Photocatalysis as a tool for synthetic organic chemistry

Project Information

PhotoReAct

Grant agreement ID: 956324

DOI

10.3030/956324

Project closed

EC signature date 4 September 2020

Start date 1 January 2021

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 989 767,02

EU contribution

€ 3 989 767,02

Coordinated by

UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Short Movie Script

Short movie about 1 minute about the advantages of photocatalysis for the public Will be distributed via our social media channels

website, twitter and instragram accounts

Social media and website are online and will be maintained by the students.

Press Release

Press release on the goals of PhotoReAct

Other (2)

PhotoReAct T-shirt

Tshirt designed by the students which will be printed for all students beneficiaries and partner organizations

Publication vacancies

online publication

Documents, reports (3)

Program Schools - Part 1

Overview of the program at the winter and summer schools

Photocatalytic method that engages uncharged radical precursors to yield novel building blocks for the synthesis of pharmaceuticals and agrochemicals - Intermediate Evaluation

Intermediate update on the status of the synthetic method

Program Schools - Part 2

Overview of the program at the winter and summer schools

Publications

Peer reviewed articles (29)

Moving Beyond Cyanoarene Thermally Activated Delayed Fluorescence Compounds as Photocatalysts: An Assessment of the Performance of a Pyrimidyl Sulfone Photocatalyst in Comparison to 4CzIPN

Author(s): Megan Amy Bryden; Francis Millward; Tomas Matulaitis; Dongyang Chen; Marco Villa; Andrea Fermi; Sultan Cetin; Paola Ceroni; Eli Zysman-Colman
Published in: The Journal of Organic Chemistry, Issue 16-05-2022, 2022, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.2c01137

Automated One‐Pot Library Synthesis with Aldehydes as Radical Precursors

Author(s): Adrián Luguera Ruiz, Brenda Pijper, Maria Lourdes Linares, Santiago Cañellas, Stefano Protti, Maurizio Fagnoni, Jesús Alcázar
Published in: Chemistry–Methods, Issue 5, 2025, ISSN 2628-9725
Publisher: Wiley
DOI: 10.1002/cmtd.202400029

Organophotocatalyzed C−Si Bond Fragmentation Using Silyl Ethers as Radical Precursors

Author(s): Adrián Luguera Ruiz, Valentina Benazzi, Federico Tucci, Francesca Rizzo, Daniele Merli, Stefano Protti, Maurizio Fagnoni
Published in: Advanced Synthesis & Catalysis, Issue 366, 2024, Page(s) 4132-4138, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202400584

Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

Author(s): Luca Capaldo; Stefano Bonciolini; Antonio Pulcinella; Manuel Nuño; Timothy Noël
Published in: Chemical Science, Issue 28-05-2022, 2022, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc01581a

Photochemical cyclopropanation in aqueous micellar media – experimental and theoretical studies

Author(s): Joseph P. Milton, Adam Milanowski, Martin Andersson, Dorota Gryko
Published in: Chemical Communications, Issue 60, 2024, Page(s) 4483-4486, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cc00828f

Development of an Automated Platform for C(sp3)−C(sp3) Bond Formation via XAT Chemistry

Author(s): Brenda Pijper, Irini Abdiaj, Daniele Leonori, Jesus Alcázar
Published in: ChemCatChem, Issue 21-12-2022, 2022, ISSN 1867-3899
Publisher: Chemistry Europe
DOI: 10.1002/cctc.202201289

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Author(s): Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne A. J. Dubois, Ranganath Gopalakrishnan, Geraldine Masson, Nicola Della Ca’, Stefano Protti, Maurizio Fagnoni, Eli Zysman-Colman, Magnus Johansson, Timothy Noël
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45804-z

Automated self-optimization, intensification, and scale-up of photocatalysis in flow

Author(s): Aidan Slattery, Zhenghui Wen, Pauline Tenblad, Jesús Sanjosé-Orduna, Diego Pintossi, Tim den Hartog, Timothy Noël
Published in: Science, Issue 383, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adj1817

Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

Author(s): Matteo Gasparetto, Balázs Fődi, Gellért Sipos
Published in: Beilstein Journal of Organic Chemistry, Issue 20, 2024, Page(s) 1922-1932, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.20.168

A strategy for ortho-phenylenediamine synthesis via dearomative-rearomative coupling of nitrobenzenes and amines

Author(s): Raquel Sánchez-Bento, Baptiste Roure, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Published in: Chem, Issue 9, 2023, Page(s) 3685-3695, ISSN 2451-9294
Publisher: Elsevier BV
DOI: 10.1016/j.chempr.2023.10.008

Geometric Isomerisation of Bifunctional Alkenyl Fluoride Linchpins: Stereodivergence in Amide and Polyene Bioisostere Synthesis

Author(s): Max Wienhold, Byeongseok Kweon, Calum McLaughlin, Matthias Schmitz, Till J. B. Zähringer, Constantin G. Daniliuc, Christoph Kerzig, Ryan Gilmour
Published in: Angewandte Chemie International Edition, Issue 62, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304150

Regio‐ and Stereo‐Selective Isomerization of Borylated 1,3‐Dienes Enabled by Selective Energy Transfer Catalysis

Author(s): Byeongseok Kweon, Lukas Blank, Julia Soika, Amélia Messara, Constantin G. Daniliuc, Ryan Gilmour
Published in: Angewandte Chemie, Issue 136, 2024, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202404233

Photochemical Functionalization of 4-Diazoisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones and Their 1-Sulfoxide Analogues

Author(s): Joseph P. Milton, Dorota Gryko
Published in: ACS Organic &amp; Inorganic Au, Issue 5, 2025, Page(s) 205-210, ISSN 2694-247X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsorginorgau.5c00017

TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines

Author(s): Matteo Leone, Joseph P. Milton, Dorota Gryko, Luc Neuville, Géraldine Masson
Published in: Chemistry – A European Journal, Issue 30, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400363

Photoredox catalyzed release of carbon-based radicals from 2-substituted-1,3-imidazolidines

Author(s): Adrián Luguera Ruiz, Elena Mariani, Stefano Protti, Maurizio Fagnoni
Published in: Organic Chemistry Frontiers, Issue 11, 2024, Page(s) 661-667, ISSN 2052-4129
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3qo01856c

Light-Induced Access to Carbazole-1,3-dicarbonitrile: A Thermally Activated Delayed Fluorescent (TADF) Photocatalyst for Cobalt-Mediated Allylations

Author(s): Emanuele Pinosa; Elena Bassan; Sultan Cetin; Marco Villa; Simone Potenti; Francesco Calogero; Andrea Gualandi; Andrea Fermi; Paola Ceroni; Pier Giorgio Cozzi
Published in: The Journal of Organic Chemistry, Issue 16-10-2022, 2022, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.2c01825

Fully Automated Flow Protocol for C(sp³)–C(sp³) Bond Formation from Tertiary Amides and Alkyl Halides

Author(s): Brenda Pijper, Raúl Martín, Alberto J. Huertas-Alonso, Maria Lourdes Linares, Enol López, Josep Llaveria, Ángel Díaz-Ortiz, Darren J. Dixon, Antonio de la Hoz, Jesús Alcázar
Published in: Organic Letters, Issue 26, 2024, Page(s) 2724-2728, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.3c01390

A Photochemical Strategy for the Synthesis of Caprolactams via Dearomative Ring Expansion of Nitroarenes

Author(s): Alessandro Ruffoni, Daniele Leonori, Raquel Sánchez-Bento, Linda Bui, Vincent K. Duong
Published in: Synthesis, Issue 56, 2024, Page(s) 2385-2391, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-2288-6944

Photocatalytic Asymmetric Acyl Radical Truce–Smiles Rearrangement for the Synthesis of Enantioenriched α‐Aryl Amides

Author(s): Wei‐Yang Ma, Matteo Leone, Etienne Derat, Pascal Retailleau, Chada Raji Reddy, Luc Neuville, Géraldine Masson
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202408154

Building a photocatalyst library of MR-TADF compounds with tunable excited-state redox potentials

Author(s): Lea Hämmerling, Eli Zysman-Colman
Published in: Chem Catalysis, Issue 4, 2024, Page(s) 101061, ISSN 2667-1093
Publisher: Elsevier BV
DOI: 10.1016/j.checat.2024.101061

Addressing Reproducibility Challenges in High-Throughput Photochemistry

Author(s): Brenda Pijper, Lucía M. Saavedra, Matteo Lanzi, Maialen Alonso, Alberto Fontana, Marta Serrano, José Enrique Gómez, Arjan W. Kleij, Jesús Alcázar, Santiago Cañellas
Published in: JACS Au, Issue 4, 2024, Page(s) 2585-2595, ISSN 2691-3704
Publisher: American Chemical Society (ACS)
DOI: 10.1021/jacsau.4c00312

Selective and scalable oxygenation of heteroatoms using the elements of nature: air, water, and light

Author(s): Damiano Diprima, Hannes Gemoets, Stefano Bonciolini, Koen Van Aken
Published in: Beilstein Journal of Organic Chemistry, Issue 19, 2023, Page(s) 1146-1154, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.19.82

Alkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines

Author(s): Luguera Ruiz, A.; La Mantia, M.; Merli, D.; Protti, S.; Fagnoni, M.
Published in: ACS Catalysis, 2022, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c03768

Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines

Author(s): Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56234-w

Syntheses of new chiral chimeric photo-organocatalysts

Author(s): Jiyaun Lyu; Matteo Leone; Aurélie Claraz; Clémence Allain; Luc Neuville; Géraldine Masson
Published in: RSC Advances, Issue 15-11-2021, 2021, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra06885g

Photocatalytic Alkylation of C(sp ³ )−H Bonds Using Sulfonylhydrazones**

Author(s): Antonio Pulcinella; Stefano Bonciolini; Florian Lukas; Andrea Sorato; Timothy Noël
Published in: Angewandte Chemie International Edition, Issue 17-11-2022, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215374

End-to-End Automated Synthesis of C(sp³)-Enriched Drug-like Molecules <i>via</i> Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Author(s): Irini Abdiaj; Santiago Cañellas; Alejandro Dieguez; Maria Lourdes Linares; Brenda Pijper; Alberto Fontana; Raquel Rodriguez; Andres Trabanco; Eduardo Palao; Jesus Alcázar
Published in: Journal of Medicinal Chemistry, Issue 15-12-2022, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01646

Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes

Author(s): Rory Mykura, Raquel Sánchez-Bento, Esteban Matador, Vincent K. Duong, Ana Varela, Lucrezia Angelini, Rodrigo J. Carbajo, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Published in: Nature Chemistry, Issue 16, 2024, Page(s) 771-779, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-023-01429-1

Multistep and multivectorial assembly line library synthesis in flow

Author(s): Brenda Pijper, Irini Abdiaj, Javier Mazuela, Maria Lourdes Linares, José Enrique Gómez, Raquel Rodriguez, Belén Chaves Arquero, Eduardo Palao, Santiago Cañellas, Jesús Alcázar
Published in: Chem Catalysis, Issue 4, 2024, Page(s) 101118, ISSN 2667-1093
Publisher: Elsevier BV
DOI: 10.1016/j.checat.2024.101118

Other (3)

Synthetic Applications of Photocatalyzed Halogen-Radical Mediated Hydrogen Atom Transfer for C−H Bond Functionalization

Author(s): Stefano Bonciolini, Timothy Noel, Luca Capaldo
Published in: EurJOC, Issue 12-05-2022, 2022, ISSN 1099-0690
Publisher: Wiley-VCH
DOI: 10.1002/ejoc.202200417

Recent Developments in Radical Mediated Synthesis of Organostannanes.

Author(s): Qianhang Ren, Adrian Luguera Ruiz, Maurizio Fagnoni, Stefano Protti, Di Qiu
Published in: Advanced Synthesis &amp; Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202500243

The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation

Author(s): John Marques Dos Santos, David Hall, Biju Basumatary, Megan Bryden, Dongyang Chen, Praveen Choudhary, Thomas Comerford, Ettore Crovini, Andrew Danos, Joydip De, Stefan Diesing, Mahni Fatahi, Máire Griffin, Abhishek Kumar Gupta, Hassan Hafeez, Lea Hämmerling, Emily Hanover, Janine Haug, Tabea Heil, Durai Karthik, Shiv Kumar, Oliver Lee, Haoyang Li, Fabien Lucas, Campbell Frank Ross Mackenzie, Ami
Published in: Chemical Reviews, Issue 124, 2025, Page(s) 13736-14110, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00755

Non-peer reviewed articles (7)

Bio-Inspired Deconjugative Isomerization of Borylated Dienoates

Author(s): Amélia Messara, Byeongseok Kweon, Ferdinand Woge, Constantin Daniliuc, Ryan Gilmour
Published in: ChemRxiv, 2025, ISSN 2573-2293
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-nlmz9

DiICz MR-TADF Emitters as Energy Transfer Photocatalysts

Author(s): Lea Hämmerling, David Hall, Eliott Blin, Tabea Heil, Eli Zysman-Colman
Published in: ChemRxiv, 2025, ISSN 2573-2293
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-gfx9c

Design and Experimental Validation of a Photocatalyst Recommender based on a Large Language Model

Author(s): Francis Millward, Michał Kulczykowski, Jay Badland-Shaw, Sara Szymkuc, Rajan Suraksha, Aniket Kumar Srivastawa, Violaine Manet, Máire Griffin, Megan Bryden, Thomas Comerford, Lea Hämmerling, Aminata Mariko, Bartosz Grzybowski, Eli Zysman-Colman
Published in: ChemRxiv, 2025, ISSN 2573-2293
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-d2cdf

Modular Synthesis of Substituted Lactams via Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow

Author(s): Damiano Diprima, Thomas Terp Paulsen, Antonio Pulcinella, Stefano Bonciolini, Alexis Gabbey, Robin Stuhr, Thomas Poulsen, Timothy Noel
Published in: ChemRxiv, 2025, ISSN 2573-2293
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-6qf93

Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

Author(s): Brenda Pijper, Jesus Alcázar, Fabricio Roman Bisogno, Gabriela Oksdath-Mansilla
Published in: Chem Catalysis, Issue 19-01-2023, 2023, ISSN 2667-1093
Publisher: Cell Press
DOI: 10.1016/j.checat.2022.100488

Challenge and opportunity: The two edges of continuous-flow photochemistry

Author(s): Gabriela Oksdath-Mansilla, Fabricio Roman Bisogno, Brenda Pijper, Jesus Alcázar
Published in: Chem Catalysis, Issue 19-01-2023, 2023, ISSN 2667-1093
Publisher: Cell Press
DOI: 10.1016/j.checat.2022.100487

Dual Nickel-Photoredox Catalyzed Amidine-Arylation Method Mediated By In Situ Generated Triazine Cocatalyst

Author(s): Matteo Gasparetto, Attila Sveiczer, Andrea Fermi, Mounir Raji, Richard J. Fair, Paola Ceroni, Gellért Sipos
Published in: ChemRxiv, 2025, ISSN 2573-2293
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-hlzgd