, Numero 59, 2024, Pagina/e 2302-2319.e12, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2024.05.013

Three-Dimensional Modeling of Solid Tumors and Their Microenvironment to Evaluate T Cell Therapy Efficacy In Vitro (si apre in una nuova finestra)

Autori: Ronja Pscheid, Esther Drent, Judith Wienke, Josephine G. M. Strijker, Mark Throsby, Jan J. Molenaar
Pubblicato in: The Journal of Immunology, Numero 211, 2025, Pagina/e 229-240, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2200573

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function (si apre in una nuova finestra)

Autori: Marta Barisa, Elisa Zappa, Henrike Muller, Rivani Shah, Juliane Buhl, Benjamin Draper, Courtney Himsworth, Chantelle Bowers, Sophie Munnings-Tomes, Marilena Nicolaidou, Sonia Morlando, Katie Birley, Clara Leboreiro-Babe, Alice Vitali, Laura Privitera, Kyle O’Sullivan, Ailsa Greppi, Magdalena Buschhaus, Mario Barrera Román, Sam de Blank, Femke van den Ham, Brenna R. van ‘t Veld, Gabrielle Ferr
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.19.580939

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells (si apre in una nuova finestra)

Autori: Rahil Noorizadeh, Barbara Sax, Tahereh Javaheri, Branka Radic Sarikas, Valerie Fock, Maximilian Kauer, Aleksandr Bykov, Veveeyan Suresh, Michaela Schlederer, Lukas Kenner, Gerhard Weber, Wolfgang Mikulits, Florian Halbritter, Richard Moriggl, Heinrich Kovar
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.07.15.603565

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