Photocatalysis as a tool for synthetic organic chemistry

Informazioni relative al progetto

PhotoReAct

ID dell’accordo di sovvenzione: 956324

DOI

10.3030/956324

Progetto chiuso

Data della firma CE 4 Settembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 989 767,02

Contributo UE

€ 3 989 767,02

Coordinato da

UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (3)

Short Movie Script

Short movie about 1 minute about the advantages of photocatalysis for the public Will be distributed via our social media channels

website, twitter and instragram accounts

Social media and website are online and will be maintained by the students.

Press Release

Press release on the goals of PhotoReAct

Other (2)

PhotoReAct T-shirt

Tshirt designed by the students which will be printed for all students beneficiaries and partner organizations

Publication vacancies

online publication

Documents, reports (3)

Program Schools - Part 1

Overview of the program at the winter and summer schools

Photocatalytic method that engages uncharged radical precursors to yield novel building blocks for the synthesis of pharmaceuticals and agrochemicals - Intermediate Evaluation

Intermediate update on the status of the synthetic method

Program Schools - Part 2

Overview of the program at the winter and summer schools

Pubblicazioni

Peer reviewed articles (29)

Moving Beyond Cyanoarene Thermally Activated Delayed Fluorescence Compounds as Photocatalysts: An Assessment of the Performance of a Pyrimidyl Sulfone Photocatalyst in Comparison to 4CzIPN

Autori: Megan Amy Bryden; Francis Millward; Tomas Matulaitis; Dongyang Chen; Marco Villa; Andrea Fermi; Sultan Cetin; Paola Ceroni; Eli Zysman-Colman
Pubblicato in: The Journal of Organic Chemistry, Numero 16-05-2022, 2022, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.2c01137

Automated One‐Pot Library Synthesis with Aldehydes as Radical Precursors

Autori: Adrián Luguera Ruiz, Brenda Pijper, Maria Lourdes Linares, Santiago Cañellas, Stefano Protti, Maurizio Fagnoni, Jesús Alcázar
Pubblicato in: Chemistry–Methods, Numero 5, 2025, ISSN 2628-9725
Editore: Wiley
DOI: 10.1002/cmtd.202400029

Organophotocatalyzed C−Si Bond Fragmentation Using Silyl Ethers as Radical Precursors

Autori: Adrián Luguera Ruiz, Valentina Benazzi, Federico Tucci, Francesca Rizzo, Daniele Merli, Stefano Protti, Maurizio Fagnoni
Pubblicato in: Advanced Synthesis & Catalysis, Numero 366, 2024, Pagina/e 4132-4138, ISSN 1615-4150
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202400584

Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

Autori: Luca Capaldo; Stefano Bonciolini; Antonio Pulcinella; Manuel Nuño; Timothy Noël
Pubblicato in: Chemical Science, Numero 28-05-2022, 2022, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sc01581a

Photochemical cyclopropanation in aqueous micellar media – experimental and theoretical studies

Autori: Joseph P. Milton, Adam Milanowski, Martin Andersson, Dorota Gryko
Pubblicato in: Chemical Communications, Numero 60, 2024, Pagina/e 4483-4486, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d4cc00828f

Development of an Automated Platform for C(sp3)−C(sp3) Bond Formation via XAT Chemistry

Autori: Brenda Pijper, Irini Abdiaj, Daniele Leonori, Jesus Alcázar
Pubblicato in: ChemCatChem, Numero 21-12-2022, 2022, ISSN 1867-3899
Editore: Chemistry Europe
DOI: 10.1002/cctc.202201289

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Autori: Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne A. J. Dubois, Ranganath Gopalakrishnan, Geraldine Masson, Nicola Della Ca’, Stefano Protti, Maurizio Fagnoni, Eli Zysman-Colman, Magnus Johansson, Timothy Noël
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-45804-z

Automated self-optimization, intensification, and scale-up of photocatalysis in flow

Autori: Aidan Slattery, Zhenghui Wen, Pauline Tenblad, Jesús Sanjosé-Orduna, Diego Pintossi, Tim den Hartog, Timothy Noël
Pubblicato in: Science, Numero 383, 2024, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adj1817

Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

Autori: Matteo Gasparetto, Balázs Fődi, Gellért Sipos
Pubblicato in: Beilstein Journal of Organic Chemistry, Numero 20, 2024, Pagina/e 1922-1932, ISSN 1860-5397
Editore: Beilstein-Institut
DOI: 10.3762/bjoc.20.168

A strategy for ortho-phenylenediamine synthesis via dearomative-rearomative coupling of nitrobenzenes and amines

Autori: Raquel Sánchez-Bento, Baptiste Roure, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Pubblicato in: Chem, Numero 9, 2023, Pagina/e 3685-3695, ISSN 2451-9294
Editore: Elsevier BV
DOI: 10.1016/j.chempr.2023.10.008

Geometric Isomerisation of Bifunctional Alkenyl Fluoride Linchpins: Stereodivergence in Amide and Polyene Bioisostere Synthesis

Autori: Max Wienhold, Byeongseok Kweon, Calum McLaughlin, Matthias Schmitz, Till J. B. Zähringer, Constantin G. Daniliuc, Christoph Kerzig, Ryan Gilmour
Pubblicato in: Angewandte Chemie International Edition, Numero 62, 2025, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304150

Regio‐ and Stereo‐Selective Isomerization of Borylated 1,3‐Dienes Enabled by Selective Energy Transfer Catalysis

Autori: Byeongseok Kweon, Lukas Blank, Julia Soika, Amélia Messara, Constantin G. Daniliuc, Ryan Gilmour
Pubblicato in: Angewandte Chemie, Numero 136, 2024, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202404233

Photochemical Functionalization of 4-Diazoisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones and Their 1-Sulfoxide Analogues

Autori: Joseph P. Milton, Dorota Gryko
Pubblicato in: ACS Organic &amp; Inorganic Au, Numero 5, 2025, Pagina/e 205-210, ISSN 2694-247X
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsorginorgau.5c00017

TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines

Autori: Matteo Leone, Joseph P. Milton, Dorota Gryko, Luc Neuville, Géraldine Masson
Pubblicato in: Chemistry – A European Journal, Numero 30, 2024, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400363

Photoredox catalyzed release of carbon-based radicals from 2-substituted-1,3-imidazolidines

Autori: Adrián Luguera Ruiz, Elena Mariani, Stefano Protti, Maurizio Fagnoni
Pubblicato in: Organic Chemistry Frontiers, Numero 11, 2024, Pagina/e 661-667, ISSN 2052-4129
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3qo01856c

Light-Induced Access to Carbazole-1,3-dicarbonitrile: A Thermally Activated Delayed Fluorescent (TADF) Photocatalyst for Cobalt-Mediated Allylations

Autori: Emanuele Pinosa; Elena Bassan; Sultan Cetin; Marco Villa; Simone Potenti; Francesco Calogero; Andrea Gualandi; Andrea Fermi; Paola Ceroni; Pier Giorgio Cozzi
Pubblicato in: The Journal of Organic Chemistry, Numero 16-10-2022, 2022, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.2c01825

Fully Automated Flow Protocol for C(sp³)–C(sp³) Bond Formation from Tertiary Amides and Alkyl Halides

Autori: Brenda Pijper, Raúl Martín, Alberto J. Huertas-Alonso, Maria Lourdes Linares, Enol López, Josep Llaveria, Ángel Díaz-Ortiz, Darren J. Dixon, Antonio de la Hoz, Jesús Alcázar
Pubblicato in: Organic Letters, Numero 26, 2024, Pagina/e 2724-2728, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.3c01390

A Photochemical Strategy for the Synthesis of Caprolactams via Dearomative Ring Expansion of Nitroarenes

Autori: Alessandro Ruffoni, Daniele Leonori, Raquel Sánchez-Bento, Linda Bui, Vincent K. Duong
Pubblicato in: Synthesis, Numero 56, 2024, Pagina/e 2385-2391, ISSN 0039-7881
Editore: Georg Thieme Verlag
DOI: 10.1055/a-2288-6944

Photocatalytic Asymmetric Acyl Radical Truce–Smiles Rearrangement for the Synthesis of Enantioenriched α‐Aryl Amides

Autori: Wei‐Yang Ma, Matteo Leone, Etienne Derat, Pascal Retailleau, Chada Raji Reddy, Luc Neuville, Géraldine Masson
Pubblicato in: Angewandte Chemie International Edition, Numero 63, 2024, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202408154

Building a photocatalyst library of MR-TADF compounds with tunable excited-state redox potentials

Autori: Lea Hämmerling, Eli Zysman-Colman
Pubblicato in: Chem Catalysis, Numero 4, 2024, Pagina/e 101061, ISSN 2667-1093
Editore: Elsevier BV
DOI: 10.1016/j.checat.2024.101061

Addressing Reproducibility Challenges in High-Throughput Photochemistry

Autori: Brenda Pijper, Lucía M. Saavedra, Matteo Lanzi, Maialen Alonso, Alberto Fontana, Marta Serrano, José Enrique Gómez, Arjan W. Kleij, Jesús Alcázar, Santiago Cañellas
Pubblicato in: JACS Au, Numero 4, 2024, Pagina/e 2585-2595, ISSN 2691-3704
Editore: American Chemical Society (ACS)
DOI: 10.1021/jacsau.4c00312

Selective and scalable oxygenation of heteroatoms using the elements of nature: air, water, and light

Autori: Damiano Diprima, Hannes Gemoets, Stefano Bonciolini, Koen Van Aken
Pubblicato in: Beilstein Journal of Organic Chemistry, Numero 19, 2023, Pagina/e 1146-1154, ISSN 1860-5397
Editore: Beilstein-Institut
DOI: 10.3762/bjoc.19.82

Alkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines

Autori: Luguera Ruiz, A.; La Mantia, M.; Merli, D.; Protti, S.; Fagnoni, M.
Pubblicato in: ACS Catalysis, 2022, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.2c03768

Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines

Autori: Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-56234-w

Syntheses of new chiral chimeric photo-organocatalysts

Autori: Jiyaun Lyu; Matteo Leone; Aurélie Claraz; Clémence Allain; Luc Neuville; Géraldine Masson
Pubblicato in: RSC Advances, Numero 15-11-2021, 2021, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/d1ra06885g

Photocatalytic Alkylation of C(sp ³ )−H Bonds Using Sulfonylhydrazones**

Autori: Antonio Pulcinella; Stefano Bonciolini; Florian Lukas; Andrea Sorato; Timothy Noël
Pubblicato in: Angewandte Chemie International Edition, Numero 17-11-2022, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215374

End-to-End Automated Synthesis of C(sp³)-Enriched Drug-like Molecules <i>via</i> Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Autori: Irini Abdiaj; Santiago Cañellas; Alejandro Dieguez; Maria Lourdes Linares; Brenda Pijper; Alberto Fontana; Raquel Rodriguez; Andres Trabanco; Eduardo Palao; Jesus Alcázar
Pubblicato in: Journal of Medicinal Chemistry, Numero 15-12-2022, 2022, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01646

Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes

Autori: Rory Mykura, Raquel Sánchez-Bento, Esteban Matador, Vincent K. Duong, Ana Varela, Lucrezia Angelini, Rodrigo J. Carbajo, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Pubblicato in: Nature Chemistry, Numero 16, 2024, Pagina/e 771-779, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-023-01429-1

Multistep and multivectorial assembly line library synthesis in flow

Autori: Brenda Pijper, Irini Abdiaj, Javier Mazuela, Maria Lourdes Linares, José Enrique Gómez, Raquel Rodriguez, Belén Chaves Arquero, Eduardo Palao, Santiago Cañellas, Jesús Alcázar
Pubblicato in: Chem Catalysis, Numero 4, 2024, Pagina/e 101118, ISSN 2667-1093
Editore: Elsevier BV
DOI: 10.1016/j.checat.2024.101118

Other (3)

Synthetic Applications of Photocatalyzed Halogen-Radical Mediated Hydrogen Atom Transfer for C−H Bond Functionalization

Autori: Stefano Bonciolini, Timothy Noel, Luca Capaldo
Pubblicato in: EurJOC, Numero 12-05-2022, 2022, ISSN 1099-0690
Editore: Wiley-VCH
DOI: 10.1002/ejoc.202200417

Recent Developments in Radical Mediated Synthesis of Organostannanes.

Autori: Qianhang Ren, Adrian Luguera Ruiz, Maurizio Fagnoni, Stefano Protti, Di Qiu
Pubblicato in: Advanced Synthesis &amp; Catalysis, Numero 367, 2025, ISSN 1615-4150
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202500243

The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation

Autori: John Marques Dos Santos, David Hall, Biju Basumatary, Megan Bryden, Dongyang Chen, Praveen Choudhary, Thomas Comerford, Ettore Crovini, Andrew Danos, Joydip De, Stefan Diesing, Mahni Fatahi, Máire Griffin, Abhishek Kumar Gupta, Hassan Hafeez, Lea Hämmerling, Emily Hanover, Janine Haug, Tabea Heil, Durai Karthik, Shiv Kumar, Oliver Lee, Haoyang Li, Fabien Lucas, Campbell Frank Ross Mackenzie, Ami
Pubblicato in: Chemical Reviews, Numero 124, 2025, Pagina/e 13736-14110, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00755

Non-peer reviewed articles (7)

Bio-Inspired Deconjugative Isomerization of Borylated Dienoates

Autori: Amélia Messara, Byeongseok Kweon, Ferdinand Woge, Constantin Daniliuc, Ryan Gilmour
Pubblicato in: ChemRxiv, 2025, ISSN 2573-2293
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-nlmz9

DiICz MR-TADF Emitters as Energy Transfer Photocatalysts

Autori: Lea Hämmerling, David Hall, Eliott Blin, Tabea Heil, Eli Zysman-Colman
Pubblicato in: ChemRxiv, 2025, ISSN 2573-2293
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-gfx9c

Design and Experimental Validation of a Photocatalyst Recommender based on a Large Language Model

Autori: Francis Millward, Michał Kulczykowski, Jay Badland-Shaw, Sara Szymkuc, Rajan Suraksha, Aniket Kumar Srivastawa, Violaine Manet, Máire Griffin, Megan Bryden, Thomas Comerford, Lea Hämmerling, Aminata Mariko, Bartosz Grzybowski, Eli Zysman-Colman
Pubblicato in: ChemRxiv, 2025, ISSN 2573-2293
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-d2cdf

Modular Synthesis of Substituted Lactams via Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow

Autori: Damiano Diprima, Thomas Terp Paulsen, Antonio Pulcinella, Stefano Bonciolini, Alexis Gabbey, Robin Stuhr, Thomas Poulsen, Timothy Noel
Pubblicato in: ChemRxiv, 2025, ISSN 2573-2293
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-6qf93

Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

Autori: Brenda Pijper, Jesus Alcázar, Fabricio Roman Bisogno, Gabriela Oksdath-Mansilla
Pubblicato in: Chem Catalysis, Numero 19-01-2023, 2023, ISSN 2667-1093
Editore: Cell Press
DOI: 10.1016/j.checat.2022.100488

Challenge and opportunity: The two edges of continuous-flow photochemistry

Autori: Gabriela Oksdath-Mansilla, Fabricio Roman Bisogno, Brenda Pijper, Jesus Alcázar
Pubblicato in: Chem Catalysis, Numero 19-01-2023, 2023, ISSN 2667-1093
Editore: Cell Press
DOI: 10.1016/j.checat.2022.100487

Dual Nickel-Photoredox Catalyzed Amidine-Arylation Method Mediated By In Situ Generated Triazine Cocatalyst

Autori: Matteo Gasparetto, Attila Sveiczer, Andrea Fermi, Mounir Raji, Richard J. Fair, Paola Ceroni, Gellért Sipos
Pubblicato in: ChemRxiv, 2025, ISSN 2573-2293
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-hlzgd